In vitro models for studying induction of cytochrome P450 enzymes

Drug-Drug Interactions

Volumn , Issue , 2001, Pages 189-216

  Silva, Jose M ^a   Nicoll Griffith, Deborah A ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

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EID: 84889354966     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (64)

1. NK Wadhwa, TJ Schroeder, Al Pesce, AS Myre, CW Clardy, MR First. Cyclosporin drug interactions: A review. Ther Drug Monit 9: 399-406, 1987.
2. JP Whitlock, MS Denison. Induction of cytochrome P450 enzymes that metabolize xenobiotics. In: Ortiz de Montellano PR, ed. Cytochrome P450: Structure, Mechanism and Biochemistry. 2nd ed. Plenum Press, New York, 1995, pp 367-390.
3. AM Breckenridge, OJ Back, FE Crawford, M MaCiver, N Orme, PH Rowe. Drug interactions with oral contraceptives: clinical and experimental studies. Int Congress Sympos Series-Royal Soc Med 31: 1-11, 1980.
4. FP Guengerich. Oxidation of 17 α-ethenylestradiol by human liver cytochrome P450. Molecular Pharmac 33: 500-508, 1988.
5. TA Kocarek, EG Schuetz, SC Strom, RA Fisher, PS Guzelian. Comparative analysis of cytochrome CYP 3A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metab Dispos 23: 415-421, 1994.
6. RB Howard, AK Christensen, FA Gibbs, LA Pesch. The enzymatic preparation of isolated intact parenchymal cells from rat liver. J Cell Biol 35: 675-684, 1967.
7. MN Berry, De Friend D. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol 43: 506-520, 1969.
8. MN Berry, AM Edwards, GK Barrit, eds. Isolated Hepatocytes: Preparation, Properties and Applications. Elsevier, New York, 1991.
9. AP Li, MA Roque, OJ Beck, DL Kaminski. Isolation and culturing of hepatocytes from human livers. J Tissue Culture Methods 14: 139-146, 1992.
10. EG Schuetz, D Li, CJ Omiecinski, UA Muller-Eberhard, HK Kleinman, B Elswick, PS Guzelian. Regulation of gene expression in adult rat hepatocytes cultured on basement membrane matrix. J Cell Physiol 143: 309-323, 1988.
11. EL LeCluyse, PL Bullock, A Parkinson, JH Hochman. Cultured rat hepatocytes. Pharm Biotechnol 8: 121-159, 1996.
12. JM Silva, PE Morin, SH Day, BP Kennedy, P Payette, T Rushmore, JA Yergey, DA Nicoll-Griffith. Refinement of an in vitro cell model for cytochrome P450 induction. Drug Metab Dispos 26: 490-496, 1998.
13. P Maurel. The use of adult human hepatocytes in primary cultureand other in vitro systems to investigate drug metabolism in man. Adv Drug Dev Rev 22: 105-132, 1996.
14. PO Seglen, PB Gordon, A Poli. Amino acid inhibition of autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes. Biochim Biophys Acta 630: 103-118, 1980.
15. R Enat, DM Jefferson, N Ruiz-Opaza, Z Gatmaitan, A Leinwand, LM Reid. Hepatocyte proliferation in vitro: its dependence on the use of serum-free hormonally deo fined medium and substrata of extracellular matrix. Proc Natl Acad Sci USA 81: 1411-1415, 1984.
16. DJ Waxman, JJ Morrissey, S Naik, HO Jauregui. Phenobarbital induction of cytochrome P450: high-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response. Biochem J 271: 113-119, 1990.
17. JS Sidhu, CJ Omiecinski. Modulation of xenobiotic-inducible cytochrome CYP gene expression by dexamethasone in primary rat hepatocytes. Pharmacogenetics 5: 24-36, 1995.
18. S Johansson, M Hook. Substrate adhesion of rat hepatocytes: on the mechanism of attachment of fibronectin. J Cell Biol 98: 810-817, 1984.
19. LM Reid, Z Gaitmaitan, I Arias, P Ponce, M Rojkind. Long-term cultures of normal rat hepatocytes on liver biomarkers. Ann NY Acad Sci 349: 70-76, 1980.
20. JC Dunn, ML Yarmush, HG Kowbe, RG Tompkins. Hepatocyte function and extracellular matrix geometry: long-term culture in a sandwich configuration. FASEB J 3: 174-177, 1989.
21. JS Sidhu, FM Farin, CJ Omiecinski. Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYP2B I, 2B2, and 3AI genes in primary adult rat hepatocyte culture. Arch Biochem Biophys 30: 103-113, 1993.
