Neurotoxicity of cancer chemotherapy

Neural Regeneration Research

Volumn 8, Issue 17, 2013, Pages 1606-1614

  Yang, Mi Young ^a,b   Moon, Chang Jong ^a  

^a Chonnam National University   (South Korea)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Behavioral dysfunction; Chemotherapy; Grants supported paper; Hippocampal dysfunction; Memory deficit; Mood disorder; Neural regeneration; Neurodegeneration; Neurogenesis; Neuron; Neuroplasticity; Neuroregeneration; Neurotoxicity; Reviews

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; FLUOROURACIL; IFOSFAMIDE; METHOTREXATE; PACLITAXEL; TAU PROTEIN; THIOTEPA; VINBLASTINE;

ANIMAL BEHAVIOR; ARTICLE; BLOOD BRAIN BARRIER; CANCER CHEMOTHERAPY; CELL DIFFERENTIATION; COGNITIVE DEFECT; CYTOTOXICITY; DEPRESSION; DRUG INDUCED DISEASE; HIPPOCAMPUS; MEMORY DISORDER; NEOPLASM; NERVE CELL LESION; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; PREVALENCE; SYNAPTIC TRANSMISSION;

EID: 84889796658     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2013.17.009     Document Type: Article

References (80)

1. Dietrich J, Monje M, Wefel J, et al. Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy. Oncologist. 2008;13(12):1285-1295.
2. Jaggi AS, Singh N. Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy. Toxicology. 2012;291(1-3):1-9.
3. Vardy J, Tannock I. Cognitive function after chemotherapy in adults with solid tumours. Crit Rev Oncol Hematol. 2007; 63(3):183-202.
4. Barton D, Loprinzi C. Novel approaches to preventing chemotherapy-induced cognitive dysfunction in breast cancer: the art of the possible. Clin Breast Cancer. 2002; 3(Suppl 3):S121-127.
5. Abrey LE. The impact of chemotherapy on cognitive outcomes in adults with primary brain tumors. J Neurooncol. 2012;108(2):285-290.
6. Galica J, Rajacich D, Kane D, et al. The impact of chemotherapy-induced cognitive impairment on the psychosocial adjustment of patients with nonmetastatic colorectal cancer. Clin J Oncol Nurs. 2012;16(2):163-169.
7. Jansen C, Miaskowski C, Dodd M, et al. Potential mechanisms for chemotherapy-induced impairments in cognitive function. Oncol Nurs Forum. 2005;32(6): 1151-1163.
8. Verstappen CC, Heimans JJ, Hoekman K, et al. Neurotoxic complications of chemotherapy in patients with cancer: clinical signs and optimal management. Drugs. 2003;63(15):1549-1563.
9. Kempermann G, Kuhn HG, Gage FH. Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc Natl Acad Sci U S A. 1997;94(19):10409-10414.
10. Mustafa S, Walker A, Bennett G, et al. 5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus. Eur J Neurosci. 2008;28(2):323-330.
11. ElBeltagy M, Mustafa S, Umka J, et al. Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil. Behav Brain Res. 2010;208(1):112-117.
12. Lee GD, Longo DL, Wang Y, et al. Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res. 2006; 12(1):198-205.
13. Mignone RG, Weber ET. Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA. Brain Res. 2006; 1111(1):26-29.
14. Briones TL, Woods J. Chemotherapy-induced cognitive impairment is associated with decreases in cell proliferation and histone modifications. BMC Neurosci. 2011;12:124.
15. Winocur G, Vardy J, Binns MA, et al. The effects of the anti-cancer drugs, methotrexate and 5-fluorouracil, on cognitive function in mice. Pharmacol Biochem Behav. 2006;85(1):66-75.
16. Rzeski W, Pruskil S, Macke A, et al. Anticancer agents are potent neurotoxins in vitro and in vivo. Ann Neurol. 2004; 56(3):351-360.
17. James SE, Burden H, Burgess R, et al. Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants. Neurotoxicology. 2008;29(4):605-612.
18. Yang M, Kim JS, Song MS, et al. Cyclophosphamide impairs hippocampus-dependent learning and memory in adult mice: Possible involvement of hippocampal neurogenesis in chemotherapy-induced memory deficits. Neurobiol Learn Mem. 2010;93(4):487-494.
19. Kitazawa H, Numakawa T, Adachi N, et al. Cyclophosphamide promotes cell survival via activation of intracellular signaling in cultured cortical neurons. Neurosci Lett. 2010;470(2):139-144.
20. Christie LA, Acharya MM, Parihar VK, et al. Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy. Clin Cancer Res. 2012; 18(7):1954-1965.
21. Lopes MA, Meisel A, Dirnagl U, et al. Doxorubicin induces biphasic neurotoxicity to rat cortical neurons. Neurotoxicology. 2008;29(2):286-293.
22. Liedke PE, Reolon GK, Kilpp B, et al. Systemic administration of doxorubicin impairs aversively motivated memory in rats. Pharmacol Biochem Behav. 2009;94(2): 239-243.
