Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2)

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 379, Issue 4, 2009, Pages 337-348

  Zolk, Oliver ^a   Solbach, Thomas F ^a   König, Jörg ^a   Fromm, Martin F ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Organic cation transporter; Pharmacophore; Topological polar surface area

Indexed keywords

AMIODARONE; AMITRIPTYLINE; CARVEDILOL; CHLOROQUINE; CHLORPROMAZINE; CIMETIDINE; CLONIDINE; DESLORATADINE; DIPHENHYDRAMINE; DISOPYRAMIDE; DOXEPIN; FENFLURAMINE; FLURAZEPAM; IMIPRAMINE; IPRATROPIUM BROMIDE; IRBESARTAN; KANAMYCIN; LEVOMETHADONE; MEFLOQUINE; METFORMIN; MEXILETINE; OCTAMER TRANSCRIPTION FACTOR 2; PROPAFENONE; PROPRANOLOL; QUINIDINE; SIBUTRAMINE; TAMOXIFEN; TRIMETHOPRIM; UNINDEXED DRUG; VERAPAMIL;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; IC 50; NUCLEOTIDE SEQUENCE; PHARMACOPHORE; PROTEIN EXPRESSION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

1-METHYL-4-PHENYLPYRIDINIUM; BIOLOGICAL TRANSPORT; CELL LINE; DRUG INTERACTIONS; HUMANS; HYDROPHOBICITY; INHIBITORY CONCENTRATION 50; METFORMIN; MODELS, MOLECULAR; MOLECULAR WEIGHT; ORGANIC CATION TRANSPORT PROTEINS; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES; TRANSFECTION;

EID: 60849100204     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0369-5     Document Type: Article

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