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Volumn 302, Issue 9, 2012, Pages

Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults

Author keywords

L type amino acid transporter; Mammalian target of rapamycin; Physical inactivity

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID TRANSPORTER; ESSENTIAL AMINO ACID; L TYPE AMINO ACID TRANSPORTER 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; PHENYLALANINE; PROTEIN KINASE B; PROTEIN S6; S6 KINASE; SERINE; SODIUM COUPLED NEUTRAL AMINO ACID TRANSPORTER 2; THREONINE; TRACER; UNCLASSIFIED DRUG;

EID: 84860506912     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00603.2011     Document Type: Article
Times cited : (177)

References (47)
  • 1
    • 34447121352 scopus 로고    scopus 로고
    • Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids
    • Adams CM. Role of the transcription factor ATF4 in the anabolic actions of insulin and the anti-anabolic actions of glucocorticoids. J Biol Chem 282: 16744-16753, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 16744-16753
    • Adams, C.M.1
  • 2
    • 69049097269 scopus 로고    scopus 로고
    • Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes
    • Baird FE, Bett KJ, MacLean C, Tee AR, Hundal HS, Taylor PM. Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes. Am J Physiol Endocrinol Metab 297: E822-E829, 2009.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Baird, F.E.1    Bett, K.J.2    Maclean, C.3    Tee, A.R.4    Hundal, H.S.5    Taylor, P.M.6
  • 3
    • 0027293210 scopus 로고
    • Changes in lower limb muscle cross-sectional area and tissue fluid volume after transition from standing to supine
    • Berg HE, Tedner B, Tesch PA. Changes in lower limb muscle cross-sectional area and tissue fluid volume after transition from standing to supine. Acta Physiol Scand 148: 379-385, 1993.
    • (1993) Acta Physiol Scand , vol.148 , pp. 379-385
    • Berg, H.E.1    Tedner, B.2    Tesch, P.A.3
  • 5
    • 0026892585 scopus 로고
    • The determination of low d5-phenylalanine enrichment (0.002-009 atom per-cent excess), after conversion to phenylethylamine, in relation to protein turnover studies by gas chromatography/electron ionization mass spec-trometry
    • Calder AG, Anderson SE, Grant I, McNurlan MA, Garlick PJ. The determination of low d5-phenylalanine enrichment (0.002-009 atom per-cent excess), after conversion to phenylethylamine, in relation to protein turnover studies by gas chromatography/electron ionization mass spec-trometry. Rapid Commun Mass spectrom 6: 421-424, 1992.
    • (1992) Rapid Commun Mass Spectrom , vol.6 , pp. 421-424
    • Calder, A.G.1    Anderson, S.E.2    Grant, I.3    McNurlan, M.A.4    Garlick, P.J.5
  • 6
    • 33845974443 scopus 로고    scopus 로고
    • Using step activity monitoring to characterize ambulatory activity in community-dwelling older adults
    • Cavanaugh JT, Coleman KL, Gaines JM, Laing L, Morey MC. Using step activity monitoring to characterize ambulatory activity in community-dwelling older adults. J Am Geriatr Soc 55: 120-124, 2007.
    • (2007) J Am Geriatr Soc , vol.55 , pp. 120-124
    • Cavanaugh, J.T.1    Coleman, K.L.2    Gaines, J.M.3    Laing, L.4    Morey, M.C.5
  • 9
    • 33749351995 scopus 로고    scopus 로고
    • Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle
    • Dreyer HC, Fujita S, Cadenas JG, Chinkes DL, Volpi E, Rasmussen BB. Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol 576: 613-624, 2006.
    • (2006) J Physiol , vol.576 , pp. 613-624
    • Dreyer, H.C.1    Fujita, S.2    Cadenas, J.G.3    Chinkes, D.L.4    Volpi, E.5    Rasmussen, B.B.6
  • 10
    • 66149097065 scopus 로고    scopus 로고
    • Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling
    • Drummond MJ, Dreyer HC, Fry CS, Glynn EL, Rasmussen BB. Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. J Appl Physiol 106: 1374-1384, 2009.
    • (2009) J Appl Physiol , vol.106 , pp. 1374-1384
    • Drummond, M.J.1    Dreyer, H.C.2    Fry, C.S.3    Glynn, E.L.4    Rasmussen, B.B.5
  • 15
    • 78649649456 scopus 로고    scopus 로고
    • Early ambulation and length of stay in older adults hospitalized for acute illness
    • Fisher SR, Kuo YF, Graham JE, Ottenbacher KJ, Ostir GV. Early ambulation and length of stay in older adults hospitalized for acute illness. Arch Intern Med 170: 1942-1943, 2010.
    • (2010) Arch Intern Med , vol.170 , pp. 1942-1943
    • Fisher, S.R.1    Kuo, Y.F.2    Graham, J.E.3    Ottenbacher, K.J.4    Ostir, G.V.5
  • 18
    • 4043114123 scopus 로고    scopus 로고