23. Lopes MA, Meisel A, Carvalho FD, et al. Neuronal nitric oxide synthase is a key factor in doxorubicin-induced toxicity to rat-isolated cortical neurons. Neurotox Res. 2011;19(1):14-22.
24. Chatton JY, Idle JR, Vagbo CB, et al. Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/ kainate receptors and induce cellular acidification in mouse cortical neurons. J Pharmacol Exp Ther. 2001; 299(3):1161-1168.
25. Gilbert MR, Harding BL, Grossman SA. Methotrexate neurotoxicity: in vitro studies using cerebellar explants from rats. Cancer Res. 1989;49(9):2502-2505.
26. Madhyastha S, Somayaji SN, Rao MS, et al. Hippocampal brain amines in methotrexate-induced learning and memory deficit. Can J Physiol Pharmacol. 2002;80(11):1076-1084.
27. Yoon SY, Choi HI, Choi JE, et al. Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron. Biochem Biophys Res Commun. 2007;363(3): 811-816.
28. Seigers R, Schagen SB, Beerling W, et al. Long-lasting suppression of hippocampal cell proliferation and impaired cognitive performance by methotrexate in the rat. Behav Brain Res. 2008;186(2):168-175.
29. Gandal MJ, Ehrlichman RS, Rudnick ND, et al. A novel electrophysiological model of chemotherapy-induced cognitive impairments in mice. Neuroscience. 2008;157(1): 95-104.
30. Seigers R, Schagen SB, Coppens CM, et al. Methotrexate decreases hippocampal cell proliferation and induces memory deficits in rats. Behav Brain Res. 2009;201(2):279-284.
31. Li Y, Vijayanathan V, Gulinello ME, et al. Systemic methotrexate induces spatial memory deficits and depletes cerebrospinal fluid folate in rats. Pharmacol Biochem Behav. 2010;94(3):454-463.
32. Seigers R, Timmermans J, van der Horn HJ, et al. Methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release. Behav Brain Res. 2010;207(2):265-272.
33. Seigers R, Pourtau L, Schagen SB, et al. Inhibition of hippocampal cell proliferation by methotrexate in rats is not potentiated by the presence of a tumor. Brain Res Bull. 2010;81(4-5):472-476.
34. Yang M, Kim JS, Kim J, et al. Neurotoxicity of methotrexate to hippocampal cells in vivo and in vitro. Biochem Pharmacol. 2011;82(1):72-80.
35. Yang M, Kim J, Kim SH, et al. Temporal profiles of synaptic plasticity-related signals in adult mouse hippocampus with methotrexate treatment. Neural Regen Res. 2012;7(21):1651-1658.
36. Yang M, Kim JS, Kim J, et al. Acute treatment with methotrexate induces hippocampal dysfunction in a mouse model of breast cancer. Brain Res Bull. 2012;89(1-2):50-56.
37. Temple S, Alvarez-Buylla A. Stem cells in the adult mammalian central nervous system. Curr Opin Neurobiol. 1999;9(1):135-141.
38. Cameron HA, Woolley CS, Gould E. Adrenal steroid receptor immunoreactivity in cells born in the adult rat dentate gyrus. Brain Res. 1993;611(2):342-346.
39. Kim JS, Jung J, Lee HJ, et al. Differences in immunoreactivities of Ki-67 and doublecortin in the adult hippocampus in three strains of mice. Acta Histochem. 2009;111(2):150-156.
40. Kim JS, Lee HJ, Kim JC, et al. Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis. J Radiat Res. 2008;49(5):517-526.
41. Kronenberg G, Reuter K, Steiner B, et al. Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli. J Comp Neurol. 2003;467(4):455-463.
42. Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci. 1996;16(6): 2027-2033.
43. Parent JM, Yu TW, Leibowitz RT, et al. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci. 1997;17(10):3727-3738.
44. Scott BW, Wang S, Burnham WM, et al. Kindling-induced neurogenesis in the dentate gyrus of the rat. Neurosci Lett. 1998;248(2):73-76.
45. Segi-Nishida E, Warner-Schmidt JL, Duman RS. Electroconvulsive seizure and VEGF increase the proliferation of neural stem-like cells in rat hippocampus. Proc Natl Acad Sci U S A. 2008;105(32):11352-11357.
46. Tada E, Parent JM, Lowenstein DH, et al. X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats. Neuroscience. 2000;99(1): 33-41.
47. Seo HS, Yang M, Song MS, et al. Toluene inhibits hippocampal neurogenesis in adult mice. Pharmacol Biochem Behav. 2010;94(4):588-594.
48. Young D, Lawlor PA, Leone P, et al. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective. Nat Med. 1999;5(4): 448-453.
49. Duman RS, Malberg J, Nakagawa S. Regulation of adult neurogenesis by psychotropic drugs and stress. J Pharmacol Exp Ther. 2001;299(2):401-407.
50. Aonurm-Helm A, Jurgenson M, Zharkovsky T, et al. Depression-like behaviour in neural cell adhesion molecule (NCAM)-deficient mice and its reversal by an NCAM-derived peptide, FGL. Eur J Neurosci. 2008;28(8): 1618-1628.
