A 3D in vitro bone organ model using human progenitor cells

European Cells and Materials

Volumn 21, Issue , 2011, Pages 445-458

  Papadimitropoulos, Adam ^a   Scherberich, Arnaud ^a   Güven, Sinan ^a   Theilgaard, Naseem ^b   Crooijmans, Hendrikus J A ^a   Santini, Francesco ^a   Scheffler, Klaus ^a   Zallone, Alberta ^c   Martin, Ivan ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b DANISH TECHNOLOGICAL INSTITUTE   (Denmark)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

Bone remodelling; Human stem cellspopulation regulation; Multi cell co culture; Non invasive tools; Perfusion bioreactor; Tissue engineering regenerative medicine

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; AMINO TERMINAL TELOPEPTIDE; C TERMINUS PROCOLLAGEN I PROPEPTIDE; CD14 ANTIGEN; PHOSPHATE; PROCOLLAGEN; UNCLASSIFIED DRUG; VITAMIN D; ACID PHOSPHATASE; BONE DENSITY CONSERVATION AGENT; BONE SIALOPROTEIN; COLECALCIFEROL; COLLAGEN TYPE 1; COLONY STIMULATING FACTOR 1; ISOENZYME; LEUKOCYTE ANTIGEN; OSTEOCLAST DIFFERENTIATION FACTOR; TARTRATE-RESISTANT ACID PHOSPHATASE; TISSUE SCAFFOLD;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL MODEL; BONE; BONE MATRIX; BONE TURNOVER; CONTROLLED STUDY; CULTURE TECHNIQUE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; SCANNING ELECTRON MICROSCOPY; STEM CELL; THREE DIMENSIONAL COCULTURE SYSTEM; ADULT STEM CELL; ANIMAL; CELL DIFFERENTIATION; CELL LINEAGE; CERAMICS; COCULTURE; CYTOLOGY; EXTRACELLULAR MATRIX; METABOLISM; MONOCYTE; NUDE MOUSE; PATHOLOGY; TISSUE ENGINEERING; TRANSPLANTATION;

ACID PHOSPHATASE; ADULT STEM CELLS; ANIMALS; ANTIGENS, CD; BONE AND BONES; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; CELL DIFFERENTIATION; CELL LINEAGE; CERAMICS; CHOLECALCIFEROL; COCULTURE TECHNIQUES; COLLAGEN TYPE I; ENDOTHELIAL CELLS; EXTRACELLULAR MATRIX; HUMANS; INTEGRIN-BINDING SIALOPROTEIN; ISOENZYMES; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; MICE, NUDE; MONOCYTES; OSTEOBLASTS; OSTEOCLASTS; RANK LIGAND; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 80053128627     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v021a33     Document Type: Article

References (43)

