Cyclophosphamide impairs hippocampus-dependent learning and memory in adult mice: Possible involvement of hippocampal neurogenesis in chemotherapy-induced memory deficits

Neurobiology of Learning and Memory

Volumn 93, Issue 4, 2010, Pages 487-494

  Yang, Miyoung ^a   Kim, Joong Sun ^a   Song, Myoung Sub ^a   Kim, Sung Ho ^a   Kang, Seong Soo ^a   Bae, Chun Sik ^a   Kim, Jong Choon ^a   Wang, Hongbing ^b   Shin, Taekyun ^c   Moon, Changjong ^a  

^a Chonnam National University   (South Korea)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c Jeju National University   (South Korea)

Author keywords

Cognitive impairment; Cyclophosphamide; Hippocampus; Neurogenesis

Indexed keywords

CYCLOPHOSPHAMIDE; DOUBLECORTIN; KI 67 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INDUCED DISEASE; HIPPOCAMPUS; LEARNING DISORDER; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PASSIVE AVOIDANCE; PATTERN RECOGNITION; PROTEIN EXPRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; AVOIDANCE LEARNING; CYCLOPHOSPHAMIDE; HIPPOCAMPUS; KI-67 ANTIGEN; LEARNING; MALE; MEMORY; MICE; MICE, INBRED ICR; MICROTUBULE-ASSOCIATED PROTEINS; NEUROGENESIS; NEUROPEPTIDES; NEUROPSYCHOLOGICAL TESTS; PATTERN RECOGNITION, PHYSIOLOGICAL; RECOGNITION (PSYCHOLOGY); TIME FACTORS;

EID: 77952551092     PISSN: 10747427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nlm.2010.01.006     Document Type: Article

References (27)

1. Ahles T., Saykin A. Breast cancer chemotherapy-related cognitive dysfunction. European Journal of Cancer Care 2002, 3:84-90.
2. Ahles T.A., Saykin A.J., Furstenberg C.T., Cole B., Mott L.A., Skalla K., et al. Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. Journal of Clinical Oncology 2002, 20:485-493.
3. Barton D., Loprinzi C. Novel approaches to preventing chemotherapy-induced cognitive dysfunction in breast cancer: The art of the possible. Clinical Breast Cancer 2002, 3:121-127.
4. Cameron H.A., Woolley C.S., McEwen B.S., Gould E. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience 1993, 56:337-344.
5. Dollery C. Cyclophosphamide. Therapeutic drugs 1999, C349-C354. Churchill Livingstone, Edinburgh.
6. Fan H.G., Houédé-Tchen N., Yi Q.L., Chemerynsky I., Downie F.P., Sabate K., et al. Fatigue, menopausal symptoms, and cognitive function in women after adjuvant chemotherapy for breast cancer: 1- and 2-year follow-up of a prospective controlled study. Journal of Clinical Oncology 2005, 23:8025-8032.
7. Jansen C., Miaskowski C., Dodd M., Dowling G., Kramer J. Potential mechanisms for chemotherapy-induced impairments in cognitive function. Oncology Nursing Forum 2005, 32:1151-1163.
8. Kim J.S., Jung J., Lee H.J., Kim J.C., Wang H., Kim S.H., et al. Differences in immunoreactivities of Ki-67 and doublecortin in the adult hippocampus in three strains of mice. Acta Histochemica 2009, 111:150-156.
9. Kim J.S., Lee H.J., Kim J.C., Kang S.S., Bae C.S., Shin T., et al. Transient impairment of hippocampus-dependent learning and memory in relatively low-dose of acute radiation syndrome is associated with inhibition of hippocampal neurogenesis. Journal of Radiation Research 2008, 49:517-526.
10. Lee G.D., Longo D.L., Wang Y., Rifkind J.M., Abdul-Raman L., Mamczarz J.A., et al. Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clinical Cancer Research 2006, 12:198-205.
11. Mirkes P.E. Cyclophosphamide teratogenesis: A review. Teratogenesis, Carcinogenesis and Mutagenesis 1985, 5:75-88.
12. Parth P., Dunlap W.P., Kennedy R.S., Ordy J.M., Lane N.E. Motor and cognitive testing of bone marrow transplant patients after chemoradiotherapy. Perceptual and Motor Skills 1989, 68:1227-1241.
13. Peissner W., Kocher M., Treuer H., Gillardon F. Ionizing radiation-induced apoptosis of proliferating stem cells in the dentate gyrus of the adult rat hippocampus. Brain Research Molecular Brain Research 1999, 71:61-68.
14. Raber J., Rola R., LeFevour A., Morhardt D., Curley J., Mizumatsu S., et al. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiation Research 2004, 162:39-47.
15. Reiriz A.B., Reolon G.K., Preissler T., Rosado J.O., Henriques J.A., Roesler R., et al. Cancer chemotherapy and cognitive function in rodent models: Memory impairment induced by cyclophosphamide in mice. Clinical Cancer Research 2006, 12:5000.
16. Schagen S.B., Muller M.J., Boogerd W., Mellenbergh G.J., van Dam F.S. Change in cognitive function after chemotherapy: A prospective longitudinal study in breast cancer patients. Journal of the National Cancer Institute 2006, 98:1742-1745.
17. Schagen S.B., Muller M.J., Boogerd W., Rosenbrand R.M., van Rhijn D., Rodenhuis S., et al. Late effects of adjuvant chemotherapy on cognitive function: A follow-up study in breast cancer patients. Annals of Oncology 2002, 13:1387-1397.
18. Shilling V., Jenkins V., Trapala I.S. The (mis)classification of chemo-fog-Methodological inconsistencies in the investigation of cognitive impairment after chemotherapy. Breast Cancer Research Treatment 2006, 95:125-129.
19. Squire L.R., Stark C.E., Clark R.E. The medial temporal lobe. Annual Reviews of Neuroscience 2004, 27:279-306.
20. Subramaniam S., Subramaniam S., Shyamala D.C. Erythrocyte antioxidant enzyme activity in CMF treated breast cancer patients. Cancer Biochemistry Biophysics 1994, 14:177-182.
21. Temple S., Alvarez-Buylla A. Stem cells in the adult mammalian central nervous system. Current Opinion in Neurobiology 1999, 9:135-141.
22. Ueno M., Katayama K., Yamauchi H., Nakayama H., Doi K. Cell cycle progression is required for nuclear migration of neural progenitor cells. Brain Research 2006, 1088:57-67.
23. van Dam F.S., Schagen S.B., Muller M.J., Boogerd W., vd Wall E., Droogleever Fortuyn M.E., et al. Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: High-dose versus standard-dose chemotherapy. Journal of the National Cancer Institute 1998, 90:210-218.
24. Vardy J., Tannock I. Cognitive function after chemotherapy in adults with solid tumours. Critical Reviews in Oncology/Hematology 2007, 63:183-202.
25. Waber D.P., Tarbell N.J., Kahn C.M., Gelber R.D., Sallan S.E. The relationship of sex and treatment modality to neuropsychologic outcome in childhood acute lymphoblastic leukemia. Journal of Clinical Oncology 1992, 10:810-817.
26. Winocur G., Wojtowicz J.M., Sekeres M., Snyder J.S., Wang S. Inhibition of neurogenesis interferes with hippocampus-dependent memory function. Hippocampus 2006, 16:296-304.
27. Zhang M., Moon C., Chan G.C., Yang L., Zheng F., Conti A.C., et al. Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory. The Journal of Neuroscience 2008, 28:4736-4744.