Adipose-derived mesenchymal cells for bone regereneration: State of the art

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Barba, Marta ^a   Cicione, Claudia ^a   Bernardini, Camilla ^a   Michetti, Fabrizio ^a,b   Lattanzi, Wanda ^a,b  

^a CATHOLIC UNIVERSITY   (Italy)

^b Latium Musculoskeletal Tissue Bank   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; BETA1 INTEGRIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 6; CD146 ANTIGEN; CD31 ANTIGEN; CD34 ANTIGEN; CELL SURFACE MARKER; ENDOGLIN; GLYCEROL 2 PHOSPHATE; INTERCELLULAR ADHESION MOLECULE 1; MICROSOMAL AMINOPEPTIDASE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; STEM CELL FACTOR RECEPTOR; THY 1 ANTIGEN; TRANSCRIPTION FACTOR RUNX2; VASCULOTROPIN;

ADIPOSE DERIVED MESENCHYMAL STEM CELL; ADIPOSE DERIVED STEM CELL; ARTICLE; BIOREACTOR; BODY FAT DISTRIBUTION; BONE DEVELOPMENT; BONE REGENERATION; BONE REMODELING; CELL ADHESION; CELL DIFFERENTIATION; CELL EXPANSION; CELL PROLIFERATION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED CLINICAL TRIAL (TOPIC); ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; FIBROBLAST; FRACTURE HEALING; GENE THERAPY; HEMATOPOIETIC CELL; HUMAN; INTRAABDOMINAL FAT; MACROPHAGE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MONOCYTE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PERIPHERAL VASCULAR DISEASE; PROADIPOCYTE; SEX DIFFERENCE; VASCULAR SMOOTH MUSCLE; WHITE ADIPOSE TISSUE; ADIPOCYTE; ADIPOSE TISSUE; CYTOLOGY; GENETICS; MESENCHYMAL STROMA CELL; METHODOLOGY; REGENERATIVE MEDICINE; REVIEW; TISSUE ENGINEERING;

ADIPOCYTES; ADIPOSE TISSUE; BONE REGENERATION; CELL DIFFERENTIATION; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; OSTEOGENESIS; REGENERATIVE MEDICINE; TISSUE ENGINEERING;

EID: 84888985261     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/416391     Document Type: Article

References (156)

1. Friedenstein A. J., Osteogenetic activity of transplanted transitional epithelium. Acta anatomica 1961 45 31 59 2-s2.0-0009011175
2. Saulnier N., Puglisi M. A., Lattanzi W., Castellini L., Pani G., Leone G., Alfieri S., Michetti F., Piscaglia A. C., Gasbarrini A., Gene profiling of bone marrow- and adipose tissue-derived stromal cells: a key role of Kruppel-like factor 4 in cell fate regulation. Cytotherapy 2011 13 3 329 340 2-s2.0-79951697269 10.3109/14653249.2010.515576
3. Liu A. R., Liu L., Chen S., Yang Y., Zhao H. J., Liu L., Guo F. M., Lu X. M., Qiu H. B., Activation of canonical wnt pathway promotes differentiation of mouse bone marrow-derived MSCs into type II alveolar epithelial cells, confers resistance to oxidative stress, and promotes their migration to injured lung tissue in vitro. Journal of Cellular Physiology 2013 228 6 1270 1283 10.1002/jcp.24282
4. Saulnier N., Lattanzi W., Puglisi M. A., Pani G., Barba M., Piscaglia A. C., Giachelia M., Alfieri S., Neri G., Gasbarrini G., Gasbarrini A., Mesenchymal stromal cells multipotency and plasticity: induction toward the hepatic lineage. European Review for Medical and Pharmacological Sciences 2009 13 supplement 1 71 78 2-s2.0-65249105997
5. Saulnier N., Piscaglia A. C., Puglisi M. A., Barba M., Arena V., Pani G., Alfieri S., Gasbarrini A., Molecular mechanisms underlying human adipose tissue-derived stromal cells differentiation into a hepatocyte-like phenotype. Digestive and Liver Disease 2010 42 12 895 901 2-s2.0-78650288413 10.1016/j.dld.2010.04.013
6. Puglisi M. A., Saulnier N., Piscaglia A. C., Tondi P., Agnes S., Gasbarrini A., Adipose tissue-derived mesenchymal stem cells and hepatic differentiation: old concepts and future perspectives. European Review for Medical and Pharmacological Sciences 2011 15 4 355 364 2-s2.0-79955155763
7. Puglisi M. A., Tesori V., Lattanzi W., Piscaglia A. C., Gasbarrini G. B., D'Ugo D. M., Gasbarrini A., Therapeutic implications of mesenchymal stem cells in liver injury. Journal of Biomedicine and Biotechnology 2011 2011 8 2-s2.0-84855535705 10.1155/2011/860578 860578
8. Yabana T., Arimura Y., Tanaka H., Goto A., Hosokawa M., Nagaishi K., Yamashita K., Yamamoto H., Adachi Y., Sasaki Y., Isobe M., Fujimiya M., Imai K., Shinomura Y., Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity. Journal of Pathology 2009 218 3 350 359 2-s2.0-67650093720 10.1002/path.2535
9. Valcz G., Krenács T., Sipos F., Leiszter K., Tóth K., Balogh Z., Csizmadia A., Muzes G., Molnár B., Tulassay Z., The role of the bone marrow derived mesenchymal stem cells in colonic epithelial regeneration. Pathology and Oncology Research 2011 17 1 11 16 2-s2.0-79952702077 10.1007/s12253-010-9262-x
10. Bussolati B., Tetta C., Camussi G., Contribution of stem cells to kidney repair. American Journal of Nephrology 2008 28 5 813 822 2-s2.0-51149109177 10.1159/000137681
11. Neirinckx V., Marquet A., Coste C., Rogister B., Wislet-Gendebien S., Adult bone marrow neural crest stem cells and mesenchymal stem cells are not able to replace lost neurons in acute MPTP-lesioned mice. PLoS ONE 2013 8 5 e64723 10.1371/journal.pone.0064723
12. Hu F., Wang X., Liang G., Lv L., Zhu Y., Sun B., Xiao Z., Effects of epidermal growth factor and basic fibroblast growth factor on the proliferation and osteogenic and neural differentiation of adipose-derived stem cells. Cellular Reprogramming 2013 15 3 224 232 10.1089/cell.2012.0077
13. Bai W. F., Xu W. C., Feng Y., Huang H., Li X. P., Deng C. Y., Zhang M. S., Fifty-Hertz electromagnetic fields facilitate the induction of rat bone mesenchymal stromal cells to differentiate into functional neurons. Cytotherapy 2013 15 8 961 970 10.1016/j.jcyt.2013.03.001
