Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures

Experimental Neurology

Volumn 251, Issue , 2014, Pages 84-90

  Simeone, Kristina A ^a   Matthews, Stephanie A ^a   Samson, Kaeli K ^a   Simeone, Timothy A ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alpha tocopherol; Antioxidant; Ascorbic acid; Epilepsy; Field potentials; Kainic acid; Kcna1 null mice; Kv1.1 knockout mice; Mitochondria; Mitochondrial complex I; Mitochondrial uncoupling; Paired pulse ratios; Pyruvate; ROS; Seizure like events; Seizures

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CYTOCHROME C OXIDASE; HYDROGEN PEROXIDE; PYRUVATE SODIUM; ROTENONE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BIOENERGY; BRAIN MITOCHONDRION; BRAIN SLICE; CONTROLLED STUDY; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG POTENTIATION; DRUG TARGETING; ELECTROENCEPHALOGRAM; ENZYME DEFICIENCY; GENETIC MODEL; HIPPOCAMPAL CA3 REGION; HIPPOCAMPAL MOSSY FIBER; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MITOCHONDRIAL RESPIRATION; MOUSE; NERVE CELL EXCITABILITY; NERVOUS SYSTEM PARAMETERS; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXIDATIVE STRESS; PAIRED PULSE RATIO; PRIORITY JOURNAL; SEIZURE BURDEN INDEX; TEMPORAL LOBE EPILEPSY; TONIC CLONIC SEIZURE; WILD TYPE;

EID: 84889588196     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.11.005     Document Type: Article

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