Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair

Stem Cells

Volumn 29, Issue 12, 2011, Pages 2018-2029

  Levi, Benjamin ^a   Hyun, Jeong S ^a   Nelson, Emily R ^a   Li, Shuli ^a   Montoro, Daniel T ^a   Wan, Derrick C ^a   Jia, Fang Jun ^a   Glotzbach, Jason C ^a   James, Aaron W ^a   Lee, Min ^b   Huang, Mei ^a   Quarto, Natalina ^a,c   Gurtner, Geoffrey C ^a   Wu, Joseph C ^a   Longaker, Michael T ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Bone morphogenetic protein; Calvarial defect; Multipotent stromal cells; Noggin; Scaffold; Skeletal tissue engineering; Tissue regeneration

Indexed keywords

BONE MORPHOGENETIC PROTEIN; NOGGIN; SHORT HAIRPIN RNA;

ADIPOSE DERIVED STEM CELL; ARTICLE; BONE DEVELOPMENT; BONE REMODELING; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PROTEIN EXPRESSION;

ADIPOSE TISSUE; ADULT; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CARRIER PROTEINS; CELL DIFFERENTIATION; FEMALE; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; HUMANS; IMPLANTS, EXPERIMENTAL; LACTIC ACID; LENTIVIRUS; MALE; MICE; MICE, NUDE; MICE, TRANSGENIC; MIDDLE AGED; OSTEOGENESIS; POLYGLYCOLIC ACID; RECOMBINANT PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SKULL; STEM CELLS; TIME FACTORS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; YOUNG ADULT;

EID: 81855168297     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.757     Document Type: Article

References (43)

