New investigation of distribution imaging and content uniformity of very low dose drugs using hot-melt extrusion method

International Journal of Pharmaceutics

Volumn 458, Issue 2, 2013, Pages 245-253

  Park, Jun Bom ^a   Kang, Chin Yang ^b   Kang, Wie Soo ^c   Choi, Han Gon ^d   Han, Hyo Kyung ^e   Lee, Beom Jin ^a  

^a Ajou University   (South Korea)

^b Sahmyook University   (South Korea)

^c Kangwon National University   (South Korea)

^d Hanyang University   (South Korea)

^e Dongguk University   (South Korea)

Author keywords

Content uniformity; Coumarin 6; Distribution imaging; Hot melt extrusion; Low dose drugs; Thermosensitive polymers

Indexed keywords

COUMARIN; GLIMEPIRIDE; LIMAPROST; MACROGOL 6000; POLOXAMER; POLYMER; TAMSULOSIN;

ARTICLE; CHEMICAL PARAMETERS; CHEMICAL PROCEDURES; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DOSAGE FORM; HEAT SENSITIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOT MELT EXTRUSION; HYDROPHILICITY; IMAGE ANALYSIS; INFRARED SPECTROSCOPY; MELTING POINT; MOLECULAR INTERACTION; PHYSICAL CHEMISTRY; POWDER; PRIORITY JOURNAL; SOLID; X RAY DIFFRACTION;

CONTENT UNIFORMITY; COUMARIN-6; DISTRIBUTION IMAGING; HOT-MELT EXTRUSION; LOW DOSE DRUGS; THERMOSENSITIVE POLYMERS;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; COUMARINS; DOSAGE FORMS; DRUG CARRIERS; FLUORESCENT DYES; HOT TEMPERATURE; MICROSCOPY, CONFOCAL; PHARMACEUTICAL PREPARATIONS; POLOXAMER; POLYETHYLENE GLYCOLS; POLYMERS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL; X-RAY DIFFRACTION;

EID: 84889087859     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.10.027     Document Type: Article

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