22. EL LeCluyse, KL Audus, JK Hochman. Formation of extensive canalicular networks by rat hepatocytes cultured on collagen-sandwich configuration. Am J Physiol 266: CI764-CI774, 1994.
23. EL LeCluyse, A Madan, G Hamilton, K Carroll, R DeHaan, A Parkinson. Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J Biochem Molecular Tox 14: 177-188, 2000.
24. TA Kocarek, EG Schuetz, PS Guzelian. Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on Matrigel. Mol Pharmacol 43: 328-334, 1992.
25. VE Kostrubsky, V Ramachandran, R Venkataramanan, K Dorko, JE Esplen, S Zhang, IF Sinclair, SA Wrighton, SC Strom. The use of human hepatocyte cultures to study the induction of cytochrome P-450. Drug Metab Dispos 27: 887-894, 1999.
26. TK Chang, L Yu, P Maurel, DJ Waxman. Enhance cyclosphosphamide and ifosfamide activation in primary human hepatocyte cultures: response of cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res 57: 1946-1954, 1997.
27. DD Surry, G McAllister, G Meneses-Lorente, De Evans DC. High-throughput ribonuclease protection assay for the determination of CYP3A mRNA induction in cultured rat hepatocytes. Xenobiotica 29: 827-838, 1999.
28. MT Donato, MJ Gomez-Lechon, JV Castell. A microassay for measuring cytochrome P450lAI and P4502BI activities in intact human and rat hepatocytes cultured on 96-well plates. Analytical Biochem 213: 29-33, 1993.
29. DJ Waxman, C Attisano, FP Guengerich, DP Lapenson. Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 betahydroxylase cytochrome P-450 enzyme. Arch Biochem Biophys 263: 424-436, 1988.
30. CL Crespi, VP Miller, JM Ackermann, DM Streser, WF Busby. Novel highthroughput fluorescent P450 assays (abstr). Toxicologist 48: 323, 1999.
31. RJ Price, D Surry, AB Renwick, G Menses-Lorente, BG Lake, DC Evans. CYP isoform induction screening in 96-well plates: use of 7-benzyloxy-4-trifluoromethylcoumarin as a substrate for studies with rat hepatocytes. Xenobiotica 30: 781-795, 2000.
32. N Chauret, N Tremblay, R Lackman, JY Gauthier, JM Silva, J Marois, J Yergey, DA Nicoll-Griffith. Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe. Analytical Biochem 276: 215-226, 1999.
33. JM Silva, S Day, N Chauret, DA Nicoll-Griffith. Fluorescent probe for CYP 3A activity in human hepatocytes cultured on a 96-well plate. ISSX Proc 15: 204, 1999.
34. JM Silva, HTS for assessing cytochrome P450 induction in primary hepatocytes. Drug Metab Rev 32, 168, 2000.
35. JB Ferrini, L Prichard, J Domergue, P Maurel. Long-term primary cultures of adult human hepatocytes. Chem Biol Interact 107: 31-45, 1997.
36. KS Park, DH Sohn, RL Veech, BJ Song. Translational activation of ethanolinducible cytochrome P450 (CYP2E1) by isoniazid. European J Pharmacol Environmental Tox Pharmacol Section 248: 7-14, 1993.
37. J Greuet, L Pichard, JC Ourlin, C Bonfils, J Domergue, P Le Treut, P Maurel. Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYPIA genes in human hepatocytes in primary culture. Hepatology 25: 1166-1175, 1997.
38. MT Donato, MJ Gomez-Lechon, R Jover, T Nakamura, JV Castell. Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytesin primary culture. J Pharmacol Exp Ther 284: 760-767, 1998.
39. LD Murphy, CE Herzog, JB Rudick, AT Fojo, SE Bates. Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression. Biochem 29: 10351-10356, 1990.
40. KL Strong, TH Rushmore, KM Richards. Quantitation of human CYP3A4, 3A5 and 3A7 RNA levels in cultured primary hepatocytes using real-time RT-PCR. ISSX Proc 15: 69, 1999.
41. WP Bowen, J Carey, A Miah, HF McMurray, PW Munday, RS James, RA Coleman, AM Brown. Measurement of cytochrome P450 geneinduction in human hepatocytes using quantitative real-time reverse transcriptase-polymerase chain reaction. Drug Metab Dispos 28: 781-788, 2000.
42. CA Heid, J Stevens, KJ Livak, PM Williams. Real time quantitative PCR. Genome Res 6: 986-994, 1996.
43. DD Surry, G Meneses-Lorente, R Heavans, A Jack, DC Evans. Rapid determination of rat hepatocyte mRNA induction potential using oligonucleotide probes for CYP1AI, 1A2, 3A and 4A1. Xenobiotica 30: 441-456, 2000.
