Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors

Journal of Controlled Release

Volumn 174, Issue 1, 2014, Pages 63-71

  Mi, Peng ^a,b   Kokuryo, Daisuke ^c   Cabral, Horacio ^a   Kumagai, Michiaki ^d   Nomoto, Takahiro ^a   Aoki, Ichio ^c   Terada, Yasuko ^e   Kishimura, Akihiro ^a   Nishiyama, Nobuhiro ^b   Kataoka, Kazunori ^a,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

Author keywords

Block copolymer; Calcium phosphate nanoparticles; Cancer diagnosis; Gd DTPA; Hydrothermal synthesis; MRI

Indexed keywords

AMINO ACIDS; BLOCK COPOLYMERS; CALCIUM PHOSPHATE; CARDIOVASCULAR SYSTEM; DIAGNOSIS; DISEASES; HYDROTHERMAL SYNTHESIS; MAGNETIC RESONANCE IMAGING; NANOMAGNETICS; NANOPARTICLES; ORGANIC-INORGANIC MATERIALS; POLYETHYLENE GLYCOLS; SELF ASSEMBLY; SOLS; TUMORS;

CALCIUM PHOSPHATE NANOPARTICLES; CANCER DIAGNOSIS; DIETHYLENETRIAMINE PENTA-ACETIC ACIDS; ENHANCED PERMEABILITY AND RETENTION EFFECTS; GD-DTPA; HYDROTHERMALLY SYNTHESIZED; MAGNETIC RESONANCE IMAGING CONTRAST AGENTS; PHYSIOLOGICAL ENVIRONMENT;

GADOLINIUM COMPOUNDS;

CALCIUM PHOSPHATE; DRUG CARRIER; GADOLINIUM PENTETATE; NANOPARTICLE; POLY(ETHYLENE GLYCOL)BETA POLY(ASPARTIC ACID)BLOCK COPOLYMER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; CARCINOMA IN SITU; CIRCULATION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HYDRODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SOLID TUMOR; TUMOR DIAGNOSIS;

BLOCK COPOLYMER; CALCIUM PHOSPHATE NANOPARTICLES; CANCER DIAGNOSIS; GD-DTPA; HYDROTHERMAL SYNTHESIS; MRI;

ANIMALS; BIOLOGICAL AVAILABILITY; CALCIUM PHOSPHATES; CELL LINE, TUMOR; CELL SURVIVAL; CONTRAST MEDIA; DRUG CARRIERS; FEMALE; GADOLINIUM DTPA; HOT TEMPERATURE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MAGNETIC RESONANCE IMAGING; MICE; MICE, NUDE; NANOPARTICLES; NEOPLASMS; POLYETHYLENE GLYCOLS;

EID: 84888590878     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.10.038     Document Type: Article

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