14. Wislet-Gendebien S., Wautier F., Leprince P., Rogister B., Astrocytic and neuronal fate of mesenchymal stem cells expressing nestin. Brain Research Bulletin 2005 68 1-2 95 102 2-s2.0-28144443717 10.1016/j.brainresbull.2005.08. 016 (Pubitemid 41698881)
15. Cai S., Shea G. K. H., Tsui A. Y. P., Chan Y. S., Shum D. K. Y., Derivation of clinically applicable schwann cells from bone marrow stromal cells for neural repair and regeneration. CNS and Neurological Disorders 2011 10 4 500 508 2-s2.0-79956281482
16. Pan Y., Cai S., Current state of the development of mesenchymal stem cells into clinically applicable Schwann cell transplants. Molecular and Cellular Biology 2012 368 127 135 10.1007/s11010-012-1351-6
17. Lattanzi W., Geloso M. C., Saulnier N., Giannetti S., Puglisi M. A., Corvino V., Gasbarrini A., Michetti F., Neurotrophic features of human adipose tissue-derived stromal cells: in vitro and in vivo studies. Journal of Biomedicine and Biotechnology 2011 2011 9 2-s2.0-84855556825 10.1155/2011/468705 468705
18. Dupin E., Sommer L., Neural crest progenitors and stem cells: from early development to adulthood. Developmental Biology 2012 366 1 83 95 2-s2.0-84859259241 10.1016/j.ydbio.2012.02.035
19. Moroni L., Fornasari P. M., Human mesenchymal stem cells: a bank perspective on the isolation, characterization and potential of alternative sources for the regeneration of musculoskeletal tissues. Journal of Cellular Physiology 2013 228 4 680 687 10.1002/jcp.24223
20. de Coppi P., Bartsch G. Jr., Siddiqui M. M., Xu T., Santos C. C., Perin L., Mostoslavsky G., Serre A. C., Snyder E. Y., Yoo J. J., Furth M. E., Soker S., Atala A., Isolation of amniotic stem cell lines with potential for therapy. Nature Biotechnology 2007 25 1 100 106 2-s2.0-33846120651 10.1038/nbt1274 (Pubitemid 46087908)
21. Barba M., Pirozzi F., Saulnier N., Vitali T., Natale M. T., Logroscino G., Robbins P. D., Gambotto A., Neri G., Michetti F., Pola E., Lattanzi W., Lim mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through Kruppel-like factor-4 downregulation and further bone-specific gene expression. Journal of Biomedicine and Biotechnology 2012 2012 11 813894 10.1155/2012/813894
22. Chao Y. H., Wu H. P., Chan C. K., Tsai C., Peng C. T., Wu K. H., Umbilical cord-derived mesenchymal stem cells for hematopoietic stem cell transplantation. Journal of Biomedicine and Biotechnology 2012 2012 5 759503 10.1155/2012/759503
23. Longo U. G., Loppini M., Berton A., La V. L., Khan W. S., Denaro V., Stem cells from umbilical cord and placenta for musculoskeletal tissue engineering. Current Stem Cell Research & Therapy 2012 7 272 281 10.2174/ 157488812800793054
24. Yang S., Huang S., Feng C., Fu X., Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration. Frontiers of Medicine 2012 6 1 41 47 10.1007/s11684-012-0175-9
25. Peroni D., Scambi I., Pasini A., Lisi V., Bifari F., Krampera M., Rigotti G., Sbarbati A., Galiè M., Stem molecular signature of adipose-derived stromal cells. Experimental Cell Research 2008 314 3 603 615 2-s2.0-38149111801 10.1016/j.yexcr.2007.10.007
26. Yoshimura K., Suga H., Eto H., Adipose-derived stem/progenitor cells: roles in adipose tissue remodeling and potential use for soft tissue augmentation. Regenerative Medicine 2009 4 2 265 273 2-s2.0-65549113854 10.2217/17460751.4.2.265
27. Weisberg S. P., McCann D., Desai M., Rosenbaum M., Leibel R. L., Ferrante A. W. Jr., Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 2003 112 12 1796 1808 2-s2.0-0348230958 10.1172/JCI200319246 (Pubitemid 38063703)
28. Xu H., Barnes G. T., Yang Q., Tan G., Yang D., Chou C. J., Sole J., Nichols A., Ross J. S., Tartaglia L. A., Chen H., Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation 2003 112 12 1821 1830 2-s2.0-9144223683 10.1172/JCI200319451 (Pubitemid 38063705)
29. Prunet-Marcassus B., Cousin B., Caton D., André M., Pénicaud L., Casteilla L., From heterogeneity to plasticity in adipose tissues: site-specific differences. Experimental Cell Research 2006 312 6 727 736 2-s2.0-33644903484 10.1016/j.yexcr.2005.11.021
30. Guercio A., Di B. S., Casella S., Di M. P., Russo C., Piccione G., Canine mesenchymal stem cells (MSCs): characterization in relation to donor age and adipose tissue-harvesting site. Cell Biology International 2013 37 8 789 798 10.1002/cbin.10090
31. Requicha J. F., Viegas C. A., Albuquerque C. M., Azevedo J. M., Reis R. L., Gomes M. E., Effect of anatomical origin and cell passage number on the stemness and osteogenic differentiation potential of canine adipose-derived stem cells. Stem Cell Reviews and Reports 2012 8 4 1211 1222 10.1007/s12015-012- 9397-0
32. von Eyben F. E., Kroustrup J. P., Larsen J. F., Celis J., Comparison of gene expression in intra-abdominal and subcutaneous fat: a study of men with morbid obesity and nonobese men using microarray and proteomics. Annals of the New York Academy of Sciences 2004 1030 508 536 2-s2.0-15044364921 10.1196/annals.1329.063 (Pubitemid 40378952)
33. Grove K. L., Fried S. K., Greenberg A. S., Xiao X. Q., Clegg D. J., A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice. International Journal of Obesity 2010 34 6 989 1000 2-s2.0-77953611520 10.1038/ijo.2010.12
34. Linder K., Arner P., Flores-Morales A., Tollet-Egnell P., Norstedt G., Differentially expressed genes in visceral or subcutaneous adipose tissue of obese men and women. Journal of Lipid Research 2004 45 1 148 154 2-s2.0-0842347854 10.1194/jlr.M300256-JLR200 (Pubitemid 38176625)
