Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6588-6592

  Stevens, Benjamin D ^a   Litchfield, John ^a   Pfefferkorn, Jeffrey A ^a   Atkinson, Karen ^a   Perreault, Christian ^a   Amor, Paul ^a   Bahnck, Kevin ^a   Berliner, Martin A ^a   Calloway, Jessica ^a   Carlo, Anthony ^a   Derksen, David R ^a   Filipski, Kevin J ^a   Gumkowski, Mike ^a   Jassal, Charanjeet ^a   MacDougall, Margit ^a   Murphy, Brendan ^a   Nkansah, Paul ^a   Pettersen, John ^a   Rotter, Charles ^a   Zhang, Yan ^a  

^a PFIZER INC   (United States)

Author keywords

Allosteric; Diabetes; Glucokinase; Hepatoselective; OATP

Indexed keywords

ANTIDIABETIC AGENT; ENZYME ACTIVATOR; GLUCOKINASE; GLUCOKINASE ACTIVATOR; PF 04991532; ROSUVASTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; DISTRIBUTION VOLUME; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; GLYCEMIC CONTROL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; HYPOGLYCEMIA; MAXIMUM PLASMA CONCENTRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TISSUE SPECIFICITY;

ALLOSTERIC; DIABETES; GLUCOKINASE; HEPATOSELECTIVE; OATP;

ALLOSTERIC REGULATION; ANIMALS; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATORS; GLUCOKINASE; HEPATOCYTES; HUMANS; HYPOGLYCEMIC AGENTS; IMIDAZOLES; INJECTIONS, INTRAVENOUS; RATS; TISSUE DISTRIBUTION;

EID: 84888884282     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.057     Document Type: Article

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