Acute treatment with methotrexate induces hippocampal dysfunction in a mouse model of breast cancer

Brain Research Bulletin

Volumn 89, Issue 1-2, 2012, Pages 50-56

  Yang, Miyoung ^a   Kim, Joong Sun ^b   Kim, Juhwan ^a   Jang, Sungwoong ^a   Kim, Sung Ho ^a   Kim, Jong Choon ^a   Shin, Taekyun ^c   Wang, Hongbing ^d   Moon, Changjong ^a  

^a Chonnam National University   (South Korea)

^b Dongnam Institute of Radiological and Medical Science   (South Korea)

^c Jeju National University   (South Korea)

^d MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Breast cancer; Cognitive impairment; Depression; Hippocampus; Inflammatory response; Methotrexate

Indexed keywords

CYCLOOXYGENASE 2; DOUBLECORTIN; INDUCIBLE NITRIC OXIDE SYNTHASE; METHOTREXATE;

AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DISEASE; BREAST CANCER; CANCER CELL CULTURE; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; DEPRESSION; DISEASE ASSOCIATION; HIPPOCAMPUS; LEARNING TEST; MALE; MEMORY; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TASK PERFORMANCE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; DEPRESSION; FEMALE; HIPPOCAMPUS; MAMMARY NEOPLASMS, EXPERIMENTAL; MEMORY DISORDERS; METHOTREXATE; MICE; MICE, INBRED C3H; TUMOR CELLS, CULTURED;

EID: 84864540348     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2012.07.003     Document Type: Article

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