35. Seale P., Bjork B., Yang W., Kajimura S., Chin S., Kuang S., Scimè A., Devarakonda S., Conroe H. M., Erdjument-Bromage H., Tempst P., Rudnicki M. A., Beier D. R., Spiegelman B. M., PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008 454 7207 961 967 2-s2.0-50049122271 10.1038/nature07182
36. Mizuno H., Tobita M., Uysal A. C., Concise review: adipose-derived stem cells as a novel tool for future regenerative medicine. Stem Cells 2012 30 5 804 810 2-s2.0-84860523401 10.1002/stem.1076
37. Sterodimas A., de Faria J., Nicaretta B., Pitanguy I., Tissue engineering with adipose-derived stem cells (ADSCs): current and future applications. Journal of Plastic, Reconstructive and Aesthetic Surgery 2010 63 11 1886 1892 2-s2.0-77958009280 10.1016/j.bjps.2009.10.028
38. Lindroos B., Suuronen R., Miettinen S., The potential of adipose stem cells in regenerative medicine. Stem Cell Reviews and Reports 2011 7 2 269 291 2-s2.0-79955038911 10.1007/s12015-010-9193-7
39. Strem B. M., Hicok K. C., Zhu M., Wulur I., Alfonso Z., Schreiber R. E., Fraser J. K., Hedrick M. H., Multipotential differentiation of adipose tissue-derived stem cells. Keio Journal of Medicine 2005 54 3 132 141 2-s2.0-27544482446 10.2302/kjm.54.132 (Pubitemid 41542713)
40. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F. C., Krause D. S., Deans R. J., Keating A., Prockop D. J., Horwitz E. M., Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006 8 4 315 317 2-s2.0-33747713246 10.1080/14653240600855905 (Pubitemid 44269669)
41. Lin K., Matsubara Y., Masuda Y., Togashi K., Ohno T., Tamura T., Toyoshima Y., Sugimachi K., Toyoda M., Marc H., Douglas A., Characterization of adipose tissue-derived cells isolated with the Celution system. Cytotherapy 2008 10 4 417 426 2-s2.0-47249151401 10.1080/14653240801982979 (Pubitemid 351983165)
42. Zimmerlin L., Donnenberg V. S., Pfeifer M. E., Meyer E. M., Péault B., Rubin J. P., Donnenberg A. D., Stromal vascular progenitors in adult human adipose tissue. Cytometry Part A 2010 77 1 22 30 2-s2.0-74049104475 10.1002/cyto.a.20813
43. Corselli M., Chen C. W., Sun B., Yap S., Rubin J. P., Peault B., The tunica adventitia of human arteries and veins as a source of mesenchymal stem cells. Stem Cells and Development 2012 21 8 1299 1308 10.1089/scd.2011.0200
44. Zimmerlin L., Donnenberg V. S., Donnenberg A. D., Pericytes: a universal adult tissue stem cell? Cytometry Part A 2012 81 1 12 14 2-s2.0-83855160794 10.1002/cyto.a.21168
45. Zimmerlin L., Donnenberg V. S., Rubin J. P., Donnenberg A. D., Mesenchymal markers on human adipose stem/progenitor cells. Cytometry A 2013 83 134 140
46. Gronthos S., Franklin D. M., Leddy H. A., Robey P. G., Storms R. W., Gimble J. M., Surface protein characterization of human adipose tissue-derived stromal cells. Journal of Cellular Physiology 2001 189 1 54 63 10.1002/jcp.1138 (Pubitemid 32830423)
47. Mitchell J. B., McIntosh K., Zvonic S., Garrett S., Floyd Z. E., Kloster A., Di Halvorsen Y., Storms R. W., Goh B., Kilroy G., Wu X., Gimble J. M., Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells 2006 24 2 376 385 2-s2.0-33746868358 10.1634/stemcells.2005-0234 (Pubitemid 44464807)
48. Bailey A. M., Kapur S., Katz A. J., Characterization of adipose-derived stem cells: an update. Current Stem Cell Research and Therapy 2010 5 2 95 102 2-s2.0-77954082044 10.2174/157488810791268555
49. Suga H., Matsumoto D., Eto H., Inoue K., Aoi N., Kato H., Araki J., Yoshimura K., Functional implications of CD34 expression in human adipose-derived stem/progenitor cells. Stem Cells and Development 2009 18 8 1201 1210 2-s2.0-67650811823 10.1089/scd.2009.0003
50. Bourin P., Bunnell B. A., Casteilla L., Dominici M., Katz A. J., March K. L., Redl H., Rubin J. P., Yoshimura K., Gimble J. M., Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy 2013 15 6 641 648 10.1016/j.jcyt.2013.02.006
51. Lattanzi W., Pola E., Pecorini G., Logroscino C. A., Robbins P. D., Gene therapy for in vivo bone formation: recent advances. European Review for Medical and Pharmacological Sciences 2005 9 3 167 174 2-s2.0-22144480071 (Pubitemid 40975766)
52. Lattanzi W., Bernardini C., Lin Y., Genes and molecular pathways of the osteogenic process. Osteogenesis 2011 InTech. http://www.intechopen.com/books/ osteogenesis/genes-and-molecular-pathways-of-the-osteogenic-process
53. Albertson K. S., Medoff R. J., Mitsunaga M. M., The use of periosteally vascularized autografts to augment the fixation of large segmental allografts. Clinical Orthopaedics and Related Research 1991 269 113 119 2-s2.0-0026356985
54. Enneking W. F., Mindell E. R., Observations on massive retrieved human allografts. Journal of Bone and Joint Surgery A 1991 73 8 1123 1142 2-s2.0-0026077828
55. Borden M., Attawia M., Khan Y., El-Amin S. F., Laurencin C. T., Tissue-engineered bone formation in vivo using a novel sintered polymeric microsphere matrix. Journal of Bone and Joint Surgery B 2004 86 8 1200 1208 2-s2.0-9144235494 10.1302/0301-620X.86B8.14267 (Pubitemid 39545613)
56. Parrilla C., Lattanzi W., Fetoni A. R., Bussu F., Pola E., Paludetti G., Ex vivo gene therapy using autologous dermal fibroblasts expressing hLMP3 for rat mandibular bone regeneration. Head and Neck 2010 32 3 310 318 2-s2.0-76249087915 10.1002/hed.21185
57. He J., Duan H., Xiong Y., Zhang W., Zhou G., Cao Y., Liu W., Participation of CD34-enriched mouse adipose cells in hair morphogenesis. Molecular Medicine Reports 2013 7 4 1111 1116 10.3892/mmr.2013.1307
