Contribution of bone marrow derived cells to the pancreatic tumor microenvironment

Frontiers in Physiology

Volumn 4 MAR, Issue , 2013, Pages

  Scarlett, Christopher J ^a,b  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Bone marrow derived stem cells; Fibrosis; Immunosuppression; Neovascularization; Pancreatic cancer; Pancreatic stellate cells; Stroma

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; EPIDERMAL GROWTH FACTOR; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; INTERLEUKIN 8; PLATELET DERIVED GROWTH FACTOR; SEPRASE; TRANSCRIPTION FACTOR PBX1; VASCULOTROPIN;

CARCINOGENESIS; CELL INTERACTION; CELL MIGRATION; CYTOKINE RELEASE; ENDOTHELIAL PROGENITOR CELL; EPITHELIUM TUMOR; FIBROBLAST; FIBROSIS; GENE MUTATION; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE DEFICIENCY; MAST CELL; MESENCHYMAL STEM CELL; MYOFIBROBLAST; NONHUMAN; PANCREAS CANCER; PANCREATIC STELLATE CELL; PANCREATITIS; PROTEIN SECRETION; SHORT SURVEY; SUPPRESSOR CELL; TUMOR CELL; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION;

EID: 84879490648     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2013.00056     Document Type: Short Survey

References (64)

