-
1
-
-
84872967522
-
Cancer statistics, 2013
-
[PMID: 23335087 DOI: 10.3322/ caac.21166]
-
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63: 11-30 [PMID: 23335087 DOI: 10.3322/ caac.21166]
-
(2013)
CA Cancer J Clin
, vol.63
, pp. 11-30
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
2
-
-
84875804295
-
Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012
-
[PMID: 23485231DOI: 10.1016/j.ejca.2012.12.027]
-
Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D, Bray F. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 2013; 49: 1374-1403 [PMID: 23485231 DOI: 10.1016/j.ejca.2012.12.027]
-
(2013)
Eur J Cancer
, vol.49
, pp. 1374-1403
-
-
Ferlay, J.1
Steliarova-Foucher, E.2
Lortet-Tieulent, J.3
Rosso, S.4
Coebergh, J.W.5
Comber, H.6
Forman, D.7
Bray, F.8
-
3
-
-
77954320936
-
Primary colon cancer: ESMO Clinical Practice Guidelines for diagnosis, adjuvant treatment and follow-up
-
[PMID: 20555107 DOI:10.1093/annonc/mdq168]
-
Labianca R, Nordlinger B, Beretta GD, Brouquet A, Cervantes A. Primary colon cancer: ESMO Clinical Practice Guidelines for diagnosis, adjuvant treatment and follow-up. Ann Oncol 2010; 21 Suppl 5: v70-v77 [PMID: 20555107 DOI:10.1093/annonc/mdq168]
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 5
-
-
Labianca, R.1
Nordlinger, B.2
Beretta, G.D.3
Brouquet, A.4
Cervantes, A.5
-
4
-
-
84870804351
-
Colorectal cancer screening: Practice guidelines
-
[PMID: 23207930 DOI: 10.1159/000341891]
-
Lieberman D. Colorectal cancer screening: practice guidelines. Dig Dis 2012; 30 Suppl 2: 34-38 [PMID: 23207930 DOI: 10.1159/000341891]
-
(2012)
Dig Dis
, vol.30
, Issue.SUPPL. 2
, pp. 34-38
-
-
Lieberman, D.1
-
5
-
-
84863707351
-
Cancer treatment and survivorship statistics, 2012
-
[PMID: 22700443 DOI:, 10.3322/caac.21149]
-
Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, Cooper D, Gansler T, Lerro C, Fedewa S, Lin C, Leach C, Cannady RS, Cho H, Scoppa S, Hachey M, Kirch R, Jemal A, Ward E. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin 2012; 62: 220-241 [PMID: 22700443 DOI:10.3322/caac.21149]
-
(2012)
CA Cancer J Clin
, vol.62
, pp. 220-241
-
-
Siegel, R.1
Desantis, C.2
Virgo, K.3
Stein, K.4
Mariotto, A.5
Smith, T.6
Cooper, D.7
Gansler, T.8
Lerro, C.9
Fedewa, S.10
Lin, C.11
Leach, C.12
Cannady, R.S.13
Cho, H.14
Scoppa, S.15
Hachey, M.16
Kirch, R.17
Jemal, A.18
Ward, E.19
-
6
-
-
77954346705
-
Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment
-
[PMID: 20555112 DOI: 10.1093/annonc/mdq222]
-
Van Cutsem E, Nordlinger B, Cervantes A. Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment. Ann Oncol 2010; 21 Suppl 5: v93-v97 [PMID: 20555112 DOI: 10.1093/annonc/mdq222]
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 5
-
-
van Cutsem, E.1
Nordlinger, B.2
Cervantes, A.3
-
7
-
-
84875536112
-
Management of advanced colorectal cancer, part 2
-
[PMID: 23456402 DOI: 10.2146/ajhp110532b]
-
Cersosimo RJ. Management of advanced colorectal cancer, part 2. Am J Health Syst Pharm 2013; 70: 491-506 [PMID: 23456402 DOI: 10.2146/ajhp110532b]
-
(2013)
Am J Health Syst Pharm
, vol.70
, pp. 491-506
-
-
Cersosimo, R.J.1
-
8
-
-
84874086467
-
Management of advanced colorectal cancer, Part 1
-
[PMID: 23413162 DOI: 10.2146/ajhp110532]
-
Cersosimo RJ. Management of advanced colorectal cancer, Part 1. Am J Health Syst Pharm 2013; 70: 395-406 [PMID: 23413162 DOI: 10.2146/ajhp110532]
-
(2013)
Am J Health Syst Pharm
, vol.70
, pp. 395-406
-
-
Cersosimo, R.J.1
-
9
-
-
33745675111
-
Biology of colorectal liver metastases: A review
-
[PMID:16788948 DOI: 10.1002/jso.20558]
-
Bird NC, Mangnall D, Majeed AW. Biology of colorectal liver metastases: A review. J Surg Oncol 2006; 94: 68-80 [PMID: 16788948 DOI: 10.1002/jso.20558]
-
(2006)
J Surg Oncol
, vol.94
, pp. 68-80
-
-
Bird, N.C.1
Mangnall, D.2
Majeed, A.W.3
-
10
-
-
0031025685
-
Invasive therapy of metastatic colorectal cancer to the liver
-
[PMID: 9092116 DOI: 10.1016/S0039-6109(05)70531-4]
-
Millikan KW, Staren ED, Doolas A. Invasive therapy of metastatic colorectal cancer to the liver. Surg Clin North Am 1997; 77: 27-48 [PMID: 9092116 DOI: 10.1016/ S0039-6109(05)70531-4]
-
(1997)
Surg Clin North Am
, vol.77
, pp. 27-48
-
-
Millikan, K.W.1
Staren, E.D.2
Doolas, A.3
-
11
-
-
37549016003
-
Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: A multifactorial model of 929 patients
-
[PMID: 18156932 DOI: 10.1097/ SLA.0b013e31815aa2c2]
-
Rees M, Tekkis PP, Welsh FK, O'Rourke T, John TG. Evaluation of long-term survival after hepatic resection for metastatic colorectal cancer: a multifactorial model of 929 patients. Ann Surg 2008; 247: 125-135 [PMID: 18156932 DOI: 10.1097/ SLA.0b013e31815aa2c2]
-
(2008)
Ann Surg
, vol.247
, pp. 125-135
-
-
Rees, M.1
Tekkis, P.P.2
Welsh, F.K.3
O'Rourke, T.4
John, T.G.5
-
12
-
-
84869024683
-
Survival after liver resection in metastatic colorectal cancer: Review and meta-analysis of prognostic factors
-
[PMID: 23152705 DOI: 10.2147/clep.s34285]
-
Kanas GP, Taylor A, Primrose JN, Langeberg WJ, Kelsh MA, Mowat FS, Alexander DD, Choti MA, Poston G. Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors. Clin Epidemiol 2012; 4: 283-301 [PMID: 23152705 DOI: 10.2147/clep.s34285]
-
(2012)
Clin Epidemiol
, vol.4
, pp. 283-301
-
-
Kanas, G.P.1
Taylor, A.2
Primrose, J.N.3
Langeberg, W.J.4
Kelsh, M.A.5
Mowat, F.S.6
Alexander, D.D.7
Choti, M.A.8
Poston, G.9
-
13
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
[PMID: 15175435 DOI: 0.1056/NEJMoa032691]
-
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, Berlin J, Baron A, Griffing S, Holmgren E, Ferrara N, Fyfe G, Rogers B, Ross R, Kabbinavar F. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342 [PMID: 15175435 DOI: 0.1056/NEJMoa032691]
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
Berlin, J.7
Baron, A.8
Griffing, S.9
Holmgren, E.10
Ferrara, N.11
Fyfe, G.12
Rogers, B.13
Ross, R.14
Kabbinavar, F.15
-
14
-
-
0034470341
-
Vasculogenesis and angiogenesis as mechanisms of vascular network formation, growth and remodeling
-
[PMID: 11245270]
-
Patan S. Vasculogenesis and angiogenesis as mechanisms of vascular network formation, growth and remodeling. J Neurooncol 2000; 50: 1-15 [PMID: 11245270]
-
(2000)
J Neurooncol
, vol.50
, pp. 1-15
-
-
Patan, S.1
-
15
-
-
0030270961
-
Pericytes in the microvasculature
-
[PMID: 8915187]
-
Hirschi KK, D'Amore PA. Pericytes in the microvasculature. Cardiovasc Res 1996; 32: 687-698 [PMID: 8915187]
-
(1996)
Cardiovasc Res
, vol.32
, pp. 687-698
-
-
Hirschi, K.K.1
D'Amore, P.A.2
-
16
-
-
77951672380
-
Angiogenesis: Future of pharmacological modulation
-
[PMID: 20606828 DOI: 10.4103/0253-7613.62395]
-
Bisht M, Dhasmana DC, Bist SS. Angiogenesis: Future of pharmacological modulation. Indian J Pharmacol 2010; 42: 2-8 [PMID: 20606828 DOI: 10.4103/0253-7613.62395]
-
(2010)
Indian J Pharmacol
, vol.42
, pp. 2-8
-
-
Bisht, M.1
Dhasmana, D.C.2
Bist, S.S.3
-
17
-
-
78650934777
-