1. HCUP. Healthcare cost and utilization project, Rockville, MD: Agency for Healthcare Research and Quality, 2007. Available at http://www.hcup-us.ahrq.gov/ . Accessed on January, 2010.
2. Nacamuli RP, Longaker MT. Bone induction in craniofacial defects. Orthod Craniofac Res 2005;8:259-266.
3. Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-926. (Pubitemid 23209960)
4. Petite H, Viateau V, Bensaid W et al. Tissue-engineered bone regeneration. Nat Biotechnol 2000;18:959-963. (Pubitemid 32977376)
5. Cahill KS, Chi JH, Day A et al. Prevalence, complications, and hospital charges associated with use of bone-morphogenetic proteins in spinal fusion procedures. JAMA 2009;302:58-66.
6. Epstein NE. Pros, cons, and costs of INFUSE in spinal surgery. Surg Neurol Int 2011;2:10.
7. Glassman SD, Carreon LY, Djurasovic M et al. RhBMP-2 versus iliac crest bone graft for lumbar spine fusion: A randomized, controlled trial in patients over sixty years of age. Spine (Phila Pa 1976) 2008;33:2843-2849.
8. Chen NF, Smith ZA, Stiner E et al. Symptomatic ectopic bone formation after off-label use of recombinant human bone morphogenetic protein-2 in transforaminal lumbar interbody fusion. J Neurosurg Spine 2010;12:40-46.
9. Wan DC, Shi YY, Nacamuli RP et al. Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling. Proc Natl Acad Sci USA 2006;103:12335-12340. (Pubitemid 44267260)
10. Panetta NJ, Gupta DM, Lee JK et al. Human adipose-derived stromal cells respond to and elaborate bone morphogenetic protein-2 during in vitro osteogenic differentiation. Plast Reconstr Surg 2010;125:483-493.
11. Huang M, Chen Z, Hu S et al. Novel minicircle vector for gene therapy in murine myocardial infarction. Circulation 2009;120:S230-S237.
12. Darquet AM, Cameron B, Wils P et al. A new DNA vehicle for nonviral gene delivery: Supercoiled minicircle. Gene Ther 1997;4:1341-1349. (Pubitemid 28004593)
13. Darquet AM, Rangara R, Kreiss P et al. Minicircle: An improved DNA molecule for in vitro and in vivo gene transfer. Gene Ther 1999;6:209-218. (Pubitemid 29089919)
14. Kay MA, He CY, Chen ZY. A robust system for production of minicircle DNA vectors. Nat Biotechnol 2010;28:1287-1289.
15. Levi B, James AW, Nelson ER et al. Human adipose derived stromal cells heal critical size mouse calvarial defects. PLoS ONE 2010;5:e11177.
16. Stafford DA, Brunet LJ, Khokha MK et al. Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development 2011;138:1005-1014.
17. Levi B, James AW, Nelson ER et al. Human adipose-derived stromal cells stimulate autogenous skeletal repair via paracrine hedgehog signaling with calvarial osteoblasts. Stem Cells Dev 2011;20:243-257.
18. Cowan CM, Shi YY, Aalami OO et al. Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nat Biotechnol 2004;22:560-567. (Pubitemid 38585908)
19. Levi B, James AW, Nelson ER et al. Acute skeletal injury is necessary for human adipose-derived stromal cell-mediated calvarial regeneration. Plast Reconstr Surg 2011;127:1118-1129.
20. Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997;390:465-471. (Pubitemid 28013118)
21. Behr B, Tang C, Germann G et al. Locally Applied VEGFA increases the osteogenic healing capacity of human adipose derived stem cells by promoting osteogenic and endothelial differentiation. Stem Cells 2010;29:286-296.
22. Hsu WK, Wang JC, Liu NQ et al. Stem cells from human fat as cellular delivery vehicles in an athymic rat posterolateral spine fusion model. J Bone Joint Surg Am 2008;90:1043-1052. (Pubitemid 351632649)
23. Peterson B, Zhang J, Iglesias R et al. Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. Tissue Eng 2005;11:120-129. (Pubitemid 40515180)
24. Jia F, Wilson KD, Sun N et al. A nonviral minicircle vector for deriving human iPS cells. Nat Methods 2010;7:197-199.
25. Shin S, Salvay DM, Shea LD. Lentivirus delivery by adsorption to tissue engineering scaffolds. J Biomed Mater Res A 2010;93:1252-1259.
26. Huang YC, Simmons C, Kaigler D et al. Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther 2005;12:418-426. (Pubitemid 40394294)
27. Wan DC, Pomerantz JH, Brunet LJ et al. Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation. J Biol Chem 2007;282:26450-26459. (Pubitemid 47443797)
28. Levi B, James AW, Nelson ER et al. Human adipose-derived stromal cells stimulate autogenous skeletal repair via paracrine hedgehog signaling with calvarial osteoblasts. Stem Cells Dev 2011;20:243-257.
29. Lendeckel S, Jodicke A, Christophis P et al. Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: Case report. J Craniomaxillofac Surg 2004;32:370-373. (Pubitemid 40045639)
30. Mesimaki K, Lindroos B, Tornwall J et al. Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells. Int J Oral Maxillofac Surg 2009;38:201-209.
31. Warnke PH, Wiltfang J, Springer I et al. Man as living bioreactor: Fate of an exogenously prepared customized tissue-engineered mandible. Biomaterials 2006;27:3163-3167. (Pubitemid 43344329)
32. Burkus JK, Gornet MF, Dickman CA et al. Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 2002;15:337-349.
33. Dragoo JL, Choi JY, Lieberman JR et al. Bone induction by BMP-2 transduced stem cells derived from human fat. J Orthop Res 2003;21:622-629. (Pubitemid 36758206)
34. Dragoo JL, Lieberman JR, Lee RS et al. Tissue-engineered bone from BMP-2-transduced stem cells derived from human fat. Plast Reconstr Surg 2005;115:1665-1673. (Pubitemid 40604737)
35. Bressan M, Davis P, Timmer J et al. Notochord-derived BMP antagonists inhibit endothelial cell generation and network formation. Dev Biol 2009;326:101-111.
36. Reese DE, Hall CE, Mikawa T. Negative regulation of midline vascular development by the notochord. Dev Cell 2004;6:699-708. (Pubitemid 38584555)
37. Kang HW, Walvick R, Bogdanov A, Jr. In vitro and In vivo imaging of antivasculogenesis induced by Noggin protein expression in human venous endothelial cells. FASEB J 2009;23:4126-4134.
38. Dai J, Kitagawa Y, Zhang J et al. Vascular endothelial growth factor contributes to the prostate cancer-induced osteoblast differentiation mediated by bone morphogenetic protein. Cancer Res 2004;64:994-999. (Pubitemid 38176902)
39. Kappes JC, Wu X. Safety considerations in vector development. Somat Cell Mol Genet 2001;26:147-158. (Pubitemid 35332983)
40. Williams DA, Baum C. Medicine gene therapy - New challenges ahead. Science 2003;302:400-401. (Pubitemid 37296253)
41. Hacein-Bey-Abina S, Von Kalle C, Schmidt M et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 2003;302:415-419. (Pubitemid 37296260)
42. Woods NB, Bottero V, Schmidt M et al. Gene therapy: Therapeutic gene causing lymphoma. Nature 2006;440:1123.
43. Kay MA, He CY, Chen ZY. A robust system for production of minicircle DNA vectors. Nat Biotechnol 2010;28:1287-1289.