58. de Francesco F., Tirino V., Desiderio V., Ferraro G., D'Andrea F., Giuliano M., Libondi G., Pirozzi G., de Rosa A., Papaccio G., Human CD34+/CD90+ ASCs are capable of growing as sphere clusters, producing high levels of VEGF and forming capillaries. PLoS ONE 2009 4 8 2-s2.0-68449104766 10.1371/journal.pone.0006537 e6537
59. Kapur S. K., Katz A. J., Review of the adipose derived stem cell secretome. Biochimie 2013 10.1016/j.biochi.2013.06.001
60. Kilroy G. E., Foster S. J., Wu X., Ruiz J., Sherwood S., Heifetz A., Ludlow J. W., Stricker D. M., Potiny S., Green P., Halvorsen Y. D. C., Cheatham B., Storms R. W., Gimble J. M., Cytokine profile of human adipose-derived stem cells: expression of angiogenic, hematopoietic, and pro-inflammatory factors. Journal of Cellular Physiology 2007 212 3 702 709 2-s2.0-34547981198 10.1002/jcp.21068 (Pubitemid 47271882)
61. Ducy P., The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism. Diabetologia 2011 54 6 1291 1297 2-s2.0-80052545899 10.1007/s00125-011-2155-z
62. Gómez-Ambrosi J., Rodríguez A., Catalán V., Frühbeck G., The bone-adipose axis in obesity and weight loss. Obesity Surgery 2008 18 9 1134 1143 2-s2.0-49649118727 10.1007/s11695-008-9548-1
63. Reid I. R., Relationships between fat and bone. Osteoporosis International 2008 19 5 595 606 2-s2.0-43149117061 10.1007/s00198-007-0492-z (Pubitemid 351642171)
64. Colnot C., Cellular and molecular interactions regulating skeletogenesis. Journal of Cellular Biochemistry 2005 95 4 688 697 2-s2.0-24744459687 10.1002/jcb.20449 (Pubitemid 41420156)
65. Ferrara N., Vascular endothelial growth factor: basic science and clinical progress. Endocrine Reviews 2004 25 4 581 611 2-s2.0-4143136640 10.1210/er.2003-0027 (Pubitemid 39099316)
66. Peng H., Usas A., Olshanski A., Ho A. M., Gearhart B., Cooper G. M., Huard J., VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis. Journal of Bone and Mineral Research 2005 20 11 2017 2027 2-s2.0-27444446737 10.1359/JBMR.050708 (Pubitemid 41532787)
67. Lattanzi W., Barba M., Novegno F., Massimi L., Tesori V., Tamburrini G., Galgano S., Bernardini C., Caldarelli M., Michetti F., Di Rocco C., Lim mineralization protein is involved in the premature calvarial ossification in sporadic craniosynostoses. Bone 2013 52 1 474 484 10.1016/j.bone.2012.09.004
68. Cook S. D., Wolfe M. W., Salkeld S. L., Rueger D. C., Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. Journal of Bone and Joint Surgery A 1995 77 5 734 750 2-s2.0-0029018646
69. Einhorn T. A., Clinical applications of recombinant human BMPs: early experience and future development. Journal of Bone and Joint Surgery A 2003 85 supplement 3 82 88 2-s2.0-0042626183 (Pubitemid 36957902)
70. Groeneveld E. H. J., Burger E. H., Bone morphogenetic proteins in human bone regeneration. European Journal of Endocrinology 2000 142 1 9 21 2-s2.0-0033975065 (Pubitemid 30094193)
71. Cowan C. M., Aalami O. O., Shi Y. Y., Chou Y. F., Mari C., Thomas R., Quarto N., Nacamuli R. P., Contag C. H., Wu B., Longaker M. T., Bone morphogenetic protein 2 and retinoic acid accelerate in vivo bone formation, osteoclast recruitment, and bone turnover. Tissue Engineering 2005 11 3-4 645 658 2-s2.0-20944437444 10.1089/ten.2005.11.645 (Pubitemid 40632579)
72. Dragoo J. L., Choi J. Y., Lieberman J. R., Huang J., Zuk P. A., Zhang J., Hedrick M. H., Benhaim P., Bone induction by BMP-2 transduced stem cells derived from human fat. Journal of Orthopaedic Research 2003 21 4 622 629 2-s2.0-0038207126 10.1016/S0736-0266(02)00238-3 (Pubitemid 36758206)
73. Miyazaki M., Zuk P. A., Zou J., Yoon S. H., Wei F., Morishita Y., Sintuu C., Wang J. C., Comparison of human mesenchymal stem cells derived from adipose tissue and bone marrow for ex vivo gene therapy in rat spinal fusion model. Spine 2008 33 8 863 869 2-s2.0-42149139129 10.1097/BRS.0b013e31816b45c3 (Pubitemid 351533854)
74. Wang C. Z., Chen S. M., Chen C. H., Wang C. K., Wang G. J., Chang J. K., Ho M. L., The effect of the local delivery of alendronate on human adipose-derived stem cell-based bone regeneration. Biomaterials 2010 31 33 8674 8683 2-s2.0-77957295515 10.1016/j.biomaterials.2010.07.096
75. Lee S. J., Kang S. W., Do H. J., Han I., Shin D. A., Kim J. H., Lee S. H., Enhancement of bone regeneration by gene delivery of BMP2/Runx2 bicistronic vector into adipose-derived stromal cells. Biomaterials 2010 31 21 5652 5659 2-s2.0-77953028086 10.1016/j.biomaterials.2010.03.019
76. James A. W., Pang S., Askarinam A., Corselli M., Zara J. N., Goyal R., Chang L., Pan A., Shen J., Yuan W., Stoker D., Zhang X., Adams J. S., Ting K., Soo C., Additive effects of sonic hedgehog and Nell-1 signaling in osteogenic versus adipogenic differentiation of human adipose-derived stromal cells. Stem Cells and Development 2012 21 2170 2178 10.1089/scd.2011.0461
77. Zhang Y., Madhu V., Dighe A. S., Irvine J. N. Jr., Cui Q., Osteogenic response of human adipose-derived stem cells to BMP-6, VEGF, and combined VEGF plus BMP-6 in vitro. Growth Factors 2012 30 333 343 10.3109/08977194.2012.720574
78. Boden S. D., Titus L., Hair G., Liu Y., Viggeswarapu M., Nanes M. S., Baranowski C., 1998 Volvo award winner in basic sciences studies: lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1). Spine 1998 23 23 2486 2492 2-s2.0-0032238373 10.1097/00007632- 199812010-00003 (Pubitemid 29003522)
79. Pola E., Gao W., Zhou Y., Pola R., Lattanzi W., Sfeir C., Gambotto A., Robbins P. D., Efficient bone formation by gene transfer of human LIM mineralization protein-3. Gene Therapy 2004 11 8 683 693 2-s2.0-1942441646 10.1038/sj.gt.3302207 (Pubitemid 38519276)