Angiogenic targets for potential disorders
-
[PMID: 20199582 DOI: 10.1111/j.1472-8206.2010.00814.x]
-
Bhadada SV, Goyal BR, Patel MM. Angiogenic targets for potential disorders. Fundam Clin Pharmacol 2011; 25: 29-47 [PMID: 20199582 DOI: 10.1111/j.1472-8206.2010.00814.x]
-
(2011)
Fundam Clin Pharmacol
, vol.25
, pp. 29-47
-
-
Bhadada, S.V.1
Goyal, B.R.2
Patel, M.M.3
-
18
-
-
0034076189
-
Mechanisms of angiogenesis and arteriogenesis
-
[PMID: 10742145 DOI:10.1038/74651]
-
Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000; 6: 389-395 [PMID: 10742145 DOI: 10.1038/74651]
-
(2000)
Nat Med
, vol.6
, pp. 389-395
-
-
Carmeliet, P.1
-
19
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
[PMID: 4938153 DOI:, 10.1056/nejm197111182852108]
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285: 1182-1186 [PMID: 4938153 DOI:10.1056/nejm197111182852108]
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
20
-
-
43249095919
-
Tumor angiogenesis
-
[PMID: 18463380 DOI: 10.1056/NEJMra0706596]
-
Kerbel RS. Tumor angiogenesis. N Engl J Med 2008; 358: 2039-2049 [PMID: 18463380 DOI: 10.1056/NEJMra0706596]
-
(2008)
N Engl J Med
, vol.358
, pp. 2039-2049
-
-
Kerbel, R.S.1
-
21
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
[PMID: 15585754 DOI: 10.1200/jco.2005.06.081]
-
Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005; 23: 1011-1027 [PMID: 15585754 DOI: 10.1200/ jco.2005.06.081]
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
22
-
-
0026395163
-
The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
-
[PMID: 1791831 DOI: 10.1210/mend-5-12-1806]
-
Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 1991; 5: 1806-1814 [PMID: 1791831 DOI: 10.1210/mend-5-12-1806]
-
(1991)
Mol Endocrinol
, vol.5
, pp. 1806-1814
-
-
Houck, K.A.1
Ferrara, N.2
Winer, J.3
Cachianes, G.4
Li, B.5
Leung, D.W.6
-
23
-
-
0032907687
-
Vascular endothelial growth factor (VEGF) and its receptors
-
[PMID: 9872925]
-
Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999; 13: 9-22 [PMID: 9872925]
-
(1999)
FASEB J
, vol.13
, pp. 9-22
-
-
Neufeld, G.1
Cohen, T.2
Gengrinovitch, S.3
Poltorak, Z.4
-
24
-
-
0025999033
-
The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
-
[PMID: 1711045]
-
Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 1991; 266: 11947-11954 [PMID: 1711045]
-
(1991)
J Biol Chem
, vol.266
, pp. 11947-11954
-
-
Tischer, E.1
Mitchell, R.2
Hartman, T.3
Silva, M.4
Gospodarowicz, D.5
Fiddes, J.C.6
Abraham, J.A.7
-
25
-
-
0024384470
-
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
-
[PMID: 2735925 DOI: 10.1016/0006-291X(89)92678-8]
-
Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 1989; 161: 851-858 [PMID: 2735925 DOI: 10.1016/0006-291X(89)92678-8]
-
(1989)
Biochem Biophys Res Commun
, vol.161
, pp. 851-858
-
-
Ferrara, N.1
Henzel, W.J.2
-
26
-
-
33344474964
-
Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
-
[PMID: 16336962 DOI:, 10.1016/j.yexcr.2005.11.012]
-
Shibuya M, Claesson-Welsh L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Exp Cell Res 2006; 312: 549-560 [PMID: 16336962 DOI:10.1016/j.yexcr.2005.11.012]
-
(2006)
Exp Cell Res
, vol.312
, pp. 549-560
-
-
Shibuya, M.1
Claesson-Welsh, L.2
-
27
-
-
77953672045
-
HIF-1alpha and cancer therapy
-
[PMID: 20033376 DOI: 10.1007/978-3-540-78281-0_3]
-
Koh MY, Spivak-Kroizman TR, Powis G. HIF-1alpha and cancer therapy. Recent Results Cancer Res 2010; 180: 15-34 [PMID: 20033376 DOI: 10.1007/978-3-540-78281-0_3]
-
(2010)
Recent Results Cancer Res
, vol.180
, pp. 15-34
-
-
Koh, M.Y.1
Spivak-Kroizman, T.R.2
Powis, G.3
-
28
-
-
70350452792
-
Targeting the hypoxia-inducible factor (HIF) pathway in cancer
-
[PMID: 19709449 DOI: 10.1017/s1462399409001173]
-
Poon E, Harris AL, Ashcroft M. Targeting the hypoxia-inducible factor (HIF) pathway in cancer. Expert Rev Mol Med 2009; 11: e26 [PMID: 19709449 DOI: 10.1017/s1462399409001173]
-
(2009)
Expert Rev Mol Med
, vol.11
-
-
Poon, E.1
Harris, A.L.2
Ashcroft, M.3
-
29
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
[PMID: 13130303 DOI: 10.1038/nrc1187]
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732 [PMID: 13130303 DOI: 10.1038/ nrc1187]
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
30
-
-
33644825389
-
Vascular endothelial growth factor-D and its receptor VEGFR-3: Two novel independent prognostic markers in gastric adenocarcinoma
-
[PMID: 16344322 DOI: 10.1200/ jco.2004.00.3467]
-
Jüttner S, Wissmann C, Jöns T, Vieth M, Hertel J, Gretschel S, Schlag PM, Kemmner W, Höcker M. Vascular endothelial growth factor-D and its receptor VEGFR-3: two novel independent prognostic markers in gastric adenocarcinoma. J Clin Oncol 2006; 24: 228-240 [PMID: 16344322 DOI: 10.1200/ jco.2004.00.3467]
-
(2006)
J Clin Oncol
, vol.24
, pp. 228-240
-
-
Jüttner, S.1
Wissmann, C.2
Jöns, T.3
Vieth, M.4
Hertel, J.5
Gretschel, S.6
Schlag, P.M.7
Kemmner, W.8
Höcker, M.9
-
31
-
-
0033660171
-
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema
-
[PMID: 11104784 DOI:10.1172/jci10259]
-
Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK, Waltenberger J, Voelkel NF. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest 2000; 106: 1311-1319 [PMID: 11104784 DOI:10.1172/jci10259]
-
(2000)
J Clin Invest
, vol.106
, pp. 1311-1319
-
-
Kasahara, Y.1
Tuder, R.M.2
Taraseviciene-Stewart, L.3
Le Cras, T.D.4
Abman, S.5
Hirth, P.K.6
Waltenberger, J.7
Voelkel, N.F.8
-
32
-
-
74549223368
-
Método para o estudo in vivo da angiogênese: Indução de neovascularização na córnea de coelho
-
González RP, Leyva A, Melo RAB, Moreira RDM, Pessoa C, Farias RF, Moraes MO. Método para o estudo in vivo da angiogênese: indução de neovascularização na córnea de coelho. Acta cir bras 2000; 15: 168-173
-
(2000)
Acta Cir Bras
, vol.15
, pp. 168-173
-
-
González, R.P.1
Leyva, A.2
Melo, R.A.B.3
Moreira, R.D.M.4
Pessoa, C.5
Farias, R.F.6
Moraes, M.O.7
-
33
-
-
20944441857
-
Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells
-
[PMID: 15735759 DOI: 10.1038/sj.onc.1208246]
-
Fan F, Wey JS, McCarty MF, Belcheva A, Liu W, Bauer TW, Somcio RJ, Wu Y, Hooper A, Hicklin DJ, Ellis LM. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene 2005; 24: 2647-2653 [PMID: 15735759 DOI: 10.1038/sj.onc.1208246]
-
(2005)
Oncogene
, vol.24
, pp. 2647-2653
-
-
Fan, F.1
Wey, J.S.2
McCarty, M.F.3
Belcheva, A.4
Liu, W.5
Bauer, T.W.6
Somcio, R.J.7
Wu, Y.8
Hooper, A.9
Hicklin, D.J.10
Ellis, L.M.11
-
34
-
-
0029021660
-
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
-
[PMID:7596436 DOI: 10.1038/376066a0]
-
Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995; 376: 66-70 [PMID: 7596436 DOI: 10.1038/376066a0]
-
(1995)
Nature
, vol.376
, pp. 66-70
-
-
Fong, G.H.1
Rossant, J.2
Gertsenstein, M.3
Breitman, M.L.4
-
35
-
-
80053460345
-
Serum vascular endothelial growth factor-C and lymphoangiogenesis are associated with the lymph node metastasis and prognosis of patients with colorectal cancer
-
[PMID: 22295309 DOI: 10.1111/j.1445-2197.2010.05539.x]
