Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3

Journal of Biological Chemistry

Volumn 288, Issue 14, 2013, Pages 9971-9981

  Datta, Debajyoti ^a,c   McClendon, Christopher L ^a,d   Jacobson, Matthew P ^a   Wells, James A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL ULTRACENTRIFUGATION; CELLULAR SUBSTRATES; CONSTITUTIVELY ACTIVES; INNATE IMMUNE RESPONSE; PHYSIOLOGICAL CONCENTRATIONS; POSITIVE COOPERATIVITY; STEADY-STATE KINETICS; SUBSTRATE-INDUCED ACTIVATION;

AMINO ACIDS; CELL DEATH; CENTRIFUGATION; DIMERIZATION; DIMERS; ENZYME ACTIVITY; MONOMERS;

SUBSTRATES;

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; HOMODIMER; INTERLEUKIN 1BETA CONVERTING ENZYME; MONOMER;

ARTICLE; BIOPHYSICS; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; ULTRACENTRIFUGATION;

ALLOSTERIC SITE; AMINO ACID CHLOROMETHYL KETONES; AREA UNDER CURVE; BIOPHYSICS; CASPASE 1; CASPASE 3; CASPASES; CATALYTIC DOMAIN; DIMERIZATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INFLAMMATION; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; ULTRACENTRIFUGATION;

EID: 84875990947     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.426460     Document Type: Article

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