Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy

British Journal of Cancer

Volumn 96, Issue 8, 2007, Pages 1183-1190

  Sultana, A ^a   Tudur Smith, C ^a   Cunningham, D ^b   Starling, N ^b   Tait, D ^b   Neoptolemos, J P ^a   Ghaneh, P ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

Chemoradiation; Chemotherapy; Combined modality; Pancreas cancer; Radiotherapy

Indexed keywords

CISPLATIN; DOXORUBICIN; FLUOROURACIL; GEMCITABINE; MITOMYCIN; SEMUSTINE; STREPTOZOCIN;

ADVANCED CANCER; BIBLIOGRAPHIC DATABASE; BLOOD TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER REGISTRY; CANCER SURVIVAL; CLINICAL TRIAL; COMPARATIVE STUDY; CONTINUOUS INFUSION; DISEASE COURSE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; HUMAN; META ANALYSIS; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PANCREAS CANCER; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SYSTEMATIC REVIEW; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; VOMITING;

COMBINED MODALITY THERAPY; HUMANS; META-ANALYSIS; PANCREATIC NEOPLASMS; RANDOMIZED CONTROLLED TRIALS;

EID: 34247252488     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603719     Document Type: Review

References (40)

1. Altman D, De Stavola B, Love S, Stepniewska K (1995) Review of survival analysis published in cancer journals. Br J Cancer 72: 511-518
2. American Cancer Society (2003) Cancer Facts and Figures 2003. American Cancer Society: Atlanta
3. Banu E, Oudard S, Banu A, Fodor A, Landi B, Lecomte T, Laurent-Puig P, Cugnenc PJ, Andrieu JM (2005) Cumulative meta-analysis of randomised trials comparing gemcitabine-based chemotherapy vs gemcitabine alone in patients with advanced or metastatic pancreatic cancer. In ASCO Annual Meeting, abstract no. 4101, Orlando, USA
4. Bria E, Carlini P, Gelibter A, Ruggeri E, Ceribelli A, Pino M, Terzoli E, Cognetti F, Giannarelli D, Milella M (2006) Current status of targeted agents in advanced pancreatic cancer (APC): A pooled analysis of 2,361 patients (pts) enrolled in six phase III trials. J Clin Oncol 24: 4126
5. Cardenes H, Chiorean E, DeWitt J, Schmidt M, Loehrer P (2006) Locally advanced pancreatic cancer: Current therapeutic approach. Oncologist 11: 612-623
6. Chauffert B, Mornex F, Bonnetain F, Triboulet J, Bouche O, Rougier P, Bosset J, Aparicio T, Masskouri F, Bedenne L (2006) Phase III trial comparing initial chemoradiotherapy (intermittent cisplatin and infusional 5-FU) followed by gemcitabine vs gemcitabine alone in patients with locally advanced non metastatic pancreatic cancer: A FFCD-SFRO study. J Clin Oncol 24: 4008
7. Childs D, Moertel C, Holbrook M, Reitemeier RJ, Colby Jr MY (1965) Treatment of malignant neoplasms of the gastrointestinal tract with a combination of 5FU and radiation. Radiology 84: 843-848
8. Cohen S, Dobelbower R, Lipsitz S, Catalano PJ, Sischy B, Smith TJ, Haller DG, Eastern Cooperative Oncology Group (2005) A randomised phase III study of radiotherapy alone or with 5-fluorouracil and mitomycin C in patients with locally advanced adenocarcinoma of the pancreas: Eastern Cooperative Oncology Group Study E8282. Int J Radiat Oncol Biol Phys 62: 1345-1350
9. Deeks J, Altman D, Bradburn M (2001) Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In Systematic Reviews in Health Care. Meta-Analysis in Context Egger M, Smith G and Altman D (eds) pp 285-312. London: BMJ, Publishing Group
10. Deeks J, Higgins J, Altman D (2004) Analysing and presenting results. In Cochrane Reviewers Handbook 4.2.2 [updated March 2004]; Section 8 pp www.cochrane.org/resources/handbook/hbook.htm.
11. Earle J, Foley J, Wieand H, Kvols LK, McKenna PJ, Krook JE, Tschetter LK, Schutt AJ, Twito DI (1994) Evaluation of external beam radiotherapy plus 5 Fluorouracil vs external beam radiotherapy plus hyacanthone in confined, unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys 28: 207-211
12. Fung M, Ishiguro H, Takayama S, Morizane T, Adachi S, Sakata T, Oncology Department Japan Clinical Research Eli Lilly Company Japan KK, Kobe Japan (2003) Survival benefit of chemotherapy treatment in advanced pancreatic cancer: a meta-analysis. In 2003 ASCO Annual Meeting, abstract no. 1155, USA
13. Garofalo M, Flannery T, Regine W (2006) The case for adjuvant chemoradiation for pancreatic cancer. Best Practice Res Clin Gastroenterol 20: 403-416
14. Gastrointestinal Tumour Study Group (1985) Radiation therapy combined with adriamycin or 5-Fluorouracil for the treatment of locally unresectable pancreatic carcinoma. Cancer 56: 2563-2568
15. Gastrointestinal Tumour Study Group (1988) Treatment of locally unresectable carcinoma of the pancreas; comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst 80: 751-755
16. Haslam J, Cavanaugh P, Stroup S (1973) Radiation therapy in the treatment of unresectable adenocarcinoma of the pancreas. Cancer 32: 1341-1345
