Suppression of PTRF alleviates the polymicrobial sepsis induced by cecal ligation and puncture in mice

Journal of Infectious Diseases

Volumn 208, Issue 11, 2013, Pages 1803-1812

  Zheng, Yijie ^a   Lee, Seonjin ^a,b   Liang, Xiaoliang ^a   Wei, Shuquan ^a,c   Moon, Hyung Geun ^a   Jin, Yang ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b Medical Genomics Research Center   (South Korea)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

CLP; Macrophage; Nitric oxide; PTRF; ROS; Sepsis; TLR4

Indexed keywords

LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NUCLEIC ACID BINDING PROTEIN; POLYMERASE I TRANSCRIPT RELEASE FACTOR; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; BLOOD ANALYSIS; CELL FUNCTION; CONTROLLED STUDY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; INTESTINE INJURY; MACROPHAGE; MALE; MORTALITY; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; POLYMICROBIAL SEPSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SEPSIS; SIGNAL TRANSDUCTION; SURVIVAL RATE; TRANSCRIPTION REGULATION;

CLP; MACROPHAGE; NITRIC OXIDE; PTRF; ROS; SEPSIS; TLR4;

ANIMALS; CECUM; CELL LINE; DISEASE MODELS, ANIMAL; LIGATION; LIPOPOLYSACCHARIDES; LIVER; MACROPHAGES; MALE; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PUNCTURES; REACTIVE OXYGEN SPECIES; RNA-BINDING PROTEINS; SEPSIS; SEQUENCE DELETION; SIGNAL TRANSDUCTION; SPECIFIC PATHOGEN-FREE ORGANISMS; TOLL-LIKE RECEPTOR 4;

EID: 84888605980     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit364     Document Type: Article

References (48)

