Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2

Molecular Pharmacology

Volumn 67, Issue 4, 2005, Pages 1067-1077

  Suhre, Wendy M ^a   Ekins, Sean ^b,d   Chang, Cheng ^c   Swaan, Peter W ^c   Wright, Stephen H ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b 19034   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d GeneGo bioinformatics software Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIMETHYL 4 PHENYLPYRIDINE 1 OXIDE; [2 (4 NITRO 2,1,3 BENZOXADIAZOL 7 YL)AMINOETHYL]TRIMETHYLAMMONIUM; AMANTADINE; CARBACHOL; CARBON 14; CHOLINE; CIMETIDINE; CLONIDINE; CRYSTAL VIOLET; EPHEDRINE; FAMOTIDINE; GUANIDINE; HISTAMINE; IBUPROFEN; METFORMIN; N 1 HYDROXYETHYLPYRIDINIUM; NICOTINE; ORGANIC CATION TRANSPORTER; ORGANIC CATION TRANSPORTER 2; PHENFORMIN; PINDOLOL; PROCAINAMIDE; RANITIDINE; SEROTONIN; TETRABUTYLAMMONIUM; TETRAPENTYLAMMONIUM; TETRAPROPYLAMMONIUM; TETRYLAMMONIUM; TYRAMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG ELIMINATION; DRUG PROTEIN BINDING; HUMAN; HYDROGEN BOND; KIDNEY TUBULE EXCRETION; MOLECULAR MODEL; NONHUMAN; ORTHOLOGY; PH; PHARMACOPHORE; PKA; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RABBIT; STEREOCHEMISTRY; TRANSPORT KINETICS;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; HUMANS; KIDNEY; MODELS, MOLECULAR; ORGANIC CATION TRANSPORT PROTEINS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RABBITS; TETRAETHYLAMMONIUM COMPOUNDS;

EID: 15744362693     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.004713     Document Type: Article

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