GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance

Diabetes

Volumn 61, Issue 5, 2012, Pages 1090-1099

  Biensø, Rasmus S ^a   Ringholm, Stine ^a   Kiilerich, Kristian ^a   Aachmann Andersen, Niels Jacob ^a,b   Krogh Madsen, Rikke ^a,b   Guerra, Borja ^c   Plomgaard, Peter ^a,b   Van Hall, Gerrit ^a,b   Treebak, Jonas T ^a   Saltin, Bengt ^a,b   Lundby, Carsten ^a,b   Calbet, Jose A L ^c   Pilegaard, Henriette ^a   Wojtaszewski, Jørgen F P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; CELL PROTEIN; GLUCOSE; GLUCOSE TRANSPORTER 4; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; HEXOKINASE; HEXOKINASE ISOENZYME; INSULIN; PALMITIC ACID; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN TBC1D4; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BED REST; BLOOD ANALYSIS; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); ENZYME ACTIVATION; ENZYME ACTIVITY; FEMORAL ARTERY; FEMORAL VEIN; GLUCOSE ASSAY; GLUCOSE INFUSION; HUMAN; IMMOBILIZATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LEG EXERCISE; MALE; MUSCLE BIOPSY; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE;

BED REST; BENZODIAZEPINONES; BLOOD GLUCOSE; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; GLYCOGEN; GLYCOGEN SYNTHASE; GTPASE-ACTIVATING PROTEINS; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; PALMITATES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84860577206     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0884     Document Type: Article

References (50)

