Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection

Drug Metabolism and Disposition

Volumn 36, Issue 8, 2008, Pages 1616-1623

  Jung, Norma ^a   Lehmann, Clara ^a   Rubbert, Andrea ^a   Knispel, Meike ^a   Hartmann, Pia ^a   Van Lunzen, Jan ^b   Stellbrink, Hans Juergen ^b   Faetkenheuer, Gerd ^a   Taubert, Dirk ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ACICLOVIR; ADEFOVIR; ANTIRETROVIRUS AGENT; ATAZANAVIR; CIDOFOVIR; COMPLEMENTARY DNA; EFAVIRENZ; EMTRICITABINE; INDINAVIR; ISONIAZID; LAMIVUDINE; MESSENGER RNA; NELFINAVIR; NEVIRAPINE; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; PENTAMIDINE; RIFAMPICIN; RITONAVIR; SAQUINAVIR; TRIMETHOPRIM; ZALCITABINE;

ACTIVE TRANSPORT; ADULT; ARTICLE; CELL STRAIN HEK293; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG ELIMINATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; ENZYME SUBSTRATE COMPLEX; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IC 50; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LIVER; LYMPH NODE; MALE; NUCLEOTIDE SEQUENCE; OVARY; PRIORITY JOURNAL; PROSTATE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME ECHOGRAPHY; TANDEM MASS SPECTROMETRY; TESTIS; TISSUE DISTRIBUTION; TRANSPORT KINETICS;

CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HIV INFECTIONS; HUMANS; LAMIVUDINE; LYMPH NODES; ORGANIC CATION TRANSPORT PROTEINS; ORGANIC CATION TRANSPORTER 1; REVERSE TRANSCRIPTASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; ZALCITABINE;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 47949132723     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.020826     Document Type: Article

References (34)