-
Wang TB, Chen ZG, Wei XQ, Wei B, Dong WG. Serum vascular endothelial growth factor-C and lymphoangiogenesis are associated with the lymph node metastasis and prognosis of patients with colorectal cancer. ANZ J Surg 2011; 81: 694-699 [PMID: 22295309 DOI: 10.1111/j.1445-2197.2010.05539.x]
-
(2011)
ANZ J Surg
, vol.81
, pp. 694-699
-
-
Wang, T.B.1
Chen, Z.G.2
Wei, X.Q.3
Wei, B.4
Dong, W.G.5
-
36
-
-
84863011445
-
VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium
-
[PMID: 22340592 DOI: 10.1016/j.ccr.2011.12.026]
-
Karnezis T, Shayan R, Caesar C, Roufail S, Harris NC, Ardipradja K, Zhang YF, Williams SP, Farnsworth RH, Chai MG, Rupasinghe TW, Tull DL, Baldwin ME, Sloan EK, Fox SB, Achen MG, Stacker SA. VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium. Cancer Cell 2012; 21: 181-195 [PMID: 22340592 DOI: 10.1016/j.ccr.2011.12.026]
-
(2012)
Cancer Cell
, vol.21
, pp. 181-195
-
-
Karnezis, T.1
Shayan, R.2
Caesar, C.3
Roufail, S.4
Harris, N.C.5
Ardipradja, K.6
Zhang, Y.F.7
Williams, S.P.8
Farnsworth, R.H.9
Chai, M.G.10
Rupasinghe, T.W.11
Tull, D.L.12
Baldwin, M.E.13
Sloan, E.K.14
Fox, S.B.15
Achen, M.G.16
Stacker, S.A.17
-
37
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
[PMID: 10221902 DOI: 10.1126/sci, ence.284.5415.770]
-
Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999; 284: 770-776 [PMID: 10221902 DOI: 10.1126/science.284.5415.770]
-
(1999)
Science
, vol.284
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
38
-
-
33747623018
-
Notch signalling: A simple pathway becomes complex
-
[PMID: 16921404 DOI: 10.1038/nrm2009]
-
Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 2006; 7: 678-689 [PMID: 16921404 DOI: 10.1038/nrm2009]
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 678-689
-
-
Bray, S.J.1
-
39
-
-
63849310246
-
Crosstalk of VEGF and Notch pathways in tumour angiogenesis: Therapeutic implications
-
[PMID: 19273260 DOI:, 10.2741/3438]
-
Li JL, Harris AL. Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. Front Biosci (Landmark Ed) 2009; 14: 3094-3110 [PMID: 19273260 DOI:10.2741/3438]
-
(2009)
Front Biosci (Landmark Ed)
, vol.14
, pp. 3094-3110
-
-
Li, J.L.1
Harris, A.L.2
-
40
-
-
37549030522
-
Delta-like 4/Notch signaling and its therapeutic implications
-
[PMID: 18094402 DOI: 10.1158/1078-0432.ccr-07-1393]
-
Yan M, Plowman GD. Delta-like 4/Notch signaling and its therapeutic implications. Clin Cancer Res 2007; 13: 7243-7246 [PMID: 18094402 DOI: 10.1158/1078-0432.ccr-07-1393]
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7243-7246
-
-
Yan, M.1
Plowman, G.D.2
-
41
-
-
34247539127
-
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
-
[PMID: 17457300 DOI: 10.1038/nrc2130]
-
Thurston G, Noguera-Troise I, Yancopoulos GD. The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth. Nat Rev Cancer 2007; 7: 327-331 [PMID: 17457300 DOI: 10.1038/nrc2130]
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 327-331
-
-
Thurston, G.1
Noguera-Troise, I.2
Yancopoulos, G.D.3
-
42
-
-
31544448010
-
Upregulation of the Notch ligand Delta-like 4 inhibits VEGFinduced endothelial cell function
-
[PMID: 16219802 DOI: 10.1182/blood-2005-03-1000]
-
Williams CK, Li JL, Murga M, Harris AL, Tosato G. Upregulation of the Notch ligand Delta-like 4 inhibits VEGFinduced endothelial cell function. Blood 2006; 107: 931-939 [PMID: 16219802 DOI: 10.1182/blood-2005-03-1000]
-
(2006)
Blood
, vol.107
, pp. 931-939
-
-
Williams, C.K.1
Li, J.L.2
Murga, M.3
Harris, A.L.4
Tosato, G.5
-
43
-
-
81855226986
-
New pathways and mechanisms regulating and responding to Delta-like ligand 4-Notch signalling in tumour angiogenesis
-
[PMID: 22103496 DOI: 10.1042/bst20110721]
-
Oon CE, Harris AL. New pathways and mechanisms regulating and responding to Delta-like ligand 4-Notch signalling in tumour angiogenesis. Biochem Soc Trans 2011; 39: 1612-1618 [PMID: 22103496 DOI: 10.1042/bst20110721]
-
(2011)
Biochem Soc Trans
, vol.39
, pp. 1612-1618
-
-
Oon, C.E.1
Harris, A.L.2
-
44
-
-
0030460424
-
Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
-
[PMID: 8980223 DOI: 10.1016/ S0092-8674(00)81812-7]
-
Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC, Yancopoulos GD. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 1996; 87: 1161-1169 [PMID: 8980223 DOI: 10.1016/ S0092-8674(00)81812-7]
-
(1996)
Cell
, vol.87
, pp. 1161-1169
-
-
Davis, S.1
Aldrich, T.H.2
Jones, P.F.3
Acheson, A.4
Compton, D.L.5
Jain, V.6
Ryan, T.E.7
Bruno, J.8
Radziejewski, C.9
Maisonpierre, P.C.10
Yancopoulos, G.D.11
-
45
-
-
15144358851
-
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
-
[PMID: 9204896 DOI: 10.1126/science.277.5322.55]
-
Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277: 55-60 [PMID: 9204896 DOI: 10.1126/science.277.5322.55]
-
(1997)
Science
, vol.277
, pp. 55-60
-
-
Maisonpierre, P.C.1
Suri, C.2
Jones, P.F.3
Bartunkova, S.4
Wiegand, S.J.5
Radziejewski, C.6
Compton, D.7
McClain, J.8
Aldrich, T.H.9
Papadopoulos, N.10
Daly, T.J.11
Davis, S.12
Sato, T.N.13
Yancopoulos, G.D.14
-
46
-
-
13044292625
-
Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans
-
[PMID: 10051567]
-
Valenzuela DM, Griffiths JA, Rojas J, Aldrich TH, Jones PF, Zhou H, McClain J, Copeland NG, Gilbert DJ, Jenkins NA, Huang T, Papadopoulos N, Maisonpierre PC, Davis S, Yancopoulos GD. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. Proc Natl Acad Sci USA 1999; 96: 1904-1909 [PMID: 10051567]
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 1904-1909
-
-
Valenzuela, D.M.1
Griffiths, J.A.2
Rojas, J.3
Aldrich, T.H.4
Jones, P.F.5
Zhou, H.6
McClain, J.7
Copeland, N.G.8
Gilbert, D.J.9
Jenkins, N.A.10
Huang, T.11
Papadopoulos, N.12
Maisonpierre, P.C.13
Davis, S.14
Yancopoulos, G.D.15
-
47
-
-
43049116169
-
Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1
-
[PMID: 18425120 DOI: 10.1038/ncb1714]
-
Fukuhara S, Sako K, Minami T, Noda K, Kim HZ, Kodama T, Shibuya M, Takakura N, Koh GY, Mochizuki N. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat Cell Biol 2008; 10: 513-526 [PMID: 18425120 DOI: 10.1038/ncb1714]
-
(2008)
Nat Cell Biol
, vol.10
, pp. 513-526
-
-
Fukuhara, S.1
Sako, K.2
Minami, T.3
Noda, K.4
Kim, H.Z.5
Kodama, T.6
Shibuya, M.7
Takakura, N.8
Koh, G.Y.9
Mochizuki, N.10
-
48
-
-
84858256112
-
Targeting angiogenesis in cancer therapy
-
[PMID: 22189475]
-
Ichihara E, Kiura K, Tanimoto M. Targeting angiogenesis in cancer therapy. Acta Med Okayama 2011; 65: 353-362 [PMID: 22189475]
-
(2011)
Acta Med Okayama
, vol.65
, pp. 353-362
-
-
Ichihara, E.1
Kiura, K.2
Tanimoto, M.3
-
49
-
-
84895057195
-
FGF Receptors: Cancer Biology and Therapeutics
-
Epub ahead of print [PMID: 23696246 DOI: 10.1002/med.21288]
-
Katoh M, Nakagama H. FGF Receptors: Cancer Biology and Therapeutics. Med Res Rev 2013; Epub ahead of print [PMID: 23696246 DOI: 10.1002/med.21288]
-
(2013)
Med Res Rev
-
-
Katoh, M.1
Nakagama, H.2
-
50
-
-
18144383021
-
Cellular signaling by fibroblast growth factor receptors