80. Bernardini C., Saulnier N., Parrilla C., Pola E., Gambotto A., Michetti F., Robbins P. D., Lattanzi W., Early transcriptional events during osteogenic differentiation of human bone marrow stromal cells induced by Lim mineralization protein 3. Gene Expression 2010 15 1 27 42 2-s2.0-78549251452 10.3727/105221610X12819686555097
81. Lattanzi W., Parrilla C., Fetoni A., Logroscino G., Straface G., Pecorini G., Stigliano E., Tampieri A., Bedini R., Pecci R., Michetti F., Gambotto A., Robbins P. D., Pola E., Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models. Gene Therapy 2008 15 19 1330 1343 2-s2.0-52049086443 10.1038/gt.2008.116
82. Martinetti R., Dolcini L., Belpassi A., Quarto R., Mastrogiacomo M., Cancedda R., Labanti M., Inspired porosity for cells and tissues. Key Engineering Materials 2004 254-256 1095 1098 2-s2.0-0347516080
83. Tampieri A., Celotti G., Landi E., From biomimetic apatites to biologically inspired composites. Analytical and Bioanalytical Chemistry 2005 381 3 568 576 2-s2.0-15244356309 10.1007/s00216-004-2943-0 (Pubitemid 40385035)
84. Dorozhkin S. V., Epple M., Biological and medical significance of calcium phosphates. Angewandte Chemie 2002 41 3130 3146 (Pubitemid 35021275)
85. Schmitz J. P., Hollinger J. O., Milam S. B., Reconstruction of bone using calcium phosphate bone cements: a critical review. Journal of Oral and Maxillofacial Surgery 1999 57 9 1122 1126 2-s2.0-0032852723 10.1016/S0278- 2391(99)90338-5 (Pubitemid 29411633)
86. Liu Q., Cen L., Yin S., Chen L., Liu G., Chang J., Cui L., A comparative study of proliferation and osteogenic differentiation of adipose-derived stem cells on akermanite and β -TCP ceramics. Biomaterials 2008 29 36 4792 4799 2-s2.0-53449097837 10.1016/j.biomaterials.2008.08.039
87. Hing K. A., Wilson L. F., Buckland T., Comparative performance of three ceramic bone graft substitutes. Spine Journal 2007 7 4 475 490 2-s2.0-34447267742 10.1016/j.spinee.2006.07.017 (Pubitemid 47044790)
88. Kruyt M. C., Wilson C. E., de Bruijn J. D., van Blitterswijk C. A., Oner C. F., Verbout A. J., Dhert W. J. A., The effect of cell-based bone tissue engineering in a goat transverse process model. Biomaterials 2006 27 29 5099 5106 2-s2.0-33745456414 10.1016/j.biomaterials.2006.05.048 (Pubitemid 43949422)
89. Petite H., Viateau V., Bensaïd W., Meunier A., de Pollak C., Bourguignon M., Oudina K., Sedel L., Guillemin G., Tissue-engineered bone regeneration. Nature Biotechnology 2000 18 9 959 963 2-s2.0-0034425983 10.1038/79449 (Pubitemid 32977376)
90. Lopez M. J., Daigle P. R., Adult multipotent stromal cell technology for bone regeneration: a review. Veterinary Surgery 2013 42 1 1 11 10.1111/j.1532-950X.2012.01077.x
91. Liao H. T., Lee M. Y., Tsai W. W., Wang H. C., Lu W. C., Osteogenesis of adipose-derived stem cells on polycaprolactone-beta-tricalcium phosphate scaffold fabricated via selective laser sintering and surface coating with collagen type I. Journal of Tissue Engineering and Regenerative Medicine 2013 10.1002/term.1811
92. Marino G., Rosso F., Cafiero G., Tortora C., Moraci M., Barbarisi M., Barbarisi A., β-Tricalcium phosphate 3D scaffold promote alone osteogenic differentiation of human adipose stem cells: in vitro study. Journal of Materials Science: Materials in Medicine 2010 21 1 353 363 2-s2.0-75049083232 10.1007/s10856-009-3840-z
93. Arrigoni E., de G. L., Di G. A., Stanco D., Dellavia C., Carnelli D., Campagnol M., Domeneghini C., Brini A. T., Adipose-derived stem cells and rabbit bone regeneration: histomorphometric, immunohistochemical and mechanical characterization. Journal of Orthopaedic Science 2013 18 2 331 339 10.1007/s00776-012-0349-y
94. Zanetti A., McCandless G., Chan J., Gimble J., Hayes D., Characterization of novel akermanite:poly-epsilon-caprolactone scaffolds for human adipose-derived stem cells bone tissue engineering. Journal of Tissue Engineering and Regenerative Medicine 2012 10.1002/term.1646
95. Gu H., Guo F., Zhou X., Gong L., Zhang Y., Zhai W., Chen L., Cen L., Yin S., Chang J., Cui L., The stimulation of osteogenic differentiation of human adipose-derived stem cells by ionic products from akermanite dissolution via activation of the ERK pathway. Biomaterials 2011 32 29 7023 7033 2-s2.0-79960834799 10.1016/j.biomaterials.2011.06.003
96. Zanetti A. S., McCandless G. T., Chan J. Y., Gimble J. M., Hayes D. J., In vitro human adipose-derived stromal/stem cells osteogenesis in akermanite: poly- ε -caprolactone scaffolds. Journal of Biomaterials Applications 2013 10.1177/0885328213490974
97. Peng C. A., Palsson B. O., Determination of specific oxygen uptake rates in human hematopoietic cultures and implications for bioreactor design. Annals of Biomedical Engineering 1996 24 3 373 381 2-s2.0-0030152222
98. Cancedda R., Giannoni P., Mastrogiacomo M., A tissue engineering approach to bone repair in large animal models and in clinical practice. Biomaterials 2007 28 29 4240 4250 2-s2.0-34547681854 10.1016/j.biomaterials.2007.06.023 (Pubitemid 47212405)
99. Janssen F. W., Hofland I., van Oorschot A., Oostra J., Peters H., van Blitterswijk C. A., Online measurement of oxygen consumption by goat bone marrow stromal cells in a combined cell-seeding and proliferation perfusion bioreactor. Journal of Biomedical Materials Research A 2006 79 2 338 348 2-s2.0-33750482958 10.1002/jbm.a.30794 (Pubitemid 44652033)
