Stress hyperglycaemia

The Lancet

Volumn 373, Issue 9677, 2009, Pages 1798-1807

  Dungan, Kathleen M ^a   Braithwaite, Susan S ^b   Preiser, Jean Charles ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; MORTALITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; STRESS HYPERGLYCEMIA; STROKE;

EID: 65649121953     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(09)60553-5     Document Type: Review

References (123)

1. Van den Berghe G., Wouters P., Weekers F., et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 345 (2001) 1359-1367
2. Van den Berghe G., Wilmer A., Hermans G., et al. Intensive insulin therapy in the medical ICU. N Engl J Med 354 (2006) 449-461
3. Brunkhorst F.M., Engel C., Bloos F., et al. German Competence Network Sepsis (SepNet). Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 358 (2008) 125-139
4. Devos P., Preiser J., and Melot C. Impact of tight glucose control by intensive insulin therapy on ICU mortality and the rate of hypoglycaemia: final results of the Glucontrol study. Intensive Care Med 33 suppl (2007) 189
5. De La Rosa G.D., Donado J.H., Restrepo A.H., et al., Grupo de Investigacion en Cuidado intensivo: GICI-HPT. Strict glycaemic control in patients hospitalised in a mixed medical and surgical intensive care unit: a randomised clinical trial. Crit Care 12 (2008) 120
6. Arabi Y.M., Dabbagh O.C., Tamim H.M., et al. Intensive versus conventional insulin therapy: a randomized controlled trial in medical and surgical critically ill patients. Crit Care Med 36 (2008) 3190-3197
7. Wiener R.S., Wiener D.C., and Larson R.J. Benefits and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA 300 (2008) 933-944
8. NICE-SUGAR Study Investigators, Finfer S., Chittock D.R., Su S.Y., et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360 (2009) 1283-1297
9. Kitabchi A.E., Freire A.X., and Umpierrez G.E. Evidence for strict inpatient blood glucose control: time to revise glycemic goals in hospitalized patients. Metabolism 57 (2008) 116-120
10. Clement S., Braithwaite S.S., Magee M.F., et al. Management of diabetes and hyperglycemia in hospitals. Diabetes Care 27 (2004) 553-591
11. Centers for Disease Control and Prevention. National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2005 (2005), Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA
12. Wallander M., Malmberg K., Ryden L., and Tenerz A. Oral glucose tolerance test: a reliable tool for early detection of glucose abnormalities in patients with acute myocardial infarction in clinical practice. Diabetes Care 31 (2008) 36-38
13. Ishihara M., Inoue I., Kawagoe T., et al. Is admission hyperglycaemia in non-diabetic patients with acute myocardial infarction a surrogate for previously undiagnosed abnormal glucose tolerance?. Eur Heart J 27 (2006) 2413-2419
14. Hashimoto K., Ikewaki K., Yagi H., et al. Glucose intolerance is common in Japanese patients with acute coronary syndrome who were not previously diagnosed with diabetes. Diabetes Care 28 (2005) 1182-1186
15. Bartnik M., Rydén L., Ferrari R., et al., Euro Heart Survey Investigators. The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe: the Euro Heart Survey on diabetes and the heart. Eur Heart J 25 (2004) 1880-1890
16. Gray C.S., Scott J.F., French J.M., Alberti K.G., and O'Connell J.E. Prevalence and prediction of unrecognised diabetes mellitus and impaired glucose tolerance following acute stroke. Age Ageing 33 (2004) 71-77
17. Vancheri F., Curcio M., Burgio A., et al. Impaired glucose metabolism in patients with acute stroke and no previous diagnosis of diabetes mellitus. QJM 98 (2005) 871-878
18. Greci L.S., Kailasam M., Malkani S., et al. Utility of HbA(1c) levels for diabetes case finding in hospitalized patients with hyperglycemia. Diabetes Care 26 (2003) 1064-1068
19. Wexler D.J., Nathan D.M., Grant R.W., Regan S., Van Leuvan A.L., and Cagliero E. Prevalence of elevated hemoglobin A1c among patients admitted to the hospital without a diagnosis of diabetes. J Clin Endocrinol Metab 93 (2008) 4238-4244
