Pivotal role of microRNAs in cardiac physiology and heart failure

Drug Discovery Today

Volumn 18, Issue 23-24, 2013, Pages 1243-1249

  Leite Moreira, André M ^a   Lourenço, André P ^a   Falcão Pires, Inês ^a   Leite Moreira, Adelino F ^a  

^a University of Porto   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ANTAGOMIR; BIOLOGICAL MARKER; CYTOSKELETON PROTEIN; INTERLEUKIN 6; JANUS KINASE; MICRORNA; MICRORNA 1; MICRORNA 122; MICRORNA 122 ANTAGONIST; MICRORNA 133; MICRORNA 142; MICRORNA 208A; MICRORNA 208B; MICRORNA 21; MICRORNA 29; MICRORNA 30; MICRORNA 499; MICRORNA 9; MIRAVIRSEN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SMALL INTERFERING RNA; SPROUTY 1 PROTEIN; SPROUTY PROTEIN; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TWINFILIN 1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

CALCIUM CELL LEVEL; DISEASE SEVERITY; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE SILENCING; HEART FAILURE; HEART FUNCTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; ANIMAL; CARDIOMEGALY; DISEASE COURSE; DISEASE MODEL; GENETICS;

ANIMALS; CARDIOMEGALY; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; HEART FAILURE; HUMANS; MICRORNAS;

EID: 84889097705     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2013.07.025     Document Type: Review

References (54)