17. Hazel J, Thirlwell M, Huggins M (1981) Multidrug chemotherapy with/without radiation for carcinoma of the stomach and pancreas: a prospective randomised trial. J Assoc Can Radiol 32: 164-165
18. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, Thun M (2006) Cancer statistics. CA Cancer J Clin 56: 106-130
19. Klassen D, MacIntyre J, Catton G, Engstrom PF, Moertel CG (1985) Treatment of locally unresectable cancer of the stomach and pancreas: A randomised comparison of 5FU alone with radiation plus concurrent and maintainence 5FU- An Eastern Cooperative Oncology Group Study. J Clin Oncol 3: 373-378
20. Li C-P, Chao Y, Chi K-H, Chan W-K, Teng H-C, Lee R-C, Chang F-Y, Lee S-D, Yen S-H (2003) Concurrent chemoradiotherapy treatment of locally advanced pancreatic cancer: gemcitabine vs 5-Fluorouracil, a randomised controlled trial. Int J Radiat Oncol Biol Phys 57: 98-104
21. Liang H (2005) Comparing gemcitabine-based combination chemotherapy with gemcitabine alone in inoperable pancreatic cancer: a meta-analysis. In ASCO Annual Meeting, abstract no. 4110, Orlando, USA
22. Light R, Pillemer D (1984) Summing Up: The Science of Reviewing Research. Harvard University Press: Cambridge, MA
23. Liu R, Traverso L (2004) Laparoscopic staging should be used routinely for locally extensive cancer of the pancreatic head. J Gastrointest Surg 8: 923-924
24. Lockhart A, Rothenberg M, Berlin J (2005) Treatment for pancreatic cancer: Current therapy and continued progress. Gastroenterology 128: 1642-1654
25. Maheshwari V, Moser A (2005) Current management of locally advanced pancreatic cancer. Nat Clin Pract Gastroenterol Hepatol 2: 356-364
26. Michl P, Pauls S, Gress TM (2005) Evidence-based diagnosis and staging of pancreatic cancer. Best Practice Res Clin Gastroenterol 20: 227-251
27. Milella M, Carlini P, Gelibter A, Ruggeri E, Ceribelli A, Pino M, Terzoli E, Cognetti F, Giannarelli D, Bria E (2006) Gemcitabine-based polychemotherapy for advanced pancreatic cancer (APC): is it ready for prime time? pooled analysis of 3682 patients (pts) enrolled in 12 phase III trials. J Clin Oncol 24: 4118
28. Moertel C, Childs D, Reitmeier R, Colby Jr MY, Holbrook MA (1969) Combined 5FU and supervoltage RT for locally unresectable GI cancer. Lancet 2: 865-867
29. Moertel C, Frytak S, Hahn RO'Connell MJ, Reitemeier RJ, Rubin J, Schutt AJ, Weiland LH, Childs DS, Holbrook MA, Lavin PT, Livstone E, Spiro H, Knowlton A, Kalser M, Barkin J, Lessner H, Mann-Kaplan R, Ramming K, Douglas Jr HO, Thomas P, Nave H, Bateman J, Lokich J, Brooks J, Chaffey J, Corson JM, Zamcheck N, Novak JW (1981) Therapy of locally unresectable pancreatic carcinoma: a randomised comparison of high dose (6000 rad) radiation alone, moderate dose radiation (4000 rad+5-Fluorouracil), and high dose radiation+5-Fluorouracil. Cancer 48: 1705-1710
30. Parmar M, Valter T, Stewart L (1998) Extracting summary statistics to perform meta-analysis of the published literature for survival end points. Statist Med 17: 2815-2834
31. Schulz K, Grimes D (2005) Multiplicity in randomised trials II: subgroup and interim analyses. Lancet 365: 1657-1661
32. Shinchi H, Takao S, Noma H, Matsuo Y, Mataki Y, Mori S, Aikou T (2002) Length and quality of survival after external-beam radiotherapy with concurrent continuous 5-Fluorouracil infusion for locally unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys 53: 146-150
33. Shoup M, Winston C, Brennan M, Bassman D, Conlon K (2004) Is there a role for staging laparoscopy in patients with locally advanced, unresectable pancreatic adenocarcinoma? J Gastrointest Surg 8: 1068-1071
34. Sterne J, Egger M, Sutton A (2001) Meta-analysis software. In Systematic Reviews in Health Care. Meta-Analysis in Context Egger M, Smith G and Altman D (eds) pp. 336-346. London: BMJ, Publishing Group
35. Sultana A, Tudur Smith C, Cunningham D, Starling N, Neoptolemos JP, Ghaneh P (2007) Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer. J Clin Oncol (in press)
36. White R, Lee C, Anscher M, Gottfried M, Wolff R, Keogan M, Pappas T, Hurwitz H, Tyler D (1999) Preoperative chemoradiation for patients with locally advanced adenocarcinoma of the pancreas. Ann Surg Oncol 6: 38-45
37. Wilkowski R, Rau H, Bruns C, Wagner A, Sauer R, Hohenberger W, Koelbl O, Heinemann V (2006) Randomised phase II trial comparing gemcitabine/cisplatin- based chemoradiotherapy to 5-FU based chemoradiotherapy in patients with locally advanced pancreatic cancer. J Clin Oncol 24: 4038
38. Williamson P, Smith C, Hutton J, Marson A (2002) Aggregate data meta-analysis with time-to-event outcome. Statist Med 21: 3337-3351
39. Yang G, Wagner T, Fuss M, Thomas C (2005) Multimodality approaches for pancreatic cancer. CA Cancer J Clin 55: 352-367
40. Yip D, Karapetis C, Strickland A, Steer C, Goldstein D (2006) Chemotherapy and radiotherapy for inoperable pancreatic cancer. In Cochrane Database of Systematic Reviews 3, Art. No. CD002093. DOI: 10.1002/14651858.CD002093.pub2