20. Furnary A.P., and Wu Y. Clinical effects of hyperglycemia in the cardiac surgery population: the Portland diabetic project. Endocr Pract 12 suppl (2006) 22-26
21. Umpierrez G.E., Isaacs S.D., Bazargan N., You X., Thaler L.M., and Kitabchi A.E. Hyperglycemia: An independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab 87 (2002) 978-982
22. Van den Berghe G., Wilmer A., Milants I., et al. Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm. Diabetes 55 (2006) 3151-3159
23. Egi M., Bellomo R., Stachowski E., et al. Blood glucose concentration and outcome of critical illness: the impact of diabetes. Crit Care Med 36 (2008) 2249-2255
24. Rady M.Y., Johnson D.J., Patel B.M., Larson J.S., and Helmers R.A. Influence of individual characteristics on outcome of glycemic control in intensive care unit patients with or without diabetes mellitus. Mayo Clin Proc 80 (2005) 1558-1567
25. Whitcomb B.A., Pradhan E.K., Pittas A.G., Roghmann M.C., and Perencevich E.N. Impact of admission hyperglycemia on hospital mortality in various intensive care unit populations. Crit Care Med 33 (2005) 2272-2277
26. Leonidou L., Mouzaki A., Michalaki M., et al. Cytokine production and hospital mortality in patients with sepsis-induced stress hyperglycemia. J Infection 55 (2007) 340-346
27. Cao J.J., Hudson M., Jankowski M., Whitehouse F., and Weaver W.D. Relation of chronic and acute glycemic control on mortality in acute myocardial infarction with diabetes mellitus. Am J Cardiol 96 (2005) 183-186
28. Aronson D., Hammerman H., Kapeliovich M.R., et al. Fasting glucose in acute myocardial infarction: incremental value for long-term mortality and relationship with left ventricular systolic function. Diabetes Care 30 (2007) 960-966
29. Worthley M.I., Shrive F.M., Anderson T.J., and Traboulsi M. Prognostic implication of hyperglycemia in myocardial infarction and primary angioplasty. Am J Med 120 (2007) e1-e7 643:
30. Nordin C., Amiruddin R., Rucker L., Choi J., Kohli A., and Marantz P.R. Diabetes and stress hyperglycemia associated with myocardial infarctions at an urban municipal hospital: prevalence and effect on mortality. Cardiol Rev 13 (2005) 223-230
31. Farrokhnia N., Björk E., Lindbäck J., and Terent A. Blood glucose in acute stroke, different therapeutic targets for diabetic and non-diabetic patients?. Acta Neurol Scand 112 (2005) 81-87
32. Fogelholm R., Murros K., Rissanen A., and Avikainen S. Admission blood glucose and short term survival in primary intracerebral haemorrhage: a population based study. J Neurol Neurosurg Psychiatry 76 (2005) 349-353
33. Petursson P., Herlitz J., Caidahl K., et al. Admission glycaemia and outcome after acute coronary syndrome. Int J Cardiol 116 (2007) 315-320
34. Ishihara M., Kagawa E., Inoue I., et al. Impact of admission hyperglycemia and diabetes mellitus on short- and long-term mortality after acute myocardial infarction in the coronary intervention era. Am J Cardiol 99 (2007) 1674-1679
35. Agwunobi A.O., Reid C., Maycock P., Little R.A., and Carlson G.L. Insulin resistance and substrate utilization in human endotoxemia. J Clin Encrinol Metab 85 (2000) 3770-3778
36. Ishihara M., Kojima S., Sakamoto T., et al. Japanese Acute Coronary Syndrome Study Investigators: Acute hyperglycemia is associated with adverse outcome after acute myocardial infarction in the coronary intervention era. Am Heart J 150 (2005) 814-820
37. Stranders I., Diamant M., van Gelder R.E., et al. Admission blood glucose level as risk indicator of death after myocardial infarction in patients with and without diabetes mellitus. Arch Intern Med 164 (2004) 982-988
38. Schiele F., Descotes-Genon V., Seronde M.F., et al., Investigators of the Réseau Franc Comtois de Cardiologie. Predictive value of admission hyperglycaemia on mortality in patients with acute myocardial infarction. Diabet Med 23 (2006) 1370-1376
39. Müdespacher D., Radovanovic D., Camenzind E., et al. Admission glycaemia and outcome in patients with acute coronary syndrome. Diab Vasc Dis Res 4 (2007) 346-352
40. Meier J.J., Deifuss S., Klamann A., Launhardt V., Schmiegel W.H., and Nauck M.A. Plasma glucose at hospital admission and previous metabolic control determine myocardial infarct size and survival in patients with and without type 2 diabetes: the Langendreer Myocardial Infarction and Blood Glucose in Diabetic Patients Assessment (LAMBDA). Diabetes Care 28 (2005) 2551-2553
41. Szczudlik A., Slowik A., Turaj W., et al. Transient hyperglycemia in ischemic stroke patients. J Neurol Sci 189 (2001) 105-111
42. Krinsley J.S. Glycemic control, diabetic status, and mortality in a heterogeneous population of critically ill patients before and during the era of intensive glycemic management: six and one-half years experience at a university-affiliated community hospital. Semin Thorac Cardiovasc Surg 18 (2006) 317-325
43. Freire A.X., Bridges L., Umpierrez G.E., Kuhl D., and Kitabchi A.E. Admission hyperglycemia and other risk factors as predictors of hospital mortality in a medical ICU population. Chest 128 (2005) 3109-3116
44. Ainla T., Baburin A., Teesalu R., and Rahu M. The association between hyperglycaemia on admission and 180-day mortality in acute myocardial infarction patients with and without diabetes. Diabet Med 22 (2005) 1321-1325
45. Kes V.B., Solter V.V., Supanc V., and Demarin V. Impact of hyperglycemia on ischemic stroke mortality in diabetic and non-diabetic patients. Ann Saudi Med 27 (2007) 352-355
46. Van den Berghe G., Wouters P.J., Bouillon R., et al. Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control. Crit Care Med 31 (2003) 359-366
47. Capes S.E., Hunt D., Malmberg K., and Gerstein H.C. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 355 (2000) 773-778
48. Kosiborod M., Rathore S.S., Inzucchi S.E., et al. Admission glucose and mortality in elderly patients hospitalized with acute myocardial infarction: implications for patients with and without recognized diabetes. Circulation 111 (2005) 3078-3086
49. Hadjadj S., Coisne D., Mauco G., et al. Prognostic value of admission plasma glucose and HbA1c in acute myocardial infarction. Diabetic Med 21 (2004) 305-310
50. Vibo R., Kõrv J., and Roose M. One-year outcome after first-ever stroke according to stroke subtype, severity, risk factors and pre-stroke treatment: a population-based study from Tartu, Estonia. Eur J Neurol 14 (2007) 435-439
51. Capes S.E., Hunt D., Malmberg K., Pathak P., and Gerstein H.C. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 32 (2001) 2426-2432
52. Stöllberger C., Exner I., Finsterer J., Slany J., and Steger C. Stroke in diabetic and non-diabetic patients: course and prognostic value of admission serum glucose. Ann Med 37 (2005) 357-364
53. Furnary A.P., and Wu Y. Eliminating the diabetic disadvantage: the Portland Diabetic Project. Semin Thorac Cardiovasc Surg 18 (2006) 302-308
54. Jones K.W., Cain A.S., Mitchell J.H., et al. Hyperglycemia predicts mortality after CABG: postoperative hyperglycemia predicts dramatic increases in mortality after coronary artery bypass graft surgery. J Diabetes Complications 22 (2008) 365-370
55. Dronge A.S., Perkal M.F., Kancir S., Concato J., Aslan M., and Rosenthal R.A. Long-term glycemic control and postoperative infectious complications. Arch Surg 141 (2006) 375-380
56. Pasternak J.J., McGregor D.G., Schroeder D.R., et al., for the IHAST Investigators. Hyperglycemia in patients undergoing cerebral aneurysm surgery: its association with long-term gross neurologic and neuropsychological function. Mayo Clin Proc 83 (2008) 406-417
57. Gandhi G.Y., Murad M.H., Flynn D.N., et al. Effect of perioperative insulin infusion on surgical morbidity and mortality: systematic review and meta-analysis of randomized trials. Mayo Clin Proc 83 (2008) 418-430
58. Kosuge M., Kimura K., Kojima S., et al., for the; Japanese Acute Coronary Syndrome Study (JACSS) Investigators. Effects of glucose abnormalities on in-hospital outcome after coronary intervention for acute myocardial infarction. Circ J 69 (2005) 375-379
59. Barth E., Albuszies G., Baumgart K., et al. Glucose metabolism and catecholamines. Crit Care Med 35 suppl (2007) 508-518
60. Andrewq R.C., and Walker B.R. Glucocorticoids and insulin resistance: old hormones, new targets. Clin Sci 96 (1999) 513-523
61. Chrousos G.P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332 (1995) 1351-1362
62. Jeevanandam M., Young D.H., and Schiller W.R. Glucose turnover, oxidation, and indices of recycling in severely traumatized patients. J Trauma 30 (1990) 582-589
63. McGuinness O.P., Fugiwara T., Murrell S., et al. Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog. Am J Physiol 265 (1993) 314-322
64. Lang C.H., Bagby G.J., Blakesley H.L., and Spitzer J.J. Importance of hyperglucagonemia in eliciting the sepsis-induced increase in glucose production. Circ Shock 29 (1989) 181-191
65. McGuinness O.P., Shau V., Benson E.M., et al. Role of epinephrine and norepinephrine in the metabolic response to stress hormone infusion in the conscious dog. Am J Physiol 273 (1997) 674-681
66. Fujiwara T., Cherrington A.D., Neal D.N., and McGuinness O.P. Role of cortisol in the metabolic response to stress hormone infusion in the conscious dog. Metabolism 45 (1996) 571-578
67. Blumberg D., Hochwald S., Burt M., Donner D., and Brennan M.F. Tumor necrosis factor alpha stimulates gluconeogenesis from alanine in vivo. J Surg Oncol 59 (1995) 220-224
68. Fan J., Li Y.H., Wojnar M.M., and Lang C.H. Endotoxin-induced alterations in insulin-stimulated phosphorylation of insulin receptor, IRS-1, and MAP kinase in skeletal muscle. Shock 6 (1996) 164-170
69. Lang C.H., Dobrescu C., and Mészáros K. Insulin-mediated glucose uptake by individual tissues during sepsis. Metabolism 39 (1990) 1096-1107
70. Green C.J., Campbell I.T., O'Sullivan E., et al. Septic patients in multiple organ failure can oxidize infused glucose, but non-oxidative disposal (storage) is impaired. Clin Sci (London) 89 (1995) 601-609
71. Dimitriadis G., Leighton B., Parry-Billings M., et al. Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle. Biochem J 321 (1997) 707-712
72. Lang C.H. Sepsis-induced insulin resistance in rats is mediated by a beta-adrenergic mechanism. Am J Physiol 263 (1992) 703-711
73. Ishizuka K., Usui I., Kanatani Y., et al. Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes. Endocrinology 148 (2007) 2994-3003
74. He J., Usui I., Ishizuka K., et al. Interleukin-1alpha inhibits insulin signaling with phosphorylating insulin receptor substrate-1 on serine residues in 3T3-L1 adipocytes. Mol Endocrinol 20 (2006) 114-124
75. Zauner A., Nimmerrichter P., Anderwald C., et al. Severity of insulin resistance in critically ill medical patients. Metabolism 56 (2007) 1-5
76. Ling P., Smith R., and Bistrian B. Hyperglycemia enhances the cytokine production and oxidative responses to a low but not high dose of endotoxin in rats. Crit Care Med 33 (2005) 1084-1089
77. Yu W.K., Li W.Q., Li N., and Li J.S. Influence of acute hyperglycemia in human sepsis on inflammatory cytokine and counterregulatory hormone concentrations. World J Gastroenterol 9 (2003) 1824-1827
78. Stentz F.B., Umpierrez G.E., Cuervo R., and Kitabchi A.E. Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises. Diabetes 53 (2004) 2079-2086
79. Dresner A., Laurent D., Marcucci M., et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103 (1999) 253-259
80. Kelley D.E., Mokan M., Simoneau J.A., and Mandarino L.J. Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92 (1993) 91-98
81. Krogh-Madsen R., Plomgaard P., Akerstrom T., Møller K., Schmitz O., and Pedersen B.K. Effect of short-term intralipid infusion on the immune response during low-dose endotoxemia in humans. Am J Physiol Endocrinol Metab 294 (2008) 371-379
82. Kim J.A., Montagnani M., Koh K.K., and Quon M.J. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 113 (2006) 1888-1904
83. Stegenga M.E., van der Crabben S.N., Blümer R.M., et al. Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. Blood 112 (2008) 82-89
84. Soop M., Duxbury H., Agwunobi A.O., et al. Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans. Am J Physiol Endocrinol Metab 282 (2002) 1276-1285
85. Lang C.H., and Dobrescu C. Gram-negative infection increases noninsulin-mediated glucose disposal. Endocrinology 128 (1991) 645-653
86. Gamelli R.L., Liu H., He L.K., and Hofmann C.A. Augmentations of glucose uptake and glucose transporter-1 in macrophages following thermal injury and sepsis in mice. J Leukoc Biol 59 (1996) 639-647
87. Zeller W.P., The S.M., Sweet M., et al. Altered glucose transporter mRNA abundance in a rat model of endotoxic shock. Biochem Biophys Res Commun 176 (1991) 535-540
88. Gamelli R.L., Liu H., He L.K., and Hofmann C.A. Alterations of glucose transporter mRNA and protein levels in brain following thermal injury and sepsis in mice. Shock 1 (1994) 395-400
89. Shangraw R.E., Jahoor F., Wolfe R.R., and Lang C.H. Pyruvate dehydrogenase inactivity is not responsible for sepsis-induced insulin resistance. Crit Care Med 24 (1996) 566-574
90. Langouche L., Vanhorebeek I., Vlasselaers D., et al. Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 115 (2005) 2277-2286
91. Vanhorebeek I., and Van den Berghe G. Diabetes of injury: novel insights. Endocrinol Metab Clin North Am 35 (2006) 859-872
92. Schetz M., Vanhorebeek I., Wouters P.J., Wilmer A., and Van den Berghe G. Tight blood glucose control is renoprotective in critically ill patients. J Am Soc Nephrol 19 (2008) 571-578
93. Cohen G., Riahi Y., Alpert E., Gruzman A., and Sasson S. The roles of hyperglycaemia and oxidative stress in the rise and collapse of the natural protective mechanism against vascular endothelial cell dysfunction in diabetes. Arch Physiol Biochem 113 (2007) 259-267
94. Egi M., Bellomo R., Stachowski E., French C.J., and Hart G. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology 105 (2006) 244-252
95. Ali N.A., O'Brien J.M., Dungan K., et al. Glucose variability and mortality in patients with sepsis. Crit Care Med 36 (2008) 2316-2321
96. Dossett L.A., Cao H., Mowery N.T., Dortch M.J., Morris Jr. J.M., and May A.K. Blood glucose variability is associated with mortality in the surgical intensive care unit. Am Surg 74 (2008) 679-685
97. Waeschle R.M., Moerer O., Hilgers R., Herrmann P., Neumann P., and Quintel M. The impact of the severity of sepsis on the risk of hypoglycaemia and glycaemic variability. Crit Care 12 (2008) R129
98. Quagliaro L., Piconi L., Assaloni R., Martinelli L., Motz E., and Ceriello A. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes 52 (2003) 2795-2804
99. Quagliaro L., Piconi L., Assaloni R., et al. Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 183 (2005) 259-267
100. Monnier L., Mas E., and Ginet C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 295 (2006) 1681-1687
101. Ceriello A., Esposito K., Piconi L., et al. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes 57 (2008) 1349-1354
102. Evans J.L., Goldfine I.D., Maddux B.A., and Grodsky G.M. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23 (2002) 599-622
103. Wright R.J., and Frier B.M. Vascular disease and diabetes: is hypoglycaemia an aggravating factor?. Diabetes Metab Res Rev 24 (2008) 353-363
104. Krinsley J.S., and Grover A. Severe hypoglycemia in critically ill patients: risk factors and outcomes. Crit Care Med 35 (2007) 2262-2267
105. Vriesendorp T.M., van Santen S., DeVries J.H., et al. Predisposing factors for hypoglycemia in the intensive care unit. Crit Care Med 34 (2006) 96-101
106. Oddo M., Schmidt M., Carrera E., et al. Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study. Crit Care Med 36 (2008) 3233-3238
107. AACE Diabetes Mellitus Clinical Practice Guidelines Task Force. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocr Pract 13 suppl (2007) 1-68
108. American Diabetes Association. Standards of medical care in diabetes-2009. Diabetes Care 32 suppl 1 (2009) 13-61
109. American Diabetes Association. Joint statement from ADA and AACE on the NICE-SUGAR study on intensive versus conventional glucose control in critically ill patients. http://www.diabetes.org/for-media/pr-NICE_SUGAR-study.jsp (accessed May 1, 2009).
110. The Endocrine Society. Endocrine Society statement to providers on NICE-SUGAR. http://www.endo-society.org/advocacy/legislative/SocietyStatementtoProvidersonNICE-SUGAR.cfm# (accessed May 1, 2009).
111. Ariza-Andraca C.R., Altamirano-Bustamante E., Frati-Munari A.C., Altamirano-Bustamante P., and Graef-Sanchez A. Delayed insulin absorption due to subcutaneous edema. Arch Invest Med 22 (1991) 229-233
112. Umpierrez G.E., Hor T., Smiley D., et al. Comparison of inpatient insulin regimens with detemir plus aspart versus neutral protamine hagedorn plus regular in medical Patients with Type 2 Diabetes. J Clin Endocrinol Metab 94 (2009) 564-569
113. Umpierrez G.E., Smiley D., Zisman A., et al. Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 Trial). Diabetes Care 30 (2007) 2181-2186
114. Schmeltz L.R., DeSantis A.J., Thiyagarajan V., et al. Reduction of surgical mortality and morbidity in diabetic patients undergoing cardiac surgery with a combined intravenous and subcutaneous insulin glucose management strategy. Diabetes Care 30 (2007) 823-828
115. Kudva Y.C., Basu A., Jenkins G.D., et al. Glycemic variation and hypoglycemia in patients with well-controlled type 1 diabetes on a multiple daily insulin injection program with use of glargine and ultralente as basal insulin. Endocr Pract 13 (2007) 244-250
116. Saudek C.D., Duckworth W.C., Giobbie-Hurder A., et al., for the Department of Veterans Affairs Implantable Insulin Pump Study Group. Implantable insulin pump vs multiple-dose insulin for non-insulin-dependent diabetes mellitus: a randomized clinical trial. JAMA 276 (1996) 1322-1327
117. Davidson P.C., Steed R.D., and Bode B.W. Glucommander: a computer-directed intravenous insulin system shown to be safe, simple, and effective in 120 618 h of operation. Diabetes Care 28 (2005) 2418-2423
118. Reed C.C., Stewart R.M., Sherman M., et al. Intensive insulin protocol improves glucose control and is associated with a reduction in intensive care unit mortality. J Am Coll Surg 204 (2007) 1048-1054
119. Kanji S., Singh A., Tierney M., Meggison H., McIntyre L., and Hebert P.C. Standardization of intravenous insulin therapy improves the efficiency and safety of blood glucose control in critically ill adults. Intensive Care Med 30 (2004) 804-810
120. Vogelzang M., Loef B.G., Regtien J.G., et al. Computer-assisted glucose control in critically ill patients. Intensive Care Med 34 (2008) 1421-1427
121. Noordzij P.G., Boersma E., Schreiner F., et al. Increased preoperative glucose levels are associated with perioperative mortality in patients undergoing noncardiac, nonvascular surgery. Eur J Endocrinol 156 (2007) 137-142
122. Dungan K., Chapman J., Braithwaite S.S., and Buse J. Glucose measurement: confounding issues in setting targets for inpatient management. Diabetes Care 30 (2007) 403-409
123. Price G.C., Stevenson K., and Walsh T.S. Evaluation of a continuous glucose monitor in an unselected general intensive care population. Crit Care Resusc 10 (2008) 209-216