1. Anderson PL, Zheng JH, King T, Bushman LR, Predhomme J, Meditz A, Gerber J, and Fletcher CV (2007) Concentrations of zidovudine- and lamivudine- triphosphate according to cell type in HIV-seronegative adults. AIDS 21:1849-1854.
2. Barry M, Mulcahy F, Merry C, Gibbons S, and Back D (1999) Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection. Clin Pharmacokinet 36:289-304.
3. Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, et al. (2007) Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood 109:4272-4279.
4. Bode H, Lenzner L, Kraemer OH, Kroesen AJ, Bendfeldt K, Schulzke JD, Fromm M, Stoltenburg-Didinger G, Zeitz M, and Ullrich R (2005) The HIV protease inhibitors saquinavir, ritonavir, and nelfinavir induce apoptosis and decrease barrier function in human intestinal epithelial cells. Antivir Ther 10:645-655.
5. Callens S, De Roo A, and Colebunders R (2003) Fanconi-like syndrome and rhabdomyolysis in a person with HIV infection on highly active antiretroviral treatment including tenofovir. J Infect 47:262-263.
6. Carr A, Morey A, Mallon P, Williams D, and Thorburn DR (2001) Fatal portal hypertension, liver failure, and mitochondrial dysfunction after HIV-1 nucleoside analogue-induced hepatitis and lactic acidaemia. Lancet 357:1412-1414.
7. Clark SJ, Creighton S, Portmann B, Taylor C, Wendon JA, and Cramp ME (2002) Acute liver failure associated with antiretroviral treatment for HIV: a report of six cases. J Hepatol 36:295-301.
8. Ey J, Schomig E, and Taubert D (2007) Dietary sources and antioxidant effects of ergothioneine. J Agric Food Chem 55:6466-6474.
9. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, and Koepsell H (1997) Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 16:871-881.
10. Grossman Z, Meier-Schellersheim M, Paul WE, and Picker LJ (2006) Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nat Med 12:289-295.
11. Haase AT (1999) Population biology of HIV-1 infection: viral and CD4+ T cell demographics and dynamics in lymphatic tissues. Annu Rev Immunol 17:625-656.
12. Hofman P and Nelson AM (2006) The pathology induced by highly active antiretroviral therapy against human immunodeficiency virus: an update. Curr Med Chem 13:3121-3132.
13. Hsu A, Granneman GR, and Bertz RJ (1998) Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agents. Clin Pharmacokinet 35:275-291.
14. Jin MJ and Han HK (2006) Interaction of zalcitabine with human organic anion transporter 1. Pharmazie 61:491-492.
15. Kinman L, Bui T, Larsen K, Tsai CC, Anderson D, Morton WR, Hu SL, and Ho RJ (2006) Optimization of lipid-indinavir complexes for localization in lymphoid tissues of HIV-infected macaques. J Acquir Immune Defic Syndr 42:155-161.
16. Leung S and Bendayan R (2001) Uptake properties of lamivudine (3TC) by a continuous renal epithelial cell line. Can J Physiol Pharmacol 79:59-66.
17. Minuesa G, Purcet S, Erkizia I, Molina-Arcas M, Bofill M, Izquierdo-Useros N, Casado FJ, Clotet B, Pastor-Anglada M, and Martinez-Picado J (2008) Expression and functionality of anti-human immunodeficiency virus and anticancer drug uptake transporters in immune cells. J Pharmacol Exp Ther 324:558-567.
18. Moore KH, Yuen GJ, Raasch RH, Eron JJ, Martin D, Mydlow PK, and Hussey EK (1996) Pharmacokinetics of lamivudine administered alone and with trimethoprim-sulfamethoxazole. Clin Pharmacol Ther 59:550-558.
19. Okuda M, Saito H, Urakami Y, Takano M, and Inui K (1996) cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun 224:500-507.
20. Orenstein JM, Feinberg M, Yoder C, Schrager L, Mican JM, Schwartzentruber DJ, Davey RT Jr, Walker RE, Falloon J, Kovacs JA, et al. (1999) Lymph node architecture preceding and following 6 months of potent antiviral therapy: follicular hyperplasia persists in parallel with p24 antigen restoration after involution and CD4 cell depletion in an AIDS patient. AIDS 13:2219-2229.
21. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45.
22. Piacenti FJ (2006) An update and review of antiretroviral therapy. Pharmacotherapy 26:1111-1133.
23. Roulet V, Satie AP, Ruffault A, Le Tortorec A, Denis H, Guist'hau O, Patard JJ, Rioux-Leclerq N, Gicquel J, Jegou B, et al. (2006) Susceptibility of human testis to human immunodeficiency virus-1 infection in situ and in vitro. Am J Pathol 169:2094-2103.
24. Ruiz L, Romeu J, Martinez-Picado J, Schmit JC, Vandamme AM, Balague M, Cabrera C, Puig T, Tural C, Segura A, et al. (1996) Efficacy of triple combination therapy with zidovudine (ZDV) plus zalcitabine (ddC) plus lamivudine (3TC) versus double (ZDV+3TC) combination therapy in patients previously treated with ZDV+ddC. AIDS 10:F61-F66.
25. Salama NN, Endsley A, and Ho RJ (2006) Recent developments in drug targets and delivery of anti-HIV drugs. Infect Disord Drug Targets 6:107-119.
26. Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, and Endou H (2002) Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther 300:918-924.
27. Takubo T, Kato T, Kinami J, Hanada K, and Ogata H (2000) Effect of trimethoprim on the renal clearance of lamivudine in rats. J Pharm Pharmacol 52:315-320.
28. Takubo T, Kato T, Kinami J, Hanada K, and Ogata H (2002) Uptake of lamivudine by rat renal brush border membrane vesicles. J Pharm Pharmacol 54:111-117.
29. Taubert D, Grimberg G, Stenzel W, and Schomig E (2007) Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons. PLoS ONE 2:e385.
30. Thomas SA (2004) Drug transporters relevant to HIV therapy. J HIV Ther 9:92-96.
31. Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, and Endou H (2000) Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther 294:844-849.
32. Zhang H, Dornadula G, Beumont M, Livornese L Jr, Van Uitert B, Henning K, and Pomerantz RJ (1998) Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy. N Engl J Med 339:1803-1809.
33. Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, and Giacomini KM (2000) Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metab Dispos 28:329-334.
34. Zimmermann AE, Pizzoferrato T, Bedford J, Morris A, Hoffman R, and Braden G (2006) Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions. Clin Infect Dis 42:283-290.