Biocompatible and pH-sensitive PLGA encapsulated MnO nanocrystals for molecular and cellular MRI

ACS Nano

Volumn 5, Issue 5, 2011, Pages 3438-3446

  Bennewitz, Margaret F ^a   Lobo, Tricia L ^b   Nkansah, Michael K ^a   Ulas, Gözde ^b   Brudvig, Gary W ^b   Shapiro, Erik M ^a,b  

^a Yale University   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Cells; Contrast agents; Manganese; Microparticles; MRI; Nanoparticles; PLGA

Indexed keywords

CELL UPTAKE; CELLULAR IMAGING; CONTRAST AGENT; ENCAPSULATION EFFICIENCY; IRON-BASED; MICRO-PARTICLES; MR IMAGES; MRI CONTRAST AGENTS; PH SENSITIVE; PHYSIOLOGICAL PH; PLGA; POLY(LACTIC-CO-GLYCOLIC ACID); SLOW RELEASE; TUMOR TARGETING;

EMULSIFICATION; ENCAPSULATION; MAGNETIC RESONANCE IMAGING; MANGANESE; MOLECULAR BIOLOGY; NANOCRYSTALS; PH;

MANGANESE OXIDE;

BIOMATERIAL; CONTRAST MEDIUM; DIAGNOSTIC AGENT; LACTIC ACID; MANGANESE DERIVATIVE; MANGANESE OXIDE; NANOMATERIAL; OXIDE; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ARTICLE; CELL TRACKING; CHEMISTRY; GLIOBLASTOMA; HUMAN; METABOLISM; METHODOLOGY; PATHOLOGY; PH; SYNTHESIS; TUMOR CELL LINE;

BIOCOMPATIBLE MATERIALS; CELL LINE, TUMOR; CELL TRACKING; CONTRAST MEDIA; GLIOBLASTOMA; HUMANS; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MANGANESE COMPOUNDS; NANOSTRUCTURES; OXIDES; POLYGLYCOLIC ACID;

EID: 80051496142     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn1019779     Document Type: Article

References (40)