44. TP Burris, PD Pelton, L Zhou, MC Osborne, E Cryan, KT Demarest. A novel method for analysis of nuclear receptor function at natural promoters: peroxisome proliferator- activated receptor y agonist actions on a P2 gene expression detected using branched DNA messenger RNA quantitation. Molecular Endocrinology 13: 410-417, 1999.
45. DP Hartley, CD Klaassen. Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology. Drug Metab Dispos 28: 608-616, 2000.
46. a Warburg. Experiments on surviving carcinoma tissue. Methods Biochem Z 142: 317-333, 1923.
47. HA Krebs. Body size and tissue respiration. Biochim Biophys Acta 4: 249-269, 1950.
48. CG Fraga, BE Leibovitz, AL Tappel. Halogenated compounds as inducers of lipid peroxidation in tissue slices. Free Radic Biol Med 3: 119-123, 1987.
49. AR Parrish, AJ Gandolfi, K Brendel K. Minireview precision-cut tissue slices: applications in pharmacology and toxicology. Life Sci 57: 1887-1905, 1995.
50. PF Smith, AJ Gandolfi, CL Krumdieck, CW Putnam, CF Zukoski, WM Davis, K Brendel. Dynamic organ culture of precision liver slices for in vitro toxicology. Life Sci 13: 1367-1375, 1985.
51. BG Lake, JA Beamand, AC Japenga, A Renwick, S Davies, RJ Price. Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices. Food Chem Toxicol 31: 377-386, 1993.
52. MS Gokhale, TE Bunton, J Zurlo, JD Yager. Cytochrome P-450 IAl1lA2 induction, albumin secretion, and histological changes in cultured liver slices. In Vitro Toxicol 8: 357-368, 1995.
53. AT Drahushuk, BP McGarrigle, HL Tai, S Kitareewan, JA Goldstein, J Olson. Validation of precision-cut liver slices in a dynamic organ culture as an invitro model for studying CYPIA1 and CYPIA2 induction. Toxic Appl Pharmacol 140: 393-403, 1996.
54. D Muller, R Glockner, M Rost. Nonooxygenation, cytochrome P4501Al-mRna in rat liver slices exposed to beta-naphthoflavone and dexamethasone in vitro. Exper Tox Pathol 48: 433-438, 1996.
55. BG Lake, C Charzat, JM Tredger, AB Renwick, JA Beamand, RJ Price. Induction of cytochrome P450 isoenzymes in cultured precision-cut rat and human liver slices. Xenobiotica 26: 297-306, 1996.
56. BG Lake, SE Ball, AB Renwick, JM Tredger, J Kao, JA Beamand, RJ Price. Induction of CYP3A isoforms in cultured precision-cut human liver slices. Xenobiotica 27: 1165-1173, 1997.
57. S Ekins, GI Murray, JA Williams, MD Burke, NC Marchant, GM Hawksworth. Quantitative differences in phase I and II enzyme activities between rat precisioncut liver slices and isolated hepatocytes. Drug Metab Dispos 23: 1274-1279, 1995.
58. S Ekins, JA Williams, GI Murray, MD Burke, NC Marchant, J Engeset, GM Hawksworth. Xenobiotic metabolism in rat, dog and human precision-cut liver slices, freshly isolated hepatocytes, and vitrified precision-cut liver slices. Drug Metab Dispos 24: 990-995, 1996.
59. SA Kliewer, JT Moore, L Wade, JL Staudinger, MA Watson, SA Jones, DD McKee, BB Oliver, TM Wilson, RF Zetterstrom, T Pedmann, JM Lehmann. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92: 73-82, 1998.
60. K Debri, AR Boobis, DS Davis, RJ Edwards. Distribution and induction ofCYP3Al and CYP3A2 in rat liver and extrahepatic tissues. Biochem Pharmacol 50: 2047-2056, 1995.
61. JM Lehmann, DD McKee, MA Watson, TM Wilson, TJ Moore, SA Kliewer. The human orphan nuclear receptorPXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102: 1016-1023, 1998.
62. SA Jones, LB Moore, JL Shenk, GB Wisely, GA Hamilton, DD McKee, NC Tomkinson, EL LeCluyse, MH Lambert, TM Wilson, SA Kliewer, JT Moore. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Molecular Endocrinol 14: 27-39, 2000.
63. LB Moore, B Goodwin B, SA Jones, GB Wisely, CJ Serabjit-Singh, TM Wilson, JL Collins, SA Kliewer. St. John’s wort induces hepatic drug metabolism through activation of the pregnane X receptor. PNAS 97: 7500-7502, 2000.
64. DA Nicoll-Griffith, JM Silva, N Chauret, S Day, Y Leblanc, P Roy, J Yergey, R Dixit, D Patrick. Application of rat hepatocyte culture to predict in vivo metabolic auto-induction: studies with DFP, a cyclooxygenase-2 inhibitor. Drug Metab Dispos 29: 159-165, 2001.