-
[PMID: 15863030 DOI: 10.1016/j.cytogfr.2005.01.001]
-
Eswarakumar VP, Lax I, Schlessinger J. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev 2005; 16: 139-149 [PMID: 15863030 DOI: 10.1016/ j.cytogfr.2005.01.001]
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 139-149
-
-
Eswarakumar, V.P.1
Lax, I.2
Schlessinger, J.3
-
51
-
-
0037699954
-
The biology of VEGF and its receptors
-
[PMID: 12778165 DOI: 10.1038/nm0603-669]
-
Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669-676 [PMID: 12778165 DOI: 10.1038/nm0603-669]
-
(2003)
Nat Med
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
Lecouter, J.3
-
52
-
-
61449240141
-
Paths of FGFR-driven tumorigenesis
-
[PMID: 19182515DOI: 10.4161/cc.8.4.7657]
-
Acevedo VD, Ittmann M, Spencer DM. Paths of FGFR-driven tumorigenesis. Cell Cycle 2009; 8: 580-588 [PMID: 19182515 DOI: 10.4161/cc.8.4.7657]
-
(2009)
Cell Cycle
, vol.8
, pp. 580-588
-
-
Acevedo, V.D.1
Ittmann, M.2
Spencer, D.M.3
-
53
-
-
63749086305
-
ErbB receptors and signaling pathways in cancer
-
[PMID: 19208461 DOI: 10.1016/j.ceb.2008.12.010]
-
Hynes NE, MacDonald G. ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol 2009; 21: 177-184 [PMID: 19208461 DOI: 10.1016/j.ceb.2008.12.010]
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 177-184
-
-
Hynes, N.E.1
Macdonald, G.2
-
54
-
-
76349113563
-
Epidermal growth factor signalling and bone metastasis
-
[PMID: 20010942DOI: 10.1038/sj.bjc.6605490]
-
Lu X, Kang Y. Epidermal growth factor signalling and bone metastasis. Br J Cancer 2010; 102: 457-461 [PMID: 20010942 DOI: 10.1038/sj.bjc.6605490]
-
(2010)
Br J Cancer
, vol.102
, pp. 457-461
-
-
Lu, X.1
Kang, Y.2
-
55
-
-
0037429706
-
EGF receptor ligands
-
[PMID: 12648462 DOI: 10.1016/S0014-4827(02)00105-2]
-
Harris RC, Chung E, Coffey RJ. EGF receptor ligands. Exp Cell Res 2003; 284: 2-13 [PMID: 12648462 DOI: 10.1016/ S0014-4827(02)00105-2]
-
(2003)
Exp Cell Res
, vol.284
, pp. 2-13
-
-
Harris, R.C.1
Chung, E.2
Coffey, R.J.3
-
56
-
-
84873592803
-
Novel antineoplastics targeting genetic changes in colorectal cancer
-
[PMID: 23288633 DOI: 10.1007/978-1-4614-6176-0_1]
-
Joudeh J, Allen JE, Das A, Prabhu V, Farbaniec M, Adler J, El-Deiry WS. Novel antineoplastics targeting genetic changes in colorectal cancer. Adv Exp Med Biol 2013; 779: 1-34 [PMID: 23288633 DOI: 10.1007/978-1-4614-6176-0_1]
-
(2013)
Adv Exp Med Biol
, vol.779
, pp. 1-34
-
-
Joudeh, J.1
Allen, J.E.2
Das, A.3
Prabhu, V.4
Farbaniec, M.5
Adler, J.6
El-Deiry, W.S.7
-
57
-
-
2142703727
-
Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
-
[PMID: 15051767 DOI: 10.1200/jco.2004.11.037]
-
Grothey A, Sargent D, Goldberg RM, Schmoll HJ. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004; 22: 1209-1214 [PMID: 15051767 DOI: 10.1200/jco.2004.11.037]
-
(2004)
J Clin Oncol
, vol.22
, pp. 1209-1214
-
-
Grothey, A.1
Sargent, D.2
Goldberg, R.M.3
Schmoll, H.J.4
-
58
-
-
33644825856
-
Overall survival of patients with advanced colorectal cancer correlates with availability of fluorouracil, irinotecan, and oxaliplatin regardless of whether doublet or single-agent therapy is used first line
-
[PMID: 16361649 DOI: 10.1200/, jco.2005.04.4792]
-
Grothey A, Sargent D. Overall survival of patients with advanced colorectal cancer correlates with availability of fluorouracil, irinotecan, and oxaliplatin regardless of whether doublet or single-agent therapy is used first line. J Clin Oncol 2005; 23: 9441-9442 [PMID: 16361649 DOI: 10.1200/jco.2005.04.4792]
-
(2005)
J Clin Oncol
, vol.23
, pp. 9441-9442
-
-
Grothey, A.1
Sargent, D.2
-
59
-
-
0035253739
-
Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
-
[PMID: 11157038]
-
Gordon MS, Margolin K, Talpaz M, Sledge GW, Holmgren E, Benjamin R, Stalter S, Shak S, Adelman D. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 2001; 19: 843-850 [PMID: 11157038]
-
(2001)
J Clin Oncol
, vol.19
, pp. 843-850
-
-
Gordon, M.S.1
Margolin, K.2
Talpaz, M.3
Sledge, G.W.4
Holmgren, E.5
Benjamin, R.6
Stalter, S.7
Shak, S.8
Adelman, D.9
-
60
-
-
84861326986
-
Bevacizumab: Overview of the literature
-
[PMID: 22594892 DOI: 10.1586/era.12.13]
-
Braghiroli MI, Sabbaga J, Hoff PM. Bevacizumab: overview of the literature. Expert Rev Anticancer Ther 2012; 12: 567-580 [PMID: 22594892 DOI: 10.1586/era.12.13]
-
(2012)
Expert Rev Anticancer Ther
, vol.12
, pp. 567-580
-
-
Braghiroli, M.I.1
Sabbaga, J.2
Hoff, P.M.3
-
61
-
-
84877094311
-
Bevacizumab in colorectal cancer: Current and future directions
-
[PMID: 23113577 DOI: 10.1586/era.12.104]
-
Yeung Y, Tebbutt NC. Bevacizumab in colorectal cancer: current and future directions. Expert Rev Anticancer Ther 2012; 12: 1263-1273 [PMID: 23113577 DOI: 10.1586/era.12.104]
-
(2012)
Expert Rev Anticancer Ther
, vol.12
, pp. 1263-1273
-
-
Yeung, Y.1
Tebbutt, N.C.2
-
62
-
-
0037208589
-
Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
-
[PMID: 12506171DOI: 10.1200/JCO.2003.10.066]
-
Kabbinavar F, Hurwitz HI, Fehrenbacher L, Meropol NJ, Novotny WF, Lieberman G, Griffing S, Bergsland E. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003; 21: 60-65 [PMID: 12506171 DOI: 10.1200/JCO.2003.10.066]
-
(2003)
J Clin Oncol
, vol.21
, pp. 60-65
-
-
Kabbinavar, F.1
Hurwitz, H.I.2
Fehrenbacher, L.3
Meropol, N.J.4
Novotny, W.F.5
Lieberman, G.6
Griffing, S.7
Bergsland, E.8
-
63
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
-
[PMID: 18421054 DOI: 10.1200/jco.2007.14.9930]
-
Saltz LB, Clarke S, Díaz-Rubio E, Scheithauer W, Figer A, Wong R, Koski S, Lichinitser M, Yang TS, Rivera F, Couture F, Sirzén F, Cassidy J. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 2008; 26: 2013-2019 [PMID: 18421054 DOI: 10.1200/ jco.2007.14.9930]
-
(2008)
J Clin Oncol
, vol.26
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Díaz-Rubio, E.3
Scheithauer, W.4
Figer, A.5
Wong, R.6
Koski, S.7
Lichinitser, M.8
Yang, T.S.9
Rivera, F.10
Couture, F.11
Sirzén, F.12
Cassidy, J.13
-
64
-
-
77955497309
-
Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: Results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study
-
[PMID: 20516443 DOI: 10.1200/jco.2009.27.7723]
-
Tebbutt NC, Wilson K, Gebski VJ, Cummins MM, Zannino D, van Hazel GA, Robinson B, Broad A, Ganju V, Ackland SP, Forgeson G, Cunningham D, Saunders MP, Stockler MR, Chua Y, Zalcberg JR, Simes RJ, Price TJ. Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study. J Clin Oncol 2010; 28: 3191-3198 [PMID: 20516443 DOI: 10.1200/ jco.2009.27.7723]
-
(2010)
J Clin Oncol
, vol.28
, pp. 3191-3198
-
-
Tebbutt, N.C.1
Wilson, K.2
Gebski, V.J.3
Cummins, M.M.4
Zannino, D.5
van Hazel, G.A.6
Robinson, B.7
Broad, A.8
Ganju, V.9
Ackland, S.P.10
Forgeson, G.11
Cunningham, D.12
Saunders, M.P.13
Stockler, M.R.14
Chua, Y.15
Zalcberg, J.R.16
Simes, R.J.17
Price, T.J.18
-
65
-
-
61449162243
-
Anti-epidermal growth factor receptor monotherapy in the treatment of metastatic colorectal cancer: Where are we today?
