Molecular Engineering II: Antibody Affinity

Handbook of Therapeutic Antibodies

Volumn 1, Issue , 2008, Pages 145-169

  Roskos, Lorin ^a   Klakamp, Scott ^a   Liang, Meina ^a   Arends, Rosalin ^b   Green, Larry ^c  

^a ASTRAZENECA   (United Kingdom)

^b PFIZER INC   (United States)

^c Abgenix Inc   (United States)

Author keywords

CDR mutations; Maturation; Measurement; Potency; Receptor

Indexed keywords

EID: 84889437181     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527619740.ch7     Document Type: Chapter

References (35)

1. Blake, R.C., Pavlov, A.R., Blake, D.A. (1999) Automated kinetic exclusion assays to quantify protein binding interactions in homogeneous solution. Anal Biochem 272: 123-134.
2. Boder, E.T., Midelfort, K.S., Wittrup, K.D. (2000) Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity. Proc Natl Acad Sci USA 97: 10701-10705.
3. Canziani, G.A., Klakamp, S., Myszka, D.G. (2004) Kinetic screening of antibodies from crude hybridoma samples using Biacore. Anal Biochem 325: 301-307.
4. Cardarelli, P.M., Quinn, M., Buckman, D., Fang, Y., Colcher, D., King, D.J., Bebbington, C., Yarranton, G. (2002) Binding to CD20 by anti-B1 antibody or F(ab′)(2) is sufficient for induction of apoptosis in B-cell lines. Cancer Immunol Immunother 51: 15-24.
5. Darling, R.J., Brault, P.A. (2004) Kinetic exclusion assay technology: characterization of molecular interactions. Assay Drug Dev Technol 2: 647-657.
6. Day, Y.S., Baird, C.L., Rich, R.L., Myszka, D.G. (2002) Direct comparison of binding equilibrium, thermodynamic, and rate constants determined by surface-and solution-based biophysical methods. Protein Sci 11: 1017-1025.
7. Defrance, T., Casamayor-Palleja, M., Krammer, P.H. (2002) The life and death of a B cell. Adv Cancer Res 86: 195-225.
8. Drake, A.W., Klakamp, S.L. (2007) A rigorous multiple independent binding site model for determining cell-based equilibrium dissociation constants. J. Immunol Methods, in press.
9. Drake, A.W., Myszka, D.G., Klakamp, S.L. (2004) Characterizing high-affinity antigen/antibody complexes by kinetic-and equilibrium-based methods. Anal Biochem 328: 35-43.
10. Foote, J., Eisen, H.N. (1995) Kinetic and affinity limits on antibodies produced during immune responses. Proc Natl Acad Sci USA 92: 1254-1256.
11. Foote, J., Eisen, H.N. (2000) Breaking the affinity ceiling for antibodies and T cell receptors. Proc Natl Acad Sci USA 97: 10679-10681.
12. Fulton, R.J., McDade, R.L., Smith, P.L., Kienker, L.J., Kettman, J.R., Jr. (1997) Advanced multiplexed analysis with the FlowMetrix system. Clin Chem 43: 1749-1756.
13. Hanes, J., Schaffitzel, C., Knappik, A., Pluckthun, A. (2000) Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display. Nat Biotechnol 18: 1287-1292.
14. Hoet, R.M., Cohen, E.H., Kent, R.B., Rookey, K., Schoonbroodt, S., Hogan, S., Rem, L., Frans, N., Daukandt, M., Pieters, H., van Hegelsom, R., Neer, N.C., Nastri, H.G., Rondon, I.J., Leeds, J.A., Hufton, S. E., Huang, L., Kashin, I., Devlin, M., Kuang, G., Steukers, M., Viswanathan, M., Nixon, A.E., Sexton, D.J., Hoogenboom, H.R., Ladner, R.C. (2005) Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity. Nat Biotechnol 23: 344-348.
15. Hoogenboom, H.R. (2005) Selecting and screening recombinant antibody libraries. Nat Biotechnol 23: 1105-1116.
16. Jia, X.C., Raya, R., Zhang, L., Foord, O., Walker, W.L., Gallo, M.L., Haak-Frendscho, M., Green, L.L., Davis, C.G. (2004) A novel method of multiplexed competitive antibody binning for the characterization of monoclonal antibodies. J Immunol Methods 288: 91-98.
