β 2-agonists upregulate PDE4 mRNA but not protein or activity in human airway smooth muscle cells from asthmatic and nonasthmatic volunteers

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 302, Issue 3, 2012, Pages

  Niimi, Kyoko ^a   Ge, Qi ^a   Moir, Lyn M ^a,b   Ammit, Alaina J ^a   Trian, Thomas ^a   Burgess, Janette K ^a,b   Black, Judith L ^a,b   Oliver, Brian G G ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b CRC for Asthma and Airways   (Australia)

Author keywords

2 adrenergic receptor agonist; Asthma; Phosphodiesterase

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CYCLIC AMP; DACTINOMYCIN; FORMOTEROL; INTERLEUKIN 6; MESSENGER RNA; PHOSPHODIESTERASE IV; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; SALBUTAMOL; SALMETEROL; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ARTICLE; ASTHMA; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR UPREGULATION; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ADULT; AGED; AGED, 80 AND OVER; ASTHMA; BUDESONIDE; CASE-CONTROL STUDIES; CELL ADHESION MOLECULES; CELLS, CULTURED; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; ETHANOLAMINES; FEMALE; GLUCOCORTICOIDS; HUMANS; INTERLEUKIN-6; ISOENZYMES; MALE; MICROFILAMENT PROTEINS; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; PHOSPHOPROTEINS; PHOSPHORYLATION; RECEPTORS, ADRENERGIC, BETA-2; RNA, MESSENGER; TACHYPHYLAXIS; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 84856633443     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00163.2011     Document Type: Article

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