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Volumn 82, Issue 2, 2013, Pages 294-298

Clinical implications of T790M mutation in patients with acquired resistance to EGFR tyrosine kinase inhibitors

Author keywords

Afatinib; Epidermal growth factor receptor; Resistance; T790M; Tyrosine kinase inhibitor

Indexed keywords

AFATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB;

EID: 84887016132     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2013.08.023     Document Type: Article
Times cited : (104)

References (32)
  • 1
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • Maemondo M., Inoue A., Kobayashi K., Sugawara S., Oizumi S., Isobe H., et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010, 362:2380-2388.
    • (2010) N Engl J Med , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3    Sugawara, S.4    Oizumi, S.5    Isobe, H.6
  • 2
    • 84875884612 scopus 로고    scopus 로고
    • Real world impact of epidermal growth factor receptor mutation status on treatment patterns in patients with non-small cell lung cancer
    • Sun J.M., Rampal S., Lee G., Lee J., Choi Y.L., Parasuraman B., et al. Real world impact of epidermal growth factor receptor mutation status on treatment patterns in patients with non-small cell lung cancer. Lung Cancer 2013, 80:191-196.
    • (2013) Lung Cancer , vol.80 , pp. 191-196
    • Sun, J.M.1    Rampal, S.2    Lee, G.3    Lee, J.4    Choi, Y.L.5    Parasuraman, B.6
  • 3
    • 38049150665 scopus 로고    scopus 로고
    • MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
    • Bean J., Brennan C., Shih J.Y., Riely G., Viale A., Wang L., et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 2007, 104:20932-20937.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20932-20937
    • Bean, J.1    Brennan, C.2    Shih, J.Y.3    Riely, G.4    Viale, A.5    Wang, L.6
  • 5
    • 84887017461 scopus 로고    scopus 로고
    • EGFR T790M decreases growth potential of lung tumor cells with drug-sensitive EGFR mutant alleles in the absence of drug selection
    • (abstract 4217)
    • Chmielecki J., Foo J., Somwar R., Regales L., Vivanco I., Shen R., et al. EGFR T790M decreases growth potential of lung tumor cells with drug-sensitive EGFR mutant alleles in the absence of drug selection. AACR 100th Annual Meeting 2009, (abstract 4217).
    • (2009) AACR 100th Annual Meeting
    • Chmielecki, J.1    Foo, J.2    Somwar, R.3    Regales, L.4    Vivanco, I.5    Shen, R.6
  • 6
    • 79952259564 scopus 로고    scopus 로고
    • Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
    • Arcila M.E., Oxnard G.R., Nafa K., Riely G.J., Solomon S.B., Zakowski M.F., et al. Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin Cancer Res 2011, 17:1169-1180.
    • (2011) Clin Cancer Res , vol.17 , pp. 1169-1180
    • Arcila, M.E.1    Oxnard, G.R.2    Nafa, K.3    Riely, G.J.4    Solomon, S.B.5    Zakowski, M.F.6
  • 8
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W., Miller V.A., Politi K.A., Riely G.J., Somwar R., Zakowski M.F., et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005, 2:e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 9
    • 84877100240 scopus 로고    scopus 로고
    • Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
    • Yu H.A., Arcila M.E., Rekhtman N., Sima C.S., Zakowski M.F., Pao W., et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res 2013, 19:2240-2247.
    • (2013) Clin Cancer Res , vol.19 , pp. 2240-2247
    • Yu, H.A.1    Arcila, M.E.2    Rekhtman, N.3    Sima, C.S.4    Zakowski, M.F.5    Pao, W.6
