The use of calcium phosphate nanoparticles encapsulating Toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activation

Biomaterials

Volumn 31, Issue 21, 2010, Pages 5627-5633

  Sokolova, Viktoriya ^a   Knuschke, Torben ^b   Kovtun, Anna ^a   Buer, Jan ^b   Epple, Matthias ^a   Westendorf, Astrid Maria ^b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Calcium phosphate; Cell activation; Cell signaling; Immunostimulation; Nanoparticle

Indexed keywords

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELLS; BROWNIAN MOTION; CALCIUM PHOSPHATE NANOPARTICLES; CELL ACTIVATION; CELL SIGNALING; CONFOCAL LASER SCANNING MICROSCOPY; CYTOKINE PRODUCTION; DENDRITIC CELLS; FUNCTIONALIZED; IMMUNOSTIMULATION; SURFACE MOLECULES; T CELL ACTIVATION; T CELLS; TOLL-LIKE RECEPTORS; ULTRACENTRIFUGATION; UP-REGULATION;

ANTIGENS; BROWNIAN MOVEMENT; CALCIUM; CELLS; CENTRIFUGATION; CONFOCAL MICROSCOPY; CYTOLOGY; DENDRIMERS; LIGANDS; NANOPARTICLES; OLIGONUCLEOTIDES; PHOSPHATES; SCANNING ELECTRON MICROSCOPY; SIGNALING;

CALCIUM PHOSPHATE;

CALCIUM PHOSPHATE; CPG OLIGODEOXYNUCLEOTIDE; CYTOKINE; FLUORESCENT DYE; HEMAGGLUTININ; NANOCARRIER; NANOPARTICLE; OLIGONUCLEOTIDE; TOLL LIKE RECEPTOR;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; IMMUNOSTIMULATION; INNATE IMMUNITY; LIGHT SCATTERING; LYMPHOCYTE PROLIFERATION; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SURFACE CHARGE; T LYMPHOCYTE ACTIVATION; ULTRACENTRIFUGATION; UPREGULATION;

ANIMALS; CALCIUM PHOSPHATES; DENDRITIC CELLS; HEMAGGLUTININS; LIGANDS; LYMPHOCYTE ACTIVATION; MATERIALS TESTING; MICE; MICE, INBRED BALB C; NANOPARTICLES; T-LYMPHOCYTES; TOLL-LIKE RECEPTORS; VIRAL VACCINES;

EID: 77953024125     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.03.067     Document Type: Article

References (30)