-
[PMID: 19144681 DOI: 10.1634/theoncolo, gist.2008-0167]
-
Peeters M, Price T, Van Laethem JL. Anti-epidermal growth factor receptor monotherapy in the treatment of metastatic colorectal cancer: where are we today? Oncologist 2009; 14: 29-39 [PMID: 19144681 DOI: 10.1634/theoncologist.2008-0167]
-
(2009)
Oncologist
, vol.14
, pp. 29-39
-
-
Peeters, M.1
Price, T.2
van Laethem, J.L.3
-
66
-
-
84861325349
-
Cetuximab in metastatic colorectal cancer
-
[PMID: 22594891 DOI: 10.1586/era.12.25]
-
Broadbridge VT, Karapetis CS, Price TJ. Cetuximab in metastatic colorectal cancer. Expert Rev Anticancer Ther 2012; 12: 555-565 [PMID: 22594891 DOI: 10.1586/era.12.25]
-
(2012)
Expert Rev Anticancer Ther
, vol.12
, pp. 555-565
-
-
Broadbridge, V.T.1
Karapetis, C.S.2
Price, T.J.3
-
67
-
-
0036362181
-
Why the epidermal growth factor receptor? The rationale for cancer therapy
-
[PMID: 12202782 DOI: 10.1634/theoncologist.7-suppl_4-2]
-
Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 2002; 7 Suppl 4: 2-8 [PMID: 12202782 DOI: 10.1634/theoncologist.7-suppl_4-2]
-
Oncologist
, vol.4
, pp. 2-8
-
-
Baselga, J.1
-
68
-
-
36749067866
-
Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer
-
[PMID: 18024868 DOI: 10.1200/jco.2007.13.2183]
-
Tabernero J, Van Cutsem E, Díaz-Rubio E, Cervantes A, Humblet Y, André T, Van Laethem JL, Soulié P, Casado E, Verslype C, Valera JS, Tortora G, Ciardiello F, Kisker O, de Gramont A. Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2007; 25: 5225-5232 [PMID: 18024868 DOI: 10.1200/jco.2007.13.2183]
-
(2007)
J Clin Oncol
, vol.25
, pp. 5225-5232
-
-
Tabernero, J.1
van Cutsem, E.2
Díaz-Rubio, E.3
Cervantes, A.4
Humblet, Y.5
André, T.6
van Laethem, J.L.7
Soulié, P.8
Casado, E.9
Verslype, C.10
Valera, J.S.11
Tortora, G.12
Ciardiello, F.13
Kisker, O.14
de Gramont, A.15
-
69
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
[PMID: 19114683 DOI: 10.1200/jco.2008.20.8397]
-
Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, de Braud F, Donea S, Ludwig H, Schuch G, Stroh C, Loos AH, Zubel A, Koralewski P. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009; 27: 663-671 [PMID: 19114683 DOI: 10.1200/jco.2008.20.8397]
-
(2009)
J Clin Oncol
, vol.27
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
Hartmann, J.T.4
Aparicio, J.5
de Braud, F.6
Donea, S.7
Ludwig, H.8
Schuch, G.9
Stroh, C.10
Loos, A.H.11
Zubel, A.12
Koralewski, P.13
-
70
-
-
79956310674
-
Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: The OPUS study
-
[PMID: 21228335 DOI: 10.1093/annonc/mdq632]
-
Bokemeyer C, Bondarenko I, Hartmann JT, de Braud F, Schuch G, Zubel A, Celik I, Schlichting M, Koralewski P. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol 2011; 22: 1535-1546 [PMID: 21228335 DOI: 10.1093/annonc/mdq632]
-
(2011)
Ann Oncol
, vol.22
, pp. 1535-1546
-
-
Bokemeyer, C.1
Bondarenko, I.2
Hartmann, J.T.3
de Braud, F.4
Schuch, G.5
Zubel, A.6
Celik, I.7
Schlichting, M.8
Koralewski, P.9
-
71
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
[PMID: 19339720 DOI: 10.1056/NEJ-, Moa0805019]
-
Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, D'Haens G, Pintér T, Lim R, Bodoky G, Roh JK, Folprecht G, Ruff P, Stroh C, Tejpar S, Schlichting M, Nippgen J, Rougier P. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009; 360: 1408-1417 [PMID: 19339720 DOI: 10.1056/NEJ-Moa0805019]
-
(2009)
N Engl J Med
, vol.360
, pp. 1408-1417
-
-
van Cutsem, E.1
Köhne, C.H.2
Hitre, E.3
Zaluski, J.4
Chang, C.C.R.5
Makhson, A.6
D'Haens, G.7
Pintér, T.8
Lim, R.9
Bodoky, G.10
Roh, J.K.11
Folprecht, G.12
Ruff, P.13
Stroh, C.14
Tejpar, S.15
Schlichting, M.16
Nippgen, J.17
Rougier, P.18
-
72
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
[PMID: 21502544 DOI: 10.1200/jco.2010.33.5091]
-
Van Cutsem E, Köhne CH, Láng I, Folprecht G, Nowacki MP, Cascinu S, Shchepotin I, Maurel J, Cunningham D, Tejpar S, Schlichting M, Zubel A, Celik I, Rougier P, Ciardiello F. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 2011; 29: 2011-2019 [PMID: 21502544 DOI: 10.1200/jco.2010.33.5091]
-
(2011)
J Clin Oncol
, vol.29
, pp. 2011-2019
-
-
van Cutsem, E.1
Köhne, C.H.2
Láng, I.3
Folprecht, G.4
Nowacki, M.P.5
Cascinu, S.6
Shchepotin, I.7
Maurel, J.8
Cunningham, D.9
Tejpar, S.10
Schlichting, M.11
Zubel, A.12
Celik, I.13
Rougier, P.14
Ciardiello, F.15
-
73
-
-
79952153189
-
Randomized phase III study of 5-fluorouracil/folinate/oxaliplatin given continuously or intermittently with or without cetuximab, as first-line treatment of metastatic colorectal cancer: The NORDIC VII Study (NCT00145314)
-
Abstr LBA20
-
Tveit K, Guren T, Glimelius B, Pfeiffer P, Sorbye H, Pyrhonen S, Kure E, Ikdahl T, Skovlund E, Christoffersen T. Randomized phase III study of 5-fluorouracil/folinate/oxaliplatin given continuously or intermittently with or without cetuximab, as first-line treatment of metastatic colorectal cancer: the NORDIC VII Study (NCT00145314). Ann Oncol 2010; 21 Suppl 8: Abstr LBA20
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 8
-
-
Tveit, K.1
Guren, T.2
Glimelius, B.3
Pfeiffer, P.4
Sorbye, H.5
Pyrhonen, S.6
Kure, E.7
Ikdahl, T.8
Skovlund, E.9
Christoffersen, T.10
-
74
-
-
79959337678
-
Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
-
[PMID: 21641636 DOI: 10.1016/ s0140-6736(11)60613-2]
-
Maughan TS, Adams RA, Smith CG, Meade AM, Seymour MT, Wilson RH, Idziaszczyk S, Harris R, Fisher D, Kenny SL, Kay E, Mitchell JK, Madi A, Jasani B, James MD, Bridgewater J, Kennedy MJ, Claes B, Lambrechts D, Kaplan R, Cheadle JP. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 2011; 377: 2103-2114 [PMID: 21641636 DOI: 10.1016/ s0140-6736(11)60613-2]
-
(2011)
Lancet
, vol.377
, pp. 2103-2114
-
-
Maughan, T.S.1
Adams, R.A.2
Smith, C.G.3
Meade, A.M.4
Seymour, M.T.5
Wilson, R.H.6
Idziaszczyk, S.7
Harris, R.8
Fisher, D.9
Kenny, S.L.10
Kay, E.11
Mitchell, J.K.12
Madi, A.13
Jasani, B.14
James, M.D.15
Bridgewater, J.16
Kennedy, M.J.17
Claes, B.18
Lambrechts, D.19
Kaplan, R.20
Cheadle, J.P.21
more..
-
75
-
-
10744221013
-
Preclinical and clinical evaluations of ABXEGF, a fully human anti-epidermal growth factor receptor antibody
-
[PMID: 14967460 DOI: 10.1016/j.ijrobp.2003.09.098]
-
Foon KA, Yang XD, Weiner LM, Belldegrun AS, Figlin RA, Crawford J, Rowinsky EK, Dutcher JP, Vogelzang NJ, Gollub J, Thompson JA, Schwartz G, Bukowski RM, Roskos LK, Schwab GM. Preclinical and clinical evaluations of ABXEGF, a fully human anti-epidermal growth factor receptor antibody. Int J Radiat Oncol Biol Phys 2004; 58: 984-990 [PMID: 14967460 DOI: 10.1016/j.ijrobp.2003.09.098]
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.58
, pp. 984-990
-
-
Foon, K.A.1
Yang, X.D.2
Weiner, L.M.3
Belldegrun, A.S.4
Figlin, R.A.5
Crawford, J.6
Rowinsky, E.K.7
Dutcher, J.P.8
Vogelzang, N.J.9
Gollub, J.10
Thompson, J.A.11
Schwartz, G.12
Bukowski, R.M.13
Roskos, L.K.14
Schwab, G.M.15
-
76
-
-
78149250536
-
Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
-
[PMID: 20921465 DOI:10.1200/jco.2009.27.4860]
-
Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, Rivera F, Kocákova I, Ruff P, Błasińska-Morawiec M, Šmakal M, Canon JL, Rother M, Oliner KS, Wolf M, Gansert J. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol 2010; 28: 4697-4705 [PMID: 20921465 DOI:10.1200/jco.2009.27.4860]
-
(2010)
J Clin Oncol
, vol.28
, pp. 4697-4705
-
-
Douillard, J.Y.1
Siena, S.2
Cassidy, J.3
Tabernero, J.4
Burkes, R.5
Barugel, M.6
Humblet, Y.7
Bodoky, G.8
Cunningham, D.9
Jassem, J.10
Rivera, F.11
Kocákova, I.12
Ruff, P.13
Błasińska-Morawiec, M.14
Šmakal, M.15
Canon, J.L.16
Rother, M.17
Oliner, K.S.18
Wolf, M.19
Gansert, J.20
more..
