Systemic medication and the inflammatory cascade

Periodontology 2000

Volumn 64, Issue 1, 2014, Pages 198-210

  Alani, Aws ^a   Seymour, Robin ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; AUTACOID; CORTICOSTEROID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR;

DRUG EFFECTS; HUMAN; PERIODONTITIS; PERIODONTIUM;

ADRENAL CORTEX HORMONES; ANTI-INFLAMMATORY AGENTS; CYCLOOXYGENASE INHIBITORS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION MEDIATORS; PERIODONTITIS; PERIODONTIUM;

EID: 84889677420     PISSN: 09066713     EISSN: 16000757     Source Type: Journal    
DOI: 10.1111/j.1600-0757.2012.00454.x     Document Type: Article

References (65)

1. Alam SQ, Bergens BM, Alam BS. Arachidonic acid, prostaglandin E2 and leukotriene C4 levels in gingiva and submandibular salivary glands of rats fed diets containing n-3 fatty acids. Lipids 1991: 26: 895-900.
2. Azoubel MC, Sarmento VA, Cangussú V, Azoubel E, Bittencourt S, Cunha FQ, Ribeiro RA, Brito GA. Adjunctive benefits of systemic etoricoxib in non-surgical treatment of aggressive periodontitis: short-term evaluation. J Periodontol 2008: 79: 1719-1725.
3. Bendyk A, Marino V, Zilm PS, Howe P, Bartold PM. Effect of dietary omega-3 polyunsaturated fatty acids on experimental periodontitis in the mouse. J Periodontal Res 2009: 44: 211-216.
4. Breivik T, Gundersen Y, Osmundsen H, Fonnum F, Opstad PK. Neonatal dexamethasone and chronic tianeptine treatment inhibit ligature-induced periodontitis in adult rats. J Periodontal Res 2006: 41: 23-32.
5. Breivik T, Thrane PS, Gjermo P, Opstad PK. Glucocorticoid receptor antagonist RU 486 treatment reduces periodontitis in Fischer 344 rats. J Periodontal Res 2000: 35: 285-290.
6. Breivik T, Opstad PK, Gjermo P, Thrane PS. Effects of hypothalamic-pituitary-adrenal axis reactivity on periodontal tissue destruction in rats. Eur J Oral Sci 2000: 108: 115-122.
7. Bromberg JS, Alfrey EJ, Barker CF, Chavin KD, Dafoe DC, Holland T, Naji A, Perloff LJ, Zellers LA, Grossman RA. Adrenal suppression and steroid supplementation in renal transplant recipients. Transplantation 1991: 51: 385-390.
8. Campan P, Planchand PO, Duran D. Pilot study on n-3 polyunsaturated fatty acids in the treatment of human experimental gingivitis. J Clin Periodontol 1997: 24: 907-913.
9. Cunha-Cruz J, Saver B, Maupome G, Hujoel PP. Statin use and tooth loss in chronic periodontitis patients. J Periodontol 2006: 77: 1061-1066.
10. Di Paola R, Mazzon E, Muià C, Crisafulli C, Terrana D, Greco S, Britti D, Santori D, Oteri G, Cordasco G, Cuzzocrea S. Effects of etanercept, a tumour necrosis factor-alpha antagonist, in an experimental model of periodontitis in rats. Br J Pharmacol 2007: 150: 286-297.
11. Elkhouli AM. The efficacy of host response modulation therapy (omega-3 plus low-dose aspirin) as an adjunctive treatment of chronic periodontitis (clinical and biochemical study). J Periodontal Res 2011: 46: 261-268.
12. El-Sharkawy H, Aboelsaad N, Eliwa M, Darweesh M, Alshahat M, Kantarci A, Hasturk H, Van Dyke TE. Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 fatty acids and low-dose aspirin. J Periodontol 2010: 81: 1635-1643.
13. Ezzat BA. Validity of prevention of glucocorticoid-induced alveolar bone loss in rat by either calcitonin or alendronate administration. Arch Oral Biol 2010: 55: 788-796.
14. Fajardo ME, Rocha ML, Sánchez-Marin FJ, Espinosa-Chávez EJ. Effect of atorvastatin on chronic periodontitis: a randomized pilot study. J Clin Periodontol 2010: 37: 1016-1022.
15. Feldman RS, Szeto B, Chauncey HH, Goldhaber P. Non-steroidal anti-inflammatory drugs in the reduction of human alveolar bone loss. J Clin Periodontol 1983: 10: 131-136.
16. Firth J, Monkkonen J, Blackburn G, Russell RGG, Rogers MJ. Clondronate and liposome encapsulated clondronate are metabolised to a toxic ATP analogue, adenosine 5-(beta, gamma-dichloromethylene) triphosphate by mammalian cells in vitro. J Bone Mineral Res 1997: 12: 1358-1367.
17. FitzGerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med 2001: 345: 433-442.
18. Friedman RJ, Schiff CF, Bromberg JS. Use of supplemental steroids in patients having orthopaedic operations. J Bone Joint Surg Am 1995: 77: 1801-1806.
19. Fu E, Hsieh YD, Nieh S, Wikesjö UM, Liu D. Effects of cyclosporin A on alveolar bone: an experimental study in the rat. J Periodontol 1999: 70: 189-194.