1. S. Sharma Epigenetics in cancer Carcinogenesis 31 2010 27 36
2. S. Vasudevan Switching from repression to activation: microRNAs can up-regulate translation Science 318 2007 1931 1934
3. F. Sato MicroRNAs and epigenetics FEBS J. 278 2011 1598 1609
4. A. Hata Functions of microRNAs in cardiovascular biology and disease Annu. Rev. Physiol. 75 2012 69 93
5. R. Yi Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs Genes Dev. 17 2003 3011 3016
6. G. Hutvagner, and M.J. Simard Argonaute proteins: key players in RNA silencing Nat. Rev. Mol. Cell Biol. 9 2008 22 32
7. J.O. Westholm, and E.C. Lai Mirtrons: microRNA biogenesis via splicing Biochimie 93 2011 1897 1904
8. P.K. Rao Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure Circ. Res. 105 2009 585 594
9. E. Bernstein Dicer is essential for mouse development Nat. Genet. 35 2003 215 217
10. J.F. Chen Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure Proc. Natl. Acad. Sci. U. S. A. 105 2008 2111 2116
11. M.T. Blahna, and A. Hata Regulation of miRNA biogenesis as an integrated component of growth factor signaling Curr. Opin. Cell Biol. 25 2013 233 240
12. N. Frey, and E.N. Olson Cardiac hypertrophy: the good, the bad, and the ugly Annu. Rev. Physiol. 65 2003 45 79
13. N. Frey Decoding calcium signals involved in cardiac growth and function Nat. Med. 6 2000 1221 1227
14. H. Nakayama The IP3 receptor regulates cardiac hypertrophy in response to select stimuli Circ. Res. 107 2010 659 666
15. H.E. Cingolani, and M.C. Camilion de Hurtado Na(+)-H(+) exchanger inhibition: a new antihypertrophic tool Circ. Res. 90 2002 751 753
16. J.P. Glaves Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump J. Mol. Biol. 405 2011 707 723
17. J. Schlesinger The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs PLoS Genet. 7 2011 E1001313
18. J. Backs CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy J. Clin. Invest. 116 2006 1853 1864
19. S. Ikeda MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes Mol. Cell. Biol. 29 2009 2193 2204
20. M. Han GATA4 expression is primarily regulated via a miR-26b-dependent post-transcriptional mechanism during cardiac hypertrophy Cardiovasc. Res. 93 2012 645 654
21. Q. Li NFATc4 is negatively regulated in miR-133a-mediated cardiomyocyte hypertrophic repression Am. J. Physiol. Heart Circ. Physiol. 298 2010 H1340 H1347
22. D.L. Dong Reciprocal repression between microRNA-133 and calcineurin regulates cardiac hypertrophy: a novel mechanism for progressive cardiac hypertrophy Hypertension 55 2010 946 952
23. K. Wang miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy J. Biol. Chem. 285 2010 11903 11912
24. P.A. da Costa Martins MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling Nat. Cell Biol. 12 2010 1220 1227
25. Z. Lin miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy Proc. Natl. Acad. Sci. U. S. A. 106 2009 12103 12108
26. M. Ceci Molecular determinants of the physiological adaptation to stress in the cardiomyocyte: a focus on AKT J. Mol. Cell. Cardiol. 37 2004 905 912
27. D.E. Kloet, and B.M. Burgering The PKB/FOXO switch in aging and cancer Biochim. Biophys. Acta 1813 2011 1926 1937
28. T.P. Garrington, and G.L. Johnson Organization and regulation of mitogen-activated protein kinase signaling pathways Curr. Opin. Cell Biol. 11 1999 211 218
29. O. Tenhunen Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart J. Biol. Chem. 279 2004 24852 24860
30. Y. Hua IGF-1 deficiency resists cardiac hypertrophy and myocardial contractile dysfunction: role of microRNA-1 and microRNA-133a J. Cell. Mol. Med. 16 2012 83 95
31. L. Elia Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions Circulation 120 2009 2377 2385
32. X.D. Xu Attenuation of microRNA-22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy J. Cell. Physiol. 227 2012 1391 1398
33. K. Wang Cardiac hypertrophy is positively regulated by MicroRNA miR-23a J. Biol. Chem. 287 2012 589 599
34. P. Fischer, and D. Hilfiker-Kleiner Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis Basic Res. Cardiol. 102 2007 279 297
35. A. Haghikia Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes Eur. Heart J. 32 2011 1287 1297
36. X.W. Song MicroRNAs are dynamically regulated in hypertrophic hearts, and miR-199a is essential for the maintenance of cell size in cardiomyocytes J. Cell. Physiol. 225 2010 437 443
37. S. Rane Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes Circ. Res. 104 2009 879 886
38. S. Sharma Repression of miR-142 by p300 and MAPK is required for survival signaling via gp130 during adaptive hypertrophy EMBO Mol. Med. 4 2012 617 632
39. Q. Li Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy J. Cell Sci. 123 2010 2444 2452
40. E. van Rooij A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance Dev. Cell 17 2009 662 673
41. T.E. Callis MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice J. Clin. Invest. 119 2009 2772 2786
42. J.T. Shieh Elevated miR-499 levels blunt the cardiac stress response PLoS ONE 6 2011 E19481
43. E.E. Creemers, and Y.M. Pinto Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart Cardiovasc. Res. 89 2011 265 272
44. R.F. Duisters miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling Circ. Res. 104 2009 170 178 176p following 178
45. S. Roy MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue Cardiovasc. Res. 82 2009 21 29
46. T. Thum MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts Nature 456 2008 980 984
47. E. van Rooij Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis Proc. Natl. Acad. Sci. U. S. A. 105 2008 13027 13032
48. M.F. Corsten Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease Circ. Cardiovasc. Genet. 3 2010 499 506
49. H. Valadi Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Nat. Cell Biol. 9 2007 654 659
50. A.G. Seto, and E. van Rooij Circulating microRNAs to identify human heart failure Eur. J. Heart Fail. 14 2012 118 119
51. D. De Paula Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting RNA 13 2007 431 456
52. R.E. Lanford Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection Science 327 2010 198 201
53. A. Ucar The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy Nat. Commun. 3 2012 1078
54. C. Yin A novel role of microRNA in late preconditioning: upregulation of endothelial nitric oxide synthase and heat shock protein 70 Circ. Res. 104 2009 572 575