-
77
-
-
84865509942
-
Treatment decisions after diagnosis of metastatic colorectal cancer
-
[PMID: 22192364 DOI: 10.1016/j.clcc.2011.11.001]
-
Cartwright TH. Treatment decisions after diagnosis of metastatic colorectal cancer. Clin Colorectal Cancer 2012; 11: 155-166 [PMID: 22192364 DOI: 10.1016/j.clcc.2011.11.001]
-
(2012)
Clin Colorectal Cancer
, vol.11
, pp. 155-166
-
-
Cartwright, T.H.1
-
78
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
[PMID: 19114685DOI: 10.1200/jco.2008.19.8135]
-
Hecht JR, Mitchell E, Chidiac T, Scroggin C, Hagenstad C, Spigel D, Marshall J, Cohn A, McCollum D, Stella P, Deeter R, Shahin S, Amado RG. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009; 27: 672-680 [PMID: 19114685 DOI: 10.1200/jco.2008.19.8135]
-
(2009)
J Clin Oncol
, vol.27
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
Scroggin, C.4
Hagenstad, C.5
Spigel, D.6
Marshall, J.7
Cohn, A.8
McCollum, D.9
Stella, P.10
Deeter, R.11
Shahin, S.12
Amado, R.G.13
-
79
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
[PMID: 19196673 DOI:10.1056/NEJMoa0808268]
-
Tol J, Koopman M, Cats A, Rodenburg CJ, Creemers GJ, Schrama JG, Erdkamp FL, Vos AH, van Groeningen CJ, Sinnige HA, Richel DJ, Voest EE, Dijkstra JR, Vink-Börger ME, Antonini NF, Mol L, van Krieken JH, Dalesio O, Punt CJ. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med 2009; 360: 563-572 [PMID: 19196673 DOI:10.1056/NEJMoa0808268]
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
Rodenburg, C.J.4
Creemers, G.J.5
Schrama, J.G.6
Erdkamp, F.L.7
Vos, A.H.8
van Groeningen, C.J.9
Sinnige, H.A.10
Richel, D.J.11
Voest, E.E.12
Dijkstra, J.R.13
Vink-Börger, M.E.14
Antonini, N.F.15
Mol, L.16
van Krieken, J.H.17
Dalesio, O.18
Punt, C.J.19
-
80
-
-
66149155832
-
Combination of surgery and chemotherapy and the role of targeted agents in the treatment of patients with colorectal liver metastases: Recommendations from an expert panel
-
[PMID: 19153115 DOI: 10.1093/annonc/mdn735]
-
Nordlinger B, Van Cutsem E, Gruenberger T, Glimelius B, Poston G, Rougier P, Sobrero A, Ychou M. Combination of surgery and chemotherapy and the role of targeted agents in the treatment of patients with colorectal liver metastases: recommendations from an expert panel. Ann Oncol 2009; 20: 985-992 [PMID: 19153115 DOI: 10.1093/annonc/mdn735]
-
(2009)
Ann Oncol
, vol.20
, pp. 985-992
-
-
Nordlinger, B.1
van Cutsem, E.2
Gruenberger, T.3
Glimelius, B.4
Poston, G.5
Rougier, P.6
Sobrero, A.7
Ychou, M.8
-
81
-
-
85027937009
-
Liver metastases from colorectal cancer: Technique of liver resection
-
[PMID: 22566374 DOI: 10.1002/jso.23138]
-
Heinrich S, Lang H. Liver metastases from colorectal cancer: technique of liver resection. J Surg Oncol 2013; 107: 579-584 [PMID: 22566374 DOI: 10.1002/jso.23138]
-
(2013)
J Surg Oncol
, vol.107
, pp. 579-584
-
-
Heinrich, S.1
Lang, H.2
-
82
-
-
82055181858
-
Treatment of colorectal liver metastases
-
[PMID: 22115124 DOI:10.1186/1477-7819-9-154]
-
Ismaili N. Treatment of colorectal liver metastases. World J Surg Oncol 2011; 9: 154 [PMID: 22115124 DOI: 10.1186/1477-7819-9-154]
-
(2011)
World J Surg Oncol
, vol.9
, pp. 154
-
-
Ismaili, N.1
-
83
-
-
81255165929
-
Multidisciplinary approach of colorectal liver metastases
-
[PMID: 21975333 DOI: 10.1007/s12094-011-0722-x]
-
Juez I, Rubio C, Figueras J. Multidisciplinary approach of colorectal liver metastases. Clin Transl Oncol 2011; 13: 721-727 [PMID: 21975333 DOI: 10.1007/s12094-011-0722-x]
-
(2011)
Clin Transl Oncol
, vol.13
, pp. 721-727
-
-
Juez, I.1
Rubio, C.2
Figueras, J.3
-
84
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
[PMID: 12177445 DOI: 10.1073/pnas.172398299]
-
Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, Boland P, Leidich R, Hylton D, Burova E, Ioffe E, Huang T, Radziejewski C, Bailey K, Fandl JP, Daly T, Wiegand SJ, Yancopoulos GD, Rudge JS. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 2002; 99: 11393-11398 [PMID: 12177445 DOI: 10.1073/pnas.172398299]
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
Croll, S.D.4
Ho, L.5
Russell, M.6
Boland, P.7
Leidich, R.8
Hylton, D.9
Burova, E.10
Ioffe, E.11
Huang, T.12
Radziejewski, C.13
Bailey, K.14
Fandl, J.P.15
Daly, T.16
Wiegand, S.J.17
Yancopoulos, G.D.18
Rudge, J.S.19
-
85
-
-
36749040908
-
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade
-
[PMID: 18000042 DOI: 10.1073/pnas.0708865104]
-
Rudge JS, Holash J, Hylton D, Russell M, Jiang S, Leidich R, Papadopoulos N, Pyles EA, Torri A, Wiegand SJ, Thurston G, Stahl N, Yancopoulos GD. VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proc Natl Acad Sci USA 2007; 104: 18363-18370 [PMID: 18000042 DOI: 10.1073/pnas.0708865104]
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 18363-18370
-
-
Rudge, J.S.1
Holash, J.2
Hylton, D.3
Russell, M.4
Jiang, S.5
Leidich, R.6
Papadopoulos, N.7
Pyles, E.A.8
Torri, A.9
Wiegand, S.J.10
Thurston, G.11
Stahl, N.12
Yancopoulos, G.D.13
-
86
-
-
84868584808
-
Phase 2 randomized, noncomparative open-label study of aflibercept and Modified FOLFOX6 in the first line treatment of metastatic colorectal cancer (AFFIRM)
-
Pericay C, Folprecht G. Phase 2 randomized, noncomparative open-label study of aflibercept and Modified FOLFOX6 in the first line treatment of metastatic colorectal cancer (AFFIRM). Ann Oncol 2012; 23 (suppl 4): 0024
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 4
, pp. 0024
-
-
Pericay, C.1
Folprecht, G.2
-
87
-
-
84867047384
-
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
-
[PMID: 22949147 DOI: 10.1200/jco.2012.42.8201]
-
Van Cutsem E, Tabernero J, Lakomy R, Prenen H, Prausová J, Macarulla T, Ruff P, van Hazel GA, Moiseyenko V, Ferry D, McKendrick J, Polikoff J, Tellier A, Castan R, Allegra C. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 2012; 30: 3499-3506 [PMID: 22949147 DOI: 10.1200/jco.2012.42.8201]
-
(2012)
J Clin Oncol
, vol.30
, pp. 3499-3506
-
-
van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
Prenen, H.4
Prausová, J.5
Macarulla, T.6
Ruff, P.7
van Hazel, G.A.8
Moiseyenko, V.9
Ferry, D.10
McKendrick, J.11
Polikoff, J.12
Tellier, A.13
Castan, R.14
Allegra, C.15
-
88
-
-
84868526153
-
Effects of prior bevacizumab (B) use on outcomes from the VELOUR study: A phase III study of aflibercept (Afl) and FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin regimen
-
Allegra CJ, Lakomy R, Tabernero J, Prausová J, Ruff P, Van Hazel G, Moiseyenko VM, Ferry DR, McKendrick JJ, Van Cutsem E. Effects of prior bevacizumab (B) use on outcomes from the VELOUR study: A phase III study of aflibercept (Afl) and FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin regimen. J Clin Oncol 2012: 30 (Suppl): 3505
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
, pp. 3505
-
-
Allegra, C.J.1
Lakomy, R.2
Tabernero, J.3
Prausová, J.4
Ruff, P.5
van Hazel, G.6
Moiseyenko, V.M.7
Ferry, D.R.8
McKendrick, J.J.9
van Cutsem, E.10
-
89
-
-
33645670595
-
Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5yloxy)-5methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor
-
[PMID: 16570908 DOI:, 10.1021/jm051106d]
-
Bhide RS, Cai ZW, Zhang YZ, Qian L, Wei D, Barbosa S, Lombardo LJ, Borzilleri RM, Zheng X, Wu LI, Barrish JC, Kim SH, Leavitt K, Mathur A, Leith L, Chao S, Wautlet B, Mortillo S, Jeyaseelan R, Kukral D, Hunt JT, Kamath A, Fura A, Vyas V, Marathe P, D'Arienzo C, Derbin G, Fargnoli J. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5yloxy)-5methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J Med Chem 2006; 49: 2143-2146 [PMID: 16570908 DOI:10.1021/jm051106d]
-
(2006)
J Med Chem
, vol.49
, pp. 2143-2146
-
-
Bhide, R.S.1
Cai, Z.W.2
Zhang, Y.Z.3
Qian, L.4
Wei, D.5
Barbosa, S.6
Lombardo, L.J.7
Borzilleri, R.M.8
Zheng, X.9
Wu, L.I.10
Barrish, J.C.11
Kim, S.H.12
Leavitt, K.13
Mathur, A.14
Leith, L.15
Chao, S.16
Wautlet, B.17
Mortillo, S.18
Jeyaseelan, R.19
Kukral, D.20
Hunt, J.T.21
Kamath, A.22
Fura, A.23
Vyas, V.24
Marathe, P.25
D'Arienzo, C.26
Derbin, G.27
Fargnoli, J.28
more..
