Insights into the mechanisms of ifosfamide encephalopathy: Drug metabolites have agonistic effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 3, 2001, Pages 1161-1168

  Chatton, Jean Yves ^a,d   Idle, Jeffrey R ^b,c   Vågbø, Cathrine Broberg ^b   Magistretti, Pierre J ^a  

^a University of Lausanne Medical Center   (Switzerland)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c University of Lausanne ^*  (Czech Republic)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALKYLATING AGENT; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; AMPA RECEPTOR ANTAGONIST; CALCIUM; CARBOCISTEINE; CARBOXYLIC ACID; CARRIER PROTEIN; CYCLOTHIAZIDE; DIZOCILPINE; DRUG METABOLITE; GLUTAMIC ACID; IFOSFAMIDE; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR AGONIST; LACTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; QUERCETIN; THIODIACETIC ACID; THIOGLYCOLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ARTICLE; BRAIN CELL; BRAIN DISEASE; CALCIUM CELL LEVEL; CELL PH; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG STRUCTURE; EMBRYO; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; RAT; RECEPTOR DOWN REGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BIOLOGICAL TRANSPORT; CARBOCYSTEINE; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; GLUTAMIC ACID; IFOSFAMIDE; MICE; MONOCARBOXYLIC ACID TRANSPORTERS; NEURONS; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID;

EID: 0035201805     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Comparative pharmacokinetics of oral and intravenous ifosfamide/mesna/methylene blue therapy
2. i changes in cultured rat hippocampal neurons
3. Modulation of AMPA/kainate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus
4. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination
5. A simple outpatient treatment with oral ifosfamide and oral etoposide for patients with small cell lung cancer (SCLC)
6. Modulation of hormone-induced calcium oscillations by intracenular pH in rat hepatocytes
7. + dynamics in mouse cortical astrocytes: Implications for cellular bioenergetics
8. Ethylene dichloride: The influence of disulfiram or ethanol on oncogenicity, metabolism, and DNA covalent binding in rats
9. Sensitive flame-photometric-detector analysis of thiodiglycolic acid in urine as a biological monitor of vinyl chloride
10. 1H NMR
11. Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer
12. 13C nuclear magnetic resonance spectroscopy
13. Urinary proton magnetic resonance studies of early ifosfamide-induced nephrotoxicity and encephalopathy
14. Dechloroethylation of ifosfamide and neurotoxicity
15. The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
16. Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine
17. Endogenous monocarboxylates sustain hippocampal synaptic function and morphological integrity during energy deprivation
18. 2+] with fluorescent indicators
19. Methylene blue and the neurotoxic mechanisms of ifosfamide encephalopathy
20. Prophylaxis and reversal of ifosfamide encephalopathy with methylene blue
21. Metabolism of bis(2-chloroethyl)ether and bis(2-chloroisopropyl)ether in the rat
22. State of the nervous system in workers engaged in the production of plastic materials: Data of screening and electrophysiological studies
23. Energy on demand
24. Increased urinary losses of carnitine during ifosfamide chemotherapy
25. Hexahydro-1,4-thiazepine-3,5-dicarboxylic acid and thiomorpholine-3,5-dicarboxylic acid are present in normal human urine
26. Tracing the human metabolism of stable isotope-labeled drugs by ex vivo NMR spectroscopy. Revision of S-carboxymethyl-L-cysteine biotransformation
27. An analytical method, using GC-MS, for the quantitative determination of urinary thiodiglycolic acid
28. Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization
29. Cell-specific localization of monocarboxylate transporter. MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy
30. + changes induced by glutamate, kainate, and D-aspartate in rat hippocampal astrocytes
31. Kinetics of monochloroacetic acid in adult male rats after intravenous injection of a subtoxic and a toxic dose
32. Lactate-supported synaptic function in the rat hippocampal slice preparation
33. Methodological approach to the evaluation of neurotoxicity data and the classification of neurotoxic chemicals
34. Experimental displacement of intracellular pH and the mechanism of its subsequent recovery
35. Thiodiglycolic acid - A novel endogenous urinary metabolite in humans
36. Inhibition and stimulation of long-chain fatty acid oxidation by chloroacetaldehyde and methylene blue in rats
37. Inhibition of lactate export by quercetin acidifies rat glial cells in vitro