1. Lauterbur, P. C. Progress in NMR. Zeugmatography Imaging. Philos. Trans. R. Soc. London, Ser. B 1980, 289, 483-487.
2. Lee, J. H.; Silva, A. C.; Merkle, H.; Koretsky, A. P. Manganese-Enhanced Magnetic Resonance Imaging of Mouse Brain After Systemic Administration of MnCl2: Dose-Dependent and Temporal Evolution of T1 Contrast. Magn. Reson. Med. 2005, 53, 640-648. (Pubitemid 40332285)
3. Tambalo, S.; Daducci, A.; Fiorini, S.; Boschi, F.; Mariani, M.; Marinone, M.; Sbarbati, A.; Marzola, P. Experimental Protocol for Activation-Induced Manganese-Enhanced MRI (AIM-MRI) Based on Quantitative Determination of Mn Content in Rat Brain by Fast T1Mapping. Magn. Reson. Med. 2009, 62, 1080-1084.
4. Angenstein, F.; Niessen, H. G.; Goldschmidt, J.; Lison, H.; Altrock, W. D.; Gundelfinger, E. D.; Scheich, H. Manganese-Enhanced MRI Reveals Structural and Functional Changes in the Cortex of Bassoon Mutant Mice. Cereb. Cortex 2007, 17, 28-36. (Pubitemid 44973892)
5. Tucciarone, J.; Chuang, K. H.; Dodd, S. J.; Silva, A.; Pelled, G.; Koretsky, A. P. Layer Specific Tracing of Corticocortical and Thalamocortical Connectivity in the Rodent Using Manganese Enhanced MRI. Neuroimage 2009, 44, 923-931.
6. Pautler, R. G.; Silva, A. C.; Koretsky, A. P. In Vivo Neuronal Tract Tracing Using Manganese-Enhanced Magnetic Resonance Imaging. Magn. Reson. Med. 1998, 40, 740-748. (Pubitemid 28493653)
7. Matsuda, K.; Wang, H. X.; Suo, C.; McCombe, D.; Horne, M. K.; Morrison, W. A.; Egan, G. F. Retrograde Axonal Tracing Using Manganese Enhanced Magnetic Resonance Imaging. Neuroimage 2010, 50, 366-374.
8. Lee, J. H.; Koretsky, A. P. Manganese Enhanced Magnetic Resonance Imaging. Curr. Pharm. Biotechnol. 2004, 5, 529-537. (Pubitemid 39654850)
9. Aoki, I.; Tanaka, C.; Takegami, T.; Ebisu, T.; Umeda, M.; Fukunaga, M.; Fukuda, K.; Silva, A. C.; Koretsky, A. P.; Naruse, S. Dynamic Activity-Induced Manganese-Dependent Contrast Magnetic Resonance Imaging (DAIM MRI). Magn. Reson. Med. 2002, 48, 927-933. (Pubitemid 35398521)
10. Silva, A. C.; Lee, J. H.; Aoki, I.; Koretsky, A. P. Manganese-Enhanced Magnetic Resonance Imaging (MEMRI): Methodological and Practical Considerations. NMR Biomed. 2004, 17, 532-543. (Pubitemid 40124779)
11. Shapiro, E. M.; Koretsky, A. P. Convertible Manganese Contrast for Molecular and Cellular MRI. Magn. Reson. Med. 2008, 60, 265-269.
12. Gilad, A. A.; Walczak, P.; McMahon, M. T.; Na, H. B.; Lee, J. H.; An, K.; Hyeon, T.; van Zijl, P. C.; Bulte, J. W. MR Tracking of Transplanted Cells With "Positive Contrast" Using Manganese Oxide Nanoparticles. Magn. Reson. Med. 2008, 60, 1-7. (Pubitemid 351956602)
13. Pan, D.; Senpan, A.; Caruthers, S. D.; Williams, T. A.; Scott, M. J.; Gaffney, P. J.; Wickline, S. A.; Lanza, G. M. Sensitive and Efficient Detection of Thrombus with Fibrin-Specific Manganese Nanocolloids. Chem. Commun. 2009, 3234-3236.
14. Shin, J.; Anisur, R. M.; Ko, M. K.; Im, G. H.; Lee, J. H.; Lee, I. S. Hollow Manganese Oxide Nanoparticles as Multifunctional Agents for Magnetic Resonance Imaging and Drug Delivery. Angew. Chem., Int. Ed. 2009, 48, 321-324.
15. Huang, C. C.; Khu, N. H.; Yeh, C. S. The Characteristics of Sub 10 Nm Manganese Oxide T1 Contrast Agents of Different Nanostructured Morphologies. Biomaterials 2010, 31, 4073-4078.
16. Choi, J. Y.; Lee, S. H.; Na, H. B.; An, K.; Hyeon, T.; Seo, T. S. In Vitro Cytotoxicity Screening of Water-Dispersible Metal Oxide Nanoparticles in Human Cell Lines. Bioprocess. Biosyst. Eng. 2010, 33, 21-30.
17. Hinds, K. A.; Hill, J. M.; Shapiro, E. M.; Laukkanen, M. O.; Silva, A. C.; Combs, C. A.; Varney, T. R.; Balaban, R. S.; Koretsky, A. P.; Dunbar, C. E. Highly Efficient Endosomal Labeling of Progenitor and Stem Cells with Large Magnetic Particles Allows Magnetic Resonance Imaging of Single Cells. Blood 2003, 102, 867-872. (Pubitemid 36917777)
18. Arbab, A. S.; Wilson, L. B.; Ashari, P.; Jordan, E. K.; Lewis, B. K.; Frank, J. A. A Model of Lysosomal Metabolism of Dextran Coated Superparamagnetic Iron Oxide (SPIO) Nanoparticles: Implications for Cellular Magnetic Resonance Imaging. NMR Biomed. 2005, 18, 383-389. (Pubitemid 41410358)
19. Bulte, J. W.; Duncan, I. D.; Frank, J. A. In Vivo Magnetic Resonance Tracking of Magnetically Labeled Cells After Transplantation. J. Cereb. Blood Flow Metab. 2002, 22, 899-907. (Pubitemid 34831596)
