MEKK1: Dual Function as a Protein Kinase and a Ubiquitin Protein Ligase

Protein Degradation

Volumn 2, Issue , 2008, Pages 79-87

  Lu, Zhimin ^a   Hunter, Tony ^b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

MEKK1; Protein kinase; Ubiquitin protein ligase

Indexed keywords

EID: 84889333374     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527620210.ch4     Document Type: Chapter

References (43)

1. Aravind, L., L. M. Iyer, and E. V. Koonin. 2003. Scores of RINGS but no PHDs in ubiquitin signaling. Cell Cycle 2:123-6.
2. Blume-Jensen, P., and T. Hunter. 2001. Oncogenic kinase signalling. Nature 411:355-65.
3. Boname, J. M., and P. G. Stevenson. 2001. MHC class I ubiquitìnation by a viral PHD/LAP finger protein. Immunity 15:627-36.
4. Borden, K. L. 2000. RING domains: master builders of molecular scaffolds? J Mol Biol 295:1103-12.
5. Borden, K. L., and P. S. Freemont. 1996. The RING finger domain: a recent example of a sequence-structure family. Curr Opin Struct Biol 6:395-401.
6. Capili, A. D., D. C. Schultz, I. F. Rauscher, and K. L. Borden. 2001. Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains. Embo J 20:165-77.
7. Capili, A. D., D. C. Schultz, I. F. Rauscher, and K. L. Borden. 2001. Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains. Embo J 20:165-77.
8. Carrano, A. C., E. Eytan, A. Hershko, and M. Pagano. 1999. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1:193-9.
9. Coscoy, L., and D. Ganem. 2003. PHD domains and E3 ubiquitin ligases: viruses make the connection. Trends Cell Biol 13:7-12.
10. Coscoy, L., and D. Ganem. 2003. Reply to Scheel and Hofmann: Progressing towards a better definition of PHD domains. Trends Cell Biol 13:287-8.
11. Coscoy, L., D. J. Sanchez, and D. Ganem. 2001. A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition. J Cell Biol 155:1265-73.
12. Deshaies, R. J. 1999. SCF and Cullin/Ring H2-based ubiquitin ligases. Annu Rev Cell Dev Biol 15:435-67.
13. Dohlman, H. G., and J. W. Thorner. 2001. Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. Annu Rev Biochem 70:703-54.
14. Esch, R. K., and B. Errede. 2002. Pheromone induction promotes Ste11 degradation through a MAPK feedback and ubiquitin-dependent mechanism. Proc Natl Acad Sci U S A 99:9160-5.
15. Fuchs, S. Y. 2002. The role of ubiquitin-proteasome pathway in oncogenic signaling. Cancer Biol Ther 1:337-41.
16. Goto, E., S. Ishido, Y. Sato, S. Ohgimoto, K. Ohgimoto, M. Nagano-Fujii, and H. Hotta. 2003. c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. J Biol Chem 278:14657-68.
17. Hagemann, C., and J. L. Blank. 2001. The ups and downs of MEK kinase interactions. Cell Signal 13:863-75.
18. Hunter, T. 2000. Signaling-2000 and beyond. Cell 100:113-27.
19. Jackson, P. K., A. G. Eldridge, E. Freed, L. Furstenthal, J. Y. Hsu, B. K. Kaiser, and J. D. Reimann. 2000. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol 10:429-39.
20. Johnson, E. S., P. C. Ma, I. M. Ota, and A. Varshavsky. 1995. A proteolytic pathway that recognizes ubiquitin as a degradation signal. J Biol Chem 270:17442-56.
21. Karandikar, M., S. Xu, and M. H. Cobb. 2000. MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem 275:40120-7.
22. Karandikar, M., S. Xu, and M. H. Cobb. 2000. MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem 275:40120-7.
