The efficacy of host response modulation therapy (omega-3 plus low-dose aspirin) as an adjunctive treatment of chronic periodontitis (Clinical and biochemical study)

Journal of Periodontal Research

Volumn 46, Issue 2, 2011, Pages 261-268

  Elkhouli, A M ^a  

^a October 6 University   (Egypt)

Author keywords

Aspirin; Bone graft; Cytokines; Omega 3 polyunsaturated fatty acids

Indexed keywords

ACETYLSALICYLIC ACID; INTERLEUKIN 10; INTERLEUKIN 1BETA; NONSTEROID ANTIINFLAMMATORY AGENT; OMEGA 3 FATTY ACID; PLACEBO;

ADULT; ARTICLE; BONE TRANSPLANTATION; CHRONIC PERIODONTITIS; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; GINGIVA BLEEDING; GINGIVITIS; HUMAN; IMMUNOLOGY; IMMUNOMODULATION; MALE; METHODOLOGY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; ORAL DRUG ADMINISTRATION; PERIODONTAL DISEASE; PERIODONTAL POCKET; PERIODONTICS; RANDOMIZED CONTROLLED TRIAL; TOOTH PLAQUE;

ADMINISTRATION, ORAL; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BONE TRANSPLANTATION; CHRONIC PERIODONTITIS; COMBINED MODALITY THERAPY; DENTAL PLAQUE INDEX; DOUBLE-BLIND METHOD; FATTY ACIDS, OMEGA-3; FEMALE; FOLLOW-UP STUDIES; FURCATION DEFECTS; GINGIVAL CREVICULAR FLUID; GINGIVAL HEMORRHAGE; GUIDED TISSUE REGENERATION, PERIODONTAL; HUMANS; IMMUNOMODULATION; INTERLEUKIN-10; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PERIODONTAL POCKET; PLACEBOS;

EID: 79951951905     PISSN: 00223484     EISSN: 16000765     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2010.01336.x     Document Type: Article

References (58)

