An investigation into low dose blend uniformity and segregation determination using NIR spectroscopy

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Volumn 288, Issue 1-3, 2006, Pages 71-76

  Ely, David ^a   Chamarthy, Sai ^a   Carvajal, M Teresa ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Axial segregation; Blend homogeneity; Low dose; NIR; Radial segregation; Segregation

Indexed keywords

BINARY MIXTURES; BLENDING; CONCENTRATION (PROCESS); DENSITY (SPECIFIC GRAVITY); FRICTION; INFRARED SPECTROSCOPY; PARTICLE SIZE ANALYSIS; PARTICLES (PARTICULATE MATTER);

AXIAL SEGREGATION; BLEND HOMOGENEITY; LOW DOSE; NIR; RADIAL SEGREGATION; SEGREGATION;

POWDER METALS;

ARTICLE; DENSITY; FRICTION; LOW DRUG DOSE; NEAR INFRARED SPECTROSCOPY; PARTICLE SIZE; POWDER; PRIORITY JOURNAL; SEGREGATION ANALYSIS;

EID: 33747156479     PISSN: 09277757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.colsurfa.2006.04.032     Document Type: Article

References (8)

1. Staniforth J. Int. J. Pharm. Tech. Prod. Mfr. 3 (1982) 1
2. Blanco M., Bañó R.G., and Bertran E. Talanta 56 (2002) 203
3. Q2B. Validation of Analytical Procedures: Methodology. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, 1996.
4. Hill K.M., and Kakalios J. Phys. Rev. E 52 (1995) R4393
5. El-Hagrasy A.S., Delgado-Lopez M., and Drennen III J.K. J. Pharm. Sci. 95 (2006) 407
6. Jørgensen A., Rantanen J., Karjalainen M., Khriachtchev L., Räsänen I E., and Yliruusi J. Pharm. Res. 19 9 (2002) 1285-1291
7. Gupta A., Peck G.E., Miller R.W., and Morris K.R. J. Pharm. Sci. 94 (2005) 2301
8. Clump C.W. Mixing theory and practice. In: Uhl V.W., and Gray J.B. (Eds). Mixing of Solids vol. II (1967), Academic Press, NY Chapter 10