51. Cameron HA, Tanapat P, Gould E. Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway. Neuroscience. 1998;82(2):349-354.
52. Gould E, Tanapat P. Stress and hippocampal neurogenesis. Biol Psychiatry. 1999;46(11):1472-1479.
53. Jacobs BL, van Praag H, Gage FH. Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry. 2000;5(3):262-269.
54. van Praag H, Christie BR, Sejnowski TJ, et al. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A. 1999; 96(23):13427-13431.
55. Vaidya VA, Fernandes K, Jha S. Regulation of adult hippocampal neurogenesis: relevance to depression. Expert Rev Neurother. 2007;7(7):853-864.
56. Mesulam MM. Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles. Neuron. 1999;24(3):521-529.
57. Neves G, Cooke SF, Bliss TV. Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat Rev Neurosci. 2008;9(1):65-75.
58. Wang Y. Probing the role of AMPAR endocytosis and long-term depression in behavioural sensitization: relevance to treatment of brain disorders, including drug addiction. Br J Pharmacol. 2008;153(Suppl 1):S389-395.
59. Crews L, Rockenstein E, Masliah E. APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis. Brain Struct Funct. 2010;214(2):111-126.
60. Hu Q, Fu H, Song H, et al. Low-level lead exposure attenuates the expression of three major isoforms of neural cell adhesion molecule. Neurotoxicology. 2011; 32(2):255-260.
61. Pessoa L. Emergent processes in cognitive-emotional interactions. Dialogues Clin Neurosci. 2010;12(4): 433-448.
62. Pasupathy A, Miller EK. Different time courses of learning-related activity in the prefrontal cortex and striatum. Nature. 2005;433(7028):873-876.
63. Drevets WC, Videen TO, Price JL, et al. A functional anatomical study of unipolar depression. J Neurosci. 1992;12(9):3628-3641.
64. Beinert T, Masuhr F, Mwela E, et al. Neuropathy under chemotherapy. Eur J Med Res. 2000;5(10):415-423.
65. Wilson CJ, Finch CE, Cohen HJ. Cytokines and cognition--the case for a head-to-toe inflammatory paradigm. J Am Geriatr Soc. 2002;50(12):2041-2056.
66. Bell IR, Edman JS, Morrow FD, et al. Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction. J Am Coll Nutr. 1992;11(2):159-163.
67. Kruman II, Mouton PR, Emokpae R, et al. Folate deficiency inhibits proliferation of adult hippocampal progenitors. Neuroreport. 2005;16(10):1055-1059.
68. Riggs KM, Spiro A 3rd, Tucker K, et al. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am J Clin Nutr. 1996;63(3):306-314.
69. Pyter LM, Cochrane SF, Ouwenga RL, et al. Mammary tumors induce select cognitive impairments. Brain Behav Immun. 2010;24(6):903-907.
70. Pyter LM, Pineros V, Galang JA, et al. Peripheral tumors induce depressive-like behaviros and cytokine production and alter hypothalamic-pituitary-adrenal axis regulation. Proc Natl Acad Sci U S A. 2009;106(22):9069-9074.
71. Reddy AT, Witek K. Neurologic complications of chemotherapy for children with cancer. Curr Neurol Neurosci Rep. 2003;3(2):137-142.
72. Ricard D, Taillia H, Renard JL. Brain damage from anticancer treatments in adults. Curr Opin Oncol. 2009; 21(6):559.
73. Myers JS, Pierce J, Pazdernik T. Neurotoxicology of chemotherapy in relation to cytokine release, the blood-brain barrier, and cognitive impairment. Oncol Nurs Forum. 2008;35(6):916-920.
74. Bigotte L, Arvidson B, Olsson Y. Cytofluorescence localization of adriamycin in the nervous system. I. Distribution of the drug in the central nervous system of normal adult mice after intravenous injection. Acta Neuropathol. 1982;57(2-3):121-129.
75. Petri B, Bootz A, Khalansky A, et al. Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants. J Control Release. 2007;117(1): 51-58.
76. Tilloy S, Monnaert V, Fenart L, et al. Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier. Bioorg Med Chem Lett. 2006;16(8):2154-2157.
77. Saykin A, Ahles T, McDonald B. Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectives. Semin Clin Neuropsychiatry. 2003;8(4):201-206.
78. Myers R, Rogers MA, Hornsey S. A reappraisal of the roles of glial and vascular elements in the development of white matter necrosis in irradiated rat spinal cord. Br J Cancer Suppl. 1986;7:221-223.
79. van der Kogel AJ. Radiation-induced damage in the central nervous system: an interpretation of target cell responses. Br J Cancer Suppl. 1986;7:207-217.
80. Okamoto M, Suzuki Y, Shirai K, et al. Effect of radiation on the development of immature hippocampal neurons in vitro. Radiat Res. 2009;172(6):718-724.