1. Lyons LC, Weltman RL, Moretti AJ, Trejo PM. Regeneration of degree II furcation defects with a 4% doxycycline hyclate bioabsorbable barrier. J Periodontol 2008;79:72-79.
2. Page RC. Periodontal therapy: prospects for the future. J Periodontol 1993;64:744-753.
3. Meadows CL, Gher ME, Quitero G, Lafferty TA. A comparison of polylactic acid granules and decalcified freeze-dried bone allograft in human periodontal osseous defects. J Periodontol 1993;64:103-109.
4. Kubler N, Reuther J, Kirchner T, Priessenitz B, Sebald W. Osteoinductive, morphologic, and biomechanical properties of autolyzed, antigen-extracted, allogeneic human bone. J Oral Maxillofac Surg 1993;51:1346-1357.
5. Gantes B, Martin M, Garrett S, Egelberg J. Treatment of periodontal furcation defects. (II). Bone regeneration in mandibular class II defects. J Clin Periodontol 1988;15(4):232-239.
6. Gantes B, Synowski BN, Garrett S, Egelberg JH. Treatment of periodontal furcation defects. Mandibular class (III) defects. J Periodontol 1991;62(6):361-365.
7. Tatakis DN. Interleukin-1 and bone metabolism: a review. J Periodontol 1993;64:416-431.
8. Goldring MB, Kran SM. Modulation by recombinant interleukin-1 of synthesis of type I and III collagens and associated procollagen mRNA levels in cultured human cells. J Biol Chem 1986;262:16724-16729.
9. Jandinsky JJ. Osteoclast activation is now interleukin-1 beta: historical perspective and biological implications. J Oral Pathol 1988;17:145-152.
10. Reynolds MA, Bowers GM. Fate of demineralized freeze-dried bone allografts in human intrabony defects. J Periodontol 1996;67:150-157.
11. Kuroki Y, Hirakawa K, Hayashi J, Imazato Y, Hirakawa M. Mechanism of the radiolucence around the implant after hip prosthetic replacement. Nippon Seikeigeka Gakkai Zasshi 1995;69(10):927-937.
12. Gamonal J, Acevedo A, Bascones A, Jorge O, Silva A. Levels of Interleukin-1β, -8, and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment. J Periodontol 2000;71:1535-1545.
13. McGuire MK, Nunn ME. Prognosis versus actual outcome. IV. The effectiveness of clinical parameters and interleukin-1 genotype in accurately predicting prognosis and tooth survival. J Periodontol 1998;70:49-56.
14. De Sanctis M, Zucchelli G. Interleukin-1 gene polymorphisms and long-term stability following guided tissue regeneration therapy. J Periodontol 2000;71(4):606-613.
15. Ninomiya JT, Struve JA, Stelloh CT, Toth JM, Croby KE. Effects of hydroxyapatite particulate debris on the production of cytokines and proteases in human fibroblasts. J Orthop Res 2001;19(4):621-628.
16. Lavigne P, Shi Q, Jolicoeur FC, Pelletier JP, Martel-Pelletier J, Fernandes JC. Modulation of IL-1 beta, IL-6, TNF-alpha and PGE(2) by pharmacological agents in explants of membranes from fail total hip replacement. Osteoarthritis Cartilage 2002;10(11):898-904.
17. Seitz M, Loetscher P, Dewald B, Towbin H, Gallati H, Baggiolini M. Interleukin-10 differentially regulates cytokine inhibitor and chemokine release from blood mononuclear cells and fibroblasts. Eur J Immunol 1995;25(4):1129-1132.
18. Yamamoto M, Fujihashi K, Hiroi T, McGhee JR, Van Dyke TE, Kiyono H. Molecular and cellular mechanisms for periodontal diseases: role of Th1 and Th2 type cytokines in induction of mucosal inflammation. J Periodontal Res 1997;32:115-119.
19. Paquette DW, Williams RC. Modulation of host inflammatory mediators as a treatment strategy for periodontal diseases. Periodontol 2000 2000;24:239-252.
20. Assuma R, Oates T, Cochran D, Amar S, Graves DT. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol 1998;160:403-409.
21. Golub L, Sorsa T, Lee HM, Ciancio S, Sorbi D, Ramamurthy N. Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodontol 1995;21:1-9.
22. Lane N, Armitage GC, Loomer P et al. Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study. J Periodontol 2005;76:1113-1122.
23. Flower R. What are all the things that aspirin does? BMJ 2003;327:572-573.
24. Van Dyke TE, Serhan CN. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. J Dent Res 2003;82:82-90.
25. Fernandes G, Venkatraman J. Role of omega-3 fatty acids in health and disease. Nutr Res 1993;13:S19-S45.
26. Van Dyke TE. The management of inflammation in periodontal disease. J Periodontol 2008;79:1601-1608.
27. Serhan CN. Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. J Periodontol 2008;79:1520-1526.
28. Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 2007;447:869-874.
29. Serhan CN, Hong S, Gronert K et al. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med 2002;196:1025-1037.