-
90
-
-
84883074556
-
Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate versus cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: The NCIC Clinical Trials Group and AGITG CO.20 Trial
-
[PMID: 23690424 DOI: 10.1200/jco.2012.46.0543]
-
Siu LL, Shapiro JD, Jonker DJ, Karapetis CS, Zalcberg JR, Simes J, Couture F, Moore MJ, Price TJ, Siddiqui J, Nott LM, Charpentier D, Liauw W, Sawyer MB, Jefford M, Magoski NM, Haydon A, Walters I, Ringash J, Tu D, O'Callaghan CJ. Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate versus cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: the NCIC Clinical Trials Group and AGITG CO.20 Trial. J Clin Oncol 2013; 31: 2477-2484 [PMID: 23690424 DOI: 10.1200/jco.2012.46.0543]
-
(2013)
J Clin Oncol
, vol.31
, pp. 2477-2484
-
-
Siu, L.L.1
Shapiro, J.D.2
Jonker, D.J.3
Karapetis, C.S.4
Zalcberg, J.R.5
Simes, J.6
Couture, F.7
Moore, M.J.8
Price, T.J.9
Siddiqui, J.10
Nott, L.M.11
Charpentier, D.12
Liauw, W.13
Sawyer, M.B.14
Jefford, M.15
Magoski, N.M.16
Haydon, A.17
Walters, I.18
Ringash, J.19
Tu, D.20
O'Callaghan, C.J.21
more..
-
91
-
-
84857008163
-
Comparison of a dual inhibitor of VEGF and FGF signaling, BMS-582664, to the activity of bevacizumab, an inhibitor exclusively of VEGF signaling, in xenograft models of colon carcinoma
-
Abstract 1618
-
Ayers M, Dito G, Henley B, Jeyaseelan R, Yoganthan S, Han X, Wu Q, Platero S, Wu S, Feltquate D. Comparison of a dual inhibitor of VEGF and FGF signaling, BMS-582664, to the activity of bevacizumab, an inhibitor exclusively of VEGF signaling, in xenograft models of colon carcinoma. Proc Am Assoc Cancer Res 2007; 48: Abstract 1618
-
(2007)
Proc Am Assoc Cancer Res
, vol.48
-
-
Ayers, M.1
Dito, G.2
Henley, B.3
Jeyaseelan, R.4
Yoganthan, S.5
Han, X.6
Wu, Q.7
Platero, S.8
Wu, S.9
Feltquate, D.10
-
92
-
-
84867075826
-
Brivanib: A review of development
-
[PMID: 23030483 DOI: 10.2217/fon.12.104]
-
Chou T, Finn RS. Brivanib: a review of development. Future Oncol 2012; 8: 1083-1090 [PMID: 23030483 DOI: 10.2217/ fon.12.104]
-
(2012)
Future Oncol
, vol.8
, pp. 1083-1090
-
-
Chou, T.1
Finn, R.S.2
-
93
-
-
79959699570
-
Phase I dose-escalation study to determine the safety, pharmacokinetics and pharmacodynamics of brivanib alaninate in combination with full-dose cetuximab in patients with advanced gastrointestinal malignancies who have failed prior therapy
-
[PMID: 21629245 DOI: 10.1038/bjc.2011.182]
-
Garrett CR, Siu LL, El-Khoueiry A, Buter J, Rocha-Lima CM, Marshall J, LoRusso P, Major P, Chemidlin J, Mokliatchouk O, Velasquez L, Hayes W, Feltquate D, Syed S, Ford S, Kollia G, Galbraith S, Nuyten DS. Phase I dose-escalation study to determine the safety, pharmacokinetics and pharmacodynamics of brivanib alaninate in combination with full-dose cetuximab in patients with advanced gastrointestinal malignancies who have failed prior therapy. Br J Cancer 2011; 105: 44-52 [PMID: 21629245 DOI: 10.1038/bjc.2011.182]
-
(2011)
Br J Cancer
, vol.105
, pp. 44-52
-
-
Garrett, C.R.1
Siu, L.L.2
El-Khoueiry, A.3
Buter, J.4
Rocha-Lima, C.M.5
Marshall, J.6
Lorusso, P.7
Major, P.8
Chemidlin, J.9
Mokliatchouk, O.10
Velasquez, L.11
Hayes, W.12
Feltquate, D.13
Syed, S.14
Ford, S.15
Kollia, G.16
Galbraith, S.17
Nuyten, D.S.18
-
94
-
-
20144370978
-
AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
-
[PMID:15899831 DOI: 10.1158/0008-5472.can-04-4409]
-
Wedge SR, Kendrew J, Hennequin LF, Valentine PJ, Barry ST, Brave SR, Smith NR, James NH, Dukes M, Curwen JO, Chester R, Jackson JA, Boffey SJ, Kilburn LL, Barnett S, Richmond GH, Wadsworth PF, Walker M, Bigley AL, Taylor ST, Cooper L, Beck S, Jürgensmeier JM, Ogilvie DJ. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005; 65: 4389-4400 [PMID: 15899831 DOI: 10.1158/0008-5472.can-04-4409]
-
(2005)
Cancer Res
, vol.65
, pp. 4389-4400
-
-
Wedge, S.R.1
Kendrew, J.2
Hennequin, L.F.3
Valentine, P.J.4
Barry, S.T.5
Brave, S.R.6
Smith, N.R.7
James, N.H.8
Dukes, M.9
Curwen, J.O.10
Chester, R.11
Jackson, J.A.12
Boffey, S.J.13
Kilburn, L.L.14
Barnett, S.15
Richmond, G.H.16
Wadsworth, P.F.17
Walker, M.18
Bigley, A.L.19
Taylor, S.T.20
Cooper, L.21
Beck, S.22
Jürgensmeier, J.M.23
Ogilvie, D.J.24
more..
-
95
-
-
0037137903
-
Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy
-
[PMID: 11774295 DOI: 10.1002/ijc.1634]
-
Lu D, Jimenez X, Zhang H, Bohlen P, Witte L, Zhu Z. Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy. Int J Cancer 2002; 97: 393-399 [PMID: 11774295 DOI: 10.1002/ijc.1634]
-
(2002)
Int J Cancer
, vol.97
, pp. 393-399
-
-
Lu, D.1
Jimenez, X.2
Zhang, H.3
Bohlen, P.4
Witte, L.5
Zhu, Z.6
-
96
-
-
79955798791
-
Ramucirumab (IMC-1121B): Monoclonal antibody inhibition of vascular endothelial growth factor receptor-2
-
[PMID: 21222245 DOI:10.1007/s11912-010-0149-5]
-
Spratlin J. Ramucirumab (IMC-1121B): Monoclonal antibody inhibition of vascular endothelial growth factor receptor-2. Curr Oncol Rep 2011; 13: 97-102 [PMID: 21222245 DOI:10.1007/s11912-010-0149-5]
-
(2011)
Curr Oncol Rep
, vol.13
, pp. 97-102
-
-
Spratlin, J.1
-
97
-
-
79954499886
-
Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
-
[PMID:21170960 DOI: 10.1002/ijc.25864]
-
Wilhelm SM, Dumas J, Adnane L, Lynch M, Carter CA, Schütz G, Thierauch KH, Zopf D. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer 2011; 129: 245-255 [PMID: 21170960 DOI: 10.1002/ijc.25864]
-
(2011)
Int J Cancer
, vol.129
, pp. 245-255
-
-
Wilhelm, S.M.1
Dumas, J.2
Adnane, L.3
Lynch, M.4
Carter, C.A.5
Schütz, G.6
Thierauch, K.H.7
Zopf, D.8
-
98
-
-
84861038995
-
Regorafenib for cancer
-
[PMID: 22577890 DOI: 10.1517/13543784.2012.684752]
-
Strumberg D, Schultheis B. Regorafenib for cancer. Expert Opin Investig Drugs 2012; 21: 879-889 [PMID: 22577890 DOI: 10.1517/13543784.2012.684752]
-
(2012)
Expert Opin Investig Drugs
, vol.21
, pp. 879-889
-
-
Strumberg, D.1
Schultheis, B.2
-
99
-
-
84872921660
-
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial
-
[PMID: 23177514 DOI: 10.1016/s0140-6736(12)61900-x]
-
Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, Humblet Y, Bouché O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Sargent DJ, Cihon F, Cupit L, Wagner A, Laurent D. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013; 381: 303-312 [PMID: 23177514 DOI: 10.1016/s0140-6736(12)61900-x]
-
(2013)
Lancet
, vol.381
, pp. 303-312
-
-
Grothey, A.1
van Cutsem, E.2
Sobrero, A.3
Siena, S.4
Falcone, A.5
Ychou, M.6
Humblet, Y.7
Bouché, O.8
Mineur, L.9
Barone, C.10
Adenis, A.11
Tabernero, J.12
Yoshino, T.13
Lenz, H.J.14
Goldberg, R.M.15
Sargent, D.J.16
Cihon, F.17
Cupit, L.18
Wagner, A.19
Laurent, D.20
more..
