CREM deficiency in mice alters the response of bone to intermittent parathyroid hormone treatment

Bone

Volumn 40, Issue 4, 2007, Pages 1135-1143

  Liu, Fei ^a   Lee, Sun Kyeong ^a   Adams, Douglas J ^a   Gronowicz, Gloria A ^a   Kream, Barbara E ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Bone mass acquisition; Bone resorption; CREM; ICER; Osteoblast; Osteoclast; PTH

Indexed keywords

COLONY STIMULATING FACTOR 1; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; REPRESSOR PROTEIN;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DENSITY; BONE MASS; BONE MINERAL; BONE TURNOVER; CALVARIA; CONTROLLED STUDY; CREM GENE; DUAL ENERGY X RAY ABSORPTIOMETRY; GENE; GENETIC TRANSCRIPTION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN INDUCTION; TIBIA; TRABECULAR BONE;

ANIMALS; BONE AND BONES; BONE DENSITY; BONE RESORPTION; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT MODULATOR; DRUG ADMINISTRATION SCHEDULE; INJECTIONS, SUBCUTANEOUS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOCLASTS; OSTEOGENESIS; PARATHYROID HORMONE; PEPTIDE FRAGMENTS;

EID: 33947134460     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2006.12.003     Document Type: Article

References (46)