30. El-Sharkawy H, Aboelsaad N, Eliwa M et al. Adjunctive treatment of chronic periodontitis with daily dietary supplementation with omega-3 fatty acids and low-dose aspirin. J Periodontol 2010;81(11):1635-1643.
31. st edition. Philadelphia: W. B. Saunders Co., 1953.
32. Oringer RJ, Al-Shammari KF, Aldredge WA et al. Effect of locally delivered minocycline microspheres on markers of bone resorption. J Periodontol 2002;73:835-842.
33. Silness J, Loe H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 1964;22:112-120.
34. Loe H, Silness J. Periodontal disease in pregnancy I. Prevalence and severity. Acta Odontol Scand 1963;21:533-540.
35. Saxton CA, van der Quderra FJ. The effect of a dentifrice containing zinc citrate and triclosan on developing gingivitis. J Periodontal Res 1989;24:75-80.
36. Griffiths GS, Curtis MA, Wilton JM. Selection of a filter paper with optimum properties for the collection of gingival crevicular fluid. J Periodontal Res 1988;23:33-38.
37. Stoller NH, Karras DC, Johnson LR. Reliability of crevicular fluid measurements taken in the presence of supragingival plaque. J Periodontol 1990;60:670-673.
38. Nakashima K, Giannopoulou C, Andersen E et al. A longitudinal study of various crevicular fluid components as markers of periodontal disease activity. J Clin Periodontol 1996;23:832-838.
39. Eley BM, Cox SW. Cathepsin B/1-, elastase-, tryptase-, trypsin- and dipeptidyl peptidase IV-like activities in GCF: correlation with clinical parameters in untreated chronic periodontitis patients. J Periodontal Res 1992;27:62-69.
40. Nakashima K, Roehrich N, Cimasoni G. Ostecalcin, prostaglandin E2 and alkaline phosphatase in gingival crevicular fluid: their relation to periodontal status. J Clin Periodontol 1994;21:327-333.
41. Kurtis B, Develioglu H, Taner IL, Balos K, Tekin IÖ. IL-6 levels in GCF from patients with non-insulin dependent diabetes mellitus, adult periodontitis and healthy subjects. J Oral Sci 1999;41:163-167.
42. Tsai CC, Ho YP, Chen CC. Levels of interleukin-1 and IL-8 in gingival crevicular fluids in adult periodontitis. J Periodontol 1995;66:852-859.
43. Egelberg J. Regeneration and repair of periodontal tissues. J Periodontal Res 1987;22:233-242.
44. Parashis A, Andronikaki-Faldami A, Tsiklakis K. Comparison of 2 regenerative procedures-guided tissue regeneration and demineralized freeze-dried bone allograft-in the treatment of intrabony defects: a clinical and radiographic study. J Periodontol 1998;69(7):751-758.
45. Becker W, Becker BE, Caffesse R. A comparison of demineralized freeze-dried bone and autologous bone to induce bone formation in human extraction sockets. J Periodontol 1994;65:1128-1133.
46. Serhan CN, Yacoubian S, Yang R. Anti-inflammatory and pro-resolving lipid mediators. Annu Rev Pathol 2008;3:279-312.
47. Xiao Y, Parry DA, Li H, Arnold R, Jackson WJ, Bartold PM. Expression of extracellular matrix molecules around demineralized freeze-dried bone allografts. J Periodontol 1996;67:1233-1244.
48. Kesavalu L, Vasudevan B, Raghu B et al. Omega-3 Fatty acid effect on alveolar bone loss in rats. J Dent Res 2006;85(7):648-652.
49. Hachicha M, Pouliot M, Petasis NA, Serhan CN. Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor- initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis. J Exp Med 1999;189:1923-1929.
50. 4 analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. Biochemistry 2000;39:4761-4768.
51. Cla'ria J, Serhan CN. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell leukocyte interactions. Proc Natl Acad Sci U S A 1995;92:9475-9479.
52. Endres S, Ghorbani R, Kelley VE et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989;320:265-271.
53. Alexander DC, Martin JC, King PJ, Powell JR, Caves J, Cohen ME. Interleukin-1 beta, prostaglandin E2, and immunoglobulin G subclasses in gingival crevicular fluid in patients undergoing periodontal therapy. J Periodontol 1996;67:755-762.
54. Kesavalu L, Bakthavatchalu V, Rahman MM et al. Omega-3 fatty acid regulates inflammatory cytokine/mediator messenger RNA expression in Porphyromonas gingivalis-induced experimental periodontal disease. Oral Microbiol Immunol 2007;22:232-239.
55. Kremer JM, Lawrence DA, Jubiz W et al. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Arthritis Rheum 1990;33:810-820.
56. Schmidt EB, Pedersen JO, Varming K et al. N-3 fatty acids and leukocyte chemotaxis: effects in hyperlipidemia, and dose-response studies in healthy males. Arterioscler Thromb 1991;11:429-435.
57. Calder PC. PUFA, inflammatory processes and rheumatoid arthritis. Proc Nutr Soc 2008;67:409-418.
58. Kris-Etherton PM, Harris WS, Apple IJ et al. Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arterioscler Thromb Vasc Biol 2003;23:151-152.