p53 E3 ubiquitin protein ligase homolog regulates p53 in vivo in the adult mouse eye lens

Molecular Vision

Volumn 19, Issue , 2013, Pages 468-2476

  Jaramillo Rangel, Gilberto ^a   Ortega Martínez, Marta ^a   Sepúlveda Saavedra, Julio ^a   Saucedo Cárdenas, Odila ^a,b   Montes de Oca Luna, Roberto ^a  

^a UNIVERSIDAD AUTÓNOMA DE NUEVO LEÓN   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53; MDM2 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; GENE EXPRESSION; GENOTYPE; HISTOLOGY; HOMOZYGOTE; IN VIVO STUDY; LENS DISEASE; MICROPHTHALMIA; MOUSE; NEWBORN; NONHUMAN; P53 GENE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; TRANSGENE; ULTRASTRUCTURE; WILD TYPE; AGE; ALLELE; ANIMAL; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HETEROZYGOTE; HUMAN; LENS; MALE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

AGE FACTORS; ALLELES; ANIMALS; FEMALE; GENE EXPRESSION REGULATION; HETEROZYGOTE; HOMOZYGOTE; HUMANS; LENS, CRYSTALLINE; MALE; MICE; MICE, TRANSGENIC; MICROPHTHALMOS; PROTO-ONCOGENE PROTEINS C-MDM2; SIGNAL TRANSDUCTION; TRANSGENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84889678894     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Aylon Y, Oren M. Living with p53, dying of p53. Cell 2007; 130:597-600. [PMID: 17719538]
2. Zuckerman V, Wolyniec K, Sionov RV, Haupt S, Haupt Y. Tumour suppression by p53: the importance of apoptosis and cellular senescence. J Pathol 2009; 219:3-15. [PMID: 19562738]
3. Wade M, Wang YV, Wahl GM. The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol 2010; 20:299-309. [PMID: 20172729]
4. Saldaña-Meyer R, Recillas-Targa F. Transcriptional and epigenetic regulation of the p53 tumor suppressor gene. Epigenetics 2011; 6:1068-77. [PMID: 21814038]
5. Maillet A, Pervaiz S. Redox regulation of p53, redox effectors regulated by p53: a subtle balance. Antioxid Redox Signal 2012; 16:1285-94. [PMID: 22117613]
6. Fakharzadeh SS, Trusko SP, George DL. Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line. EMBO J 1991; 10:1565-9. [PMID: 2026149]
7. Bouska A, Lushnikova T, Plaza S, Eischen CM. Mdm2 promotes genetic instability and transformation independent of p53. Mol Cell Biol 2008; 28:4862-74. [PMID: 18541670]
8. Thomasova D, Mulay SR, Bruns H, Anders HJ. p53-independent roles of MDM2 in NF-kB signaling: implications for cancer therapy, wound healing, and autoimmune diseases. Neoplasia 2012; 14:1097-101. [PMID: 23308042]
9. Jones SN, Roe AE, Donehower LA, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 1995; 378:206-8. [PMID: 7477327]
10. Montes de Oca Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 1995; 378:203-6. [PMID: 7477326]
11. Xiong S. Mouse models of Mdm2 and Mdm4 and their clinical implications. Chin J Cancer 2013; 32:371-5. [PMID: 23327795]
12. Chow RL, Lang RA. Early eye development in vertebrates. Annu Rev Cell Dev Biol 2001; 17:255-96. [PMID: 11687490]
13. Wride MA. Lens fibre cell differentiation and organelle loss: many paths lead to clarity. Philos Trans R Soc Lond B Biol Sci 2011; 366:1219-33. [PMID: 21402582]
14. Morgenbesser SD, Williams BO, Jacks T, DePinho RA. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 1994; 371:72-4. [PMID: 8072529]
15. Fromm L, Overbeek PA. Inhibition of cell death by lens-specific overexpression of bcl-2 in transgenic mice. Dev Genet 1997; 20:276-87. [PMID: 9216067]
16. Hettmann T, Barton K, Leiden JM. Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol 2000; 222:110-23. [PMID: 10885750]
17. Wang Y, Ko BC, Yang JY, Lam TT, Jiang Z, Zhang J, Chung SK, Chung SS. Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks. J Biol Chem 2005; 280:19986-91. [PMID: 15774462]
18. Yang YG, Frappart PO, Frappart L, Wang ZQ, Tong WM. A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis. DNA Repair (Amst) 2006; 5:885-93. [PMID: 16790366]
19. Wiley LA, Rajagopal R, Dattilo LK, Beebe DC. The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens. Dis Model Mech 2011; 4:484-95. [PMID: 21504908]
20. Xiao F, Zhang JS, Zhao JY, Wu D. Regulation of Eaf2 in mouse lens cells apoptosis induced by ultraviolet radiation. Int J Ophthalmol 2012; 5:570-5. [PMID: 23166866]
21. Liu FY, Tang XC, Deng M, Chen P, Ji W, Zhang X, Gong L, Woodward Z, Liu J, Zhang L, Sun S, Liu JP, Wu K, Wu MX, Liu XL, Yu MB, Liu Y, Li DW. The tumor suppressor p53 regulates c-Maf and Prox-1 to control lens differentiation. Curr Mol Med 2012; 12:917-28. [PMID: 22827438]
