Characterization of itraconazole semisolid dosage forms prepared by hot melt technique

Archives of Pharmacal Research

Volumn 29, Issue 11, 2006, Pages 1055-1060

  Shim, Sang Young ^a   Ji, Chang Won ^a   Sah, Hongkee ^b   Park, Eun Seok ^c   Lee, Beom Jin ^a  

^a Kangwon National University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

Dissolution; Itraconazole; Semisolid dosage forms; Solubility

Indexed keywords

EID: 33845366952     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02969291     Document Type: Article

References (13)

1. Amidon, G. L., Lennernas, H., Shah, V. P., and Crison, J. R., A theoretical basis for a biopharmaceutics drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res., 12, 413-420 (1995).
2. Cao, Q. -R., Kim, T. -W., Choi, C. -Y., Kwon, K. A., and Lee, B. - J., Preparation and dissolution of PVP-based solid dispersion capsules containing solubilizers. J. Kor. Pharm. Sci., 33, 7-14 (2003).
3. Charman, S. S., Charman, W. N., Rogg, M. C., Wilson, T. D., Dutko, F. J., and Pouton, C. W., Self-emulsifying drug delivery systems: formulation and biopharmaceutics evaluation of an investigational lipophilic compound. Pharm Res., 9, 87-93 (1992).
4. Heo, M. -Y., Piao, Z. -Z., Kim, T. -W., Cao, Q. -R., Kim, A., and Lee, B. -J., Effect of solubilizing and microemulsifying excipients in polyethylene glycol 6000 solid dispersion on enhanced dissolution and bioavailability of ketoconazole. Arch. Pharm. Res., 28, 604-611 (2005).
5. Kim, T. -W., Choi, C. -Y., Cao, Q. -R., Kwon, K. A., and Lee, B. - J., Dissolution profiles of solid dispersions containing poorly water-soluble drugs and solubilizing compositions. J. Kor. Pharm. Sci., 32, 191-197 (2002).
6. Koks, C. H. W., Meenhorst, P. L., Bult, A., and Beijnen, J. H., Itraconazole solution: summary of Pharmacokinetic features and review of activity in the treatment of fluconazole-resistant oral candidosis in HIV-infected persons. Pharmacol. Res., 46, 195-201 (2002).
7. Nazzal, S., Smalyukh, I. I., Lavrentovich, O. D., and Khan, M. A., Preparation and in vitro characterization of a eutetic based smisolid self - nanoemulsified drug delivery system (SNEDDS) of ubiquinone : mechanism and progress of emulsion formation. Int. J. Pharm., 235, 247-265 (2002).
8. Peeters, J., Neeskens, P., Tollenaere, J. P., Van Remoortere, P., and Brewster, M., Characterization of the interaction of 2-hydroxypropyl-b- cyclodextrin with itraconazole at pH 2, 4 and 7. J. Pharm. Sci., 91, 1414-1422 (2002).
9. Rambali, B., Verreck, G., Baert, L., and Massart, D. L., Itraconazole formulation studies of the melt-extrusion process with mixture design. Drug Dev. Ind. Pharm., 29, 641-652 (2003).
10. Serajuddin, A. T. M., Solid dispersion of poorly water-soluble drugs: Early promises, subsequent problems, and recent breakthroughs. J. Pharm. Sci., 88, 1058-1066 (1999).
11. Six, K., Daems, T., de Hoon, J., Hecken, A. V., Depre, M., Bouche, M. -P., Prinsen, P., Verreck, G.., Peeters, J., Brewster, M. E., and den Mooter, G.. V., Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion. Eur. J. Pharm. Sci., 24, 179-186 (2005).
12. Wang, X., Michoel, A., and den Mooter, G. V., Solid state characteristics of ternary solid dispersions composed of PVP VA64, Myrj 52 and itraconazole. Int. J. Pharm., 303, 54-61 (2005).
13. Woo, J. -S. and Yi, H. -G., Antifungal oral composition containing itraconazole and process for preparing same. US Patent, 6,039,981, March (2000).