20. Garrett IR, Mundy GR. The role of statins as potential targets for bone formation. Arthritis Res 2002: 4: 237-240.
21. Gray DW. Mycophenolate mofetil for transplantation: new drug, old problems?Lancet 1995: 346: 390.
22. Heasman PA, Benn DK, Kelly PJ, Seymour RA, Aitken D. The use of topical flurbiprofen as an adjunct to non-surgical management of periodontal disease. J Clin Periodontol 1993: 20: 457-464.
23. Heasman PA, Seymour RA, Boston PF. The effect of a topical non-steroidal anti-inflammatory drug on the development of experimental gingivitis in man. J Clin Periodontol 1989: 16: 353-358.
24. Hilgert JB, Hugo FN, Bandeira DR, Bozzetti MC. Stress, cortisol, and periodontitis in a population aged 50years and over. J Dent Res 2006: 85: 324-328.
25. Jeffcoat MK, Cizza G, Shih WJ, Genco R, Lombardi A. Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis. J Int Acad Periodontol 2007: 9: 70-76.
26. Kesavalu L, Bakthavatchalu V, Rahman MM, Su J, Raghu B, Dawson D, Fernandes G, Ebersole JL. Omega-3 fatty acid regulates inflammatory cytokine/mediator messenger RNA expression in Porphyromonas gingivalis-induced experimental periodontal disease. Oral Microbiol Immunol 2007: 22: 232-239.
27. Leung DY, Bloom JW. Update on glucocorticoid action and resistance. J Allergy Clin Immunol 2003: 111: 3-22.
28. Lindy O, Suomalainen K, Mäkelä M, Lindy S. Statin use is associated with fewer periodontal lesions: a retrospective study. BMC Oral Health 2008: 15: 16.
29. Manelli F, Giustina A. Glucocorticoid-induced osteoporosis. Trends Endocrinol Metab 2000: 11: 79-85.
30. Martuscelli G, Fiorellini JP, Crohin CC, Howell TH. The effect of interleukin-11 on the progression of ligature-induced periodontal disease in the beagle dog. J Periodontol 2000: 71: 573-578.
31. Mayer Y, Balbir-Gurman A, Machtei EE. Anti-tumor necrosis factor-alpha therapy and periodontal parameters in patients with rheumatoid arthritis. J Periodontol 2009: 80: 1414-1420.
32. Miranda LA, Islabão AG, Fischer RG, Figueredo CM, Oppermann RV, Gustafsson A. Decreased interleukin-1beta and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis. J Periodontol 2007: 78: 1612-1619.
33. Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G. Stimulation of bone formation in vitro and in rodents by statins. Science 1999: 286: 1946-1949.
34. Nassar PO, Nassar CA, Guimarães MR, Aquino SG, Andia DC, Muscara MN, Spolidorio DM, Rossa C Jr, Spolidorio LC. Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats. J Periodontal Res 2009: 44: 479-488.
35. Newton R. Molecular mechanisms of glucocorticoid action: what is important?Thorax 2000: 55: 603-613.
36. Nicopoulou-Karayianni K, Tzoutzoukos P, Mitsea A, Karayiannis A, Tsiklakis K, Jacobs R, Lindh C, van der Stelt P, Allen P, Graham J, Horner K, Devlin H, Pavitt S, Yuan J. Tooth loss and osteoporosis: the OSTEODENT Study. J Clin Periodontol 2009: 36: 190-197.
37. Nyman S, Schroeder HE, Lindhe J. Suppression of inflammation and bone resorption by indomethacin during experimental periodontitis in dogs. J Periodontol 1979: 50: 450-461.
38. Offenbacher S, Braswell LD, Loos AS, Johnson HG, Hall CM, McClure H, Orkin JL, Strobert EA, Green MD, Odle BM. Effects of flurbiprofen on the progression of periodontitis in Macaca mulatta. J Periodontal Res 1987: 22: 473-481.
39. Ortiz P, Bissada NF, Palomo L, Han YW, Al-Zahrani MS, Panneerselvam A, Askari A. Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors. J Periodontol 2009: 80: 535-540.
40. Patel V, McLeod NM, Rogers SN, Brennan PA. Bisphosphonate osteonecrosis of the jaw - a literature review of UK policies versus international policies on bisphosphonates, risk factors and prevention. Br J Oral Maxillofac Surg 2011: 49: 251-257.
41. Pers JO, Saraux A, Pierre R, Youinou P. Anti-TNF-alpha immunotherapy is associated with increased gingival inflammation without clinical attachment loss in subjects with rheumatoid arthritis. J Periodontol 2008: 79: 1645-1651.
42. Peers SH, Smillie F, Elderfield AJ, Flower RJ. Glucocorticoid- and non-glucocorticoid induction of lipocortins (annexins) 1 and 2 in rat peritoneal leucocytes in vivo. Br J Pharmacol 1993: 108: 66-72.