17. Karlsson, R., Falt, A. (1997) Experimental design for kinetic analysis of protein-protein interactions with surface plasmon resonance biosensors. J Immunol Methods 200: 121-133.
18. Mendez, M.J., Green, L.L., Corvalan, J.R., Jia, X.C., Maynard-Currie, C.E., Yang, X. D., Gallo, M.L., Louie, D.M., Lee, D.V., Erickson, K.L., Luna, J., Roy, C.M., Abderrahim, H., Kirschenbaum, F., Noguchi, M., Smith, D.H., Fukushima, A., Hales, J.F., Klapholz, S., Finer, M. H., Davis, C.G., Zsebo, K.M., Jakobovits, A. (1997) Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nat Genet 15: 146-156.
19. Miraglia, S., Swartzman, E.E., Mellentin-Michelotti, J., Evangelista, L., Smith, C., Gunawan, I., Lohman, K., Goldberg, E.M., Manian, B., Yuan, P.M. (1999) Homogeneous cell-and bead-based assays for high throughput screening using fluorometric microvolume assay technology. J BiomolScreen 4: 193-204.
20. Morton, T.A., Myszka, D.G. (1998) Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors. Methods Enzymol 295: 268-294.
21. Myszka, D.G. (1999a) Improving biosensor analysis. J Mol Recognit 12: 279-284.
22. Myszka, D.G. (1999b) Survey of the 1998 optical biosensor literature. J Mol Recognit 12: 390-408.
23. Navratilova, I., Eisenstien, E., Myszka, D.G. (2005) Measuring long association phases using Biacore. Anal Biochem 344: 295-297.
24. Rathanaswami, P., Roalstad, S., Roskos, L., Su, Q.J., Lackie, S., Babcook, J. (2005) Demonstration of an in vivo generated subpicomolar affinity fully human monoclonal antibody to interleukin-8. Biochem Biophys Res Commun 334: 1004-1013.
25. Rich, R.L., Myszka, D.G. (2000) Survey of the 1999 surface plasmon resonance biosensor literature. J Mol Recognit 13: 388-407.
26. Rich, R.L., Myszka, D.G. (2005) Survey of the year 2004 commercial optical biosensor literature. J Mol Recognit 18: 431-478.
27. Roskos, L.K., Davis G.C., Schwab, G.M. (2004) The clinical pharmacology of therapeutic monoclonal antibodies. Drug Dev Res 61: 108-120.
28. Schier, R., Marks, J.D., Wolf, E.J., Apell, G., Wong, C., McCartney, J.E., Bookman, M.A., Huston, J.S., Houston, L.L., Weiner, L.M. (1995) In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library. Immunotechnology 1: 73-81.
29. Sundberg, E.J., Mariuzza, R.A. (2002) Molecular recognition in antibody-antigen complexes. Adv Protein Chem 61: 119-160.
30. Tabrizi, M.A., Tseng, C.M., Roskos, L.K. (2006) Elimination mechanisms of therapeutic monoclonal antibodies. Drug DiscovToday 11: 81-88.
31. Van Regenmortel, M.H. (2003) Improving the quality of BIACORE-based affinity measurements. Dev Biol (Basel) 112: 141-151.
32. Wabl, M., Cascalho, M., Steinberg, C. (1999) Hypermutation in antibody affinity maturation. Curr Opin Immunol 11: 186-189.
33. Wu, X., Feng, J., Komori, A., Kim, E.C., Zan, H., Casali, P. (2003) Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair. J Clin Immunol 23: 235-246.
34. Xie, L., Mark, J.R., Glass, T.R., Navoa, R., Wang, Y., Grace, M.J. (2005) Measurement of the functional affinity constant of a monoclonal antibody for cell surface receptors using kinetic exclusion fluorescence immunoassay. J Immunol Methods 304: 1-14.
35. Zahnd, C., Spinelli, S., Luginbuhl, B., Amstutz, P., Cambillau, C., Pluckthun, A. (2004) Directed in vitro evolution and crystallographic analysis of a peptide-binding single chain antibody fragment (scFv) with low picomolar affinity. J Biol Chem 279: 18870-18877.