Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles

Journal of Controlled Release

Volumn 161, Issue 3, 2012, Pages 868-874

  Pittella, Frederico ^a,b   Miyata, Kanjiro ^a   Maeda, Yoshinori ^b   Suma, Tomoya ^b   Watanabe, Sumiyo ^a   Chen, Qixian ^b   Christie, R James ^a   Osada, Kensuke ^b   Nishiyama, Nobuhiro ^a   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Calcium phosphate; Charge conversional polymer; Nanoparticle; PEG; siRNA; VEGF

Indexed keywords

ACIDIC CONDITIONS; CALCIUM IONS; CANCER THERAPY; CATIONIC GROUPS; DELIVERY VEHICLE; GENE SILENCING; HYBRID NANOPARTICLE; IN-VIVO; IONIC CONDITIONS; PANCREATIC CANCERS; PH SENSITIVE; POLYMER HYBRID; SIRNA; SMALL INTERFERING RNA (SIRNA); SMART POLYMERS; SOLID TUMORS; SYSTEMIC ADMINISTRATION; TUMOR GROWTH; VASCULAR ENDOTHELIUM GROWTH FACTORS; VEGF;

BIOCOMPATIBILITY; BLOCK COPOLYMERS; CALCIUM PHOSPHATE; CELLS; CYTOLOGY; FUNCTIONAL GROUPS; GENETIC ENGINEERING; ONCOLOGY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYMERS; RNA; TUMORS;

NANOPARTICLES;

CALCIUM PHOSPHATE; CHARGE CONVERSIONAL POLYMER; MACROGOL; NANOPARTICLE; POLYMER; SMALL INTERFERING RNA; SMALL INTERFERING RNA VASCULOTROPIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCOMPATIBILITY; CANCER CELL CULTURE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; ENDOSOME; FEMALE; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS CANCER; PARTICLE SIZE; PRIORITY JOURNAL; SOLID TUMOR; TREATMENT OUTCOME; TUMOR GROWTH; TUMOR VOLUME;

ANIMALS; CALCIUM PHOSPHATES; CELL LINE, TUMOR; DRUG CARRIERS; FEMALE; GENE SILENCING; HUMANS; MICE; MICE, NUDE; NANOPARTICLES; PANCREATIC NEOPLASMS; POLYETHYLENE GLYCOLS; RNA, MESSENGER; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84864619239     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.005     Document Type: Article

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