1. Venables MC, Jeukendrup AE. Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus. Diabetes Metab Res Rev 2009;25(Suppl. 1):S18-S23
2. Chen YD, Golay A, Swislocki AL, Reaven GM. Resistance to insulin suppression of plasma free fatty acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1987;64:17-21 (Pubitemid 17015871)
3. DeFronzo RA, Ferrannini E, Sato Y, Felig P, Wahren J. Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Invest 1981;68:1468-1474 (Pubitemid 12194401)
4. King DS, Dalsky GP, ClutterWE, et al. Effects of exercise and lack of exercise on insulin sensitivity and responsiveness. J Appl Physiol 1988;64:1942-1946
5. Mikines KJ, Richter EA, Dela F, Galbo H. Seven days of bed rest decrease insulin action on glucose uptake in leg and whole body. J Appl Physiol 1991;70:1245-1254
6. Richter EA, Kiens B, Mizuno M, Strange S. Insulin action in human thighs after one-legged immobilization. J Appl Physiol 1989;67:19-23 (Pubitemid 19196442)
7. Vind BF, Pehmoller C, Treebak JT, et al. Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training. Diabetologia 2010;54:157-167
8. Zierath JR, He L, Gumà A, Odegoard Wahlström E, Klip A, Wallberg-Henriksson H. Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia 1996;39:1180-1189
9. Højlund K, Staehr P, Hansen BF, et al. Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes. Diabetes 2003;52:1393-1402 (Pubitemid 36666193)
10. Højlund K, Glintborg D, Andersen NR, et al. Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment. Diabetes 2008;57:357-366
11. Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H. Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes 2005;54:1692-1697 (Pubitemid 40770759)
12. Højlund K, Birk JB, Klein DK, et al. Dysregulation of glycogen synthase COOH- and NH2-terminal phosphorylation by insulin in obesity and type 2 diabetes mellitus. J Clin Endocrinol Metab 2009;94:4547-4556
13. Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, et al. Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects. Metabolism 2004;53:1233-1242 (Pubitemid 39140763)
14. Frøsig C, Rose AJ, Treebak JT, Kiens B, Richter EA, Wojtaszewski JF. Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160. Diabetes 2007;56:2093-2102 (Pubitemid 47195824)
15. O'Gorman DJ, Karlsson HK, McQuaid S, et al. Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes. Diabetologia 2006;49:2983-2992 (Pubitemid 44730302)
16. Mikines KJ, Dela F, Tronier B, Galbo H. Effect of 7 days of bed rest on dose-response relation between plasma glucose and insulin secretion. Am J Physiol 1989;257:E43-E48
17. Richter EA, Mikines KJ, Galbo H, Kiens B. Effect of exercise on insulin action in human skeletal muscle. J Appl Physiol 1989;66:876-885 (Pubitemid 19072944)
18. Dela F, Mikines KJ, von Linstow M, Secher NH, Galbo H. Effect of training on insulin-mediated glucose uptake in human muscle. Am J Physiol 1992; 263:E1134-E1143 (Pubitemid 23024458)
19. Mikines KJ, Sonne B, Farrell PA, Tronier B, Galbo H. Effect of physical exercise on sensitivity and responsiveness to insulin in humans. Am J Physiol 1988;254:E248-E259
20. Hansen PA, Nolte LA, Chen MM, Holloszy JO. Increased GLUT-4 translocation mediates enhanced insulin sensitivity of muscle glucose transport after exercise. J Appl Physiol 1998;85:1218-1222 (Pubitemid 28465044)
21. Holloszy JO. Exercise-induced increase in muscle insulin sensitivity. J Appl Physiol 2005;99:338-343
22. Wojtaszewski JF, Hansen BF, Gade, et al. Insulin signaling and insulin sensitivity after exercise in human skeletal muscle. Diabetes 2000;49: 325-331 (Pubitemid 30131776)
23. Wojtaszewski JF, Hansen BF, Kiens B, Richter EA. Insulin signaling in human skeletal muscle: time course and effect of exercise. Diabetes 1997; 46:1775-1781 (Pubitemid 27456410)
24. Arias EB, Kim J, Funai K, Cartee GD. Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle. Am J Physiol Endocrinol Metab 2007;292:E1191-E1200 (Pubitemid 46536520)
25. Treebak JT, Frøsig C, Pehmøller C, et al. Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle. Diabetologia 2009;52:891-900
26. Howlett KF, Mathews A, Garnham A, Sakamoto K. The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle. Am J Physiol Endocrinol Metab 2008;294:E401-E407 (Pubitemid 351231468)
27. Wojtaszewski JF, Nielsen P, Kiens B, Richter EA. Regulation of glycogen synthase kinase-3 in human skeletal muscle: effects of food intake and bicycle exercise. Diabetes 2001;50:265-269 (Pubitemid 32127281)
28. Pilegaard H, Saltin B, Neufer PD. Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J Physiol 2003;546:851-858 (Pubitemid 36204518)
29. Bergstrom J. Muscle electrolytes in man. Scand J Clin Lab Invest 1962;14 (Suppl. 68):1-110
30. Van Hall G, Bülow J, Sacchetti M, Al Mulla N, Lyngso D, Simonsen L. Regional fat metabolism in human splanchnic and adipose tissues; the effect of exercise. J Physiol 2002;543:1033-1046
31. Passonneau JV, Lauderdale VR. A comparison of three methods of glycogen measurement in tissues. Anal Biochem 1974;60:405-412
32. Lowry OH, Passonneau JV. A Flexible System of Enzymatic Analysis. New York, Academic Press, 1972
33. Thomas JA, Schlender KK, Larner J. A rapid filter paper assay for UDP-glucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose. Anal Biochem 1968;25:486-499
34. Prats C, Helge JW, Nordby P, et al. Dual regulation of muscle glycogen synthase during exercise by activation and compartmentalization. J Biol Chem 2009;284:15692-15700
35. Kiilerich K, Ringholm S, Bienso RS. Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest. J Appl Physiol 2011;111:751-757
36. Sonne MP, Alibegovic AC, Højbjerre L, Vaag A, Stallknecht B, Dela F. Effect of 10 days of bed rest on metabolic and vascular insulin action: a study in individuals at risk for type 2 diabetes. J Appl Physiol 2010;108: 830-837
37. Newsom SA, Schenk S, Thomas KM, et al. Energy deficit after exercise augments lipid mobilization but does not contribute to the exercise-induced increase in insulin sensitivity. J Appl Physiol 2010;108:554-560
38. Vukovich MD, Arciero PJ, Kohrt WM, Racette SB, Hansen PA, Holloszy JO. Changes in insulin action and GLUT-4 with 6 days of inactivity in endurance runners. J Appl Physiol 1996;80:240-244 (Pubitemid 26034868)
39. Host HH, Hansen PA, Nolte LA, Chen MM, Holloszy JO. Rapid reversal of adaptive increases in muscle GLUT-4 and glucose transport capacity after training cessation. J Appl Physiol 1998;84:798-802 (Pubitemid 28110604)
40. Garvey WT, Maianu L, Zhu JH, Brechtel-Hook G, Wallace P, Baron AD. Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. J Clin Invest 1998;101:2377-2386 (Pubitemid 28270432)
41. Pilegaard H, Ordway GA, Saltin B, Neufer PD. Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol Endocrinol Metab 2000;279:E806-E814
42. Williams RS, Neufer PD. Regulation of gene expression in skeletal muscle by contractile activity. In The Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD, American Physiological Society, 1996, p. 1124-1150
43. Krogh-Madsen R, Thyfault JP, Broholm C, et al. A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity. J Appl Physiol 2010;108:1034-1040
44. Thong FS, Dugani CB, Klip A. Turning signals on and off: GLUT4 traffic in the insulin-signaling highway. Physiology (Bethesda) 2005;20:271-284 (Pubitemid 41215201)
45. Chasiotis D, Sahlin K, Hultman E. Regulation of glycogenolysis in human muscle in response to epinephrine infusion. J Appl Physiol 1983;54:45-50 (Pubitemid 13110549)
46. Cohen P. The structure and regulation of protein phosphatases. Annu Rev Biochem 1989;58:453-508 (Pubitemid 19172978)
47. Nielsen JN, Wojtaszewski JF. Regulation of glycogen synthase activity and phosphorylation by exercise. Proc Nutr Soc 2004;63:233-237 (Pubitemid 38787471)
48. Jensen J, Jebens E, Brennesvik EO, et al. Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling. Am J Physiol Endocrinol Metab 2006;290:E154-E162
49. Nielsen JN, Derave W, Kristiansen S, Ralston E, Ploug T, Richter EA. Glycogen synthase localization and activity in rat skeletal muscle is strongly dependent on glycogen content. J Physiol 2001;531:757-769 (Pubitemid 32243753)
50. Danforth WH. Glycogen synthetase activity in skeletal muscle. Interconversion of two forms and control of glycogen synthesis. J Biol Chem 1965;240:588-593