5-fluorouracil suppresses nitric oxide biosynthesis in colon carcinoma cells

Cancer Research

Volumn 56, Issue 9, 1996, Pages 1978-1982

  Jin, Yang ^a   Heck, Diane E ^a   DeGeorge, George ^a   Tian, Yanan ^a   Laskin, Jeffrey D ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; COLON CARCINOMA; DRUG EFFECT; DRUG EFFICACY; ENZYME INHIBITION; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; COLONIC NEOPLASMS; ENZYME INHIBITORS; FLUOROURACIL; HUMANS; INTERFERON TYPE II; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RECEPTORS, INTERFERON; TUMOR CELLS, CULTURED;

EID: 0030010220     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Jenkins, D. C., Charles, I. G , Thomsen, L. L , Moss, D. W , Holmes, L. S., Baylis, S. A., Rhodes, P., Westmore, K., Emson, P. C., and Moncada, S. Role of nitric oxide in tumor growth Proc. Natl Acad. Sci. USA, 92. 4392-4396, 1995.
2. Jenkins, D. C., Charles, I. G., Baylis, S. A., Lelchuk, R., Radomski, M. W., and Moncada, S. Human colon cancer cell lines show a diverse pattern of nitric oxide synthase gene expression and nitric oxide generation. Br J Cancer., 70. 847-849, 1994.
3. Sherman, P. A , Laubach, V. E., Reep, B. R., and Wood, E. R. Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line. Biochemistry, 32: 11600-11605, 1993.
4. Laskin, J. D , Heck, D. E., and Laskin, D. L. Multifunctional role of nitric oxide in inflammation. Trends Endocrinol Metab , 5. 377-382, 1994.
5. Moertel, C. G Chemotherapy for colorectal cancer N Engl J. Med , 330: 1136-1142, 1994.
6. Parker, W B , and Cheng, Y-C. Metabolism and mechanism of action of 5-fluorouracil Pharmacol Ther., 48 381-395, 1990.
7. Heck, D. E., Laskin, D. L., Gardner, C A , and Laskin, J. D Epidermal growth factor suppresses nitric oxide and hydrogen peroxide in keratinocytes. Potential role of nitric oxide in the regulation of wound healing. J. Biol. Chem., 267. 21277-21280, 1992.
8. Mariano, T. M., and Pestka, S Receptor binding studies. In. F. R. Balkwill (ed.), Cytokines: A Practical Approach, pp 95-108. Oxford, United Kingdom: Oxford University Press, 1991.
9. Chu, S. C., Wu, H-P., Banks, T. C , Eissa, N. T., and Moss, J Structural diversity in the 5′-untranslated region of cytokine-stimulated human inducible nitric oxide synthase mRNA. J. Biol. Chem., 270: 10625-10630, 1995.
10. Meijer, A. J., Lamers, W. H., and Chamuleau, R. A. F M Nitrogen metabolism and ornithine cycle function. Physiol. Rev , 70: 701-748, 1990.
11. Evans, R. M., Laskin, J D., and Hakala, M. T. Assessment of growth limiting events caused by 5-fluorouracil in mouse and human cells. Cancer Res., 40. 4113-4122, 1980
12. Wilkinson, D. S., and Pitot, H. C. Inhibition of ribosomal ribonucleic acid maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluorouridine. J. Biol. Chem., 248: 63-68, 1973.
13. Lenz, H-J., Manno, D. J., Danenberg, K. D., and Danenberg, P. V. Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing. J. Biol. Chem., 269. 31962-31968, 1994
14. Darnell, J. E., Jr., Kerr, I M , and Stark, G. R. Jak-STAT pathways and transcriptional activation in response to interferons and other extracellular signaling proteins. Science (Washington DC), 264: 1415-1421, 1994.
15. Chhatwal, V J. S., Ngoi, S. S., Chan, S. T. F., Chia, Y W., and Moochhala, S. M. Aberrant expression of nitric oxide synthase in human polyps, neoplastic colonic mucosa and surrounding peritumoral normal mucosa. Carcinogenesis (Lond.), 15: 2081-2085, 1994.
16. Bors, W., Saran, M., and Michael, C Analysis of oxygen radicals: methods and mechanisms. In: Oberly, L. W. (ed.), Superoxide Dismutase, Vol. 2, pp. 31-62. Boca Raton, FL: CRC Press, 1982.
17. Li, L., Kilbourn, R. G., Adams, J , and Fidler, I. J. Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells. Cancer Res., 51: 2531-2535, 1991.
18. Dong, Z., Staroselsky, A. H , Qi, X., Xie, K., and Fidler, I. J. Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells. Cancer Res., 54: 789-793, 1994.
19. Xie, K., Huang, S., Dong, Z., Gutman, M., and Fidler, I. J. Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362. Cancer Res., 55: 3123-3131, 1995.
20. Xie, K., Huang, S., Dong, Z., Juang, S-h., Gutman, M , Xie, Q-W., Nathan, C., and Fidler, I. J. Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogated metastasis by K-1735 murine melanoma cells. J. Exp. Med., 181: 1333-1343, 1995.