Combinatorial pharmacophore modeling of organic cation transporter 2 (OCT2) inhibitors: Insights into multiple inhibitory mechanisms

Molecular Pharmaceutics

Volumn 10, Issue 12, 2013, Pages 4611-4619

  Xu, Yuan ^a   Liu, Xian ^a   Li, Shanshan ^a   Zhou, Nannan ^b   Gong, Likun ^a   Luo, Cheng ^a   Luo, Xiaomin ^a   Zheng, Mingyue ^a   Jiang, Hualiang ^a,b   Chen, Kaixian ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

drug clearance; drug drug interaction (DDI); multiple inhibition mechanism; organic cation transporter 2 (OCT2); pharmacophore

Indexed keywords

ADRENOSTERONE; CARVEDILOL; CISAPRIDE; DIFENIDOL; MEDROXYPROGESTERONE; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 2 INHIBITOR; PEROSPIRONE; PHENYLTOLOXAMINE; PROTEIN INHIBITOR; SPIRONOLACTONE; TRIPELENNAMINE; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DRUG BINDING; DRUG BINDING SITE; DRUG CLEARANCE; HYDROGEN BOND; HYPOTHESIS; MOLECULAR RECOGNITION; MOLECULAR WEIGHT; PHARMACOPHORE; PRIORITY JOURNAL;

LIGANDS; ORGANIC CATION TRANSPORT PROTEINS; P-GLYCOPROTEIN; PHARMACEUTICAL PREPARATIONS;

EID: 84889241220     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400423g     Document Type: Article

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