20. Shapiro, E. M.; Skrtic, S.; Koretsky, A. P. Sizing It Up: Cellular MRI Using Micron-Sized Iron Oxide Particles. Magn. Reson. Med. 2005, 53, 329-338. (Pubitemid 40171047)
21. Shapiro, E. M.; Gonzalez-Perez, O.; Garcia-Verdugo, J. M.; Alvarez-Buylla, A.; Koretsky, A. P. Magnetic Resonance Imaging of the Migration of Neuronal Precursors Generated in the Adult Rodent Brain. Neuroimage 2006, 32, 1150-1157. (Pubitemid 44278680)
22. Yin, M.; O'Brien, S. Synthesis of Monodisperse Nanocrystals of Manganese Oxides. J. Am. Chem. Soc. 2003, 125, 10180-10181. (Pubitemid 37022222)
23. Borenfreund, E.; Babich, H.; Martin-Alguacil, N. Comparisons of Two In Vitro Cytotoxicity Assays: The Neutral Red (NR) and Tetrazolium MTT Tests. Toxicol. In Vitro 1988, 2, 1-6. (Pubitemid 18077868)
24. Reed, G. H.; Ray, W. J., Jr. Electron Paramagnetic Resonance Studies of Manganese (II) Coordination in the Phosphoglucomutase System. Biochemistry 1971, 10, 3190-3197.
25. Louie, A. Y.; Huber, M. M.; Ahrens, E. T.; Rothbacher, U.; Moats, R.; Jacobs, R. E.; Fraser, S. E.; Meade, T. J. In Vivo Visualization of Gene Expression Using Magnetic Resonance Imaging. Nat. Biotechnol. 2000, 18, 321-325. (Pubitemid 30159486)
26. Li, W. H.; Parigi, G.; Fragai, M.; Luchinat, C.; Meade, T. J. Mechanistic Studies of a Calcium-Dependent MRI Contrast Agent. Inorg. Chem. 2002, 41, 4018-4024.
27. Major, J. L.; Parigi, G.; Luchinat, C.; Meade, T. J. The Synthesis and In Vitro Testing of a Zinc-Activated MRI Contrast Agent. Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 13881-13886. (Pubitemid 350003305)
28. Toft, K. G.; Hustvedt, S. O.; Grant, D.; Martinsen, I.; Gordon, P. B.; Friisk, G. A.; Korsmo, A. J.; Skotland, T. Metabolism and Pharmacokinetics of MnDPDP in Man. Acta Radiologica 1997, 38, 677-689. (Pubitemid 127453087)
29. Schmidt, P. P.; Toft, K. G.; Skotland, T.; Andersson, K. K. Stability and Transmetallation of the Magnetic Resonance Contrast Agent MnDPDP Measured by EPR. J. Biol. Inorg. Chem. 2002, 7, 241-248. (Pubitemid 36056376)
30. Martin, D. R.; Semelka, R. C.; Chung, J. J.; Balci, N. C.; Wilber, K. Sequential Use of Gadolinium Chelate and Mangafodipir Trisodium for the Assessment of Focal Liver Lesions: Initial Observations. Magn. Reson. Imaging 2000, 18, 955-963.
31. King, L. J.; Burkill, G. J. C.; Scurr, E. D.; Vlavianos, P.; Murray-Lyons, I.; Healy, J. C. MnDPDP Enhanced Magnetic Resonance Imaging of Focal Liver Lesions. Clin. Radiol. 2002, 57, 1047-1057. (Pubitemid 35452739)
32. Shapiro, E. M.; Sharer, K.; Skrtic, S.; Koretsky, A. P. In Vivo Detection of Single Cells by MRI. Magn. Reson. Med. 2006, 55, 242-249. (Pubitemid 43238090)
33. Tannock, I. F.; Rotin, D. Acid pH in Tumors and Its Potential for Therapeutic Exploitation. Cancer Res. 1989, 49, 4373-4384. (Pubitemid 19208329)
34. Kamaly, N.; Kalber, T.; Thanou, M.; Bell, J. D.; Miller, A. D. Folate Receptor Targeted Bimodal Liposomes for Tumor Magnetic Resonance Imaging. Bioconjugate Chem. 2009, 20, 648-655.
35. Mamot, C.; Rochlitz, C. Targeting the Epidermal Growth Factor Receptor (EGFR)-A New Therapeutic Option in Oncology?. Swiss Med. Wkly. 2006, 136, 4-12. (Pubitemid 43151760)
36. Pirko, I.; Ciric, B.; Johnson, A. J.; Gamez, J.; Rodriguez, M.; Macura, S. Magnetic Resonance Imaging of Immune Cells in Inflammation of Central Nervous System. Croat. Med. J. 2003, 44, 463-468. (Pubitemid 37092806)
37. Hu, D. E.; Kettunen, M. I.; Brindle, K. M. Monitoring T-Lymphocyte Trafficking in Tumors Undergoing Immune Rejection. Magn. Reson. Med. 2005, 54, 1473-1479. (Pubitemid 41740777)
38. Ahrens, E. T.; Flores, R.; Xu, H.; Morel, P. A. In Vivo Imaging Platform for Tracking Immunotherapeutic Cells. Nat. Biotechnol. 2005, 23, 983-987. (Pubitemid 41114032)
39. Wu, Y. L.; Ye, Q.; Foley, L. M.; Hitchens, T. K.; Sato, K.; Williams, J. B.; Ho, C. In Situ Labeling of Immune Cells with Iron Oxide Particles: An Approach To Detect Organ Rejection by Cellular MRI. Proc. Natl. Acad. Sci. U. S. A. 2006, 103, 1852-1857. (Pubitemid 43228782)
40. Aoki, I.; Takahashi, Y.; Chuang, K. H.; Silva, A. C.; Igarashi, T.; Tanaka, C.; Childs, R. W.; Koretsky, A. P. Cell Labeling for Magnetic Resonance Imaging with the T1 Agent Manganese Chloride. NMR Biomed. 2006, 19, 50-59. (Pubitemid 43250789)