New clopidogrel napadisilate salt and its solid dispersion with improved stability and bioequivalence to the commercial clopidogrel bisulphate salt in beagle dogs

International Journal of Pharmaceutics

Volumn 415, Issue 1-2, 2011, Pages 129-139

  Kim, Yong Il ^a,b   Kim, Kyung Soo ^b,c   Suh, Kwee Hyun ^b   Shanmugam, Srinivasan ^a,b   Woo, Jong Soo ^b   Yong, Chul Soon ^a   Choi, Han Gon ^a,c  

^a Yeungnam University   (South Korea)

^b Hanmi Pharmaceutical Co Ltd   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Bioavailability; Bioequivalence; Clopidogrel napadisilate; Solid dispersion; Solubility; Stability

Indexed keywords

2 (2 CHLOROPHENYL) 2 (4,5,6,7 TETRAHYDROTHIENO[3,2 C]PYRIDIN 5 YL)ACETIC ACID; CLOPIDOGREL; CLOPIDOGREL NAPADISILATE; HYDROXYPROPYLMETHYLCELLULOSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOEQUIVALENCE; DISPERSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SOLUBILITY; DRUG STABILITY; EXPERIMENTAL DOG; MALE; NONHUMAN; PRIORITY JOURNAL; SOLID DISPERSION; WATER CONTENT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; DOGS; DRUG COMPOUNDING; DRUG STABILITY; MALE; MOLECULAR STRUCTURE; PLATELET AGGREGATION INHIBITORS; POWDER DIFFRACTION; SOLUBILITY; TABLETS; TANDEM MASS SPECTROMETRY; THERAPEUTIC EQUIVALENCY; TICLOPIDINE; X-RAY DIFFRACTION;

EID: 79960165396     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.05.059     Document Type: Article

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