1. Akita, S., Kubota, K., Kobayashi, A., Misawa, R., Shimizu, A., Nakata, T., et al. (2012). Role of bone marrow cells in the development of pancreatic fibrosis in a rat model of pancreatitis induced by a choline-deficient/ethionine-supplemented diet. Biochem. Biophys. Res. Commun. 420, 743-749.
2. Alison, M. R., Lovell, M. J., Direkze, N. C., Wright, N. A., and Poulsom, R. (2006). Stem cell plasticity and tumour formation. Eur. J. Cancer 42, 1247-1256.
3. Apte, M. V., Haber, P. S., Applegate, T. L., Norton, I. D., McCaughan, G. W., Korsten, M. A., et al. (1998). Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut 43, 128-133.
4. Apte, M. V., Park, S., Phillips, P. A., Santucci, N., Goldstein, D., Kumar, R. K., et al. (2004). Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas 29, 179-187.
5. Bachem, M. G., Schneider, E., Gross, H., Weidenbach, H., Schmid, R. M., Menke, A., et al. (1998). Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 115, 421-432.
6. Beckermann, B. M., Kallifatidis, G., Groth, A., Frommhold, D., Apel, A., Mattern, J., et al. (2008). VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma. Br. J. Cancer 99, 622-631.
7. Bruscia, E. M., Ziegler, E. C., Price, J. E., Weiner, S., Egan, M. E., and Krause, D. S. (2006). Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice. Stem Cells 24, 2299-2308.
8. Chan, D. A., Kawahara, T. L., Sutphin, P. D., Chang, H. Y., Chi, J. T., and Giaccia, A. J. (2009). Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell 15, 527-538.
9. Chang, D. Z., Ma, Y., Ji, B., Wang, H., Deng, D., Liu, Y., et al. (2011). Mast cells in tumor microenvironment promotes the in vivo growth of pancreatic ductal adenocarcinoma. Clin. Cancer Res. 17, 7015-7023.
10. Choi, J. B., Uchino, H., Azuma, K., Iwashita, N., Tanaka, Y., Mochizuki, H., et al. (2003). Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 46, 1366-1374.
11. Clark, C. E., Hingorani, S. R., Mick, R., Combs, C., Tuveson, D. A., and Vonderheide, R. H. (2007). Dynamics of the immune reaction to pancreatic cancer from inception to invasion. Cancer Res. 67, 9518-9527.
12. De Wever, O., and Mareel, M. (2003). Role of tissue stroma in cancer cell invasion. J. Pathol. 200, 429-447.
13. Diaz-Flores, L. Jr., Madrid, J. F., Gutierrez, R., Varela, H., Valladares, F., Alvarez-Arguelles, H., et al. (2006). Adult stem and transit-amplifying cell location. Histol. Histopathol. 21, 995-1027.
14. Ding, Z., Maubach, G., Masamune, A., and Zhuo, L. (2009). Glial fibrillary acidic protein promoter targets pancreatic stellate cells. Dig. Liver Dis. 41, 229-236.
15. Direkze, N. C., Hodivala-Dilke, K., Jeffery, R., Hunt, T., Poulsom, R., Oukrif, D., et al. (2004). Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res. 64, 8492-8495.
16. Erkan, M., Hausmann, S., Michalski, C. W., Schlitter, A. M., Fingerle, A. A., Dobritz, M., et al. (2012). How fibrosis influences imaging and surgical decisions in pancreatic cancer. Front. Physiol. 3:389. doi: 10.3389/fphys.2012.00389
17. Erkan, M., Weis, N., Pan, Z., Schwager, C., Samkharadze, T., Jiang, X., et al. (2010). Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells. Mol. Cancer 9, 88.
18. Evans, A., and Costello, E. (2012). The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion. Front. Physiol. 3:270. doi: 10.3389/fphys.2012.00270
19. Feig, C., Gopinathan, A., Neesse, A., Chan, D. S., Cook, N., and Tuveson, D. A. (2012). The pancreas cancer microenvironment. Clin. Cancer Res. 18, 4266-4276.
20. Gabrilovich, D. I., and Nagaraj, S. (2009). Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-174.
21. Galli, S. J., Nakae, S., and Tsai, M. (2005). Mast cells in the development of adaptive immune responses. Nat. Immunol. 6, 135-142.
22. Gao, D., Nolan, D. J., Mellick, A. S., Bambino, K., McDonnell, K., and Mittal, V. (2008a). Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 319, 195-198.
23. Gao, X., Song, L., Shen, K., Wang, H., Niu, W., and Qin, X. (2008b). Transplantation of bone marrow derived cells promotes pancreatic islet repair in diabetic mice. Biochem. Biophys. Res. Commun. 371, 132-137.
24. Hasegawa, Y., Ogihara, T., Yamada, T., Ishigaki, Y., Imai, J., Uno, K., et al. (2007). Bone marrow (BM) transplantation promotes beta-cell regeneration after acute injury through BM cell mobilization. Endocrinology 148, 2006-2015.
25. Herzog, E. L., Chai, L., and Krause, D. S. (2003). Plasticity of marrow-derived stem cells. Blood 102, 3483-3493.
26. Hess, D., Li, L., Martin, M., Sakano, S., Hill, D., Strutt, B., et al. (2003). Bone marrow-derived stem cells initiate pancreatic regeneration. Nat. Biotechnol. 21, 763-770.
27. Houghton, J., Stoicov, C., Nomura, S., Rogers, A. B., Carlson, J., Li, H., et al. (2004). Gastric cancer originating from bone marrow-derived cells. Science 306, 1568-1571.
28. Hwang, R. F., Moore, T., Arumugam, T., Ramachandran, V., Amos, K. D., Rivera, A., et al. (2008). Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res. 68, 918-926.
29. Ianus, A., Holz, G. G., Theise, N. D., and Hussain, M. A. (2003). In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest. 111, 843-850.
30. Jang, Y. Y., Collector, M. I., Baylin, S. B., Diehl, A. M., and Sharkis, S. J. (2004). Hematopoietic stem cells convert into liver cells within days without fusion. Nat. Cell Biol. 6, 532-539.
31. Kalesnikoff, J., and Galli, S. J. (2008). New developments in mast cell biology. Nat. Immunol. 9, 1215-1223.
32. Kallifatidis, G., Beckermann, B. M., Groth, A., Schubert, M., Apel, A., Khamidjanov, A., et al. (2008). Improved lentiviral transduction of human mesenchymal stem cells for therapeutic intervention in pancreatic cancer. Cancer Gene Ther. 15, 231-240.