22. Deng M, Chen P, Liu F, Fu S, Tang H, Fu Y, Xiong Z, Hui S, Ji W, Zhang X, Zhang L, Gong L, Hu X, Hu W, Sun S, Liu J, Xiao L, Liu WB, Xiao YM, Liu SJ, Liu Y, Li DW. The p53-Bak apoptotic signaling axis plays an essential role in regulating differentiation of the ocular lens. Curr Mol Med 2012; 12:901-16. [PMID: 22671997]
23. Pomerantz J, Schreiber-Agus N, Liégeois NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee HW, Cordon-Cardo C, DePinho RA. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 1998; 92:713-23. [PMID: 9529248]
24. Geatrell JC, Gan PM, Mansergh FC, Kisiswa L, Jarrin M, Williams LA, Evans MJ, Boulton ME, Wride MA. Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development. Exp Eye Res 2009; 88:1137-51. [PMID: 19450442]
25. Nakamura T, Pichel JG, Williams-Simons L, Westphal H. An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele. Proc Natl Acad Sci USA 1995; 92:6142-6. [PMID: 7597093]
26. Graw J. Mouse models of cataract. J Genet 2009; 88:469-86. [PMID: 20090208]
27. Kruse JP, Gu W. Modes of p53 regulation. Cell 2009; 137:609-22. [PMID: 19450511]
28. Danovi D, Meulmeester E, Pasini D, Migliorini D, Capra M, Frenk R, de Graaf P, Francoz S, Gasparini P, Gobbi A, Helin K, Pelicci PG, Jochemsen AG, Marine JC. Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity. Mol Cell Biol 2004; 24:5835-43. [PMID: 15199139]
29. Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 2001; 29:92-5. [PMID: 11528400]
30. Gannon HS, Jones SN. Using mouse models to explore MDM-p53 signaling in development, cell growth, and tumorigenesis. Genes Cancer 2012; 3:209-18. [PMID: 23150754]
31. Tollini LA, Zhang Y. p53 regulation goes live-Mdm2 and MdmX co-star: lessons learned from mouse modeling. Genes Cancer 2012; 3:219-25. [PMID: 23150755]
32. Boesten LS, Zadelaar SM, De Clercq S, Francoz S, van Nieuwkoop A, Biessen EA, Hofmann F, Feil S, Feil R, Jochemsen AG, Zurcher C, Havekes LM, van Vlijmen BJ, Marine JC. Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death. Cell Death Differ 2006; 13:2089-98. [PMID: 16729027]
33. Francoz S, Froment P, Bogaerts S, De Clercq S, Maetens M, Doumont G, Bellefroid E, Marine JC. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci USA 2006; 103:3232-7. [PMID: 16492744]
34. Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Mol Cell Biol 2006; 26:192-8. [PMID: 16354690]
35. Maetens M, Doumont G, Clercq SD, Francoz S, Froment P, Bellefroid E, Klingmuller U, Lozano G, Marine JC. Distinct roles of Mdm2 and Mdm4 in red cell production. Blood 2007; 109:2630-3. [PMID: 17105817]
36. Pokroy R, Tendler Y, Pollack A, Zinder O, Weisinger G. p53 expression in the normal murine eye. Invest Ophthalmol Vis Sci 2002; 43:1736-41. [PMID: 12036973]
37. Valentin-Vega YA, Okano H, Lozano G. The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival. Cell Death Differ 2008; 15:1772-81. [PMID: 18636077]
38. Valentin-Vega YA, Box N, Terzian T, Lozano G. Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities. Differentiation 2009; 77:442-9. [PMID: 19371999]
39. Michael R, Vrensen GF, van Marle J, Gan L, Söderberg PG. Apoptosis in the rat lens after in vivo threshold dose ultraviolet irradiation. Invest Ophthalmol Vis Sci 1998; 39:2681-7. [PMID: 9856778]
40. Ayala M, Strid H, Jacobsson U, Söderberg PG. p53 expression and apoptosis in the lens after ultraviolet radiation exposure. Invest Ophthalmol Vis Sci 2007; 48:4187-91. [PMID: 17724205]
41. Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef LG, Masucci M, Pramanik A, Selivanova G. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med 2004; 10:1321-8. [PMID: 15558054]
42. Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004; 303:844-8. [PMID: 14704432]
43. Shangary S, Qin D, McEachern D, Liu M, Miller RS, Qiu S, Nikolovska-Coleska Z, Ding K, Wang G, Chen J, Bernard D, Zhang J, Lu Y, Gu Q, Shah RB, Pienta KJ, Ling X, Kang S, Guo M, Sun Y, Yang D, Wang S. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci USA 2008; 105:3933-8. [PMID: 18316739]
44. Ringshausen I, O'Shea CC, Finch AJ, Swigart LB, Evan GI. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 2006; 10:501-14. [PMID: 17157790]
45. Liu G, Terzian T, Xiong S, Van Pelt CS, Audiffred A, Box NF, Lozano G. The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development. J Pathol 2007; 213:360-8. [PMID: 17893884]