Comparative lipid binding study on the cerebroside sulfate activator (saposin B)

Journal of Neuroscience Research

Volumn 63, Issue 1, 2001, Pages 82-89

  Fluharty, Claire B ^a   Johnson, Jeffery ^a   Whitelegge, Julian ^a   Faull, Kym F ^a   Fluharty, Arvan L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b 68 177 NPI   (United States)

Author keywords

Arylsulf atase A; Cerebroside sulfate; Cerebroside sulfate activator; Glycosphingolipids; Lipid binding; Lysosomal hydrolases; Metachromatic leukodystrophy; Phosphoinositides; Phospholipids; Saposin B; Sulfatide

Indexed keywords

GLYCOSPHINGOLIPID; PROTEIN; SPHINGOLIPID ACTIVATOR PROTEIN; SULFATIDE;

ARTICLE; BINDING COMPETITION; CONCENTRATION (PARAMETERS); DEGENERATIVE DISEASE; GEL FILTRATION; LIPOLYSIS; MASS SPECTROMETRY; METACHROMATIC LEUKODYSTROPHY; NONHUMAN; PH; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION;

ANIMALS; BINDING, COMPETITIVE; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; CEREBROSIDES; GLYCOPROTEINS; LEUKODYSTROPHY, METACHROMATIC; MEMBRANE LIPIDS; SAPOSINS; SPHINGOLIPID ACTIVATOR PROTEINS; SWINE;

EID: 0035153728     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20010101)63:1<82::AID-JNR10>3.0.CO;2-D     Document Type: Article

References (24)

1. Cerebroside sulfate activator protein (saposin B): Chromatographic and electrospray mass spectrometric properties
2. Disulfide connectivity in cerebroside sulfate activator is not necessary for biological activity or a-helical content but is necessary for trypsin resistance and strong ligand binding
3. The activator of cerebroside-sulphatase. Binding studies with enzyme and substrate demonstrating the detergent function of the activator protein
4. The activator of cerebroside-sulphatase. A model of the activation
5. Studies on the function of the activator of sulphatase A
6. The cerebroside sulfate activator protein (Saposin B, SAP-1): A many faceted protein
7. 35S-labeled brain sulfatide
8. The cerebroside sulfate activator from pig kidney: Purification and molecular structure
9. The cerebroside sulfate activator from pig kidney: Derivitization, cerebroside sulfate binding, and metabolic correction
10. Interaction of GM2 activator protein with glycosphingolipids
11. Binding and transport of gangliosides by prosaposin
12. Metachromatic leukodystrophy and multiple sulfatase deficiency: Sulfatide lipidosis
13. Activator-dependent hydrolysis of myelin cerebroside sulfate by arylsulfatase A
14. Purification and properties of galatosylceramide sulfatase activator protein from human liver
15. Saposin-like proteins (SAPLIP) carry out diverse functions on a common backbone structure
16. The role of phosphoinositide 3-kinase lipid products in cell function
17. Sphingolipid activator proteins
18. Binding of cerbrosides and sulfatides to saposins A-D
19. Cerebroside sulfatase activator deficiency induced metachromatic leukodystrophy
20. pH-dependent conformational properties of saposins and their interactions with phospholipid membranes
21. Saposins and their interactions with lipids
22. Glycosphingolipid specifity of the human sulfatide activator protein
23. Studies on the sphingolipid activator protein for the enzymatic hydrolysis of GM1 ganglioside and sulfatide
24. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways