-
4
-
-
0032484008
-
Inhibition of human caspases by peptide-based and macromolecular inhibitors
-
Garcia-Calvo M., Peterson E.P., Leiting B., Ruel R., Nicholson D.W., Thornberry N.A. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 1998, 273:32608-33261.
-
(1998)
J Biol Chem
, vol.273
, pp. 32608-33261
-
-
Garcia-Calvo, M.1
Peterson, E.P.2
Leiting, B.3
Ruel, R.4
Nicholson, D.W.5
Thornberry, N.A.6
-
5
-
-
78049347657
-
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation
-
Wang X.J., Cao Q., Liu X., Wang K.T., Mi W., Zhang Y., Li L.F., LeBlanc A.C., Su X.D. Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation. EMBO Rep 2010, 11:841-847.
-
(2010)
EMBO Rep
, vol.11
, pp. 841-847
-
-
Wang, X.J.1
Cao, Q.2
Liu, X.3
Wang, K.T.4
Mi, W.5
Zhang, Y.6
Li, L.F.7
LeBlanc, A.C.8
Su, X.D.9
-
6
-
-
84878145247
-
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
-
Thomsen N.D., Koerber J.T., Wells J.A. Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc Natl Acad Sci USA 2013, 110:8477-8482.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 8477-8482
-
-
Thomsen, N.D.1
Koerber, J.T.2
Wells, J.A.3
-
7
-
-
9944263528
-
Searching for new allosteric sites in enzymes
-
Hardy J.A., Wells J.A. Searching for new allosteric sites in enzymes. Curr Opin Struct Biol 2004, 14:706-715.
-
(2004)
Curr Opin Struct Biol
, vol.14
, pp. 706-715
-
-
Hardy, J.A.1
Wells, J.A.2
-
9
-
-
48749120889
-
An allosteric circuit in caspase-1
-
Datta D., Scheer J.M., Romanowski M.J., Wells J.A. An allosteric circuit in caspase-1. J Mol Biol 2008, 381:1157-1167.
-
(2008)
J Mol Biol
, vol.381
, pp. 1157-1167
-
-
Datta, D.1
Scheer, J.M.2
Romanowski, M.J.3
Wells, J.A.4
-
10
-
-
84875990947
-
Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3
-
Datta D., McClendon C.L., Jacobson M.P., Wells J.A. Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. J Biol Chem 2013, 288:9971-9981.
-
(2013)
J Biol Chem
, vol.288
, pp. 9971-9981
-
-
Datta, D.1
McClendon, C.L.2
Jacobson, M.P.3
Wells, J.A.4
-
11
-
-
4344654060
-
Discovery of an allosteric site in the caspases
-
Hardy J.A., Lam J., Nguyen J.T., O'Brien T., Wells J.A. Discovery of an allosteric site in the caspases. Proc Natl Acad Sci USA 2004, 101:12461-12466.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12461-12466
-
-
Hardy, J.A.1
Lam, J.2
Nguyen, J.T.3
O'Brien, T.4
Wells, J.A.5
-
12
-
-
84891747181
-
Tailoring Small Molecules for an Allosteric Site on Procaspse-6
-
in press
-
Murray J., Giannetti A.M., Steffek M., Gibbons P., Hearn B.R., Cohen F., Tam C., Pozniak C., Bravo B., Lewcock J.W., et al. Tailoring Small Molecules for an Allosteric Site on Procaspse-6. ChemMedChem 2013, in press.
-
(2013)
ChemMedChem
-
-
Murray, J.1
Giannetti, A.M.2
Steffek, M.3
Gibbons, P.4
Hearn, B.R.5
Cohen, F.6
Tam, C.7
Pozniak, C.8
Bravo, B.9
Lewcock, J.W.10
-
13
-
-
80052307868
-
A bifunctional allosteric site in the dimer interface of procaspase-3
-
Schipper J.L., MacKenzie S.H., Sharma A., Clark A.C. A bifunctional allosteric site in the dimer interface of procaspase-3. Biophys Chem 2011, 159:100-109.
-
(2011)
Biophys Chem
, vol.159
, pp. 100-109
-
-
Schipper, J.L.1
MacKenzie, S.H.2
Sharma, A.3
Clark, A.C.4
-
14
-
-
84855418058
-
Identification of specific tethered inhibitors for caspase-5
-
Gao J., Wells J.A. Identification of specific tethered inhibitors for caspase-5. Chem Biol Drug Des 2012, 79:209-215.
-
(2012)
Chem Biol Drug Des
, vol.79
, pp. 209-215
-
-
Gao, J.1
Wells, J.A.2
-
15
-
-
84870481635
-
A caspase cascade regulating developmental axon degeneration
-
Simon D.J., Weimer R.M., McLaughlin T., Kallop D., Stanger K., Yang J., O'Leary D.D., Hannoush R.N., Tessier-Lavigne M. A caspase cascade regulating developmental axon degeneration. J Neurosci 2012, 32:17540-17553.
-
(2012)
J Neurosci
, vol.32
, pp. 17540-17553
-
-
Simon, D.J.1
Weimer, R.M.2
McLaughlin, T.3
Kallop, D.4
Stanger, K.5
Yang, J.6
O'Leary, D.D.7
Hannoush, R.N.8
Tessier-Lavigne, M.9
-
16
-
-
84879247889
-
Caspase-6 as a novel early target in the treatment of Alzheimer's disease
-
LeBlanc A.C. Caspase-6 as a novel early target in the treatment of Alzheimer's disease. Eur J Neurosci 2013, 37:2005-2018.
-
(2013)
Eur J Neurosci
, vol.37
, pp. 2005-2018
-
-
LeBlanc, A.C.1
-
17
-
-
84881612851
-
Small-molecule procaspase activators identified using fluorescence polarization
-
Vickers C.J., Gonzalez-Paez G.E., Umotoy J.C., Cayanan-Garrett C., Brown S.J., Wolan D.W. Small-molecule procaspase activators identified using fluorescence polarization. Chembiochem 2013, 14:1419-1422.
-
(2013)
Chembiochem
, vol.14
, pp. 1419-1422
-
-
Vickers, C.J.1
Gonzalez-Paez, G.E.2
Umotoy, J.C.3
Cayanan-Garrett, C.4
Brown, S.J.5
Wolan, D.W.6
-
18
-
-
83055197029
-
Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation
-
Zorn J.A., Wille H., Wolan D.W., Wells J.A. Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. J Am Chem Soc 2011, 133:19630-19633.
-
(2011)
J Am Chem Soc
, vol.133
, pp. 19630-19633
-
-
Zorn, J.A.1
Wille, H.2
Wolan, D.W.3
Wells, J.A.4
-
19
-
-
84866931834
-
Fibrils colocalize caspase-3 with procaspase-3 to foster maturation
-
Zorn J.A., Wolan D.W., Agard N.J., Wells J.A. Fibrils colocalize caspase-3 with procaspase-3 to foster maturation. J Biol Chem 2012 2012, 287:33781-33795.
-
(2012)
J Biol Chem 2012
, vol.287
, pp. 33781-33795
-
-
Zorn, J.A.1
Wolan, D.W.2
Agard, N.J.3
Wells, J.A.4
-
20
-
-
63449138094
-
PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition
-
Peterson Q.P., Goode D.R., West D.C., Ramsey K.N., Lee J.J., Hergenrother P.J. PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition. J Mol Biol 2009, 388:144-158.
-
(2009)
J Mol Biol
, vol.388
, pp. 144-158
-
-
Peterson, Q.P.1
Goode, D.R.2
West, D.C.3
Ramsey, K.N.4
Lee, J.J.5
Hergenrother, P.J.6
-
21
-
-
84865389577
-
A class of allosteric caspase inhibitors identified by high-throughput screening
-
Feldman T., Kabaleeswaran V., Jang S.B., Antczak C., Djaballah H., Wu H., Jiang X. A class of allosteric caspase inhibitors identified by high-throughput screening. Mol Cell 2012, 47:585-595.
-
(2012)
Mol Cell
, vol.47
, pp. 585-595
-
-
Feldman, T.1
Kabaleeswaran, V.2
Jang, S.B.3
Antczak, C.4
Djaballah, H.5
Wu, H.6
Jiang, X.7
-
22
-
-
84862882878
-
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization
-
Stanger K., Steffek M., Zhou L., Pozniak C.D., Quan C., Franke Y., Tom J., Tam C., Krylova I., Elliott J.M., et al. Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization. Nat Chem Biol 2012, 8:655-660.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 655-660
-
-
Stanger, K.1
Steffek, M.2
Zhou, L.3
Pozniak, C.D.4
Quan, C.5
Franke, Y.6
Tom, J.7
Tam, C.8
Krylova, I.9
Elliott, J.M.10
-
23
-
-
84870781145
-
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6
-
Heise C.E., Murray J., Augustyn K.E., Bravo B., Chugha P., Cohen F., Giannetti A.M., Gibbons P., Hannoush R.N., Hearn B.R., et al. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. PLoS ONE 2012, 7:e45086.
-
(2012)
PLoS ONE
, vol.7
-
-
Heise, C.E.1
Murray, J.2
Augustyn, K.E.3
Bravo, B.4
Chugha, P.5
Cohen, F.6
Giannetti, A.M.7
Gibbons, P.8
Hannoush, R.N.9
Hearn, B.R.10
|