1. De Cesare D., and Sassone-Corsi P. Transcriptional regulation by cyclic AMP-responsive factors. Prog. Nucleic Acid Res. Mol. Biol. 64 (2000) 343-369
2. Muller F.U., Lewin G., Matus M., Neumann J., Riemann B., Wistuba J., et al. Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2+-ATPase in mice lacking the CREM gene. FASEB J. 17 (2003) 103-105
3. Isoda T., Paolocci N., Haghighi K., Wang C., Wang Y., Georgakopoulos D., et al. Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator). FASEB J. 17 (2003) 144-151
4. Stehle J.H., Foulkes N.S., Molina C.A., Simonneaux V., Pevet P., and Sassone-Corsi P. Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland. Nature 365 (1993) 314-320
5. Maldonado R., Smadja C., Mazzucchelli C., Sassone-Corsi P., and Mazucchelli C. Altered emotional and locomotor responses in mice deficient in the transcription factor CREM. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 14094-14099
6. Nantel F., Monaco L., Foulkes N.S., Masquilier D., LeMeur M., Henriksen K., et al. Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature 380 (1996) 159-162
7. Blendy J.A., Kaestner K.H., Weinbauer G.F., Nieschlag E., and Schutz G. Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature 380 (1996) 162-165
8. Daniel P.B., Rohrbach L., and Habener J.F. Novel cyclic adenosine 3′,5′-monophosphate (cAMP) response element modulator theta isoforms expressed by two newly identified cAMP-responsive promoters active in the testis. Endocrinology 141 (2000) 3923-3930
9. Herdegen T., and Leah J.D. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res. Brain Res. Rev. 28 (1998) 370-490
10. Qi H., Li M., and Wronski T.J. A comparison of the anabolic effects of parathyroid hormone at skeletal sites with moderate and severe osteopenia in aged ovariectomized rats. J. Bone Miner. Res. 10 (1995) 948-955
11. Iida-Klein A., Zhou H., Lu S.S., Levine L.R., Ducayen-Knowles M., Dempster D.W., et al. Anabolic action of parathyroid hormone is skeletal site specific at the tissue and cellular levels in mice. J. Bone Miner. Res. 17 (2002) 808-816
12. Brommage R., Hotchkiss C.E., Lees C.J., Stancill M.W., Hock J.M., and Jerome C.P. Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys. J. Clin. Endocrinol. Metab. 84 (1999) 3757-3763
13. Body J.J., Gaich G.A., Scheele W.H., Kulkarni P.M., Miller P.D., Peretz A., et al. A randomized double-blind trial to compare the efficacy of teriparatide [recombinant human parathyroid hormone (1-34)] with alendronate in postmenopausal women with osteoporosis. J. Clin. Endocrinol. Metab. 87 (2002) 4528-4535
14. Rubin M.R., and Bilezikian J.P. The anabolic effects of parathyroid hormone therapy. Clin. Geriatr. Med. 19 (2003) 415-432
15. Swarthout J.T., D'Alonzo R.C., Selvamurugan N., and Partridge N.C. Parathyroid hormone-dependent signaling pathways regulating genes in bone cells. Gene 282 (2002) 1-17
16. Rixon R.H., Whitfield J.F., Gagnon L., Isaacs R.J., Maclean S., Chakravarthy B., et al. Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase. J. Bone Miner. Res. 9 (1994) 1179-1189
17. Armamento-Villareal R., Ziambaras K., Abbasi-Jarhomi S.H., Dimarogonas A., Halstead L., Fausto A., et al. An intact N terminus is required for the anabolic action of parathyroid hormone on adult female rats. J. Bone Miner. Res. 12 (1997) 384-392
18. Ma Y.L., Cain R.L., Halladay D.L., Yang X., Zeng Q., Miles R.R., et al. Catabolic effects of continuous human PTH (1-38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology 142 (2001) 4047-4054
19. Tetradis S., Nervina J.M., Nemoto K., and Kream B.E. Parathyroid hormone induces expression of the inducible cAMP early repressor in osteoblastic MC3T3-E1 cells and mouse calvariae. J. Bone Miner. Res. 13 (1998) 1846-1851
20. Nervina J.M., Tetradis S., Huang Y.F., Harrison D., Molina C., and Kream B.E. Expression of inducible cAMP early repressor is coupled to the cAMP-protein kinase A signaling pathway in osteoblasts. Bone 32 (2003) 483-490
21. Sher L.B., Woitge H.W., Adams D.J., Gronowicz G.A., Krozowski Z., Harrison J.R., et al. Transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone. Endocrinology 145 (2004) 922-929
22. Parfitt A.M., Drezner M.K., Glorieux F.H., Kanis J.A., Malluche H., Meunier P.J., et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2 (1987) 595-610
23. Gundberg C.M., Clough M.E., and Carpenter T.O. Development and validation of a radioimmunoassay for mouse osteocalcin: paradoxical response in the Hyp mouse. Endocrinology 130 (1992) 1909-1915
24. Lee S.K., and Lorenzo J.A. Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation. Endocrinology 140 (1999) 3552-3561
25. Takasu H., and Bringhurst F.R. Type-1 parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH(1-34). Endocrinology 139 (1998) 4293-4299
26. Frolik C.A., Cain R.L., Sato M., Harvey A.K., Chandrasekhar S., Black E.C., et al. Comparison of recombinant human PTH(1-34) (LY333334) with a C-terminally substituted analog of human PTH-related protein(1-34) (RS-66271): In vitro activity and in vivo pharmacological effects in rats. J. Bone Miner. Res. 14 (1999) 163-172
27. Jilka R.L., Weinstein R.S., Bellido T., Roberson P., Parfitt A.M., and Manolagas S.C. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J. Clin. Invest. 104 (1999) 439-446
28. Zhou H., Iida-Klein A., Lu S.S., Ducayen-M. Knowles L.R., Levine D.W., and Dempster R. Anabolic action of parathyroid hormone on cortical and cancellous bone differs between axial and appendicular skeletal sites in mice. Bone 32 (2003) 513-520
29. Martin T.J. Does bone resorption inhibition affect the anabolic response to parathyroid hormone?. Trends Endocrinol. Metab. 15 (2004) 49-50
30. Qin L., Raggatt L.J., and Partridge N.C. Parathyroid hormone: a double-edged sword for bone metabolism. Trends Endocrinol. Metab. 15 (2004) 60-65
31. Dobnig H., and Turner R.T. Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells. Endocrinology 136 (1995) 3632-3638
32. Locklin R.M., Khosla S., Turner R.T., and Riggs B.L. Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone. J. Cell. Biochem. 89 (2003) 180-190
33. Wang Z.Q., Ovitt C., Grigoriadis A.E., Mohle-Steinlein U., Ruther U., and Wagner E.F. Bone and haematopoietic defects in mice lacking c-fos. Nature 360 (1992) 741-745
34. Okada Y., Pilbeam C., Raisz L., and Tanaka Y. Role of cyclooxygenase-2 in bone resorption. J. UOEH 25 (2003) 185-195
35. Ono K., Akatsu T., Murakami T., Kitamura R., Yamamoto M., Shinomiya N., et al. Involvement of cyclo-oxygenase-2 in osteoclast formation and bone destruction in bone metastasis of mammary carcinoma cell lines. J. Bone Miner. Res. 17 (2002) 774-781
36. Gao Y., Morita I., Maruo N., Kubota T., Murota S., and Aso T. Expression of IL-6 receptor and GP130 in mouse bone marrow cells during osteoclast differentiation. Bone 22 (1998) 487-493
37. Kurihara N., Bertolini D., Suda T., Akiyama Y., and Roodman G.D. IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J. Immunol. 144 (1990) 4226-4230
38. Menaa C., Kurihara N., and Roodman G.D. CFU-GM-derived cells form osteoclasts at a very high efficiency. Biochem. Biophys. Res. Commun. 267 (2000) 943-946
39. Liu F., Huang Y.F., and Kream B.E. Identification of novel cAMP responsive element modulator (CREM) isoforms expressed by osteoblasts. Calcif. Tissue Int. (2005) [Jul 28]
40. Tinti C., Conti B., Cubells J.F., Kim K.S., Baker H., and Joh T.H. Inducible cAMP early repressor can modulate tyrosine hydroxylase gene expression after stimulation of cAMP synthesis. J. Biol. Chem. 271 (1996) 25375-25381
41. Pfeffer M., Maronde E., Korf H.W., and Stehle J.H. Antisense experiments reveal molecular details on mechanisms of ICER suppressing cAMP-inducible genes in rat pinealocytes. J. Pineal Res. 29 (2000) 24-33
42. Bodor J., Bodorova J., Bare C., Hodge D.L., Young H.A., and Gress R.E. Differential inducibility of the transcriptional repressor ICER and its role in modulation of Fas ligand expression in T and NK lymphocytes. Eur. J. Immunol. 32 (2002) 203-212
43. Bodor J., and Habener J.F. Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. J. Biol. Chem. 273 (1998) 9544-9551
44. Mao D., Warner E.A., Gurwitch S.A., and Dowd D.R. Differential regulation and transcriptional control of immediate early gene expression in forskolin-treated WEHI7.2 thymoma cells. Mol. Endocrinol. 12 (1998) 492-503
45. Lamas M., and Sassone-Corsi P. The dynamics of the transcriptional response to cyclic adenosine 3′,5′-monophosphate: recurrent inducibility and refractory phase. Mol. Endocrinol. 11 (1997) 1415-1424
46. Qin L., Qiu P., Wang L., Li X., Swarthout J.T., Soteropoulos P., Tolias P., and Partridge N.C. Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblasts revealed by microarray and bioinformatics. J. Biol. Chem. 278 (2003) 19723-19731