1. Levy MM, Fink MP, Marshall JC, et al. 2001 Sccm/Esicm/Accp/Ats/Sis international sepsis definitions conference. Crit Care Med 2003; 31:1250-6.
2. Munford RS. Severe sepsis and septic shock: The role of gram-negative bacteremia. Annu Rev Pathol 2006; 1:467-96.
3. Annane D, Bellissant E, Cavaillon JM. Septic shock. Lancet 2005; 365:63-78.
4. Biswas SK, Chittezhath M, Shalova IN, Lim JY. Macrophage polarization and plasticity in health and disease. Immunol Res 2012; 53:11-24.
5. Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011; 11:723-37.
6. De Jong HK, Van der Poll T, Wiersinga WJ. The systemic proinflammatory response in sepsis. J Innate Immun 2010; 2:422-30.
7. Heemskerk S, Masereeuw R, Russel FG, Pickkers P. Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury. Nat Rev Nephrol 2009; 5:629-40.
8. Aasen AO, Wang JE. Mediator responses in surgical infections. Surg Infect (Larchmt) 2006; 7:3-4.
9. Simkova V, Baumgart K, Radermacher P, Barth E, Calzia E. Year in review 2006: critical care-multiple organ failure, sepsis, and shock. Crit Care 2007; 11:221.
10. Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: Toll-like receptor 4- And spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res 2009; 104:210-8.
11. Ogawa R, Pacelli R, Espey MG, et al. Comparison of control of listeria by nitric oxide redox chemistry from murine macrophages and no donors: insights into listeriocidal activity of oxidative and nitrosative stress. Free Radic Biol Med 2001; 30:268-76.
12. Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8:958-69.
13. Salomao R, Brunialti MK, Rapozo MM, Baggio-Zappia GL, Galanos C, Freudenberg M. Bacterial sensing, cell signaling, and modulation of the immune response during sepsis. Shock 2012; 38:227-42.
14. Fessler MB, Parks JS. Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling. J Immunol 2011; 187:1529-35.
15. Almeida CJ, Witkiewicz AK, Jasmin JF, Tanowitz HB, Sotgia F, Frank PG, Lisanti MP. Caveolin-2-deficient mice show increased sensitivity to endotoxemia. Cell Cycle 2011; 10:2151-61.
16. Tsai TH, Chen SF, Huang TY, et al. Impaired CD14 and CD36 expression, bacterial clearance, and Toll-like receptor 4-Myd88 signaling in caveolin-1-deleted macrophages and mice. Shock 2011; 35:92-9.
17. Feng H, Guo L, Song Z, et al. Caveolin-1 protects against sepsis by modulating inflammatory response, alleviating bacterial burden, and suppressing thymocyte apoptosis. J Biol Chem 2010; 285:25154-60.
18. Hill MM, Bastiani M, Luetterforst R, et al. PTRF-cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell 2008; 132:113-24.
19. Mason SW, Sander EE, Grummt I. Identification of a transcript release activity acting on ternary transcription complexes containing murine RNA polymerase I. Embo J 1997; 16:163-72.
20. Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I. Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. Embo J 1998; 17:2855-64.
21. Baker CC, Chaudry IH, Gaines HO, Baue AE. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 1983; 94:331-5.
22. Rittirsch D, Huber-Lang MS, Flierl MA, Ward PA. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc 2009; 4:31-6.
23. Bennett B. Isolation and cultivation in vitro of macrophages from various sources in the mouse. Am J Pathol 1966; 48:165-81.
24. Zhang M, Lee SJ, An C, et al. Caveolin-1 mediates fas-bid signaling in hyperoxia-induced apoptosis. Free Radic Biol Med 2011; 50:1252-62.
25. Jin Y, Heck DE, DeGeorge G, Tian Y, Laskin JD. 5-fluorouracil suppresses nitric oxide biosynthesis in colon carcinoma cells. Cancer Res 1996; 56:1978-82.
26. Hubbard WJ, Choudhry M, Schwacha MG, Kerby JD, Rue LR, Bland KI, Chaudry IH. Cecal ligation and puncture. Shock 2005; 24:52-7.
27. Banks JG, Foulis AK, Ledingham IM, Macsween RN. Liver function in septic shock. J Clin Pathol 1982; 35:1249-52.
28. Stuehr DJ, Gross SS, Sakuma I, Levi R, Nathan CF. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. J Exp Med 1989; 169:1011-20.
29. Victor VM, Rocha M, Esplugues JV, Fuente M. Role of free radicals in sepsis: Antioxidant therapy. Curr Pharm Des 2005; 11:3141-58.
30. Fubini B, Hubbard A. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic Biol Med 2003; 34:1507-16.
31. Cobb JP, Hotchkiss RS, Swanson PE, et al. Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice. Surgery 1999; 126:438-42.
32. Hollenberg SM, Broussard M, Osman J, Parrillo JE. Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase. Circ Res 2000; 86:774-8.
33. Lidington D, Li F, Tyml K. Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle. Cardiovasc Res 2007; 74:151-8.
34. Weberpals M, Hermes M, Hermann S, et al. NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits. J Neurosci 2009; 29:14177-84.
35. Duma D, Fernandes D, Bonini MG, Stadler K, Mason RP, Assreuy J. NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses. Eur J Pharmacol 2011; 668:285-92.
36. Gross A, Spiesser S, Terraza A, Rouot B, Caron E, Dornand J. Expression and bactericidal activity of nitric oxide synthase in Brucella suis-infected murine macrophages. Infect Immun 1998; 66: 1309-16.
37. Alam MS, Akaike T, Okamoto S, et al. Role of nitric oxide in host defense in murine salmonellosis as a function of its antibacterial and antiapoptotic activities. Infect Immun 2002; 70:3130-42.
38. Eriksson S, Chambers BJ, Rhen M. Nitric oxide produced by murine dendritic cells is cytotoxic for intracellular Salmonella enterica sv. Typhimurium. Scand J Immunol 2003; 58:493-502.
39. Ketteler M, Cetto C, Kirdorf M, Jeschke GS, Schafer JH, Distler A. Nitric oxide in sepsis-syndrome: potential treatment of septic shock by nitric oxide synthase antagonists. Kidney Int 1998; 64:27-30.
40. Buras JA, Holzmann B, Sitkovsky M. Animal models of sepsis: setting the stage. Nat Rev Drug Discov 2005; 4:854-65.
41. Ebong S, Call D, Nemzek J, Bolgos G, Newcomb D, Remick D. Immunopathologic alterations in murine models of sepsis of increasing severity. Infect Immun 1999; 67:6603-10.
42. Turnbull IR, Buchman TG, Javadi P, Woolsey CA, Hotchkiss RS, Karl IE, Coopersmith CM. Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium. Shock 2004; 22:364-8.
43. Maio A, Torres MB, Reeves RH. Genetic determinants influencing the response to injury, inflammation, and sepsis. Shock 2005; 23:11-7.
44. Dienstknecht T, Schwacha MG, Kang SC, Rue LW, Bland KI, Chaudry IH. Sex steroid-mediated regulation of macrophage/monocyte function in a two-hit model of trauma-hemorrhage and sepsis. Cytokine 2004; 25:110-8.
45. Zellweger R, Zhu XH, Wichmann MW, Ayala A, De Maso CM, Chaudry IH. Prolactin administration following hemorrhagic shock improves macrophage cytokine release capacity and decreases mortality from subsequent sepsis. J Immunol 1996; 157:5748-54.
46. Nabi IR. Cavin fever: regulating caveolae. Nat Cell Biol. 2009; 11:789-91.
47. Hansen CG, Bright NA, Howard G, Nichols BJ. SDPR induces membrane curvature and functions in the formation of caveolae. Nat Cell Biol 2009; 11:807-14.
48. Liu L, Brown D, McKee M, et al. Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab 2008; 8:310-7.