23. Knuutiia, S., A. M. Bjorkqvist, K. Autio, M. Tarkkanen, M. Wolf, O. Monni, J. Szymanska, M. L. Larramendy, J. Tapper, H. Pere, W. El-Rifai, S. Hemmer, V. M. Wasenius, V. Vidgren, and Y. Zhu. 1998. DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies. Am J Pathol 152:1107-23.
24. Koegl, M., T. Hoppe, S. Schlenker, H. D. Ulrich, T. U. Mayer, and S. Jentsch. 1999. A novel ubiquitination factor, E4, is involved in multi-ubiquitin chain assembly. Cell 96: 635-44.
25. Lange-Carter, C. A., C. M. Pleiman, A. M. Gardner, K. J. Blumer, and G. L. Johnson. 1993. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260:315-9.
26. Lu, Z., S. Xu, C. Joazeiro, M. H. Cobb, and T. Hunter. 2002. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol Cell 9:945-56.
27. Manning, G., G. D. Plowman, T. Hunter, and S. Sudarsanam. 2002. Evolution of protein kinase signaling from yeast to man. Trends Biochem Sci 27:514-20.
28. Manning, G., D. B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam. 2002. The protein kinase complement of the human genome. Science 298:1912-34.
29. Mansouri, M., E. Bartee, K. Gouveia, B. T. Hovey Nerenberg, J. Barrett, L. Thomas, G. Thomas, G. McFadden, and K. Fruh. 2003. The PHD/LAP-domain protein M153R of myxomavirus is a ubiquitin ligase that induces the rapid internalization and lysosomal destruction of CD4. J Virol 77:1427-40.
30. Montagnoli, A., F. Fiore, E. Eytan, A. C. Carrano, G. F. Draetta, A. Hershko, and M. Pagano. 1999. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev 13:1181-9.
31. Pascual, J., M. Martinez-Yamout, H. J. Dyson, and P. E. Wright. 2000. Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor. J Mol Biol 304:723-9.
32. Pascual, J., M. Martinez-Yamout, H. J. Dyson, and P. E. Wright. 2000. Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor. J Mol Biol 304:723-9.
33. Polakis, P. 2000. Wnt signaling and cancer. Genes Dev 14:1837-51.
34. Scheel, H., and K. Hofmann. 2003. No evidence for PHD fingers as ubiquitin ligases. Trends Cell Biol 13:285-7; author reply 287-8.
35. Sutterluty, H., E. Chatelain, A. Marti, C. Wirbeiauer, M. Senften, U. Muller, and W. Krek. 1999. p45SKP2 promotes p27Kipl degradation and induces S phase in quiescent cells. Nat Cell Biol 1:207-14.
36. Tsvetkov, L. M., K. H. Yeh, S. J. Lee, H. Sun, and H. Zhang. 1999. p27(Kipl) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27. Curr Biol 9:661-4.
37. Uchida, D., S. Hatakeyama, A. Matsushima, H. Han, S. Ishido, H. Hotta, J. Kudoh, N. Shimizu, V. Doucas, K. I. Nakayama, N. Kuroda, and M. Matsumoto. 2004. AIRE Functions As an E3 Ubiquitin Ligase. J Exp Med 199:167-72.
38. Viach, J., S. Hennecke, and B. Amati. 1997. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. Embo J 16:5334-44.
39. Wang, Y., Q. Ge, D. Houston, J. Thorner, B. Errede, and H. G. Dohlman. 2003. Regulation of Ste7 ubiquitination by Ste11 phosphorylation and the Skp1-Cullin-F-box complex. J Biol Chem 278:22284-9.
40. Witowsky, J. A., and G. L. Johnson. 2003. Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways. J Biol Chem 278:1403-6.
41. Xu, S., D. Robbins, J. Frost, A. Dang, C. Lange-Carter, and M. H. Cobb. 1995. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A 92:6808-12.
42. Xu, S., D. J. Robbins, L. B. Christerson, J. M. English, C. A. Vanderbilt, and M. H. Cobb. 1996. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc Natl Acad Sci U S A 93:5291-5.
43. Yujiri, T., S. Sather, G. R. Fanger, and G. L. Johnson. 1998. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science 282:1911-4.