Effect of biocompatible polymers on the physicochemical and dissolution properties of fenofibrate in nanoparticle system

Journal of Pharmaceutical Investigation

Volumn 43, Issue 6, 2013, Pages 507-512

  Choi, Jong Hak ^a   Lee, Kibum ^a   Hong, Sungho ^a   Lee, Seok Kyu ^a   Oh, Yu Kyoung ^b   Choi, Seung Kyu ^a   Choi, Han Gon ^c  

^a Sejong Science High School   (South Korea)

^b Seoul National University   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Biocompatible polymers; Dissolution; Fenofibrate; Nanoparticle preparation method; Solubility

Indexed keywords

BIOMATERIAL; CARBOMER; ETHYL CELLULOSE; FENOFIBRATE; HYDROXYPROPYLMETHYLCELLULOSE; NANOPARTICLE; POVIDONE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; THERMAL ANALYSIS; X RAY POWDER DIFFRACTION;

EID: 84888426098     PISSN: 20935552     EISSN: 20936214     Source Type: Journal    
DOI: 10.1007/s40005-013-0100-5     Document Type: Article

References (18)

1. Cho KH, Choi HG (2013) Development of novel bepotastine salicylate salt bioequivalent to the commercial bepotastine besilate in beagle dogs. Drug Dev Ind Pharm 39(6): 901-908.
2. Hernandez JI, Gharly ES, Malave A, Marti A (1994) Controlled-release matrix of acetaminophen-ethylcellulose solid dispersion. Drug Dev Ind Pharm 20: 1253-1265.
3. Joe JH, Lee WM, Park YJ, Joe KH, Oh DH, Seo YG, Woo JS, Yong CS, Choi HG (2010) Effect of the solid-dispersion method on the solubility and crystalline property of tacrolimus. Int J Pharm 395: 161-166.
4. Kang JH, Oh DH, Oh YK, Yong CS, Choi HG (2012) Effects of solid carriers on the crystalline properties, dissolution and bioavailability of flurbiprofen in solid self-nanoemulsifying drug delivery system (solid SNEDDS). Eur J Pharm Biopharm 80(2): 289-297.
5. Kim YI, Kim KS, Suh KH, Shanmugam S, Woo JS, Yong CS, Choi HG (2011) New clopidogrel napadisilate salt and its solid dispersion with improved stability and bioequivalence to the commercial clopidogrel bisulphate salt in beagle dogs. Int J Pharm 415: 129-139.
6. Lee SN, Poudel BK, Tran TH, Marasini N, Pradhan R, Lee YI, Lee DW, Woo JS, Choi HG, Yong CS, Kim JO (2013) A novel surface-attached carvedilol solid dispersion with enhanced solubility and dissolution. Arch Pharm Res 36(1): 79-85.
7. Li DX, Oh YK, Lim SJ, Kim JO, Yang HJ, Sung JH, Yong CS, Choi HG (2008) Novel gelatin microcapsule with bioavailability enhancement of ibuprofen using spray drying technique. Int J Pharm 355: 277-284.
8. Li DX, Jang KY, Kang WK, Bae KJ, Lee MH, Oh YK, Jee JP, Park YJ, Oh DH, Seo YG, Kim YR, Kim JO, Woo JS, Yong CS, Choi HG (2010) Enhanced solubility and bioavailability of sibutramine base by solid dispersion system with aqueous medium. Biol Pharm Bull 33: 279-284.
9. Lim HT, Balakrishnan P, Oh DH, Joe KH, Kim YR, Hwang DH, Lee YB, Yong CS, Choi HG (2010) Development of novel sibutramine base-loaded solid dispersion with gelatin and HPMC: physicochemical characterization and pharmacokinetics in beagle dogs. Int J Pharm 397: 225-230.
10. Marasini N, Tran TH, Poudel BK, Cho HJ, Choi YK, Chi SC, Choi HG, Yong CS, Kim JO (2013) Fabrication and evaluation of pH-modulated solid dispersion for telmisartan by spray-drying technique. Int J Pharm 441: 424-432.
11. Newa M, Bhandari KH, Li DX, Kwon TH, Kim JA, Yoo BK, Woo JS, Lyoo WS, Yong CS, Choi HG (2007) Preparation, characterization and in vivo evaluation of ibuprofen binary solid dispersions with poloxamer 188. Int J Pharm 343: 228-237.
12. Oh DH, Park YJ, Kang JH, Yong CS, Choi HG (2011) Physicochemical characterization and in vivo evaluation of flurbiprofen-loaded solid dispersion without crystalline change. Drug Deliv 18(1): 46-53.
13. Oh DH, Kang JH, Kim DW, Lee BJ, Kim JO, Yong CS, Choi HG (2012) Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) prepared with hydrophilic and hydrophobic solid carrier. Int J Pharm 420(2): 412-418.
14. Park YJ, Ryu DS, Li DX, Quan QZ, Oh DH, Kim JO, Seo YG, Lee YI, Yong CS, Woo JS, Choi HG (2009) Physicochemical characterization of tacrolimus-loaded solid dispersion with sodium carboxylmethyl cellulose and sodium lauryl sulfate. Arch Pharm Res 32(6): 893-898.
15. Tran TH, Poudel BK, Marasini N, Chi SC, Choi HG, Yong CS, Kim JO (2013) Preparation and evaluation of raloxifene-loaded solid dispersion nanoparticle by spray-drying technique without an organic solvent. Int J Pharm 443: 50-57.
16. Yan YD, Sung JH, Kim KK, Kim DW, Kim JO, Lee BJ, Yong CS, Choi HG (2012) Novel valsartan-loaded solid dispersion with enhanced bioavailability and no crystalline changes. Int J Pharm 422: 202-210.
17. Yoshida T, Kurimoto I, Yoshihara K, Umejima H, Ito N, Watanabe S, Sako K, Kikuchi A (2012) Aminoalkyl methacrylate copolymers for improving the solubility of tacrolimus. I: evaluation of solid dispersion formulations. Int J Pharm 428: 18-24.
18. Zhang M, Li H, Lang B, O'Donnell K, Zhang H, Wang Z, Dong Y, Wu C, Williams RO 3rd (2012) Formulation and delivery of improved amorphous fenofibrate solid dispersions prepared by thin film freezing. Eur J Pharm Biopharm 82(3): 534-544.