DNA binding studies and cytotoxicity of a dinuclear PtII diazapyrenium-based metallo-supramolecular rectangular box

Chemistry - A European Journal

Volumn 18, Issue 35, 2012, Pages 10983-10990

  Terenzi, Alessio ^a,b   Ducani, Cosimo ^a,d   Blanco, Víctor ^c   Zerzankova, Lenka ^e,f   Westendorf, Aron F ^f   Peinador, Carlos ^c   Quintela, José M ^c   Bednarski, Patrick J ^f   Barone, Giampaolo ^b   Hannon, Michael J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF PALERMO   (Italy)

^c UNIVERSITY OF A CORUÑA   (Spain)

^d UNIVERSITY OF SALENTO   (Italy)

^e INSTITUTE OF BIOPHYSICS   (Czech Republic)

^f UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

cytotoxicity; metallodrugs; noncovalent DNA binding; PtII rectangular box; supramolecular chemistry

Indexed keywords

BINDING CONSTANT; CANCER CELLS; CIS-PLATIN; DINUCLEAR; DNA BINDING; DNA BINDING STUDIES; HUMAN CANCER CELLS; IN-VITRO; INTERCALATORS; LINEAR DICHROISM; METAL-FREE LIGANDS; METALLACYCLES; METALLO-SUPRAMOLECULAR; METALLODRUGS; PCR ASSAY; RECTANGULAR BOX;

CELL CULTURE; CELLS; CYTOTOXICITY; DNA; FLUORESCENCE SPECTROSCOPY; LIGANDS; PLATINUM; PLATINUM COMPOUNDS; SUPRAMOLECULAR CHEMISTRY;

POLYMERASE CHAIN REACTION;

2,7 DIAZAPYRENIUM; 2,7-DIAZAPYRENIUM; ANTINEOPLASTIC AGENT; CISPLATIN; DNA; INTERCALATING AGENT; LIGAND; PHENANTHROLINE DERIVATIVE; PLATINUM; PLATINUM COMPLEX;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CHEMISTRY; CIRCULAR DICHROISM; CONFORMATION; DNA DENATURATION; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; IC 50; KINETICS; SPECTROFLUOROMETRY; THERMODYNAMICS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CIRCULAR DICHROISM; CISPLATIN; DNA, NEOPLASM; HUMANS; INHIBITORY CONCENTRATION 50; INTERCALATING AGENTS; KINETICS; LIGANDS; MOLECULAR CONFORMATION; NUCLEIC ACID DENATURATION; ORGANOPLATINUM COMPOUNDS; PHENANTHROLINES; PLATINUM; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS;

EID: 84865220502     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201201519     Document Type: Article

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