Enhanced solubility and bioavailability of sibutramine base by solid dispersion system with aqueous medium

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 2, 2010, Pages 279-284

  Li, Dong Xun ^a   Jang, Ki Young ^a   Kang, Wonku ^c   Bae, Kyoungjin ^c   Lee, Mann Hyung ^c   Oh, Yu Kyoung ^d   Jee, Jun Pil ^d   Park, Young Joon ^b   Oh, Dong Hoon ^a   Seo, Youn Gee ^a   Kim, Young Ran ^a   Kim, Jong Oh ^a   Woo, Jong Soo ^a   Yong, Chul Soon ^a   Choi, Han Gon ^a  

^a Yeungnam University   (South Korea)

^b Samil Pharmaceutical Co Ltd   (South Korea)

^c Catholic University of Daegu   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Pharmacokinetics; Sibutramine base; Solid dispersion; Solubility; Water

Indexed keywords

CITRIC ACID; DRUG CARRIER; HYDROXYPROPYLMETHYLCELLULOSE; POLOXAMER; SIBUTRAMINE; WATER;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; HYDROPHILICITY; MAXIMUM PLASMA CONCENTRATION; MELTING POINT; NONHUMAN; PHYSICAL CHEMISTRY; RAT; SCANNING ELECTRON MICROSCOPY; SOLID; SPRAY DRYING; SURFACE PROPERTY; X RAY DIFFRACTION;

ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CYCLOBUTANES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; WATER;

EID: 76049117937     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.279     Document Type: Article

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