100. Wang Y., Uemura T., Dong J., Kojima H., Tanaka J., Tateishi T., Application of perfusion culture system improves in vitro and in vivo osteogenesis of bone marrow-derived osteoblastic cells in porous ceramic materials. Tissue Engineering 2003 9 6 1205 1214 2-s2.0-0344152914 10.1089/10763270360728116 (Pubitemid 37467668)
101. Wang C., Cen L., Yin S., Liu Q., Liu W., Cao Y., Cui L., A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells. Biomaterials 2010 31 4 621 630 2-s2.0-75549092041 10.1016/j.biomaterials. 2009.09.086
102. Fröhlich M., Grayson W. L., Marolt D., Gimble J. M., Kregar-Velikonja N., Vunjak-Novakovic G., Bone grafts engineered from human adipose-derived stem cells in perfusion bioreactor culture. Tissue Engineering A 2010 16 1 179 189 2-s2.0-77049097956 10.1089/ten.tea.2009.0164
103. Declercq H. A., De C. T., Krysko O., Bachert C., Cornelissen M. J., Bone grafts engineered from human adipose-derived stem cells in dynamic 3D-environments. Biomaterials 2013 34 4 1004 1017 10.1016/j.biomaterials.2012. 10.051
104. Silva A. R., Paula A. C., Martins T. M., Goes A. M., Pereria M. M., Synergistic effect between bioactive glass foam and a perfusion bioreactor on osteogenic differentiation of human adipose stem cells. Journal of Biomedical Materials Research Part A 2013 10.1002/jbm.a.34758
105. Scherberich A., Galli R., Jaquiery C., Farhadi J., Martin I., Three-dimensional perfusion culture of human adipose tissue-derived endothelial and osteoblastic progenitors generates osteogenic constructs with intrinsic vascularization capacity. Stem Cells 2007 25 7 1823 1829 2-s2.0-34547209373 10.1634/stemcells.2007-0124 (Pubitemid 47121862)
106. Papadimitropoulos A., Scherberich A., Güven S., Theilgaard N., Crooijmans H. J. A., Santini F., Scheffler K., Zallone A., Martin I., A 3D in vitro bone organ model using human progenitor cells. European Cells & Materials 2011 21 445 458 2-s2.0-80053128627
107. Güven S., Mehrkens A., Saxer F., Schaefer D. J., Martinetti R., Martin I., Scherberich A., Engineering of large osteogenic grafts with rapid engraftment capacity using mesenchymal and endothelial progenitors from human adipose tissue. Biomaterials 2011 32 25 5801 5809 2-s2.0-79957896949 10.1016/j.biomaterials.2011.04.064
108. Behr B., Tang C., Germann G., Longaker M. T., Quarto N., Locally applied vascular endothelial growth factor A increases the osteogenic healing capacity of human adipose-derived stem cells by promoting osteogenic and endothelial differentiation. Stem Cells 2011 29 2 286 296 2-s2.0-79952172937 10.1002/stem.581
109. Cui L., Liu B., Liu G., Zhang W., Cen L., Sun J., Yin S., Liu W., Cao Y., Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model. Biomaterials 2007 28 36 5477 5486 2-s2.0-35349020566 10.1016/j.biomaterials.2007.08.042 (Pubitemid 47610689)
110. Deng Y., Zhou H., Zou D., Xie Q., Bi X., Gu P., Fan X., The role of miR-31-modified adipose tissue-derived stem cells in repairing rat critical-sized calvarial defects. Biomaterials 2013 34 28 6717 6728 10.1016/j.biomaterials.2013.05.042
111. Hong J. M., Kim B. J., Shim J. H., Kang K. S., Kim K. J., Rhie J. W., Cha H. J., Cho D. W., Enhancement of bone regeneration through facile surface functionalization of solid freeform fabrication-based three-dimensional scaffolds using mussel adhesive proteins. Acta Biomaterialia 2012 2-s2.0-84859826532 10.1016/j.actbio.2012.03.041
112. Kim H. P., Ji Y. H., Rhee S. C., Dhong E. S., Park S. H., Yoon E. S., Enhancement of bone regeneration using osteogenic-induced adipose-derived stem cells combined with demineralized bone matrix in a rat critically-sized calvarial defect model. Current Stem Cell Research and Therapy 2012 7 3 165 172 2-s2.0-84860281254 10.2174/157488812799859847
113. Kim J. Y., Jin G. Z., Park I. S., Kim J. N., Chun S. Y., Park E. K., Kim S. Y., Yoo J., Kim S. H., Rhie J. W., Cho D. W., Evaluation of solid free-form fabrication-based scaffolds seeded with osteoblasts and human umbilical vein endothelial cells for use in vivo osteogenesis. Tissue Engineering A 2010 16 7 2229 2236 2-s2.0-77954494837 10.1089/ten.tea.2009.0644
114. Ko E., Yang K., Shin J., Cho S. W., Polydopamine-assisted osteoinductive Peptide immobilization of polymer scaffolds for enhanced bone regeneration by human adipose-derived stem cells. Biomacromolecules 2013 14 3202 3213 10.1021/bm4008343
115. Levi B., James A. W., Nelson E. R., Hu S., Sun N., Peng M., Wu J., Longaker M. T., Studies in adipose-derived stromal cells: migration and participation in repair of cranial injury after systemic injection. Plastic and Reconstructive Surgery 2011 127 3 1130 1140 2-s2.0-79952744344 10.1097/PRS.0b013e3182043712
116. Levi B., James A. W., Nelson E. R., Peng M., Wan D. C., Commons G. W., Lee M., Wu B., Longaker M. T., Acute skeletal injury is necessary for human adipose-derived stromal cell-mediated calvarial regeneration. Plastic and Reconstructive Surgery 2011 127 3 1118 1129 2-s2.0-79952771583 10.1097/PRS.0b013e318205f274
117. Levi B., Nelson E. R., Li S., James A. W., Hyun J. S., Montoro D. T., Lee M., Glotzbach J. P., Commons G. W., Longaker M. T., Dura mater stimulates human adipose-derived stromal cells to undergo bone formation in mouse calvarial defects. Stem Cells 2011 29 8 1241 1255 2-s2.0-79960874212 10.1002/stem.670
118. Levi B., James A. W., Nelson E. R., Li S., Peng M., Commons G. W., Lee M., Wu B., Longaker M. T., Human adipose-derived stromal cells stimulate autogenous skeletal repair via paracrine hedgehog signaling with calvarial osteoblasts. Stem Cells and Development 2011 20 2 243 257 2-s2.0-78951481661 10.1089/scd.2010.0250