1. Byrd W., de Lorimier A., Zheng Z.-R., Cassels F.J. Microencapsulated subunit vaccine approach to enterotoxigenic Escherichia coli and other mucosal pathogens. Adv Drug Deliv Rev 2005, 57:1362-1380.
2. Reddy S.T., Swartz M.A., Hubbell J.A. Targeting dendritic cells with biomaterials: developing the next generation of vaccines. Trends Immunol 2006, 12:573-579.
3. Datta S.K., Cho H.J., Takabayashi K., Horner A.A., Raz E. Antigen-immunostimulatory oligonucleotide conjugates (AIC): mechanisms and applications. Immunol Rev 2004, 199:217-226.
4. Jérôme V., Graser A., Müller R., Kontermann R.E., Konur A. Cytotoxic T lymphocytes responding to low dose TRP2 antigen are Induced against B16 melanoma by liposome-encapsulated TRP2 peptide and CpG DNA adjuvant. J Immunother 2006, 29:294-305.
5. Kaiser-Schulz G., Heit A., Quintanilla-Martinez L., Hammerschmidt F., Hess S., Jennen L., et al. Polylactide-coglycolide microspheres co-encapsulating recombinant tandem prion protein with CpG-oligonucleotide break self-tolerance to prion protein in wild-type mice and induce CD4 and CD8 T cell responses. J Immunol 2007, 179:2797-2807.
6. Epple M., Ganesan K., Heumann R., Klesing J., Kovtun A., Neumann S., et al. Application of calcium phosphate nanoparticles in biomedicine. J Mater Chem 2010, 20:18-23.
7. Dorozhkin S.V., Epple M. Biological and medical significance of calcium phosphates. Angew Chem Int Ed 2002, 41:3130-3146.
8. Neumann S., Kovtun A., Dietzel I.D., Epple M., Heumann R. The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimise intracellular calcium disturbance during transfection. Biomaterials 2009, 30:6794-6802.
9. Sokolova V.V., Radtke I., Heumann R., Epple M. Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles. Biomaterials 2006, 27:3147-3153.
10. Sokolova V., Kovtun A., Prymak O., Meyer-Zaika W., Kubareva E.A., Romanova E.A., et al. Functionalisation of calcium phosphate nanoparticles by oligonucleotides and their application to gene silencing. J Mater Chem 2007, 17:721-727.
11. Sokolova V., Epple M. Inorganic nanoparticles as carriers of nucleic acids into cells. Angew Chem Int Ed 2008, 47:1382-1395.
12. Schulz O., Diebold S.S., Chen M., Näslund T.I., Nolte M.A., Alexopoulou L., et al. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 2005, 433:887-892.
13. Verdijk R.M., Mutis T., Esendam B., Kamp J., Melief C.J., Brand A., et al. Polyriboinosinic polyribocytidylic acid (poly(I: C)) induces stable maturation of functionally active human dendritic cells. J Immunol 1999, 163:57-61.
14. Napolitani G., Rinaldi A., Bertoni F., Sallusto F., Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 2005, 6:769-776.
15. Sokolova V., Kovtun A., Heumann R., Epple M. Tracking the pathway of calcium phosphate/DNA nanoparticles during cell transfection by incorporation of red-fluorescing tetramethylrhodamine isothiocyanate-bovine serum albumin into these nanoparticles. J Biol Inorg Chem 2007, 12:174-179.
16. Kirberg J., Baron A., Jakob S., Rolink A., Karjalainen K., von Boehmer H. Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J Exp Med 1994, 180:25-34.
17. Foged C., Brodin B., Frokjaer S., Sundblad A. Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model. Int J Pharm 2005, 298:315-322.
18. Zwiorek K., Bourquin C., Battiany J., Winter G., Endres S., Hartmann G., et al. Delivery by cationic gelatin nanoparticles strongly increases the immunostimulatory effects of CpG oligonucleotides. Pharm Res 2008, 25:551-562.
19. Hart D.N. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 1997, 90:3245-3287.
20. Ponsaerts P., van Tendeloo V.F., Berneman Z.N. Cancer immunotherapy using RNA-loaded dendritic cells. Clin Exp Immunol 2003, 134:378-384.
21. Macatonia S.E., Hosken N.A., Litton M., Vieira P., Hsieh C.S., Culpepper J.A., et al. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 1995, 154:5071-5079.
22. Choy J.H., Kwak S.Y., Jeong Y.J., Park J.S. Inorganic layered double hydroxides as nonviral vectors. Angew Chem Int Ed 2000, 39:4042-4045.
23. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature 1998, 392:245-252.
24. Langenkamp A., Messi M., Lanzavecchia A., Sallusto F. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol 2000, 1:311-316.
25. Diwan M., Tafaghodi M., Samuel J. Enhancement of immune responses by co-delivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheres. J Control Release 2002, 85:247-262.
26. Chikh G., de Jong S.D., Sekirov L., Raney S.G., Kazem M., Wilson K.D., et al. Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles. Int Immunol 2009, 21:757-767.
27. Suzuki Y., Wakita D., Chamoto K., Narita Y., Tsuji T., Takeshima T., et al. Liposome-encapsulated CpG oligodeoxynucleotides as a potent adjuvant for inducing type 1 innate immunity. Cancer Res 2004, 64:8754-8760.
28. Fearon K., Marshall J.D., Abbate C., Subramanian S., Yee P., Gregorio J., et al. A minimal human immunostimulatory CpG motif that potently induces IFN-gamma and IFN-alpha production. Eur J Immunol 2003, 33:2114-2122.
29. Marshall J.D., Higgins D., Abbate C., Yee P., Teshima G., Ott G., et al. Polymyxin B enhances ISS-mediated immune responses across multiple species. Cell Immunol 2004, 229:93-105.
30. Kerkmann M., Lochmann D., Weyermann J., Marschner A., Poeck H., Wagner M., et al. Immunostimulatory properties of CpG-oligonucleotides are enhanced by the use of protamine nanoparticles. Oligonucleotides 2006, 16:313-322.