Caveolin-2-deficient mice show increased sensitivity to endotoxemia

Cell Cycle

Volumn 10, Issue 13, 2011, Pages 2151-2161

  De Almeida, Cecilia J ^a,c   Witkiewicz, Agnieszka K ^a   Jasmin, Jean François ^a,b   Tanowitz, Herbert B ^d   Sotgia, Federica ^a,b   Frank, Philippe G ^a,b   Lisanti, Michael P ^a,b  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Caveolin; Endotoxemia; Inflammation; Lipopolysaccharide; Nitric oxide; Permeability; Sepsis

Indexed keywords

CAVEOLIN 1; CAVEOLIN 2; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROTEIN; STAT1 PROTEIN; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENDOTOXEMIA; INTESTINE CELL; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SENSITIVITY ANALYSIS; SEPSIS; WILD TYPE;

MUS;

EID: 79960014887     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.13.16234     Document Type: Article

References (35)

1. Wang XM, Kim HP, Song R, Choi AM. Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway. Am J Respir Cell Mol Biol 2006; 34:434-42.
2. Scherer PE, Lewis RY, Volonte D, Engelman JA, Galbiati F, Couet J, et al. Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo. J Biol Chem 1997; 272:29337-46. (Pubitemid 27498228)
3. Couet J, Li S, Okamoto T, Ikezu T, Lisanti MP. Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J Biol Chem 1997; 272:6525-33. (Pubitemid 27118133)
4. Park DS, Lee H, Frank PG, Razani B, Nguyen AV, Parlow AF, et al. Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation and hyperactivation of the Jak-2/STAT5a signaling cascade. Mol Biol Cell 2002; 13:3416-30. (Pubitemid 35191364)
5. Cohen AW, Hnasko R, Schubert W, Lisanti MP. Role of caveolae and caveolins in health and disease. Physiol Rev 2004; 84:1341-79. (Pubitemid 39287953)
6. Breuza L, Corby S, Arsanto JP, Delgrossi MH, Scheiffele P, Le Bivic A. The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells. J Cell Sci 2002; 115:4457-67. (Pubitemid 36004407)
7. Fujimoto T, Kogo H, Nomura R, Une T. Isoforms of caveolin-1 and caveolar structure. J Cell Sci 2000; 113:3509-17.
8. Sowa G, Pypaert M, Fulton D, Sessa WC. The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation. Proc Natl Acad Sci USA 2003; 100:6511-6. (Pubitemid 36666612)
9. Shmuel M, Nodel-Berner E, Hyman T, Rouvinski A, Altschuler Y. Caveolin 2 regulates endocytosis and trafficking of the M1 muscarinic receptor in MDCK epithelial cells. Mol Biol Cell 2007; 18:1570-85. (Pubitemid 46717541)
10. Garrean S, Gao XP, Brovkovych V, Shimizu J, Zhao YY, Vogel SM, et al. Caveolin-1 regulates NFkappaB activation and lung inflammatory response to sepsis induced by lipopolysaccharide. J Immunol 2006; 177:4853-60. (Pubitemid 44469821)
11. Medina FA, de Almeida CJ, Dew E, Li J, Bonuccelli G, Williams TM, et al. Caveolin-1-deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar Typhimurium infection. Infect Immun 2006; 74:6665-74. (Pubitemid 44913140)
12. Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, et al. Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol 2000; 165:4272-80.
13. Lei MG, Morrison DC. Differential expression of caveolin-1 in lipopolysaccharide-activated murine macrophages. Infect Immun 2000; 68:5084-9.
14. Lei MG, Tan X, Qureshi N, Morrison DC. Regulation of cellular caveolin-1 protein expression in murine macrophages by microbial products. Infect Immun 2005; 73:8136-43. (Pubitemid 41740301)
15. Wang XM, Kim HP, Nakahira K, Ryter SW, Choi AM. The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. J Immunol 2009; 182:3809-18.