33. Kraman, M., Bambrough, P. J., Arnold, J. N., Roberts, E. W., Magiera, L., Jones, J. O., et al. (2010). Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha. Science 330, 827-830.
34. Krause, D. S., Theise, N. D., Collector, M. I., Henegariu, O., Hwang, S., Gardner, R., et al. (2001). Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105, 369-377.
35. Lechner, A., Yang, Y. G., Blacken, R. A., Wang, L., Nolan, A. L., and Habener, J. F. (2004). No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 53, 616-623.
36. Li, A., Cheng, X. J., Moro, A., Singh, R. K., Hines, O. J., and Eibl, G. (2011). CXCR2-dependent endothelial progenitor cell mobilization in pancreatic cancer growth. Transl. Oncol. 4, 20-28.
37. Lin, W. R., Inatomi, O., Lee, C. Y., Kallis, Y. N., Otto, W. R., Jeffery, R., et al. (2012). Bone marrow-derived cells contribute to cerulein-induced pancreatic fibrosis in the mouse. Int. J. Exp. Pathol. 93, 130-138.
38. Lowenfels, A. B., Maisonneuve, P., Cavallini, G., Ammann, R. W., Lankisch, P. G., Andersen, J. R., et al. (1993). Pancreatitis and the risk of pancreatic cancer. N. Engl. J. Med. 328, 1433-1437.
39. Luo, G., Long, J., Zhang, B., Liu, C., Xu, J., Ni, Q., et al. (2012). Stroma and pancreatic ductal adenocarcinoma: an interaction loop. Biochim. Biophys. Acta 1826, 170-178.
40. Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., et al. (2001). Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat. Med. 7, 1194-1201.
41. Marigo, I., Dolcetti, L., Serafini, P., Zanovello, P., and Bronte, V. (2008). Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells. Immunol. Rev. 222, 162-179.
42. Marrache, F., Pendyala, S., Bhagat, G., Betz, K. S., Song, Z., and Wang, T. C. (2008). Role of bone marrow-derived cells in experimental chronic pancreatitis. Gut 57, 1113-1120.
43. Mathews, V., Hanson, P. T., Ford, E., Fujita, J., Polonsky, K. S., and Graubert, T. A. (2004). Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury. Diabetes 53, 91-98.
44. Minami, E., Laflamme, M. A., Saffitz, J. E., and Murry, C. E. (2005). Extracardiac progenitor cells repopulate most major cell types in the transplanted human heart. Circulation 112, 2951-2958.
45. Mizukami, Y. (2012). Bone marrow-derived proangiogenic cells in pancreatic cancer. J. Gastroenterol. Hepatol. 27(Suppl. 2), 23-26.
46. Nakamura, K., Sasajima, J., Mizukami, Y., Sugiyama, Y., Yamazaki, M., Fujii, R., et al. (2010). Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PLoS ONE 5:e8824. doi: 10.1371/journal.pone.0008824
47. Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., et al. (2009). Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461.
48. Pan, J. J., Oh, S. H., Lee, W. C., and Petersen, B. E. (2009). Bone marrow-derived progenitor cells could modulate pancreatic cancer tumorigenesis via peritumoral microenvironment in a rat model. Oncol. Res. 17, 339-345.
49. Phillips, P. (2012). "Pancreatic stellate cells and fibrosis," in Pancreatic Cancer and Tumor Microenvironment, eds P. J. Grippo and H. G. Munshi (Trivandrum: Transworld Research Network), 29-53.
50. Porembka, M. R., Mitchem, J. B., Belt, B. A., Hsieh, C. S., Lee, H. M., Herndon, J., et al. (2012). Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth. Cancer Immunol. Immunother. 61, 1373-1385.
51. Poulsom, R., Alison, M. R., Forbes, S. J., and Wright, N. A. (2002). Adult stem cell plasticity. J. Pathol. 197, 441-456.
52. Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., and Hingorani, S. R. (2012). Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21, 418-429.
53. Raman, D., Baugher, P. J., Thu, Y. M., and Richmond, A. (2007). Role of chemokines in tumor growth. Cancer Lett. 256, 137-165.
54. Scarlett, C. J., Colvin, E. K., Pinese, M., Chang, D. K., Morey, A. L., Musgrove, E. A., et al. (2011). Recruitment and activation of pancreatic stellate cells from the bone marrow in pancreatic cancer: a model of tumor-host interaction. PLoS ONE 6:e26088. doi: 10.1371/journal.pone.0026088
55. Schreiber, H., and Rowley, D. A. (2010). Cancer. Awakening immunity. Science 330, 761-762.
56. Serafini, P., Borrello, I., and Bronte, V. (2006). Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Semin. Cancer Biol. 16, 53-65.
57. Shojaei, F., Wu, X., Zhong, C., Yu, L., Liang, X. H., Yao, J., et al. (2007). Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450, 825-831.
58. Sparmann, G., Kruse, M. L., Hofmeister-Mielke, N., Koczan, D., Jaster, R., Liebe, S., et al. (2010). Bone marrow-derived pancreatic stellate cells in rats. Cell Res. 20, 288-298.
59. Taneera, J., Rosengren, A., Renstrom, E., Nygren, J. M., Serup, P., Rorsman, P., et al. (2006). Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate. Diabetes 55, 290-296.
60. Vonlaufen, A., Joshi, S., Qu, C., Phillips, P. A., Xu, Z., Parker, N. R., et al. (2008). Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Cancer Res. 68, 2085-2093.
61. Wagers, A. J., Sherwood, R. I., Christensen, J. L., and Weissman, I. L. (2002). Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 297, 2256-2259.
62. Wang, X., Ge, S., Gonzalez, I., McNamara, G., Rountree, C. B., Xi, K. K., et al. (2006). Formation of pancreatic duct epithelium from bone marrow during neonatal development. Stem Cells 24, 307-314.
63. Watanabe, T., Masamune, A., Kikuta, K., Hirota, M., Kume, K., Satoh, K., et al. (2009). Bone marrow contributes to the population of pancreatic stellate cells in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 297, G1138-G1146.
64. Wente, M. N., Keane, M. P., Burdick, M. D., Friess, H., Buchler, M. W., Ceyhan, G. O., et al. (2006). Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis. Cancer Lett. 241, 221-227.