Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates

Xenobiotica

Volumn 37, Issue 6, 2007, Pages 618-634

  Umehara, K I ^a   Iwatsubo, T ^a   Noguchi, K ^a   Kamimura, H ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

hOCT rOct; Organic cation transporters; Transporter inhibition; Transporter uptake; Uptake of cationic compounds

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; BIGUANIDE DERIVATIVE; BUTYRIC ACID; CIMETIDINE; FAMOTIDINE; GLIBENCLAMIDE; HISTAMINE H2 RECEPTOR ANTAGONIST; METFORMIN; ORGANIC CATION TRANSPORTER; PHENFORMIN; RANITIDINE; TETRYLAMMONIUM; TOLBUTAMIDE;

ARTICLE; CELL STRAIN HEK293; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG UPTAKE; HUMAN; HUMAN CELL; KINETICS; NUCLEOTIDE SEQUENCE; TRANSPORT KINETICS;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; BIGUANIDES; CELL LINE; CIMETIDINE; DRUG DESIGN; FAMOTIDINE; HISTAMINE H2 ANTAGONISTS; HUMANS; ION TRANSPORT; KINETICS; METFORMIN; ORGANIC CATION TRANSPORT PROTEINS; PHENFORMIN; RANITIDINE; RATS; TETRAETHYLAMMONIUM;

RATTUS;

EID: 34447118244     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250701397705     Document Type: Article

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