16. Razani B, Engelman JA, Wang XB, Schubert W, Zhang XL, Marks CB, et al. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem 2001; 276:38121-38.
17. Boughton-Smith NK, Evans SM, Hawkey CJ, Cole AT, Balsitis M, Whittle BJ, et al. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet 1993; 342:338-40. (Pubitemid 23227564)
18. Unno N, Wang H, Menconi MJ, Tytgat SH, Larkin V, Smith M, et al. Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology 1997; 113:1246-57. (Pubitemid 27418978)
19. Forsythe RM, Xu DZ, Lu Q, Deitch EA. Lipopolysaccharide-induced enterocyte-derived nitric oxide induces intestinal monolayer permeability in an autocrine fashion. Shock 2002; 17:180-4.
20. Vallance BA, Dijkstra G, Qiu B, van der Waaij LA, van Goor H, Jansen PL, et al. Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity. Am J Physiol Gastrointest Liver Physiol 2004; 287:865-74.
21. Kubes P, McCafferty DM. Nitric oxide and intestinal inflammation. Am J Med 2000; 109:150-8.
22. Gao JJ, Filla MB, Fultz MJ, Vogel SN, Russell SW, Murphy WJ. Autocrine/paracrine IFN-alphabeta mediates the lipopolysaccharide-induced activation of transcription factor Stat1alpha in mouse macrophages: pivotal role of Stat1alpha in induction of the inducible nitric oxide synthase gene. J Immunol 1998; 161:4803-10. (Pubitemid 28492057)
23. Jacobs AT, Ignarro LJ. Lipopolysaccharide-induced expression of interferon-beta mediates the timing of inducible nitric-oxide synthase induction in RAW 264.7 macrophages. J Biol Chem 2001; 276:47950-7.
24. Albrecht EW, Stegeman CA, Heeringa P, Henning RH, van Goor H. Protective role of endothelial nitric oxide synthase. J Pathol 2003; 199:8-17. (Pubitemid 36061187)
25. Hokari R, Kato S, Matsuzaki K, Kuroki M, Iwai A, Kawaguchi A, et al. Reduced sensitivity of inducible nitric oxide synthase-deficient mice to chronic colitis. Free Radic Biol Med 2001; 31:153-63. (Pubitemid 32607582)
26. Palatka K, Serfozo Z, Vereb Z, Hargitay Z, Lontay B, Erdodi F, et al. Changes in the expression and distribution of the inducible and endothelial nitric oxide synthase in mucosal biopsy specimens of inflammatory bowel disease. Scand J Gastroenterol 2005; 40:670-80. (Pubitemid 40827529)
27. Guo FH, Comhair SA, Zheng S, Dweik RA, Eissa NT, Thomassen MJ, et al. Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis. J Immunol 2000; 164:5970-80. (Pubitemid 30389845)
28. Ohmori Y, Hamilton TA. Requirement for STAT1 in LPS-induced gene expression in macrophages. J Leukoc Biol 2001; 69:598-604. (Pubitemid 32294845)
29. Samardzic T, Jankovic V, Stosic-Grujicic S, Trajkovic V. STAT1 is required for iNOS activation, but not IL-6 production in murine fibroblasts. Cytokine 2001; 13:179-82.
30. Stempelj M, Kedinger M, Augenlicht L, Klampfer L. Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate. J Biol Chem 2007; 282:9797-804. (Pubitemid 47104628)
31. Connelly L, Palacios-Callender M, Ameixa C, Moncada S, Hobbs AJ. Biphasic regulation of NFkappaB activity underlies the pro- and anti-inflammatory actions of nitric oxide. J Immunol 2001; 166:3873-81. (Pubitemid 32224913)
32. 2+-calmodulin and caveolin. J Biol Chem 1997; 272:15583-6.
33. Feron O, Dessy C, Moniotte S, Desager JP, Balligand JL. Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase. J Clin Invest 1999; 103:897-905. (Pubitemid 29152636)
34. Bucci M, Gratton JP, Rudic RD, Acevedo L, Roviezzo F, Cirino G, et al. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nat Med 2000; 6:1362-7.
35. Shah M, Patel K, Fried VA, Sehgal PB. Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever. J Biol Chem 2002; 277:45662-9. (Pubitemid 36159178)