119. Levi B., Hyun J. S., Nelson E. R., Li S., Montoro D. T., Wan D. C., Jia F. J., Glotzbach J. C., James A. W., Lee M., Huang M., Quarto N., Gurtner G. C., Wu J. C., Longaker M. T., Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair. Stem Cells 2011 29 12 2018 2029 2-s2.0-81855168297 10.1002/stem.757
120. Lin C. Y., Chang Y. H., Li K. C., Lu C. H., Sung L. Y., Yeh C. L., Lind K. J., Huang S. F., Yenb T. C., Hu Y. C., The use of ASCs engineered to express BMP2 or TGF-beta3 within scaffold constructs to promote calvarial bone repair. Biomaterials 2013 34 37 9401 9412 10.1016/j.biomaterials.2013.08.051
121. Liu G., Zhang Y., Liu B., Sun J., Li W., Cui: L., Bone regeneration in a canine cranial model using allogeneic adipose derived stem cells and coral scaffold. Biomaterials 2013 34 2655 2664 10.1016/j.biomaterials.2013.01.004
122. Lo D. D., Hyun J. S., Chung M. T., Montoro D. T., Zimmermann A., Grova M. M., Lee M., Wan D. C., Longaker M. T., Repair of a critical-sized calvarial defect model using adipose-derived stromal cells harvested from lipoaspirate. Journal of Visualized Experiments 2012 68 article e4221 10.3791/4221
123. Rhee S. C., Ji Y. H., Gharibjanian N. A., Dhong E. S., Park S. H., Yoon E. S., In vivo evaluation of mixtures of uncultured freshly isolated adipose-derived stem cells and demineralized bone matrix for bone regeneration in a rat critically sized calvarial defect model. Stem Cells and Development 2011 20 2 233 242 2-s2.0-78951477715 10.1089/scd.2009.0525
124. Smith D. M., Cooper G. M., Afifi A. M., Mooney M. P., Cray J., Rubin J. P., Marra K. G., Losee J. E., Regenerative surgery in cranioplasty revisited: the role of adipose-derived stem cells and BMP-2. Plastic and Reconstructive Surgery 2011 128 5 1053 1060 2-s2.0-80155187529 10.1097/PRS.0b013e31822b65e4
125. Yoon E., Dhar S., Chun D. E., Gharibjanian N. A., Evans G. R. D., In vivo osteogenic potential of human adipose-derived stem cells/poly lactide-co-glycolic acid constructs for bone regeneration in a rat critical-sized calvarial defect model. Tissue Engineering 2007 13 3 619 627 2-s2.0-34147208886 10.1089/ten.2006.0102 (Pubitemid 46579887)
126. Jo C. H., Yoon P. W., Kim H., Kang K. S., Yoon K. S., Comparative evaluation of in vivo osteogenic differentiation of fetal and adult mesenchymal stem cell in rat critical-sized femoral defect model. Cell and Tissue Research 2013 353 1 41 52 10.1007/s00441-013-1619-5
127. Stockmann P., Park J., von Wilmowsky C., Nkenke E., Felszeghy E., Dehner J. F., Schmitt C., Tudor C., Schlegel K. A., Guided bone regeneration in pig calvarial bone defects using autologous mesenchymal stem/progenitor cells-a comparison of different tissue sources. Journal of Cranio-Maxillofacial Surgery 2012 40 4 310 320 2-s2.0-79959626761 10.1016/j.jcms.2011.05.004
128. Choi J. W., Park E. J., Shin H. S., Shin I. S., Ra J. C., Koh K. S., In vivo differentiation of undifferentiated human adipose tissue-derived mesenchymal stem cells in critical-sized calvarial bone defects. Annals of Plastic Surgery 2012 10.1097/SAP.0b013e31825f70f5
129. Chou Y. F., Zuk P. A., Chang T. L., Benhaim P., Wu B. M., Adipose-derived stem cells and BMP2. Part 1: BMP2-treated adipose-derived stem cells do not improve repair of segmental femoral defects. Connective Tissue Research 2011 52 2 109 118 2-s2.0-79952305301 10.3109/03008207.2010.484514
130. Li X., Liu H., Niu X., Yu B., Fan Y., Feng Q., Cui F. Z., Watari F., The use of carbon nanotubes to induce osteogenic differentiation of human adipose-derived MSCs in vitro and ectopic bone formation in vivo. Biomaterials 2012 33 19 4818 4827 2-s2.0-84859880099 10.1016/j.biomaterials.2012.03.045
131. Man Y., Wang P., Guo Y., Xiang L., Yang Y., Qu Y., Gong P., Deng L., Angiogenic and osteogenic potential of platelet-rich plasma and adipose-derived stem cell laden alginate microspheres. Biomaterials 2012 33 34 8802 8811 10.1016/j.biomaterials.2012.08.054
132. Schubert T., Xhema D., Vériter S., Schubert M., Behets C., Delloye C., Gianello P., Dufrane D., The enhanced performance of bone allografts using osteogenic-differentiated adipose-derived mesenchymal stem cells. Biomaterials 2011 32 34 8880 8891 2-s2.0-80053113940 10.1016/j.biomaterials.2011.08.009
133. Shen F. H., Werner B. C., Liang H., Shang H., Yang N., Li X., Shimer A. L., Balian G., Katz A. J., Implications of adipose-derived stromal cells in a 3D culture system for osteogenic differentiation: an in vitro and in vivo investigation. The Spine Journal 2013 13 32 43 10.1016/j.spinee.2013.01.002
134. Qing W., Guang-Xing C., Lin G., Liu Y., The osteogenic study of tissue engineering bone with BMP2 and BMP7 gene-modified rat adipose-derived stem cell. Journal of Biomedicine and Biotechnology 2012 2012 7 410879 10.1155/2012/41087
135. Cao Z., Hou S., Sun D., Wang X., Tang J., Osteochondral regeneration by a bilayered construct in a cell-free or cell-based approach. Biotechnology Letters 2012 34 6 1151 1157 2-s2.0-84860426991 10.1007/s10529-012-0884-9
136. Fernandez F. B., Shenoy S., Suresh Babu S., Varma H. K., John A., Short-term studies using ceramic scaffolds in lapine model for osteochondral defect amelioration. Biomedical Materials 2012 7 3 2-s2.0-84858988584 10.1088/1748-6041/7/3/035005 035005
137. Hao W., Dong J., Jiang M., Wu J., Cui F., Zhou D., Enhanced bone formation in large segmental radial defects by combining adipose-derived stem cells expressing bone morphogenetic protein 2 with nHA/RHLC/PLA scaffold. International Orthopaedics 2010 34 8 1341 1349 2-s2.0-78549282729 10.1007/s00264-009-0946-3