-
100
-
-
0032893263
-
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
-
[PMID: 9892193]
-
Fong TA, Shawver LK, Sun L, Tang C, App H, Powell TJ, Kim YH, Schreck R, Wang X, Risau W, Ullrich A, Hirth KP, McMahon G. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 1999; 59: 99-106 [PMID: 9892193]
-
(1999)
Cancer Res
, vol.59
, pp. 99-106
-
-
Fong, T.A.1
Shawver, L.K.2
Sun, L.3
Tang, C.4
App, H.5
Powell, T.J.6
Kim, Y.H.7
Schreck, R.8
Wang, X.9
Risau, W.10
Ullrich, A.11
Hirth, K.P.12
McMahon, G.13
-
101
-
-
12244277954
-
Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent
-
[PMID: 10888034]
-
Mendel DB, Laird AD, Smolich BD, Blake RA, Liang C, Hannah AL, Shaheen RM, Ellis LM, Weitman S, Shawver LK, Cherrington JM. Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Anticancer Drug Des 2000; 15: 29-41 [PMID: 10888034]
-
(2000)
Anticancer Drug Des
, vol.15
, pp. 29-41
-
-
Mendel, D.B.1
Laird, A.D.2
Smolich, B.D.3
Blake, R.A.4
Liang, C.5
Hannah, A.L.6
Shaheen, R.M.7
Ellis, L.M.8
Weitman, S.9
Shawver, L.K.10
Cherrington, J.M.11
-
102
-
-
33644684217
-
Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment
-
[PMID: 16474853 DOI: 10.1358/ dot.2005.41.12.937959]
-
Strumberg D. Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment. Drugs Today (Barc) 2005; 41: 773-784 [PMID: 16474853 DOI: 10.1358/ dot.2005.41.12.937959]
-
(2005)
Drugs Today (Barc)
, vol.41
, pp. 773-784
-
-
Strumberg, D.1
-
103
-
-
33644747449
-
BAY 43-9006 inhibition of oncogenic RET mutants
-
[PMID: 16507829 DOI: 10.1093/jnci/djj069]
-
Carlomagno F, Anaganti S, Guida T, Salvatore G, Troncone G, Wilhelm SM, Santoro M. BAY 43-9006 inhibition of oncogenic RET mutants. J Natl Cancer Inst 2006; 98: 326-334 [PMID: 16507829 DOI: 10.1093/jnci/djj069]
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 326-334
-
-
Carlomagno, F.1
Anaganti, S.2
Guida, T.3
Salvatore, G.4
Troncone, G.5
Wilhelm, S.M.6
Santoro, M.7
-
104
-
-
84877098937
-
Sorafenib in combination with oxaliplatin, leucovorin, and fluorouracil (modified FOLFOX6) as first-line treatment of metastatic colorectal cancer: The RESPECT trial
-
[PMID: 23532888 DOI:, 10.1158/1078-0432.ccr-13-0107]
-
Tabernero J, Garcia-Carbonero R, Cassidy J, Sobrero A, Van Cutsem E, Köhne CH, Tejpar S, Gladkov O, Davidenko I, Salazar R, Vladimirova L, Cheporov S, Burdaeva O, Rivera F, Samuel L, Bulavina I, Potter V, Chang YL, Lokker NA, O'Dwyer PJ. Sorafenib in combination with oxaliplatin, leucovorin, and fluorouracil (modified FOLFOX6) as first-line treatment of metastatic colorectal cancer: the RESPECT trial. Clin Cancer Res 2013; 19: 2541-2550 [PMID: 23532888 DOI:10.1158/1078-0432.ccr-13-0107]
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2541-2550
-
-
Tabernero, J.1
Garcia-Carbonero, R.2
Cassidy, J.3
Sobrero, A.4
van Cutsem, E.5
Köhne, C.H.6
Tejpar, S.7
Gladkov, O.8
Davidenko, I.9
Salazar, R.10
Vladimirova, L.11
Cheporov, S.12
Burdaeva, O.13
Rivera, F.14
Samuel, L.15
Bulavina, I.16
Potter, V.17
Chang, Y.L.18
Lokker, N.A.19
O'Dwyer, P.J.20
more..
-
105
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
[PMID: 12538485]
-
Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003; 9: 327-337 [PMID: 12538485]
-
(2003)
Clin Cancer Res
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
Louie, S.G.4
Christensen, J.G.5
Li, G.6
Schreck, R.E.7
Abrams, T.J.8
Ngai, T.J.9
Lee, L.B.10
Murray, L.J.11
Carver, J.12
Chan, E.13
Moss, K.G.14
Haznedar, J.O.15
Sukbuntherng, J.16
Blake, R.A.17
Sun, L.18
Tang, C.19
Miller, T.20
Shirazian, S.21
McMahon, G.22
Cherrington, J.M.23
more..
-
106
-
-
0038204144
-
SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
-
[PMID: 12531805 DOI: 10.1182/blood-2002-07-2307]
-
O'Farrell AM, Abrams TJ, Yuen HA, Ngai TJ, Louie SG, Yee KW, Wong LM, Hong W, Lee LB, Town A, Smolich BD, Manning WC, Murray LJ, Heinrich MC, Cherrington JM. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood 2003; 101: 3597-3605 [PMID: 12531805 DOI: 10.1182/blood-2002-07-2307]
-
(2003)
Blood
, vol.101
, pp. 3597-3605
-
-
O'Farrell, A.M.1
Abrams, T.J.2
Yuen, H.A.3
Ngai, T.J.4
Louie, S.G.5
Yee, K.W.6
Wong, L.M.7
Hong, W.8
Lee, L.B.9
Town, A.10
Smolich, B.D.11
Manning, W.C.12
Murray, L.J.13
Heinrich, M.C.14
Cherrington, J.M.15
-
107
-
-
9144274970
-
SU11248 inhibits tumor growth and CSF-1Rdependent osteolysis in an experimental breast cancer bone metastasis model
-
[PMID: 14713109]
-
Murray LJ, Abrams TJ, Long KR, Ngai TJ, Olson LM, Hong W, Keast PK, Brassard JA, O'Farrell AM, Cherrington JM, Pryer NK. SU11248 inhibits tumor growth and CSF-1Rdependent osteolysis in an experimental breast cancer bone metastasis model. Clin Exp Metastasis 2003; 20: 757-766 [PMID: 14713109]
-
(2003)
Clin Exp Metastasis
, vol.20
, pp. 757-766
-
-
Murray, L.J.1
Abrams, T.J.2
Long, K.R.3
Ngai, T.J.4
Olson, L.M.5
Hong, W.6
Keast, P.K.7
Brassard, J.A.8
O'Farrell, A.M.9
Cherrington, J.M.10
Pryer, N.K.11
-
108
-
-
84876089340
-
Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: A randomized, phase III trial
-
[PMID: 23358972 DOI: 10.1200/ jco.2012.45.1930]
-
Carrato A, Swieboda-Sadlej A, Staszewska-Skurczynska M, Lim R, Roman L, Shparyk Y, Bondarenko I, Jonker DJ, Sun Y, De la Cruz JA, Williams JA, Korytowsky B, Christensen JG, Lin X, Tursi JM, Lechuga MJ, Van Cutsem E. Fluorouracil, leucovorin, and irinotecan plus either sunitinib or placebo in metastatic colorectal cancer: a randomized, phase III trial. J Clin Oncol 2013; 31: 1341-1347 [PMID: 23358972 DOI: 10.1200/ jco.2012.45.1930]
-
(2013)
J Clin Oncol
, vol.31
, pp. 1341-1347
-
-
Carrato, A.1
Swieboda-Sadlej, A.2
Staszewska-Skurczynska, M.3
Lim, R.4
Roman, L.5
Shparyk, Y.6
Bondarenko, I.7
Jonker, D.J.8
Sun, Y.9
De la Cruz, J.A.10
Williams, J.A.11
Korytowsky, B.12
Christensen, J.G.13
Lin, X.14
Tursi, J.M.15
Lechuga, M.J.16
van Cutsem, E.17
-
109
-
-
18344369461
-
PTK 787/ZK 222584, a tyrosine kinase inhibitor of all known VEGF receptors, represses tumor growth with high efficacy
-
[PMID: 15742376 DOI: 10.1002/cbic.200400305]
-
Hess-Stumpp H, Haberey M, Thierauch KH. PTK 787/ZK 222584, a tyrosine kinase inhibitor of all known VEGF receptors, represses tumor growth with high efficacy. Chembiochem 2005; 6: 550-557 [PMID: 15742376 DOI: 10.1002/ cbic.200400305]
-
(2005)
Chembiochem
, vol.6
, pp. 550-557
-
-
Hess-Stumpp, H.1
Haberey, M.2
Thierauch, K.H.3
-
110
-
-
79956334386
-
Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma
-
[PMID: 21464406 DOI:10.1200/jco.2010.29.4496]
-
Hecht JR, Trarbach T, Hainsworth JD, Major P, Jäger E, Wolff RA, Lloyd-Salvant K, Bodoky G, Pendergrass K, Berg W, Chen BL, Jalava T, Meinhardt G, Laurent D, Lebwohl D, Kerr D. Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma. J Clin Oncol 2011; 29: 1997-2003 [PMID: 21464406 DOI:10.1200/jco.2010.29.4496]
-
(2011)
J Clin Oncol
, vol.29
, pp. 1997-2003
-
-
Hecht, J.R.1
Trarbach, T.2
Hainsworth, J.D.3
Major, P.4
Jäger, E.5
Wolff, R.A.6
Lloyd-Salvant, K.7
Bodoky, G.8
Pendergrass, K.9
Berg, W.10
Chen, B.L.11
Jalava, T.12
Meinhardt, G.13
Laurent, D.14
Lebwohl, D.15
Kerr, D.16
-
111
-
-
79956297102
-
Randomized, placebocontrolled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adenocarcinoma
-
[PMID: 21464401 DOI:10.1200/jco.2010.29.5436]
-
Van Cutsem E, Bajetta E, Valle J, Köhne CH, Hecht JR, Moore M, Germond C, Berg W, Chen BL, Jalava T, Lebwohl D, Meinhardt G, Laurent D, Lin E. Randomized, placebocontrolled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adenocarcinoma. J Clin Oncol 2011; 29: 2004-2010 [PMID: 21464401 DOI:10.1200/jco.2010.29.5436]
-
(2011)
J Clin Oncol
, vol.29
, pp. 2004-2010
-
-
van Cutsem, E.1
Bajetta, E.2
Valle, J.3
Köhne, C.H.4
Hecht, J.R.5
Moore, M.6
Germond, C.7
Berg, W.8
Chen, B.L.9
Jalava, T.10
Lebwohl, D.11
Meinhardt, G.12
Laurent, D.13
Lin, E.14
|