A novel test for selection on cis-regulatory elements reveals positive and negative selection acting on mammalian transcriptional enhancers

Molecular Biology and Evolution

Volumn 30, Issue 11, 2013, Pages 2509-2518

  Smith, Justin D ^a   McManus, Kimberly F ^a   Fraser, Hunter B ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Cis regulation; Enhancer; Natural selection; Neutral; Noncoding

Indexed keywords

ARTICLE; DOWN REGULATION; ENHANCER REGION; GENETIC TRANSCRIPTION; MAMMAL; MUTAGENESIS; MUTATION; NATURAL SELECTION; NONHUMAN; PHYLOGENY; POINT MUTATION; PRESSURE; PRIMATE; UPREGULATION;

CIS-REGULATION; ENHANCER; NATURAL SELECTION; NEUTRAL; NONCODING;

ANIMALS; COMPUTATIONAL BIOLOGY; ENHANCER ELEMENTS, GENETIC; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MAMMALS; MODELS, GENETIC; MUTATION; PHYLOGENY; PROMOTER REGIONS, GENETIC; REGULATORY ELEMENTS, TRANSCRIPTIONAL; REGULATORY SEQUENCES, NUCLEIC ACID; SELECTION, GENETIC;

EID: 84888616764     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/mst134     Document Type: Article

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