1. Banfi A, Muraglia A, Dozin B, Mastrogiacomo M, Cancedda R, Quarto R (2000) Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy. Exp Hematol 28: 707-715.
2. Boyle WJ, Simonet WS, Lacey DL (2003) Osteoclast differentiation and activation. Nature 423: 337-342.
3. Braccini A, Wendt D, Jaquiery C, Jakob M, Heberer M, Kenins L, Wodnar-Filipowicz A, Quarto R, Martin I (2005) Three-dimensional perfusion culture of human bone marrow cells and generation of osteoinductive grafts. Stem Cells 23: 1066-1072.
4. Caravan P, Das B, Dumas S, Epstein FH, Helm PA, Jacques V, Koerner S, Kolodziej A, Shen L, Sun WC, Zhang Z (2007) Collagen-targeted MRI contrast agent for molecular imaging of fibrosis. Angew Chem Int Ed Engl 46: 8171-8173.
5. Collin-Osdoby P (1994) Role of vascular endothelial cells in bone biology. J Cell Biochem 55: 304-309.
6. David V, Guignandon A, Martin A, Malaval L, Lafage-Proust MH, Rattner A, Mann V, Noble B, Jones DB, Vico L (2008) Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain. Tissue Eng Part A 14: 117-126.
7. Detsch R, Mayr H, Ziegler G (2008) Formation of osteoclast-like cells on HA and TCP ceramics. Acta Biomater 4: 139-148.
8. Di Maggio MN, Piccinini E, Jaworski M, Trumpp A, Wendt DJ, Martin I (2011) Toward modeling the bone marrow niche using scaffold-based 3D culture systems. Biomaterials 32: 321-329.
9. Domaschke H, Gelinsky M, Burmeister B, Fleig R, Hanke T, Reinstorf A, Pompe W, Rosen-Wolff A (2006) In vitro ossification and remodeling of mineralized collagen I scaffolds. Tissue Eng 12: 949-958.
10. Gronthos S, Zannettino AC, Graves SE, Ohta S, Hay SJ, Simmons PJ (1999) Differential cell surface expression of the STRO-1 and alkaline phosphatase antigens on discrete developmental stages in primary cultures of human bone cells. J Bone Miner Res 14: 47-56.
11. Hauge EM, Qvesel D, Eriksen EF, Mosekilde L, Melsen F (2001) Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers. J Bone Miner Res 16: 1575-1582.
12. Heinemann C, Heinemann S, Worch H, Hanke T (2011) Development of an osteoblast/osteoclast co-culture derived by human bone marrow stromal cells and human monocytes for biomaterials testing. Eur Cell Mater 21: 80-93.
13. Hutmacher DW, Loessner D, Rizzi S, Kaplan DL, Mooney DJ, Clements JA (2010) Can tissue engineering concepts advance tumor biology research? Trends Biotechnol 28: 125-133.
14. Kirkpatrick CJ, Fuchs S, Hermanns MI, Peters K, Brochhausen C, Unger RE (2007) Cell culture models of higher complexity in tissue engineering and regenerative medicine. Biomaterials 34: 5193-5198.
15. Kitazawa S, Kajimoto K, Kondo T, Kitazawa R (2003) Vitamin D3 supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter. J Cell Biochem 89: 771-777.
16. Komano Y, Nanki T, Hayashida K, Taniguchi K, Miyasaka N (2006) Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts. Arthritis Res Ther 8: R152.
17. Komlev VS, Mastrogiacomo M, Pereira RC, Peyrin F, Rustichelli F, Cancedda R (2010) Biodegradation of porous calcium phosphate scaffolds in an ectopic bone formation model studied by X-ray computed microtomograph. Eur Cell Mater 19: 136-146.
18. Kuwana M, Okazaki Y, Kodama H, Izumi K, Yasuoka H, Ogawa Y, Kawakami Y, Ikeda Y (2003) Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation. J Leukoc Biol 74: 833-845.
19. Kuwana M, Okazaki Y, Kodama H, Satoh T, Kawakami Y, Ikeda Y (2006) Endothelial differentiation potential of human monocyte-derived multipotential cells. Stem Cells 24: 2733-2743.
20. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93: 165-176.
21. Martin I, Riboldi SA, Jakob M, Wendt D (2010) SnapShot: Bioreactors systems in tissue engineering (TE) & regenerative medicine (RM). Biomaterials 31: 3114-3115.
22. Matsuo K, Irie N (2008) Osteoclast-osteoblast communication. Arch Biochem Biophys 473: 201-209.
23. Meghji S, Hill PA, Harris M (1997) Bone organ cultures. In. UK: Chapman and Hall, 106-126.
24. Miao D, Scutt A (2002) Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo. BMC Musculoskelet Disord 3: 16.
25. Nakagawa K, Abukawa H, Shin MY, Terai H, Troulis MJ, Vacanti JP (2004) Osteoclastogenesis on tissueengineered bone. Tissue Eng 10: 93-100.
26. Pampaloni F, Reynaud EG, Stelzer EH (2007) The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 8: 839-845.
27. Pampaloni F, Stelzer EH, Masotti A (2009) Threedimensional tissue models for drug discovery and toxicology. Recent Pat Biotechnol 3: 103-117.
28. Parfitt AM (1994) Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem 55: 273-286.
29. Parfitt AM (2000) The mechanism of coupling: a role for the vasculature. Bone 26: 319-323.
30. Pearce AI, Richards RG, Milz S, Schneider E, Pearce SG (2007) Animal models for implant biomaterial research in bone: a review. Eur Cell Mater 13: 1-10.
31. Pogoda P, Priemel M, Rueger JM, Amling M (2005) Bone remodeling: new aspects of a key process that controls skeletal maintenance and repair. Osteoporos Int 16 Suppl 2: S18-S24.
32. Scherberich A, Galli R, Jaquiery C, Farhadi J, Martin I (2007) Three-dimensional perfusion culture of human adipose tissue-derived endothelial and osteoblastic progenitors generates osteogenic constructs with intrinsic vascularization capacity. Stem Cells 25: 1823-1829.
33. Simpson AE, Stoddart MJ, Davies CM, Jahn K, Furlong PI, Gasser JA, Jones DB, Noble BS, Richards RG (2009) TGFbeta3 and loading increases osteocyte survival in human cancellous bone cultured ex vivo. Cell Biochem Funct 27: 23-29.
34. Sorensen MG, Henriksen K, Schaller S, Henriksen DB, Nielsen FC, Dziegiel MH, Karsdal MA (2007) Characterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood. J Bone Miner Metab 25: 36-45.
35. Takahashi N, Yamana H, Yoshiki S, Roodman GD, Mundy GR, Jones SJ, Boyde A, Suda T (1988) Osteoclastlike cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 122: 1373-1382.
36. Tortelli F, Cancedda R (2009) Three-dimensional cultures of osteogenic and chondrogenic cells: a tissue engineering approach to mimic bone and cartilage in vitro. Eur Cell Mater 17: 1-14.
37. Tortelli F, Pujic N, Liu Y, Laroche N, Vico L, Cancedda R (2009) Osteoblast and osteoclast differentiation in an in vitro three-dimensional model of bone. Tissue Eng Part A 15: 2373-2383.
38. Wendt D, Marsano A, Jakob M, Heberer M, Martin I (2003) Oscillating perfusion of cell suspensions through three-dimensional scaffolds enhances cell seeding efficiency and uniformity. Biotechnol Bioeng 84: 205-214.
39. Yamada S, Heymann D, Bouler JM, Daculsi G (1997) Osteoclastic resorption of biphasic calcium phosphate ceramic in vitro. J Biomed Mater Res 37: 346-352.
40. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesisinhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95: 3597-3602.
41. Yeh SP, Chang JG, Lo WJ, Liaw YC, Lin CL, Lee CC, Chiu CF (2006) Induction of CD45 expression on bone marrow-derived mesenchymal stem cells. Leukemia 20: 894-896
42. Yin JJ, Pollock CB, Kelly K (2005) Mechanisms of cancer metastasis to the bone. Cell Res 15: 57-62.
43. Zaidi M, Alam AS, Bax BE, Shankar VS, Bax CM, Gill JS, Pazianas M, Huang CL, Sahinoglu T, Moonga BS (1993) Role of the endothelial cell in osteoclast control: new perspectives. Bone 14: 97-102.