    • The deleterious effects of bed rest among community-living older persons
    • Gill TM, Allore H, Guo Z. The deleterious effects of bed rest among community-living older persons. J Gerontol A Biol Sci Med Sci 59: 755-761, 2004.
    • (2004) J Gerontol a Biol Sci Med Sci , vol.59 , pp. 755-761
    • Gill, T.M.1    Allore, H.2    Guo, Z.3
  • 19
    • 57649232182 scopus 로고    scopus 로고
    • Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion
    • Glover EI, Phillips SM, Oates BR, Tang JE, Tarnopolsky MA, Selby A, Smith K, Rennie MJ. Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion. J Physiol 586: 6049-6061, 2008.
    • (2008) J Physiol , vol.586 , pp. 6049-6061
    • Glover, E.I.1    Phillips, S.M.2    Oates, B.R.3    Tang, J.E.4    Tarnopolsky, M.A.5    Selby, A.6    Smith, K.7    Rennie, M.J.8
  • 20
    • 77954752950 scopus 로고    scopus 로고
    • Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy
    • Glover EI, Yasuda N, Tarnopolsky MA, Abadi A, Phillips SM. Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy. Appl Physiol Nutr Metab 35: 125-133, 2010.
    • (2010) Appl Physiol Nutr Metab , vol.35 , pp. 125-133
    • Glover, E.I.1    Yasuda, N.2    Tarnopolsky, M.A.3    Abadi, A.4    Phillips, S.M.5
  • 21
    • 78149245600 scopus 로고    scopus 로고
    • Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women
    • Glynn EL, Fry CS, Drummond MJ, Timmerman KL, Dhanani S, Volpi E, Rasmussen BB. Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr 140: 1970-1976, 2010.
    • (2010) J Nutr , vol.140 , pp. 1970-1976
    • Glynn, E.L.1    Fry, C.S.2    Drummond, M.J.3    Timmerman, K.L.4    Dhanani, S.5    Volpi, E.6    Rasmussen, B.B.7
  • 22
    • 9444290436 scopus 로고    scopus 로고
    • Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans
    • Guillet C, Prod'homme M, Balage M, Gachon P, Giraudet C, Morin L, Grizard J, Boirie Y. Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB j 18: 1586-1587, 2004.
    • (2004) FASEB J , vol.18 , pp. 1586-1587
    • Guillet, C.1    Prod'homme, M.2    Balage, M.3    Gachon, P.4    Giraudet, C.5    Morin, L.6    Grizard, J.7    Boirie, Y.8
  • 24
    • 78651329227 scopus 로고    scopus 로고
    • Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining
    • Hvid L, Aagaard P, Justesen L, Bayer ML, Andersen JL, Ortenblad N, Kjaer M, Suetta C. Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining. J Appl Physiol 109: 1628-1634, 2010.
    • (2010) J Appl Physiol , vol.109 , pp. 1628-1634
    • Hvid, L.1    Aagaard, P.2    Justesen, L.3    Bayer, M.L.4    Andersen, J.L.5    Ortenblad, N.6    Kjaer, M.7    Suetta, C.8
  • 25
    • 14644417747 scopus 로고    scopus 로고
    • Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells
    • Hyde R, Hajduch E, Powell DJ, Taylor PM, Hundal HS. Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cells. FASEB J 19: 461-463, 2005.
    • (2005) FASEB J , vol.19 , pp. 461-463
    • Hyde, R.1    Hajduch, E.2    Powell, D.J.3    Taylor, P.M.4    Hundal, H.S.5
  • 26
    • 0037134492 scopus 로고    scopus 로고
    • Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells
    • Hyde R, Peyrollier K, Hundal HS. Insulin promotes the cell surface recruitment of the SAT2/ATA2 system A amino acid transporter from an endosomal compartment in skeletal muscle cells. J Biol Chem 277: 13628-13634, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 13628-13634
    • Hyde, R.1    Peyrollier, K.2    Hundal, H.S.3
  • 27
    • 31544482447 scopus 로고    scopus 로고
    • Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids
    • Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr 82: 1065-1073, 2005.
    • (2005) Am J Clin Nutr , vol.82 , pp. 1065-1073
    • Katsanos, C.S.1    Kobayashi, H.2    Sheffield-Moore, M.3    Aarsland, A.4    Wolfe, R.R.5
  • 28
    • 33745853476 scopus 로고    scopus 로고
    • A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
    • Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 291: E381-E387, 2006.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Katsanos, C.S.1    Kobayashi, H.2    Sheffield-Moore, M.3    Aarsland, A.4    Wolfe, R.R.5
  • 29
    • 0036720367 scopus 로고    scopus 로고
    • Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise
    • Kimball SR, Farrell PA, Jefferson LS. Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise. J Appl Physiol 93: 1168-1180, 2002.
    • (2002) J Appl Physiol , vol.93 , pp. 1168-1180
    • Kimball, S.R.1    Farrell, P.A.2    Jefferson, L.S.3
  • 30
    • 34247534568 scopus 로고    scopus 로고
    • Effect of 10 days of bed rest on skeletal muscle in healthy older adults
