Capsaicin induces apoptosis in human osteosarcoma cells through AMPK-dependent and AMPK-independent signaling pathways

Molecular and Cellular Biochemistry

Volumn 384, Issue 1-2, 2013, Pages 229-237

  Ying, Hui ^a   Wang, Zhi ^a   Zhang, Yan ^a   Yang, Tie Yi ^a   Ding, Zhi Hong ^a   Liu, Shu Yi ^a   Shao, Jin ^a   Liu, Yue ^a   Fan, Xin Bing ^a  

^a Pudong New District Gongli Hospital   (China)

Author keywords

AMPK; Apoptosis; Capsaicin; JNK; mTOR; Osteosarcoma; p53

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; CAPSAICIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; RNA; STRESS ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MITOCHONDRION; NUCLEOTIDE SEQUENCE; OSTEOSARCOMA CELL; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANTIPRURITICS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BONE NEOPLASMS; CAPSAICIN; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MULTIPROTEIN COMPLEXES; OSTEOSARCOMA; PROTO-ONCOGENE PROTEINS C-BCL-2; RIBONUCLEOTIDES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84889063722     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1802-8     Document Type: Article

References (37)

1. Hegyi M, Semsei AF, Jakab Z, Antal I, Kiss J, Szendroi M, Csoka M, Kovacs G (2011) Good prognosis of localized osteosarcoma in young patients treated with limb-salvage surgery and chemotherapy. Pediatr Blood Cancer 57:415-422
2. Jaffe N (2009) Osteosarcoma: review of the past, impact on the future. The American experience. Cancer Treat Res 152:239-262
3. Tuoya Baba N, Shimoishi Y, Murata Y, Tada M, Koseki M, Takahata K (2006) Apoptosis induction by Dohevanil, a DHA substitutive analog of capsaicin, in MCF-7 cells. Life Sci 78:1515-1519
4. Jung MY, Kang HJ, Moon A (2001) Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation. Cancer Lett 165:139-145
5. Qiao S, Li W, Tsubouchi R, Haneda M, Murakami K, Yoshino M (2005) Involvement of peroxynitrite in capsaicin-induced apoptosis of C6 glioma cells. Neurosci Res 51:175-183
6. Sanchez AM, Malagarie-Cazenave S, Olea N, Vara D, Chiloeches A, Diaz-Laviada I (2007) Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. Apoptosis 12:2013-2024
7. 2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells. Anticancer Res 26:1965-1971
8. Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R, Martin SR, Carling D, Gamblin SJ (2011) Structure of mammalian AMPK and its regulation by ADP. Nature 472:230-233
9. Hardie DG, Carling D (1997) The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur J Biochem 246:259-273
10. Inoki K, Kim J, Guan KL (2012) AMPK and mTOR in cellular energy homeostasis and drug targets. Annu Rev Pharmacol Toxicol 52:381-400
11. Luo Z, Saha AK, Xiang X, Ruderman NB (2005) AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci 26:69-76
12. Mihaylova MM, Shaw RJ (2011) The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 13:1016-1023
13. Cao C, Wan Y (2009) Parameters of protection against ultraviolet radiation-induced skin cell damage. J Cell Physiol 220:277-284
14. Chen MB, Shen WX, Yang Y, Wu XY, Gu JH, Lu PH (2010) Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell. J Cell Physiol 226(7):1915-1925
15. Chen MB, Wu XY, Gu JH, Guo QT, Shen WX, Lu PH (2011) Activation of AMP-activated protein kinase contributes to doxorubicin-induced cell death and apoptosis in cultured myocardial H9c2 cells. Cell Biochem Biophys 60:311-322
16. Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M (2009) TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J 28:677-685
17. Kang MR, Park SK, Lee CW, Cho IJ, Jo YN, Yang JW, Kim JA, Yun J, Lee KH, Kwon HJ, Kim BW, Lee K, Kang JS, Kim HM (2012) Widdrol induces apoptosis via activation of AMP-activated protein kinase in colon cancer cells. Oncol Rep 27:1407-1412
18. Zhang WB, Wang Z, Shu F, Jin YH, Liu HY, Wang QJ, Yang Y (2010) Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition. J Biol Chem 285:40461-40471
19. Zheng QY, Jin FS, Yao C, Zhang T, Zhang GH, Ai X (2012) Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells. Biochem Biophys Res Commun 419:714-747
20. Hwang JT, Park IJ, Shin JI, Lee YK, Lee SK, Baik HW, Ha J, Park OJ (2005) Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem Biophys Res Commun 338:694-699
21. Bogachus LD, Turcotte LP (2010) Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells. Am J Physiol Cell Physiol 299:C1549-C1561
22. Niu W, Bilan PJ, Ishikura S, Schertzer JD, Contreras-Ferrat A, Fu Z, Liu J, Boguslavsky S, Foley KP, Liu Z, Li J, Chu G, Panakkezhum T, Lopaschuk GD, Lavandero S, Yao Z, Klip A (2010) Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells. Am J Physiol Endocrinol Metab 298:E1058-E1071
23. Vivanco I, Sawyers CL (2002) The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2:489-501
24. Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB (2005) Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4:988-1004
25. Inoki K, Zhu T, Guan KL (2003) TSC2 mediates cellular energy response to control cell growth and survival. Cell 115:577-590
26. Hardie DG (2008) AMPK and Raptor: matching cell growth to energy supply. Mol Cell 30:263-265
27. Wan X, Harkavy B, Shen N, Grohar P, Helman LJ (2007) Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 26:1932-1940
28. Ito K, Nakazato T, Yamato K, Miyakawa Y, Yamada T, Hozumi N, Segawa K, Ikeda Y, Kizaki M (2004) Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res 64:1071-1078
29. Zhang R, Humphreys I, Sahu RP, Shi Y, Srivastava SK (2008) In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis 13:1465-1478
30. Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB (2005) AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 18:283-293
31. Nieminen AI, Eskelinen VM, Haikala HM, Tervonen TA, Yan Y, Partanen JI, Klefstrom J (2013) Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis. Proc Natl Acad Sci U S A 110:E1839-E1848
32. Rumsfield JA, West DP (1991) Topical capsaicin in dermatologic and peripheral pain disorders. DICP 25:381-387
33. Zhang WY, Li Wan Po A (1994) The effectiveness of topically applied capsaicin. A meta-analysis. Eur J Clin Pharmacol 46:517-522
34. Donnerer J, Amann R, Schuligoi R, Lembeck F (1990) Absorption and metabolism of capsaicinoids following intragastric administration in rats. Naunyn Schmiedebergs Arch Pharmacol 342:357-361
35. Suresh D, Srinivasan K (2010) Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J Med Res 131:682-691
36. Berberoglu S, Oguz A, Aribal E, Ataoglu O (1997) Osteoblastoma response to radiotherapy and chemotherapy. Med Pediatr Oncol 28:305-309
37. Camitta B, Wells R, Segura A, Unni KK, Murray K, Dunn D (1991) Osteoblastoma response to chemotherapy. Cancer 68:999-1003