138. Kang B. J., Ryu H. H., Park S. S., Koyama Y., Kikuchi M., Woo H. M., Kim W. H., Kweon O. K., Comparing the osteogenic potential of canine mesenchymal stem cells derived from adipose tissues, bone marrow, umbilical cord blood, and Wharton's jelly for treating bone defects. Journal of Veterinary Science 2012 13 299 310 10.4142/jvs.2012.13.3.299
139. Keibl C., Fügl A., Zanoni G., Tangl S., Wolbank S., Redl H., van Griensven M., Human adipose derived stem cells reduce callus volume upon BMP-2 administration in bone regeneration. Injury 2011 42 8 814 820 2-s2.0-79959991096 10.1016/j.injury.2011.03.007
140. Lee S. W., Padmanabhan P., Ray P., Gambhir S. S., Doyle T., Contag C., Goodman S. B., Biswal S., Stem cell-mediated accelerated bone healing observed with in vivo molecular and small animal imaging technologies in a model of skeletal injury. Journal of Orthopaedic Research 2009 27 3 295 302 2-s2.0-62249191413 10.1002/jor.20736
141. Li J., Zhao Q., Wang E., Zhang C., Wang G., Yuan Q., Transplantation of Cbfa1-overexpressing adipose stem cells together with vascularized periosteal flaps repair segmental bone defects. Journal of Surgical Research 2012 176 1 e13 e20 2-s2.0-84857027869 10.1016/j.jss.2011.12.011
142. Schubert T., Poilvache H., Galli C., Gianello P., Dufrane D Galactosyl-knock-out engineered pig as a xenogenic donor source of adipose MSCs for bone regeneration. Biomaterials 2013 34 3279 3289 10.1016/j.biomaterials. 2013.01.057
143. Sheyn D., Pelled G., Zilberman Y., Talasazan F., Frank J. M., Gazit D., Gazit Z., Nonvirally engineered porcine adipose tissue-derived stem cells: use in posterior spinal fusion. Stem Cells 2008 26 4 1056 1064 2-s2.0-49249127420 10.1634/stemcells.2007-0858
144. Sheyn D., Kallai I., Tawackoli W., Cohn Yakubovich D., Oh A., Su S., Da X., Lavi A., Kimelman-Bleich N., Zilberman Y., Li N., Bae H., Gazit Z., Pelled G., Gazit D., Gene-modified adult stem cells regenerate vertebral bone defect in a rat model. Molecular Pharmaceutics 2011 8 5 1592 1601 2-s2.0-80053531201 10.1021/mp200226c
145. Shoji T., Ii M., Mifune Y., Matsumoto T., Kawamoto A., Kwon S. M., Kuroda T., Kuroda R., Kurosaka M., Asahara T., Local transplantation of human multipotent adipose-derived stem cells accelerates fracture healing via enhanced osteogenesis and angiogenesis. Laboratory Investigation 2010 90 4 637 649 2-s2.0-77950366650 10.1038/labinvest.2010.39
146. Parrilla C., Saulnier N., Bernardini C., Patti R., Tartaglione T., Fetoni A. R., Pola E., Paludetti G., Michetti F., Lattanzi W., Undifferentiated human adipose tissue-derived stromal cells induce mandibular bone healing in rats. Archives of Otolaryngology 2011 137 5 463 470 2-s2.0-79956061052 10.1001/archoto.2011.61
147. Wilson S. M., Goldwasser M. S., Clark S. G., Monaco E., Bionaz M., Hurley W. L., Rodriguez-Zas S., Feng L., Dymon Z., Wheeler M. B., Adipose-derived mesenchymal stem cells enhance healing of mandibular defects in the ramus of swine. Journal of Oral and Maxillofacial Surgery 2012 70 3 e193 203 2-s2.0-84859934323
148. Gimble J. M., Guilak F., Bunnell B. A., Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. Stem Cell Research and Therapy 2010 1 2, article 19 2-s2.0-79960259749 10.1186/scrt19
149. Sandor G. K., Tuovinen V. J., Wolff J., Patrikoski M., Jokinen J., Nieminen E., Mannerstr?m B., Lappalainen O. P., Sepp?nen R., Miettinen S., Adipose stem cell tissue-engineered construct used to treat large anterior mandibular defect: a case report and review of the clinical application of good manufacturing practice-level adipose stem cells for bone regeneration. Journal of Oral and Maxillofacial Surgery 2013 71 938 950 10.1016/j.joms.2012.11.014
150. Abbott A., Stem-cell ruling riles researchers. Nature 2013 495 418 419 10.1038/495418a
151. Casteilla L., Planat-Benard V., Laharrague P., Cousin B., Adipose-derived stromal cells: their identity and uses in clinical trials, an update. World Journal of Stem Cells 2011 3 25 33
152. Thesleff T., Lehtimäki K., Niskakangas T., Mannerström B., Miettinen S., Suuronen R., Öhman J., Cranioplasty with adipose-derived stem cells and biomaterial: a novel method for cranial reconstruction. Neurosurgery 2011 68 6 1535 1540 2-s2.0-79955917089 10.1227/NEU.0b013e31820ee24e
153. Lendeckel S., Jödicke A., Christophis P., Heidinger K., Wolff J., Fraser J. K., Hedrick M. H., Berthold L., Howaldt H. P., Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. Journal of Cranio-Maxillofacial Surgery 2004 32 6 370 373 2-s2.0-11044234825 10.1016/j.jcms.2004.06.002 (Pubitemid 40045639)
154. Mesimäki K., Lindroos B., Törnwall J., Mauno J., Lindqvist C., Kontio R., Miettinen S., Suuronen R., Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. International Journal of Oral and Maxillofacial Surgery 2009 38 3 201 209 2-s2.0-67049086482 10.1016/j.ijom.2009.01.001
155. Bellotti C., Stanco D., Ragazzini S., Romagnoli L., Martella E., Lazzati S., Marchetti C., Donati D., Lucarelli E., Analysis of the karyotype of expanded human adipose-derived stem cells for bone reconstruction of the maxillo-facial region. International Journal of Immunopathology and Pharmacology 2013 26 3 9
156. Bianchi F., Maioli M., Leonardi E., Olivi E., Pasquinelli G., Valente S., Mendez A. J., Ricordi C., Raffaini M., Tremolada C., Ventura C., A new non-enzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirate. Cell Transplant 2013 22 11 2063 2077