43. Pinho Mde N, Pereira LB, de Souza SL, Palioto DB, Grisi MF, Novaes AB Jr, Taba M Jr. Short-term effect of COX-2 selective inhibitor as an adjunct for the treatment of periodontal disease: a clinical double-blind study in humans. Braz Dent J 2008: 19: 323-328.
44. Preshaw PM. Host response modulation in periodontics. Periodontol 2000 2008: 48: 92-110.
45. Queiroz-Junior CM, Pacheco CM, Maltos KL, Caliari MV, Duarte ID, Francischi JN. Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats. J Periodontal Res 2009: 44: 153-160.
46. Reddy MS, Geurs NC, Gunsolley JC. Periodontal host modulation with antiproteinase, anti-inflammatory and bone sparing agents. A systematic review. Ann Periodontol 2003: 8: 12-37.
47. Reiff RL, White CL, Overman P, ElAttar T, Platt RD. Aspirin, buffered aspirin, and effervescent buffer rinses in reducing gingival inflammation in patients with gingivitis and early periodontitis. Quintessence Int 1988: 19: 287-290.
48. Renvert S, Lindahl C, Roos-Jansåker AM, Lessem J. Short-term effects of an anti-inflammatory treatment on clinical parameters and serum levels of C-reactive protein and proinflammatory cytokines in subjects with periodontitis. J Periodontol 2009: 80: 892-900.
49. Rocha M, Nava LE, Vazquez de la Torre C, Sánchez-Márin F, Garay-Sevilla ME, Malacara JM. Clinical and radiological improvement of periodontal disease in patients with type 2 diabetes mellitus treated with alendronate: a randomised, placebo-controlled trial. J Periodontol 2001: 72: 204-209.
50. Saver BG, Hujoel PP, Cunha-Cruz J, Maupomé G. Are statins associated with decreased tooth loss in chronic periodontitis?J Clin Periodontol 2007: 34: 214-219.
51. Seto H, Ohba H, Tokunaga K, Hama H, Horibe M, Nagata T. Topical administration of simvastatin recovers alveolar bone loss in rats. J Periodontal Res 2008: 43: 261-267.
52. Seymour RA. Effects of medications on the periodontal tissues in health and disease. Periodontol 2000 2006: 40: 120-129.
53. Seymour RA, Heasman PA. Drugs and the periodontium. J Clin Periodontol 1988: 15: 1-16.
54. Sukhova GK, Williams JK, Libby P. Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol. Arterioscler Thromb Vasc Biol 2002: 22: 1452-1458.
55. Thomason JM, Girdler NM, Kendall-Taylor P, Wastell H, Weddel A, Seymour RA. An investigation into the need for supplementary steroids in organ transplant patients undergoing gingival surgery. A double-blind, split-mouth, cross-over study. J Clin Periodontol 1999: 26: 577-582.
56. Undas A, Brozek J, Musial J. Anti-inflammatory and antithrombotic effects of statins in the management of coronary artery disease. Clin Lab 2002: 48: 287-296.
57. van Beck E, Lowik C, van der Plujum G. The role of geranylgeranylation in both bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro. A clue to the mechanism of action of nitrogen-containing bisphosphonates. J Bone Mineral Res 1999: 14: 722-729.
58. Vardar S, Buduneli E, Türkoǧlu O, Berdeli AH, Baylas H, Başkesen A, Atilla G. Therapeutic versus prophylactic plus therapeutic administration of omega-3 fatty acid on endotoxin-induced periodontitis in rats. J Periodontol 2004: 75: 1640-1646.
59. Vardar-Sengul S, Buduneli E, Turkoglu O, Buduneli N, Atilla G, Wahlgren J, Sorsa T, Baylas H. The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis. J Periodontol 2008: 79: 1934-1941.
60. Vaziri H, Naserhojjati-Roodsari R, Tahsili-Fahadan N, Khojasteh A, Mashhadi-Abbas F, Eslami B, Dehpour AR. Effect of simvastatin administration on periodontitis-associated bone loss in ovariectomized rats. J Periodontol 2007: 78: 1561-1567.
61. Vogel RI, Copper SA, Schneider LG, Goteiner D. The effects of topical steroidal and systemic nonsteroidal anti-inflammatory drugs on experimental gingivitis in man. J Periodontol 1984: 55: 247-251.
62. Waite IM, Saxton CA, Young A, Wagg BJ, Corbett M. The periodontal status of subjects receiving non-steroidal anti-inflammatory drugs. J Periodontal Res 1981: 16: 100-108.
63. Weaks-Dybvig M, Sanavi F, Zander H, Rifkin BR. The effect of indomethacin on alveolar bone loss in experimental periodontitis. J Periodontal Res 1982: 17: 90-100.
64. Weitz-Schmidt G. Statins as anti-inflammatory agents. Trends Pharmacol Sci 2002: 23: 482-486.
65. Williams RC, Jeffcoat MK, Howell TH, Hall CM, Johnson HG, Wechter WJ, Goldhaber P. Indomethacin or flurbiprofen treatment of periodontitis in beagles: comparison of effect on bone loss. J Periodontal Res 1987: 22: 403-407.