Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA

Brain Research

Volumn 1111, Issue 1, 2006, Pages 26-29

  Mignone, Robert G ^a   Weber, E Todd ^a  

^a RIDER UNIVERSITY   (United States)

Author keywords

Cell proliferation; Chemotherapy; Dentate gyrus; Hippocampus; Neurogenesis

Indexed keywords

ANTIMITOTIC AGENT; FLUOROURACIL; THIOTEPA;

ANIMAL BEHAVIOR; ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CELL PROLIFERATION; COGNITION; CONTROLLED STUDY; DENTATE GYRUS; DRUG MECHANISM; HIPPOCAMPUS; MITOSIS; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, ALKYLATING; BLOOD-BRAIN BARRIER; CELL DIFFERENTIATION; CELL PROLIFERATION; DENTATE GYRUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROURACIL; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MITOSIS; NEURONS; STEM CELLS; THIOTEPA;

EID: 33748300962     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.06.093     Document Type: Article

References (28)

1. Bourke R.S., West C.R., Chheda G., and Tower D.B. Kinetics of entry and distribution of 5-fluorouracil in cerebrospinal fluid and brain following intravenous injection in a primate. Cancer Res. 33 (1973) 1735-1746
2. Bremner J.D., Narayan M., Anderson E.R., Staib L.H., Miller H.L., and Charney D.S. Hippocampal volume reduction in major depression. Am. J. Psych. 157 (2000) 115-118
3. Cameron H.A., and McKay R.D. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol. 435 (2001) 406-417
4. Duman R.S. Depression: a case of neuronal life and death?. Biol. Psychiatry 56 (2004) 140-145
5. Duman R.S., Malberg J., Nakagawa S., and D'Sa C. Neuronal plasticity and survival in mood disorders. Biol. Psychiatry 48 (2000) 732-739
6. Formica V., Leary A., Cunningham D., and Chua Y.J. 5-fluorouracil can cross brain-blood barrier and cause encephalopathy: should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma. Cancer Chemother. Pharmacol. 7 (2005) 1-3
7. Hastings N.B., and Gould E. Rapid extension of axons into the CA3 region by adult-generated granule cells. J. Comp. Neurol. 413 (1999) 146-154
8. Jacobs B.L., Praag H., and Gage F.H. Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol. Psychiatry 5 (2000) 262-269
9. Jessberger S., and Kempermann G. Adult-born hippocampal neurons mature into activity-dependent responsiveness. Eur. J. Neurosci. 18 (2003) 2707-2712
10. Kaplan M.S., and Hinds J.W. Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs. Science 197 (1977) 1092-1094
11. Kempermann G. Regulation of adult hippocampal neurogenesis-Implications for novel theories of major depression. Bipolar Disord. 4 (2002) 17-33
12. Kempermann G., and Gage F.H. Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task. Eur. J. Neurosci. 16 (2002) 129-136
13. Kempermann G., Kuhn H.G., and Gage F.H. More hippocampal neurons in adult mice living in an enriched environment. Nature 386 (1997) 493-495
14. Leuner B., Gould E., and Shors T.J. Is there a link between adult neurogenesis and learning?. Hippocampus 16 (2006) 216-224
15. MacQueen G.M., Campbell S., McEwen B.S., Macdonald K., Amano S., Joffe R.T., Nahmias C., and Young L.T. Course of illness, hippocampal function, and hippocampal volume in major depression. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 1387-1392
16. Malberg J.E., and Duman R.S. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology 28 (2003) 1562-1571
17. Malberg J.E., Eisch A.J., Nestler E.J., and Duman R.S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20 (2000) 9104-9110
18. Sakane T., Yamashita S., Yata N., and Sezaki H. Transnasal delivery of 5-fluorouracil to the brain in rat. J. Drug Target. 7 (1999) 233-240
19. Santarelli L., Saxe M., Gross C., Surget A., Battaglia F., Dulawa S., Weisstaub N., Lee J., Duman R., Arancio O., Belzung C., and Hen R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301 (2003) 805-809
20. Sapolsky R.M. Is impaired neurogenesis relevant to the affective symptoms of depression?. Psychiatry 56 (2004) 137-139
21. Warner-Schmidt J.L., and Duman R.S. Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. Hippocampus 16 (2006) 239-249
22. Sheline Y.I., Sanghavi M., Mintun M.A., and Gado M.H. Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J. Neurosci. 19 (1999) 5034-5043
23. Sheline Y.I., Gado M.H., and Kraemer H.C. Untreated depression and hippocampal volume loss. Am. J. Psychiatry 160 (2003) 1516-1518
24. Strong J.M. Pharmacokinetics of intraventricular and intravenous N,N′,N″-triethylene-thiophosphoramide (thiotepa) in rhesus monkeys and humans. Cancer Res. 46 (1986) 6101-6104
25. Williams R.W., and Rakic P. Three-dimensional counting: an accurate and direct method to estimate numbers of cells in sectioned material. J. Comp. Neurol. 278 (1988) 344-352
26. Winocur G., Wojtowicz J.M., Sekeres M., Snyder J.S., and Wang S. Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 16 (2006) 296-304
27. van Maanen M.J., Smeets C.J.M., and Beijnen J.H. Chemistry, pharmacology and pharmacokinetics of N,N′,N″-triethylenethiophosphoramide (ThioTEPA). Cancer Treat. Rev. 26 (2000) 257-268
28. van Praag H., Schinder A.F., Christie B.R., Toni N., Palmer T.D., and Gage F.H. Functional neurogenesis in the adult hippocampus. Nature 415 (2002) 1030-1034