    • Kortebein P, Ferrando A, Lombeida J, Wolfe R, Evans WJ. Effect of 10 days of bed rest on skeletal muscle in healthy older adults. JAMA 297: 1772-1774, 2007.
    • (2007) JAMA , vol.297 , pp. 1772-1774
    • Kortebein, P.1    Ferrando, A.2    Lombeida, J.3    Wolfe, R.4    Evans, W.J.5
  • 31
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 32
    • 50349087339 scopus 로고    scopus 로고
    • Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake
    • Malmberg SE, Adams CM. Insulin signaling and the general amino acid control response. Two distinct pathways to amino acid synthesis and uptake. J Biol Chem 283: 19229-19234, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 19229-19234
    • Malmberg, S.E.1    Adams, C.M.2
  • 35
    • 0036310982 scopus 로고    scopus 로고
    • The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
    • Peng T, Golub TR, Sabatini DM. The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol Cell Biol 22: 5575-5584, 2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 5575-5584
    • Peng, T.1    Golub, T.R.2    Sabatini, D.M.3
  • 36
    • 0034283186 scopus 로고    scopus 로고
    • L-Leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: Evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport
    • Peyrollier K, Hajduch E, Blair AS, Hyde R, Hundal HS. L-Leucine availability regulates phosphatidylinositol 3-kinase, p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of system A amino acid transport. Biochem J 350: 361-368, 2000.
    • (2000) Biochem J , vol.350 , pp. 361-368
    • Peyrollier, K.1    Hajduch, E.2    Blair, A.S.3    Hyde, R.4    Hundal, H.S.5
  • 38
    • 78549272025 scopus 로고    scopus 로고
    • Forty-eight hours of unloading and 24 h of reloading lead to changes in global gene expression patterns related to ubiquitination and oxidative stress in humans
    • Reich KA, Chen YW, Thompson PD, Hoffman EP, Clarkson PM. Forty-eight hours of unloading and 24 h of reloading lead to changes in global gene expression patterns related to ubiquitination and oxidative stress in humans. J Appl Physiol 109: 1404-1415, 2010.
    • (2010) J Appl Physiol , vol.109 , pp. 1404-1415
    • Reich, K.A.1    Chen, Y.W.2    Thompson, P.D.3    Hoffman, E.P.4    Clarkson, P.M.5
  • 39
    • 58349106216 scopus 로고    scopus 로고
    • Regulation of placental amino acid transporter activity by mammalian target of rapamy-cin
    • Roos S, Kanai Y, Prasad PD, Powell TL, Jansson T. Regulation of placental amino acid transporter activity by mammalian target of rapamy-cin. Am J Physiol Cell Physiol 296: C142-C150, 2009.
    • (2009) Am J Physiol Cell Physiol , vol.296
    • Roos, S.1    Kanai, Y.2    Prasad, P.D.3    Powell, T.L.4    Jansson, T.5
  • 40
    • 70349246381 scopus 로고    scopus 로고
    • Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling
    • Roos S, Lagerlof O, Wennergren M, Powell TL, Jansson T. Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling. Am J Physiol Cell Physiol 297: C723-C731, 2009.
    • (2009) Am J Physiol Cell Physiol , vol.297
    • Roos, S.1    Lagerlof, O.2    Wennergren, M.3    Powell, T.L.4    Jansson, T.5
  • 43
    • 67650079061 scopus 로고    scopus 로고
    • Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity
    • Symons TB, Sheffield-Moore M, Chinkes DL, Ferrando AA, Paddon-Jones D. Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity. J Appl Physiol 107: 34-38, 2009.
    • (2009) J Appl Physiol , vol.107 , pp. 34-38
    • Symons, T.B.1    Sheffield-Moore, M.2    Chinkes, D.L.3    Ferrando, A.A.4    Paddon-Jones, D.5
  • 44
    • 68849100887 scopus 로고    scopus 로고
    • A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects
    • Symons TB, Sheffield-Moore M, Wolfe RR, Paddon-Jones D. A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. J Am Dietetic Assoc 109: 1582-1586, 2009.
    • (2009) J Am Dietetic Assoc , vol.109 , pp. 1582-1586
    • Symons, T.B.1    Sheffield-Moore, M.2    Wolfe, R.R.3    Paddon-Jones, D.4
  • 46
    • 0034485454 scopus 로고    scopus 로고
    • The response of muscle protein anabolism to combined hyperaminoacidemia and glucoseinduced hyperinsulinemia is impaired in the elderly
    • Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacidemia and glucoseinduced hyperinsulinemia is impaired in the elderly. J Cclin Endocrinol Metab 85: 4481-4490, 2000.
    • (2000) J Cclin Endocrinol Metab , vol.85 , pp. 4481-4490
    • Volpi, E.1    Mittendorfer, B.2    Rasmussen, B.B.3    Wolfe, R.R.4


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