  • 10
    • 40049099220 scopus 로고    scopus 로고
    • The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
    • Yun C.H., Mengwasser K.E., Toms A.V., Woo M.S., Greulich H., Wong K.K., et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A 2008, 105:2070-2075.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 2070-2075
    • Yun, C.H.1    Mengwasser, K.E.2    Toms, A.V.3    Woo, M.S.4    Greulich, H.5    Wong, K.K.6
  • 11
    • 84872696927 scopus 로고    scopus 로고
    • Rebiopsy of non-small cell lung cancer patients with acquired resistance to EGFR-TKI: comparison between T790M mutation-positive and -negative populations
    • SUPPL, (abstr 7528)
    • Hata A., Katakami N., Yoshioka H., Takeshita J., Tanaka K., Nanjo S., et al. Rebiopsy of non-small cell lung cancer patients with acquired resistance to EGFR-TKI: comparison between T790M mutation-positive and -negative populations. J Clin Oncol 2012, Suppl (30). (abstr 7528).
    • (2012) J Clin Oncol , Issue.30
    • Hata, A.1    Katakami, N.2    Yoshioka, H.3    Takeshita, J.4    Tanaka, K.5    Nanjo, S.6
  • 12
    • 79952711946 scopus 로고    scopus 로고
    • Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation
    • Oxnard G.R., Arcila M.E., Sima C.S., Riely G.J., Chmielecki J., Kris M.G., et al. Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation. Clin Cancer Res 2011, 17:1616-1622.
    • (2011) Clin Cancer Res , vol.17 , pp. 1616-1622
    • Oxnard, G.R.1    Arcila, M.E.2    Sima, C.S.3    Riely, G.J.4    Chmielecki, J.5    Kris, M.G.6
  • 13
    • 84858007882 scopus 로고    scopus 로고
    • T790M is associated with a favorable prognosis in Japanese patients treated with an EGFR-TKI
    • Uramoto H., Yano S., Tanaka F. T790M is associated with a favorable prognosis in Japanese patients treated with an EGFR-TKI. Lung Cancer 2012, 76:129-130.
    • (2012) Lung Cancer , vol.76 , pp. 129-130
    • Uramoto, H.1    Yano, S.2    Tanaka, F.3
  • 15
    • 79952264325 scopus 로고    scopus 로고
    • Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations
    • Rosell R., Molina M.A., Costa C., Simonetti S., Gimenez-Capitan A., Bertran-Alamillo J., et al. Pretreatment EGFR T790M mutation and BRCA1 mRNA expression in erlotinib-treated advanced non-small-cell lung cancer patients with EGFR mutations. Clin Cancer Res 2011, 17:1160-1168.
    • (2011) Clin Cancer Res , vol.17 , pp. 1160-1168
    • Rosell, R.1    Molina, M.A.2    Costa, C.3    Simonetti, S.4    Gimenez-Capitan, A.5    Bertran-Alamillo, J.6
  • 16
    • 84863011443 scopus 로고    scopus 로고
    • Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer
    • Su K.Y., Chen H.Y., Li K.C., Kuo M.L., Yang J.C., Chan W.K., et al. Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer. J Clin Oncol 2012, 30:433-440.
    • (2012) J Clin Oncol , vol.30 , pp. 433-440
    • Su, K.Y.1    Chen, H.Y.2    Li, K.C.3    Kuo, M.L.4    Yang, J.C.5    Chan, W.K.6
  • 17
    • 84859418112 scopus 로고    scopus 로고
    • The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor
    • Kim Y., Ko J., Cui Z., Abolhoda A., Ahn J.S., Ou S.H., et al. The EGFR T790M mutation in acquired resistance to an irreversible second-generation EGFR inhibitor. Mol Cancer Ther 2012, 11:784-791.
    • (2012) Mol Cancer Ther , vol.11 , pp. 784-791
    • Kim, Y.1    Ko, J.2    Cui, Z.3    Abolhoda, A.4    Ahn, J.S.5    Ou, S.H.6
  • 18
    • 77954584507 scopus 로고    scopus 로고
    • Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer
    • Sequist L.V., Besse B., Lynch T.J., Miller V.A., Wong K.K., Gitlitz B., et al. Neratinib, an irreversible pan-ErbB receptor tyrosine kinase inhibitor: results of a phase II trial in patients with advanced non-small-cell lung cancer. J Clin Oncol 2010, 28:3076-3083.
    • (2010) J Clin Oncol , vol.28 , pp. 3076-3083
    • Sequist, L.V.1    Besse, B.2    Lynch, T.J.3    Miller, V.A.4    Wong, K.K.5    Gitlitz, B.6
  • 19
    • 84874544125 scopus 로고    scopus 로고
    • EGFR mutation testing in patients with advanced non-small cell lung cancer: a comprehensive evaluation of real-world practice in an East Asian tertiary hospital
    • Choi Y.L., Sun J.M., Cho J., Rampal S., Han J., Parasuraman B., et al. EGFR mutation testing in patients with advanced non-small cell lung cancer: a comprehensive evaluation of real-world practice in an East Asian tertiary hospital. PLoS ONE 2013, 8:e56011.
    • (2013) PLoS ONE , vol.8
    • Choi, Y.L.1    Sun, J.M.2    Cho, J.3    Rampal, S.4    Han, J.5    Parasuraman, B.6
  • 20
    • 84861977785 scopus 로고    scopus 로고
    • T790M and acquired resistance of EGFR TKI: a literature review of clinical reports
    • Ma C., Wei S., Song Y. T790M and acquired resistance of EGFR TKI: a literature review of clinical reports. J Thorac Dis 2011, 3:10-18.
    • (2011) J Thorac Dis , vol.3 , pp. 10-18
    • Ma, C.1    Wei, S.2    Song, Y.3
  • 21
    • 80052437758 scopus 로고    scopus 로고
    • New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer
    • Oxnard G.R., Arcila M.E., Chmielecki J., Ladanyi M., Miller V.A., Pao W. New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer. Clin Cancer Res 2011, 17:5530-5537.
    • (2011) Clin Cancer Res , vol.17 , pp. 5530-5537
    • Oxnard, G.R.1    Arcila, M.E.2    Chmielecki, J.3    Ladanyi, M.4    Miller, V.A.5    Pao, W.6
  • 22
    • 33947287270 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib
    • Mulloy R., Ferrand A., Kim Y., Sordella R., Bell D.W., Haber D.A., et al. Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib. Cancer Res 2007, 67:2325-2330.
    • (2007) Cancer Res , vol.67 , pp. 2325-2330
    • Mulloy, R.1    Ferrand, A.2    Kim, Y.3    Sordella, R.4    Bell, D.W.5    Haber, D.A.6
  • 23
    • 34250329445 scopus 로고    scopus 로고
    • EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    • Vikis H., Sato M., James M., Wang D., Wang Y., Wang M., et al. EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Res 2007, 67:4665-4670.
    • (2007) Cancer Res , vol.67 , pp. 4665-4670
    • Vikis, H.1    Sato, M.2    James, M.3    Wang, D.4    Wang, Y.5    Wang, M.6
  • 24
    • 37549061078 scopus 로고    scopus 로고
    • PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib
    • Engelman J.A., Zejnullahu K., Gale C.M., Lifshits E., Gonzales A.J., Shimamura T., et al. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res 2007, 67:11924-11932.
    • (2007) Cancer Res , vol.67 , pp. 11924-11932
    • Engelman, J.A.1    Zejnullahu, K.2    Gale, C.M.3    Lifshits, E.4    Gonzales, A.J.5    Shimamura, T.6
  • 25
    • 49149118719 scopus 로고    scopus 로고
    • BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
    • Li D., Ambrogio L., Shimamura T., Kubo S., Takahashi M., Chirieac L.R., et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008, 27:4702-4711.
    • (2008) Oncogene , vol.27 , pp. 4702-4711
    • Li, D.1    Ambrogio, L.2    Shimamura, T.3    Kubo, S.4    Takahashi, M.5    Chirieac, L.R.6
  • 26
    • 84862785051 scopus 로고    scopus 로고
    • Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial
    • Miller V.A., Hirsh V., Cadranel J., Chen Y.M., Park K., Kim S.W., et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol 2012, 13:528-538.
    • (2012) Lancet Oncol , vol.13 , pp. 528-538
    • Miller, V.A.1    Hirsh, V.2    Cadranel, J.3    Chen, Y.M.4    Park, K.5    Kim, S.W.6
  • 27
    • 42249086436 scopus 로고    scopus 로고
    • The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor
    • Godin-Heymann N., Ulkus L., Brannigan B.W., McDermott U., Lamb J., Maheswaran S., et al. The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor. Mol Cancer Ther 2008, 7:874-879.
    • (2008) Mol Cancer Ther , vol.7 , pp. 874-879
    • Godin-Heymann, N.1    Ulkus, L.2    Brannigan, B.W.3    McDermott, U.4    Lamb, J.5    Maheswaran, S.6
  • 28
    • 84868451429 scopus 로고    scopus 로고
    • CO-1686, an orally available, mutant-selective inhibitor of the epidermal growth factor receptor (EGFR) causes tumor shrinkage in non-small cell lung cancer (NSCLC) with T790M mutations
    • Walter A.O., Tjin R., Haringsma H., Lin K., Dubrovskiy A., Lee K., et al. CO-1686, an orally available, mutant-selective inhibitor of the epidermal growth factor receptor (EGFR) causes tumor shrinkage in non-small cell lung cancer (NSCLC) with T790M mutations. Mol Cancer Ther 2011, 10(Suppl 1):C189.
    • (2011) Mol Cancer Ther , vol.10 , Issue.SUPPL 1
    • Walter, A.O.1    Tjin, R.2    Haringsma, H.3    Lin, K.4    Dubrovskiy, A.5    Lee, K.6
  • 29
    • 72949092456 scopus 로고    scopus 로고
    • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
    • Zhou W., Ercan D., Chen L., Yun C.H., Li D., Capelletti M., et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 2009, 462:1070-1074.
    • (2009) Nature , vol.462 , pp. 1070-1074
    • Zhou, W.1    Ercan, D.2    Chen, L.3    Yun, C.H.4    Li, D.5    Capelletti, M.6
  • 30
    • 84887022708 scopus 로고    scopus 로고
    • National Institutes of Health. Study to evaluate safety, pharmacokinetics, and preliminary efficacy of CO-1686 in previously treated mutant epidermal growth factor receptor (EGFR) non-small cell lung cancer (NSCLC). Available from: accessed 13.04.2013.
    • National Institutes of Health. Study to evaluate safety, pharmacokinetics, and preliminary efficacy of CO-1686 in previously treated mutant epidermal growth factor receptor (EGFR) non-small cell lung cancer (NSCLC). Available from: http://www.clinicaltrials.gov/show/NCT01526928, accessed 13.04.2013.
  • 31
    • 84887021489 scopus 로고    scopus 로고
    • National Institutes of Health. Clinical Trials Registry. AZD9291 First time in patients ascending dose study. Available from: accessed 21.06.2013.
    • National Institutes of Health. Clinical Trials Registry. AZD9291 First time in patients ascending dose study. Available from: http://www.clinicaltrials.gov/show/NCT01802632, accessed 21.06.2013.
  • 32
    • 84885353771 scopus 로고    scopus 로고
    • First-in-human evaluation of CO-1686, an irreversible, selective and potent tyrosine kinase inhibitor of EGFR T790M
    • (abstract 2524)
    • Sequist L.V., Soria J.C., Gadgeel S.M., Wakelee H., Camidge D.R., Varga A., et al. First-in-human evaluation of CO-1686, an irreversible, selective and potent tyrosine kinase inhibitor of EGFR T790M. J Clin Oncol 2013, Suppl (30). (abstract 2524).
    • (2013) J Clin Oncol , Issue.30 SUPPL
    • Sequist, L.V.1    Soria, J.C.2    Gadgeel, S.M.3    Wakelee, H.4    Camidge, D.R.5    Varga, A.6


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